NO20045073L - Fremgangsmate for fremstilling av krystaller, derved oppnaelige krystaller og deres anvendelse i farmasoytiske formuleringer - Google Patents
Fremgangsmate for fremstilling av krystaller, derved oppnaelige krystaller og deres anvendelse i farmasoytiske formuleringerInfo
- Publication number
- NO20045073L NO20045073L NO20045073A NO20045073A NO20045073L NO 20045073 L NO20045073 L NO 20045073L NO 20045073 A NO20045073 A NO 20045073A NO 20045073 A NO20045073 A NO 20045073A NO 20045073 L NO20045073 L NO 20045073L
- Authority
- NO
- Norway
- Prior art keywords
- crystals
- mum
- obtainable
- preparation
- pharmaceutical formulations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Dermatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
Abstract
Det er beskrevet en fremgangsmåte for fremstilling av krystaller hvis gjennomsnittlige partikkelstørrelse ligger innenfor et på forhånd bestemt område mens den maksimale partikkelstørrelsen ikke overskrider en gitt verdi. Ved fremgangsmåten ifølge oppflrmelsen underkastes en overmettet oppløsning av spesielt 1 ip- benzaldoxim-estta-4,9-dien våtmaling under krystalhsasjon ved hjelp av en våtmalingsirmretning, hvorved det oppnås en primærkomsuspensjon. Det er videre beskrevet krystaller som oppnås ved frem- gangsmåten ifølge oppfmnelsen og farmasøytiske formuleringer irmeholdende nevnte krystaller.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10218109A DE10218109A1 (de) | 2002-04-23 | 2002-04-23 | Verfahren zum Herstellen von Kristallen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
PCT/EP2003/005102 WO2003090714A1 (de) | 2002-04-23 | 2003-04-22 | Verfahren zum herstellen von kristallen, danach erhältliche kristalle und deren verwendung in pharmazeutischen formulierungen |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20045073L true NO20045073L (no) | 2004-11-22 |
Family
ID=29264788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20045073A NO20045073L (no) | 2002-04-23 | 2004-11-22 | Fremgangsmate for fremstilling av krystaller, derved oppnaelige krystaller og deres anvendelse i farmasoytiske formuleringer |
Country Status (20)
Country | Link |
---|---|
US (1) | US7192942B2 (no) |
EP (1) | EP1496865B1 (no) |
JP (1) | JP4490114B2 (no) |
KR (1) | KR20040106379A (no) |
CN (1) | CN1646101A (no) |
AT (1) | ATE332686T1 (no) |
AU (1) | AU2003240652A1 (no) |
BR (1) | BR0308744A (no) |
CA (1) | CA2479991C (no) |
DE (2) | DE10218109A1 (no) |
DK (1) | DK1496865T3 (no) |
ES (1) | ES2268368T3 (no) |
IL (1) | IL163985A0 (no) |
MX (1) | MXPA04010468A (no) |
NO (1) | NO20045073L (no) |
PL (1) | PL371339A1 (no) |
PT (1) | PT1496865E (no) |
RU (1) | RU2314315C2 (no) |
WO (1) | WO2003090714A1 (no) |
ZA (1) | ZA200409395B (no) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10218107A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen von Steroiden, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
KR20080110807A (ko) * | 2006-03-14 | 2008-12-19 | 머크 앤드 캄파니 인코포레이티드 | 마이크로 분쇄 및 마이크로-시드상의 결정화에 의한 결정성유기 미세입자 조성물의 생성 방법과 장치 및 이의 용도 |
DE102009034368A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034366A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034367A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
DE102009034526A1 (de) | 2009-07-21 | 2011-02-10 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
DE102010007719A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
DE102010007722A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
RU2464321C2 (ru) * | 2010-12-20 | 2012-10-20 | Федеральное государственное образовательное учреждение высшего профессионального образования "Вологодская государственная молочнохозяйственная академия им. Н.В. Верещагина" | Способ производства молочного сахара |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
ES2885523T3 (es) * | 2011-11-23 | 2021-12-14 | Therapeuticsmd Inc | Formulaciones y terapias de reposición hormonal de combinación naturales |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
