NO20051010L - Triazolderivater som transformerende vekst faktor (TGF) inhibitorer - Google Patents

Triazolderivater som transformerende vekst faktor (TGF) inhibitorer

Info

Publication number
NO20051010L
NO20051010L NO20051010A NO20051010A NO20051010L NO 20051010 L NO20051010 L NO 20051010L NO 20051010 A NO20051010 A NO 20051010A NO 20051010 A NO20051010 A NO 20051010A NO 20051010 L NO20051010 L NO 20051010L
Authority
NO
Norway
Prior art keywords
tgf
growth factor
transforming growth
triazole derivatives
inhibitors
Prior art date
Application number
NO20051010A
Other languages
English (en)
Inventor
Michael John Munchhof
Laura Cook Blumberg
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20051010L publication Critical patent/NO20051010L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Nye triazolderivater med formel (la-c), mellomprodukter for deres fremstilling, farmasøytiske preparater inneholdende dem og medisinsk anvendelse av dem er beskrevet. Forbindelsene ifølge foreliggende oppfinnelse er kraftige inhibitorer av transformerende vekstfaktor ("TGF")-ß-signaliseringsbane. De er anvendelige ved behandling av forskjellige TGFrelaterte sykdomstilstander omfattende for eksempel kreft og fibrotiske sykdommer.
NO20051010A 2002-09-18 2005-02-24 Triazolderivater som transformerende vekst faktor (TGF) inhibitorer NO20051010L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41207902P 2002-09-18 2002-09-18
US48453503P 2003-07-02 2003-07-02
PCT/IB2003/003825 WO2004026307A1 (en) 2002-09-18 2003-09-08 Triazole derivatives as transforming growth factor (tgf) inhibitors

Publications (1)

Publication Number Publication Date
NO20051010L true NO20051010L (no) 2005-05-31

Family

ID=32033582

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051010A NO20051010L (no) 2002-09-18 2005-02-24 Triazolderivater som transformerende vekst faktor (TGF) inhibitorer

Country Status (25)

Country Link
US (2) US7053095B2 (no)
EP (1) EP1542685A1 (no)
JP (1) JP2006502236A (no)
KR (1) KR20050057393A (no)
CN (1) CN1681502A (no)
AP (1) AP2005003260A0 (no)
AR (1) AR041276A1 (no)
AU (1) AU2003260810A1 (no)
BR (1) BR0314577A (no)
CA (1) CA2497971A1 (no)
CO (1) CO5540390A2 (no)
EA (1) EA200500376A1 (no)
EC (1) ECSP055681A (no)
HR (1) HRP20050251A2 (no)
IS (1) IS7713A (no)
MA (1) MA27442A1 (no)
MX (1) MXPA05002982A (no)
NO (1) NO20051010L (no)
OA (1) OA12927A (no)
PA (1) PA8583401A1 (no)
PE (1) PE20050074A1 (no)
PL (1) PL375974A1 (no)
TW (1) TW200412346A (no)
UY (1) UY27981A1 (no)
WO (1) WO2004026307A1 (no)

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US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
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MX2019007890A (es) 2016-12-30 2020-01-20 Frequency Therapeutics Inc Compuestos de 1h-pirrol-2,5-diona y metodos de uso de los mismos para inducir la auto-renovacion de celulas madre/progenitoras de soporte.
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Also Published As

Publication number Publication date
IS7713A (is) 2005-02-24
AP2005003260A0 (en) 2005-03-31
CN1681502A (zh) 2005-10-12
BR0314577A (pt) 2005-08-09
HRP20050251A2 (en) 2005-10-31
KR20050057393A (ko) 2005-06-16
ECSP055681A (es) 2005-05-30
US20040110798A1 (en) 2004-06-10
AR041276A1 (es) 2005-05-11
PE20050074A1 (es) 2005-03-21
JP2006502236A (ja) 2006-01-19
CA2497971A1 (en) 2004-04-01
US20060128761A1 (en) 2006-06-15
CO5540390A2 (es) 2005-07-29
US7053095B2 (en) 2006-05-30
OA12927A (en) 2006-10-13
UY27981A1 (es) 2004-04-30
MXPA05002982A (es) 2005-06-22
AU2003260810A1 (en) 2004-04-08
PA8583401A1 (es) 2004-04-23
MA27442A1 (fr) 2005-07-01
EP1542685A1 (en) 2005-06-22
EA200500376A1 (ru) 2005-08-25
TW200412346A (en) 2004-07-16
PL375974A1 (en) 2005-12-12
WO2004026307A1 (en) 2004-04-01

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