NO20021164L - T2R-smaksreseptorer - Google Patents

T2R-smaksreseptorer

Info

Publication number
NO20021164L
NO20021164L NO20021164A NO20021164A NO20021164L NO 20021164 L NO20021164 L NO 20021164L NO 20021164 A NO20021164 A NO 20021164A NO 20021164 A NO20021164 A NO 20021164A NO 20021164 L NO20021164 L NO 20021164L
Authority
NO
Norway
Prior art keywords
taste receptors
receptors
taste
Prior art date
Application number
NO20021164A
Other languages
English (en)
Other versions
NO20021164D0 (no
Inventor
Charles S Zuker
Jon Elliot Adler
Nick Ryba
Ken Mueller
Mark Hoon
Original Assignee
Us Gov Sec Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/393,634 external-priority patent/US6558910B2/en
Application filed by Us Gov Sec Health filed Critical Us Gov Sec Health
Publication of NO20021164D0 publication Critical patent/NO20021164D0/no
Publication of NO20021164L publication Critical patent/NO20021164L/no

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
NO20021164A 1999-09-10 2002-03-08 T2R-smaksreseptorer NO20021164L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/393,634 US6558910B2 (en) 1999-09-10 1999-09-10 SF, a novel family of taste receptors
US09/510,332 US7244584B2 (en) 1999-09-10 2000-02-22 T2R, a novel family of taste receptors
PCT/US2000/024821 WO2001018050A2 (en) 1999-09-10 2000-09-08 T2r taste receptor family

Publications (2)

Publication Number Publication Date
NO20021164D0 NO20021164D0 (no) 2002-03-08
NO20021164L true NO20021164L (no) 2002-05-10

Family

ID=27014384

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021164A NO20021164L (no) 1999-09-10 2002-03-08 T2R-smaksreseptorer

Country Status (10)

Country Link
US (8) US7465550B2 (no)
EP (1) EP1214343A2 (no)
JP (1) JP4339542B2 (no)
CN (1) CN1289525C (no)
AU (2) AU773600B2 (no)
CA (1) CA2384777A1 (no)
IL (1) IL148593A0 (no)
MX (1) MXPA02002538A (no)
NO (1) NO20021164L (no)
WO (1) WO2001018050A2 (no)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU773600B2 (en) 1999-09-10 2004-05-27 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The T2R, taste receptor family
US6558910B2 (en) 1999-09-10 2003-05-06 The Regents Of The University Of California SF, a novel family of taste receptors
TW201006846A (en) * 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
MXPA02009843A (es) 2000-04-07 2004-09-06 Senomyx Inc Receptores t2r del sabor y genes que codifican para los mismos.
TW201022287A (en) * 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US20080244761A1 (en) 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US7301009B2 (en) 2001-06-26 2007-11-27 Senomyx, Inc. Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
US7883856B2 (en) 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US8030008B2 (en) 2001-04-05 2011-10-04 Senomyx, Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
EP2003451B1 (en) 2001-06-26 2012-05-30 Senomyx, Inc. T1r1-t1r3 hetero-oligomeric umami taste receptors and cell lines that express said receptors and use thereof for identification of umami taste compounds
CN1610830A (zh) * 2001-07-10 2005-04-27 塞诺米克斯公司 特异性t2r味觉受体在鉴定阻断苦味觉的化合物中的应用
AU2002326429B2 (en) * 2001-07-20 2007-09-20 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Phenylthiocarbamide (PTC) taste receptor
JP2005522187A (ja) * 2001-10-12 2005-07-28 ザ レジェンツ オブ ザ ユニバーシティー オブ カリフォルニア サン ディエゴ 胃腸化学感覚受容体
WO2004011617A2 (en) 2002-07-29 2004-02-05 Senomyx, Inc. Identification of a novel bitter taste receptor, t2r76
EP2270153A3 (en) * 2002-09-25 2011-08-10 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Bitter taste receptors
US7919236B2 (en) 2002-12-18 2011-04-05 Givaudan Sa G-proteins
WO2005007891A2 (en) 2003-06-19 2005-01-27 The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Variants of human taste receptor genes
US7829299B2 (en) 2004-11-18 2010-11-09 Deutsches Institut fur Ernahrungforschung Potsdam-Rehbrucke Stiftung des Offentlichen Rechts Agonists of bitter taste receptors and uses thereof
CA2597085A1 (en) 2005-02-08 2006-08-17 Senomyx, Inc. Phuman t2r receptors for acetaminophen, ranitidine, strychnine and denatonium and related assays for identifying human bitter taste modulators
JPWO2007074937A1 (ja) 2005-12-27 2009-06-04 学校法人日本大学 亜鉛欠乏性味覚異常検査法
US20110097741A1 (en) * 2006-04-20 2011-04-28 Jay Patrick Slack Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays
WO2007121604A2 (en) 2006-04-20 2007-11-01 Givaudan Sa Method relating to sweetness enhancement
EP2008095A1 (en) 2006-04-20 2008-12-31 Givaudan SA Functional method to identify tastants
WO2008030429A2 (en) * 2006-09-05 2008-03-13 Senomyx, Inc. Novel haplotype of human t2r receptor ht2r50 and its use in assays for identifying human bitter taste modulators
WO2008086634A2 (en) 2007-01-18 2008-07-24 Givaudan Sa Chimeric umami taste receptor, nucleic acid encoding it and use thereof
US8187822B2 (en) 2007-03-30 2012-05-29 Givaudan S.A. Methods to identify modulators
EP2167643A4 (en) * 2007-06-08 2010-06-16 Senomyx Inc IDENTIFICATION OF TRPML3 (MCOLN3) AS A SALT TASTE RECEPTOR AND USE IN EXPERIMENTS TO IDENTIFY MODULATORS AND / OR TASTE THERAPEUTIC SUBSTANCES THAT MODULATE THE TRANSPORT, ABSORPTION OR EXPRESSION OF SODIUM AND / OR PRODUCTION OR LIBERATION
CA2696995C (en) 2007-08-21 2017-11-21 Senomyx, Inc. Identification of human t2r receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof
KR20100122491A (ko) * 2008-02-01 2010-11-22 크로모셀 코포레이션 세포주 및 이의 제조 및 사용 방법
US9525148B2 (en) 2008-04-03 2016-12-20 Qd Vision, Inc. Device including quantum dots
EP2567229A1 (en) 2010-05-07 2013-03-13 Givaudan SA Methods to identify modulators
SG184962A1 (en) 2010-05-07 2012-11-29 Givaudan Sa Methods to identify modulators of tas2r4s receptors
JP2013528661A (ja) 2010-06-17 2013-07-11 カリフォルニア インスティチュート オブ テクノロジー ホルモン調節方法およびシステムならびに関連する方法、作用剤および組成物
US9128079B2 (en) 2011-08-08 2015-09-08 The Coca-Cola Company Methods of using lung or bronchial epithelial cells to identify bitter taste modulators
WO2013159227A1 (en) * 2012-04-25 2013-10-31 University Of Manitoba Bitter taste receptor constitutively active mutants
US9169311B2 (en) 2013-03-15 2015-10-27 Applied Food Biotechnology, Inc. Feline bitter taste receptors and methods
BR112015023737A2 (pt) 2013-03-15 2017-10-24 Applied Food Biotech Inc polipeptídeo do receptor felino tas2r isolado (ftas2r), composição, polinucleotídeo isolado, par de iniciadores, vetor de expressão, célula hospedeira, cultura celular, oligonucleotídeo, anticorpo isolado ou um fragmento desse, método para identificar um composto que interage com um polipeptídeo do receptor felino tas2r, método para identificar um composto que modula um polipeptídeo do receptor felino tas2r, método para preparar uma composição comestível, método para formular uma composição comestível com palatabilidade intensificada, método para administrar um composto amargo a um animal que necessita desse, método para preparar uma composição comestível para controlar a palatabilidade da composição comestível para um animal, método para produzir uma composição de sabor para revestimento ou incorporação em uma composição comestível a ser administrada para um animal, e composição de sabor para revestimento ou incorporação em uma composição comestível a ser administrada para um animal
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives
US9766236B2 (en) * 2013-05-10 2017-09-19 Pepsico, Inc. Taste receptor internalization assay
US10107794B2 (en) 2013-05-10 2018-10-23 Pepsico, Inc. Methods of using U2-OS cells to identify potential sweet taste modulators
EP3104712B1 (en) 2014-02-12 2020-05-06 Firmenich Incorporated Improved process for the synthesis of substituted 1-benzyl-3-(1-(isoxazol-4-ylmethyl)-1h-pyrazol-4-yl)imidazolidine-2,4-diones

