NO20050832L - Selektive estrogenreseptormodulatorer inneholdende en fenylsulonylgruppe - Google Patents

Selektive estrogenreseptormodulatorer inneholdende en fenylsulonylgruppe

Info

Publication number
NO20050832L
NO20050832L NO20050832A NO20050832A NO20050832L NO 20050832 L NO20050832 L NO 20050832L NO 20050832 A NO20050832 A NO 20050832A NO 20050832 A NO20050832 A NO 20050832A NO 20050832 L NO20050832 L NO 20050832L
Authority
NO
Norway
Prior art keywords
estrogen receptor
selective estrogen
phenylsulonyl
group
receptor modulators
Prior art date
Application number
NO20050832A
Other languages
English (en)
Inventor
Timothy Alan Shepherd
Scott Alan Frank
Jeffrey Alan Dodge
Scott Alan Jones
Owen Brendan Wallace
Robert Dean Dally
Kin Chiu Fong
Conrad Wilson Hummel
George Sal Lewis
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO20050832L publication Critical patent/NO20050832L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Foreliggende oppfinnelse angår en selektiv østrogenreseptormodulator med formel I eller et fermasøytisk syreaddisjonssalt derav, anvendelig for eksempel ved behandling av endometriose og/eller livmorleiomyoma/Ieiomyomata.
NO20050832A 2002-07-22 2005-02-16 Selektive estrogenreseptormodulatorer inneholdende en fenylsulonylgruppe NO20050832L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39786902P 2002-07-22 2002-07-22
US45023303P 2003-02-25 2003-02-25
PCT/IB2003/003349 WO2004009086A1 (en) 2002-07-22 2003-07-16 Selective estrogen receptor modulators containing a phenylsulfonyl group

Publications (1)

Publication Number Publication Date
NO20050832L true NO20050832L (no) 2005-02-16

Family

ID=30773044

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050832A NO20050832L (no) 2002-07-22 2005-02-16 Selektive estrogenreseptormodulatorer inneholdende en fenylsulonylgruppe

Country Status (25)

Country Link
US (2) US7399867B2 (no)
EP (1) EP1530470B9 (no)
JP (2) JP4656939B2 (no)
CN (1) CN1668303B (no)
AT (1) ATE433322T1 (no)
AU (1) AU2003253129B2 (no)
BR (1) BR0312675A (no)
CA (1) CA2490580C (no)
CO (1) CO5680445A2 (no)
CR (1) CR7657A (no)
DE (1) DE60327931D1 (no)
EA (1) EA008024B1 (no)
EC (1) ECSP055549A (no)
ES (1) ES2326593T3 (no)
HK (1) HK1078003A1 (no)
HR (1) HRP20041233A2 (no)
IL (1) IL165745A0 (no)
MX (1) MXPA05000898A (no)
MY (1) MY141879A (no)
NO (1) NO20050832L (no)
NZ (1) NZ537138A (no)
PE (1) PE20040678A1 (no)
PL (1) PL374845A1 (no)
TW (1) TWI314860B (no)
WO (1) WO2004009086A1 (no)