EP4151219A4 (en) | 2020-05-15 | 2024-05-15 | Shionogi & Co | DRUG COMPOSITION WITH INHIBITED IMPURITIES PRODUCTION |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD275398B5 (de) | 1988-09-07 | 1993-12-23 | Dresden Arzneimittel | Verfahren zur herstellung von feinverteilten pharmazeutischen wirkstoffen |
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
AU660852B2 (en) * | 1992-11-25 | 1995-07-06 | Elan Pharma International Limited | Method of grinding pharmaceutical substances |
DE4332283A1 (de) * | 1993-09-20 | 1995-04-13 | Jenapharm Gmbh | Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
KR0151363B1 (ko) * | 1993-12-27 | 1998-10-01 | 시모무라 스스무 | 4-히드록시-4'-이소프로폭시디페닐 술폰 현상조성물, 습식분쇄방법, 및 분산액 |
US5718388A (en) * | 1994-05-25 | 1998-02-17 | Eastman Kodak | Continuous method of grinding pharmaceutical substances |
US5534270A (en) * | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
AU8145198A (en) | 1997-06-16 | 1999-01-04 | Vertex Pharmaceuticals Incorporated | Methods of increasing the bioavailability of stable crystal polymorphs of a compound |
EA003837B1 (ru) * | 1998-12-25 | 2003-10-30 | Дайити Файн Кемикал Ко., Лтд. | Способ получения пантотената кальция |
EP1157996A1 (de) * | 2000-05-23 | 2001-11-28 | JENAPHARM GmbH | Neue Festkörperformen des Mesoprogestins 11Beta-[4E-(Hydroxyiminomethyl)-phenyl]-17Alpha-methoxymethyl-17Beta-methoxy-estra-4,9-dien-3-on |
DE10218107A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen von Steroiden, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
-
2002
- 2002-04-23 DE DE10218109A patent/DE10218109A1/de not_active Ceased
-
2003
- 2003-04-17 US US10/417,559 patent/US7192942B2/en not_active Expired - Lifetime
- 2003-04-22 RU RU2004134327/04A patent/RU2314315C2/ru not_active IP Right Cessation
- 2003-04-22 ES ES03730046T patent/ES2268368T3/es not_active Expired - Lifetime
- 2003-04-22 KR KR10-2004-7017078A patent/KR20040106379A/ko not_active Application Discontinuation
- 2003-04-22 AU AU2003240652A patent/AU2003240652A1/en not_active Abandoned
- 2003-04-22 EP EP03730046A patent/EP1496865B1/de not_active Expired - Lifetime
- 2003-04-22 PL PL03371339A patent/PL371339A1/xx not_active Application Discontinuation
- 2003-04-22 MX MXPA04010468A patent/MXPA04010468A/es active IP Right Grant
- 2003-04-22 CN CNA038090341A patent/CN1646101A/zh active Pending
- 2003-04-22 PT PT03730046T patent/PT1496865E/pt unknown
- 2003-04-22 CA CA2479991A patent/CA2479991C/en not_active Expired - Lifetime
- 2003-04-22 BR BR0308744-1A patent/BR0308744A/pt not_active IP Right Cessation
- 2003-04-22 IL IL16398503A patent/IL163985A0/xx unknown
- 2003-04-22 DE DE50304230T patent/DE50304230D1/de not_active Expired - Lifetime
- 2003-04-22 DK DK03730046T patent/DK1496865T3/da active
- 2003-04-22 JP JP2003587351A patent/JP4490114B2/ja not_active Expired - Fee Related
- 2003-04-22 WO PCT/EP2003/005102 patent/WO2003090714A1/de active IP Right Grant
- 2003-04-22 AT AT03730046T patent/ATE332686T1/de not_active IP Right Cessation
-
2004
- 2004-11-22 ZA ZA200409395A patent/ZA200409395B/xx unknown
- 2004-11-22 NO NO20045073A patent/NO20045073L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US7192942B2 (en) | 2007-03-20 |
CA2479991C (en) | 2010-06-22 |
MXPA04010468A (es) | 2004-12-13 |
WO2003090714A1 (de) | 2003-11-06 |
IL163985A0 (en) | 2005-12-18 |
PL371339A1 (en) | 2005-06-13 |
ATE332686T1 (de) | 2006-08-15 |
DE10218109A1 (de) | 2003-11-20 |
DK1496865T3 (da) | 2006-10-09 |
CA2479991A1 (en) | 2003-11-06 |
DE50304230D1 (de) | 2006-08-24 |
JP4490114B2 (ja) | 2010-06-23 |
BR0308744A (pt) | 2005-01-11 |
ZA200409395B (en) | 2006-02-22 |
RU2314315C2 (ru) | 2008-01-10 |
RU2004134327A (ru) | 2006-02-27 |
PT1496865E (pt) | 2006-10-31 |
CN1646101A (zh) | 2005-07-27 |
EP1496865A1 (de) | 2005-01-19 |
AU2003240652A1 (en) | 2003-11-10 |
EP1496865B1 (de) | 2006-07-12 |
KR20040106379A (ko) | 2004-12-17 |
ES2268368T3 (es) | 2007-03-16 |
JP2005523333A (ja) | 2005-08-04 |
US20030225050A1 (en) | 2003-12-04 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |