NO20013808L - Anti-inflammatoriske indolderivater - Google Patents
Anti-inflammatoriske indolderivaterInfo
- Publication number
- NO20013808L NO20013808L NO20013808A NO20013808A NO20013808L NO 20013808 L NO20013808 L NO 20013808L NO 20013808 A NO20013808 A NO 20013808A NO 20013808 A NO20013808 A NO 20013808A NO 20013808 L NO20013808 L NO 20013808L
- Authority
- NO
- Norway
- Prior art keywords
- group
- alkyl
- 6alkyl
- mono
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Forbindelser med formel (I) eller et farmasøytisk akseptabelt salt, in vivo hydrolyserbar ester eller amid derav, hvor X er CH2 eller SO2; R1 er en eventuelt substituert aryl eller heteroaryl ring; R4 er en gruppe OR15 eller S(O)qR15, hvor q er O, 1 eller 2 og R15 er en substituert hydrogen-inneholdende alkylgruppe; og R2, R3, R5, R6 og R7 er spesifiserte organiske grupper. Disse forbindelsene er nyttige i terapi, spesielt i inflammatorisk sykdom og fremgangsmåter for fremstilling av disse samt farmasøytiske sammensetninger som inneholder dem er beskrevet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9902452.3A GB9902452D0 (en) | 1999-02-05 | 1999-02-05 | Chemical compounds |
PCT/GB2000/000275 WO2000046198A1 (en) | 1999-02-05 | 2000-01-31 | Anti-inflammatory indole derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20013808D0 NO20013808D0 (no) | 2001-08-03 |
NO20013808L true NO20013808L (no) | 2001-10-02 |
Family
ID=10847075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20013808A NO20013808L (no) | 1999-02-05 | 2001-08-03 | Anti-inflammatoriske indolderivater |
Country Status (14)
Country | Link |
---|---|
US (1) | US6569888B1 (no) |
EP (1) | EP1150954B1 (no) |
JP (1) | JP2002536361A (no) |
KR (1) | KR20010101976A (no) |
CN (1) | CN1351591A (no) |
AT (1) | ATE279391T1 (no) |
AU (1) | AU2304500A (no) |
BR (1) | BR0007987A (no) |
CA (1) | CA2357013A1 (no) |
DE (1) | DE60014851T2 (no) |
GB (1) | GB9902452D0 (no) |
NO (1) | NO20013808L (no) |
WO (1) | WO2000046198A1 (no) |
ZA (1) | ZA200105020B (no) |
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US7271180B2 (en) | 2001-01-23 | 2007-09-18 | Wyeth | 1-Aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands |
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DK0954305T3 (da) | 1996-02-26 | 2003-08-25 | Advanced Res & Tech Inst | Anvendelse af carbonanhydraseinhibitorer til behandling af maculaødem |
JP2000507556A (ja) | 1996-03-28 | 2000-06-20 | スミスクライン・ビーチャム・コーポレイション | ケモカインのカルボン酸インドール阻害剤 |
EP0822185A1 (en) | 1996-07-31 | 1998-02-04 | Pfizer Inc. | B-3-adrenergic agonists as antidiabetic and antiobesity agents |
JP2000516611A (ja) | 1996-08-14 | 2000-12-12 | ワーナー―ランバート・コンパニー | Mcp―1アンタゴニストとしての2―フェニルベンズイミダゾール誘導体 |
GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
GB9716656D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
IL136954A0 (en) | 1997-12-24 | 2001-06-14 | Aventis Pharma Gmbh | Indole derivatives as inhibitors of factor xa |
-
1999
- 1999-02-05 GB GBGB9902452.3A patent/GB9902452D0/en not_active Ceased
-
2000
- 2000-01-31 JP JP2000597269A patent/JP2002536361A/ja active Pending
- 2000-01-31 CA CA002357013A patent/CA2357013A1/en not_active Abandoned
- 2000-01-31 BR BR0007987-1A patent/BR0007987A/pt not_active Application Discontinuation
- 2000-01-31 DE DE60014851T patent/DE60014851T2/de not_active Expired - Fee Related
- 2000-01-31 EP EP00901741A patent/EP1150954B1/en not_active Expired - Lifetime
- 2000-01-31 WO PCT/GB2000/000275 patent/WO2000046198A1/en not_active Application Discontinuation
- 2000-01-31 AU AU23045/00A patent/AU2304500A/en not_active Abandoned
- 2000-01-31 KR KR1020017009820A patent/KR20010101976A/ko not_active Application Discontinuation
- 2000-01-31 AT AT00901741T patent/ATE279391T1/de not_active IP Right Cessation
- 2000-01-31 CN CN00803469A patent/CN1351591A/zh active Pending
- 2000-01-31 US US09/889,494 patent/US6569888B1/en not_active Expired - Fee Related
-
2001
- 2001-06-19 ZA ZA200105020A patent/ZA200105020B/en unknown
- 2001-08-03 NO NO20013808A patent/NO20013808L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2304500A (en) | 2000-08-25 |
US6569888B1 (en) | 2003-05-27 |
DE60014851T2 (de) | 2006-02-02 |
WO2000046198A8 (en) | 2001-04-19 |
ATE279391T1 (de) | 2004-10-15 |
EP1150954B1 (en) | 2004-10-13 |
ZA200105020B (en) | 2002-09-30 |
EP1150954A1 (en) | 2001-11-07 |
KR20010101976A (ko) | 2001-11-15 |
GB9902452D0 (en) | 1999-03-24 |
JP2002536361A (ja) | 2002-10-29 |
NO20013808D0 (no) | 2001-08-03 |
DE60014851D1 (de) | 2004-11-18 |
BR0007987A (pt) | 2001-10-30 |
CA2357013A1 (en) | 2000-08-10 |
CN1351591A (zh) | 2002-05-29 |
WO2000046198A1 (en) | 2000-08-10 |
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