NO20052995L - 1,5-diaryl-pyrrol-3-karboksamid-derivater, og deres anvendelse som kannabinoid reseptormodulatorer. - Google Patents

1,5-diaryl-pyrrol-3-karboksamid-derivater, og deres anvendelse som kannabinoid reseptormodulatorer.

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Publication number
NO20052995L
NO20052995L NO20052995A NO20052995A NO20052995L NO 20052995 L NO20052995 L NO 20052995L NO 20052995 A NO20052995 A NO 20052995A NO 20052995 A NO20052995 A NO 20052995A NO 20052995 L NO20052995 L NO 20052995L
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group
alkyl group
optionally substituted
alkyl
heterocyclic group
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NO20052995A
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NO20052995D0 (no
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Stig Jonas Bostrom
Anna Ingrid Kristina Berggren
Stig Thomas Elebring
Peter Greasley
Johan Michael Wilstermann
Leifeng Cheng
Mats Nagard
Emma Terricabras
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Astrazeneca Ab
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Publication of NO20052995D0 publication Critical patent/NO20052995D0/no
Publication of NO20052995L publication Critical patent/NO20052995L/no

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Foreliggende oppfinnelse angår en forbindelse med formel I hvor R1 og R2 uavhengig representerer fenyl, tienyl eller pyridyl som hver eventuelt er substituert med én, to eller tre grupper representert ved Z; og R3er H, en C1-3alkylgruppe, en C1-3alkoksymetylgruppe, trifluormetyl, en hydroksyC1-3alkylgruppe, en aminoC1-3alkylgruppe, C1-3alkoksykarbonyl, karboksy, cyano, karbamoyl, mono- eller di- C1-3alkylkarbamoyl, acetyl eller hydrazinokarbonyl med formelen CONHNRaRb hvor Ra og Rb er som definert for henholdsvis R4 og R5; X er CO eller SO2; Y er fraværende eller representerer NH eventuelt substituert med en C1-3alkylgruppe; R4 og R5 representerer uavhengig: en C1-6alkylgruppe; en (amino)C1-4alkylgruppe hvor amino eventuelt er substituert med én eller flere C1-3alkylgrupper; en eventuelt substituert ikke-aromatisk C3-15karbocyklisk gruppe; en (C3-12cykloalkyl)C1-3a1kylgruppe; en gruppe -(CH2)r(fenyl )5; naftyl; antracenyl; en mettet 5- til 8-leddet heterocyklisk gruppe inneholdende ett nitrogen og eventuelt ett av de følgende: oksygen, svovel eller et ytterligere nitrogen hvor den heterocykliske gruppen eventuelt er substituert; 1-adamantylmetyl; en gruppe -(CH2)Het, hvor Het representerer en aromatisk heterocyklisk gruppe eventuelt substituert; eller R4 representerer H og R5 er som definert ovenfor; eller R og R sammen med nitrogenatomet som de er bundet til representerer en mettet 5- til 8-leddet heterocyklisk gruppe; R6 er H, en C1-3alkylgruppe, en C1-3alkoksymetylgruppe, trifluormetyl, en hydroksyC1-3alkylgruppe, C1-3alkoksykarbonyl, karboksy, cyano, karbamoyl, mono- eller di- C1-3alkylkarbamoyl, acetyl eller hydrazinokarbonyl med formelen -CONHNRaRb; med forbehold; fremgangsmåter for fremstilling av slike forbindelser, anvendelse av dem ved behandling av fedme, psykiatriske og nevrologiske lidelser, spesielt fedme, metoder for deres terapeutiske anvendelse og farmasøytiske preparater inneholdende dem.
NO20052995A 2002-12-24 2005-06-17 1,5-diaryl-pyrrol-3-karboksamid-derivater, og deres anvendelse som kannabinoid reseptormodulatorer. NO20052995L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0230088.7A GB0230088D0 (en) 2002-12-24 2002-12-24 Therapeutic agents
PCT/GB2003/005569 WO2004058249A1 (en) 2002-12-24 2003-12-18 1,5-diaryl-pyrrole-3-carboxamide derivatives and their use as cannabinoid receptor modulators

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NO20052995D0 NO20052995D0 (no) 2005-06-17
NO20052995L true NO20052995L (no) 2005-07-22

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Country Status (20)

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US (1) US20060122230A1 (no)
EP (1) EP1578417A1 (no)
JP (1) JP2006513201A (no)
KR (1) KR20050086931A (no)
CN (1) CN1753668A (no)
AR (1) AR042658A1 (no)
AU (1) AU2003290292A1 (no)
BR (1) BR0317705A (no)
CA (1) CA2511601A1 (no)
CL (1) CL2003002720A1 (no)
GB (1) GB0230088D0 (no)
IS (1) IS7944A (no)
MX (1) MXPA05006919A (no)
NO (1) NO20052995L (no)
PL (1) PL377296A1 (no)
RU (1) RU2005117783A (no)
TW (1) TW200503692A (no)
UY (1) UY28144A1 (no)
WO (1) WO2004058249A1 (no)
ZA (1) ZA200504822B (no)

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UY28144A1 (es) 2004-07-30
MXPA05006919A (es) 2005-08-18
BR0317705A (pt) 2005-11-22
EP1578417A1 (en) 2005-09-28
AU2003290292A1 (en) 2004-07-22
RU2005117783A (ru) 2006-02-10
JP2006513201A (ja) 2006-04-20
KR20050086931A (ko) 2005-08-30
WO2004058249A1 (en) 2004-07-15
NO20052995D0 (no) 2005-06-17
ZA200504822B (en) 2006-03-29
TW200503692A (en) 2005-02-01
GB0230088D0 (en) 2003-01-29
AR042658A1 (es) 2005-06-29
CN1753668A (zh) 2006-03-29
IS7944A (is) 2005-07-18
PL377296A1 (pl) 2006-01-23
CA2511601A1 (en) 2004-07-15
US20060122230A1 (en) 2006-06-08

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