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3665893A (en) 1992-02-12 1993-09-03 United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The Sequences characteristic of human gene transcription product
ATE282706T1 (de) 1996-09-04 2004-12-15 Syngenta Mogen Bv Gegen pilze gerichtete proteine, dafuer kodierende dna und wirtsorganismen, die diese beinhalten
WO1999042470A1 (en) 1998-02-18 1999-08-26 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO2000038536A2 (en) 1998-12-23 2000-07-06 Mount Sinai School Of Medicine Of New York University Inhibitors of the bitter taste response
US6558910B2 (en) 1999-09-10 2003-05-06 The Regents Of The University Of California SF, a novel family of taste receptors
AU773600B2 (en) 1999-09-10 2004-05-27 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The T2R, taste receptor family

Also Published As

Publication number Publication date
JP2003510037A (ja) 2003-03-18
JP4339542B2 (ja) 2009-10-07
CA2384777A1 (en) 2001-03-15
US20150260733A1 (en) 2015-09-17
US20180128842A1 (en) 2018-05-10
US20100062456A1 (en) 2010-03-11
US8624012B2 (en) 2014-01-07
AU7366400A (en) 2001-04-10
US8329885B2 (en) 2012-12-11
US20120009598A1 (en) 2012-01-12
WO2001018050A9 (en) 2002-02-07
US20130189712A1 (en) 2013-07-25
US7868150B2 (en) 2011-01-11
WO2001018050A2 (en) 2001-03-15
CN1387536A (zh) 2002-12-25
NO20021164D0 (no) 2002-03-08
CN1289525C (zh) 2006-12-13
US20050048586A1 (en) 2005-03-03
AU773600B2 (en) 2004-05-27
AU2004203826A1 (en) 2004-09-16
WO2001018050A3 (en) 2002-01-10
MXPA02002538A (es) 2005-07-01
US7595166B2 (en) 2009-09-29
US20140120553A1 (en) 2014-05-01
IL148593A0 (en) 2002-09-12
US9063124B2 (en) 2015-06-23
US9817000B2 (en) 2017-11-14
EP1214343A2 (en) 2002-06-19
US20080108088A1 (en) 2008-05-08
US7465550B2 (en) 2008-12-16

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