NO20035761L - T1R heterooligomere smaksreseptorer og cellelinjer som uttrykker nevnte reseptorer og anvendelse derav for identifisering av smaksforbindelser - Google Patents

T1R heterooligomere smaksreseptorer og cellelinjer som uttrykker nevnte reseptorer og anvendelse derav for identifisering av smaksforbindelser

Info

Publication number
NO20035761L
NO20035761L NO20035761A NO20035761A NO20035761L NO 20035761 L NO20035761 L NO 20035761L NO 20035761 A NO20035761 A NO 20035761A NO 20035761 A NO20035761 A NO 20035761A NO 20035761 L NO20035761 L NO 20035761L
Authority
NO
Norway
Prior art keywords
receptors
taste
sweet
umami
discovered
Prior art date
Application number
NO20035761A
Other languages
English (en)
Inventor
Jon Elliot Adler
Lena Staszewski
Xiaodong Li
Shawn O'connell
Sergey Zozulya
Mark Zoller
Hong Xu
Fernando Echeverri
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29588022&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20035761(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/897,427 external-priority patent/US6955887B2/en
Priority claimed from US10/035,045 external-priority patent/US7241880B2/en
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of NO20035761L publication Critical patent/NO20035761L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Det er oppdaget at TIR-reseptorer går sammen om å danne funksjonelle smaksreseptorer.Særlig er det oppdaget at koekspresjon av T1R1 og T1R3 resulterer i en smaksreseptor som responderer på umamismaksstimuli, inklusivt mononatriumglutamat. Videre er det oppdaget at koekspresjon av T1R2- og T1R3 reseptorer resulterer i en smaksreseptor som responderer på søtsmaksstimuli,. inklusivt naturlig forekommende og kunstige søtningsmidler. Dessuten beskrives anvendelsen av heterooligomere smaksreseptorer omfattende T1R1/T1R3 og T1R2/T1R3 i tester for å identifisere forbindelser som responderer henholdsvis på umamismaksstimuli og søtsmaksstimuli.Videre beskrives konstitutive cellelinjer som stabilt eller transient koeksprimerer en kombinasjon av T1R1 og T1R3, eller T1R2 og T1R3, under konstitutive eller induserbare betingelser. Anvendelsen av disse cellelinjene i cellebaserte tester for å identifisere umamismaks- og søtsmaksmodulerende forbindelser, beskrives også, særlig massescreeningstester som påviser reseptoraktivitet ved bruk av fiuorometrisk avbildning. Endelig beskrives oppdagelsen av at enkelte forbindelser, feks. lactisol, inhiberer både aktivitetene av humane T1R2/ T1R3- og TlRl/TlR3-reseptorer, og følgelig søt- og umami-smaken, hvilket tyder på at disse reseptorene kan være de eneste søt- og umami-reseptorer.
NO20035761A 2001-06-26 2003-12-22 T1R heterooligomere smaksreseptorer og cellelinjer som uttrykker nevnte reseptorer og anvendelse derav for identifisering av smaksforbindelser NO20035761L (no)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US30043401P 2001-06-26 2001-06-26
US09/897,427 US6955887B2 (en) 2001-03-30 2001-07-03 Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling
US30474901P 2001-07-13 2001-07-13
US31049301P 2001-08-08 2001-08-08
US33177101P 2001-11-21 2001-11-21
US33947201P 2001-12-14 2001-12-14
US10/035,045 US7241880B2 (en) 2001-01-03 2002-01-03 T1R taste receptors and genes encoding same
US37209002P 2002-04-15 2002-04-15
US37414302P 2002-04-22 2002-04-22
US37452202P 2002-04-23 2002-04-23
PCT/US2002/019970 WO2003001876A2 (en) 2001-06-26 2002-06-26 T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds

Publications (1)

Publication Number Publication Date
NO20035761L true NO20035761L (no) 2004-02-20

Family

ID=29588022

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20035761A NO20035761L (no) 2001-06-26 2003-12-22 T1R heterooligomere smaksreseptorer og cellelinjer som uttrykker nevnte reseptorer og anvendelse derav for identifisering av smaksforbindelser

Country Status (6)

Country Link
EP (4) EP2293067B1 (no)
CN (1) CN100489102C (no)
AU (1) AU2002326315B2 (no)
CA (1) CA2451317C (no)
NO (1) NO20035761L (no)
WO (1) WO2003001876A2 (no)

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Also Published As

Publication number Publication date
CN100489102C (zh) 2009-05-20
CN1520516A (zh) 2004-08-11
EP2003451A2 (en) 2008-12-17
EP2293067A2 (en) 2011-03-09
EP2327985A3 (en) 2012-01-18
WO2003001876A8 (en) 2004-08-19
EP1412750B1 (en) 2012-05-23
EP1412750A2 (en) 2004-04-28
EP2293067A3 (en) 2012-01-18
WO2003001876A2 (en) 2003-01-09
EP2293067B1 (en) 2016-04-20
EP1412750A4 (en) 2005-02-09
WO2003001876A3 (en) 2003-12-04
CA2451317C (en) 2016-03-29
CA2451317A1 (en) 2003-01-09
EP2327985A2 (en) 2011-06-01
EP2003451B1 (en) 2012-05-30
EP2327985B1 (en) 2016-05-25
AU2002326315B2 (en) 2007-07-05
EP2003451A3 (en) 2008-12-24
EP2327985B2 (en) 2019-08-21

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