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CN1910167B (zh) * 2004-01-22 2011-08-10 伊莱利利公司 用于治疗血管舒缩症状的选择性***受体调节剂
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KR101319675B1 (ko) * 2008-09-29 2013-10-22 일라이 릴리 앤드 캄파니 골관절염의 치료를 위한 선택적 에스트로겐 수용체 조절자
DE102008057230A1 (de) * 2008-11-11 2010-05-12 Bayer Schering Pharma Aktiengesellschaft Synergistische pharmazeutische Kombination mit einem Estrogenrezeptorantagonisten und einem Progestin
EP2406230A1 (en) 2009-03-11 2012-01-18 Pfizer Inc. Substituted indazole amides and their use as glucokinase activators
KR20190042762A (ko) 2010-06-16 2019-04-24 앙도르쉐르슈 인코포레이티드 에스트로겐-관련 질병의 치료 또는 예방 방법
JP6292744B2 (ja) * 2012-09-19 2018-03-14 富士カプセル株式会社 医薬品組成物
KR102279999B1 (ko) 2013-02-19 2021-07-22 노파르티스 아게 선택적 에스트로겐 수용체 분해제로서의 벤조티오펜 유도체 및 그의 조성물
ES2953140T3 (es) 2019-03-08 2023-11-08 Syngenta Crop Protection Ag Compuestos de azol-amida activos de manera plaguicida
CN113631552A (zh) 2019-03-20 2021-11-09 先正达农作物保护股份公司 杀有害生物活性的唑酰胺化合物
WO2020193341A1 (en) 2019-03-22 2020-10-01 Syngenta Crop Protection Ag N-[1-(5-bromo-2-pyrimidin-2-yl-1,2,4-triazol-3-yl)ethyl]-2-cyclopropyl-6-(trifluoromethyl)pyridine-4-carboxamide derivatives and related compounds as insecticides
TW202102489A (zh) 2019-03-29 2021-01-16 瑞士商先正達農作物保護公司 殺有害生物活性之二𠯤-醯胺化合物
CN113661165A (zh) 2019-04-05 2021-11-16 先正达农作物保护股份公司 杀有害生物活性的二嗪-酰胺化合物
CN114269732A (zh) 2019-08-23 2022-04-01 先正达农作物保护股份公司 杀有害生物活性的吡嗪-酰胺化合物
CN110526881B (zh) * 2019-08-27 2020-09-22 河南省锐达医药科技有限公司 一种萘胺类化合物及其生物学可接受的盐，其制备方法和应用
WO2021170881A1 (en) 2020-02-27 2021-09-02 Syngenta Crop Protection Ag Pesticidally active diazine-bisamide compounds
WO2022237904A1 (zh) * 2021-05-14 2022-11-17 江苏亚虹医药科技股份有限公司 一种含萘环的化合物、含其的药物组合物及其应用
BR112023025644A2 (pt) 2021-06-09 2024-02-27 Syngenta Crop Protection Ag Compostos de diazina-amida pesticidamente ativos
WO2023283315A1 (en) * 2021-07-07 2023-01-12 South Dakota Board Of Regents Compositions and methods for treatment of cervical and ovarian cancer
WO2024042187A1 (en) 2022-08-25 2024-02-29 Sanofi Novel substituted benzothiophene-6-carboxylic acid derivatives, processes for their preparation and therapeutic uses thereof

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Also Published As

Publication number Publication date
CN1668303A (zh) 2005-09-14
WO2004009086A1 (en) 2004-01-29
JP2010195820A (ja) 2010-09-09
EP1530470A1 (en) 2005-05-18
CN1668303B (zh) 2010-10-27
CR7657A (es) 2005-07-13
EA200500248A1 (ru) 2005-06-30
IL165745A0 (en) 2006-01-15
JP4656939B2 (ja) 2011-03-23
TW200414901A (en) 2004-08-16
HRP20041233A2 (en) 2005-02-28
ATE433322T1 (de) 2009-06-15
PL374845A1 (en) 2005-11-14
MXPA05000898A (es) 2005-05-16
JP5220800B2 (ja) 2013-06-26
ES2326593T3 (es) 2009-10-15
US7399867B2 (en) 2008-07-15
EP1530470B9 (en) 2010-04-07
US20080214612A1 (en) 2008-09-04
CO5680445A2 (es) 2006-09-29
EA008024B1 (ru) 2007-02-27
ECSP055549A (es) 2005-03-10
JP2005538089A (ja) 2005-12-15
PE20040678A1 (es) 2004-10-06
CA2490580C (en) 2012-12-11
BR0312675A (pt) 2005-05-03
US7585977B2 (en) 2009-09-08
NZ537138A (en) 2007-11-30
CA2490580A1 (en) 2004-01-29
DE60327931D1 (de) 2009-07-23
AU2003253129A1 (en) 2004-02-09
AU2003253129B2 (en) 2008-12-11
US20060183736A1 (en) 2006-08-17
EP1530470B1 (en) 2009-06-10
MY141879A (en) 2010-07-16
HK1078003A1 (en) 2006-03-03
TWI314860B (en) 2009-09-21

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