NO20012836L - Tiourea-inhibitorer for herpes virus - Google Patents

Tiourea-inhibitorer for herpes virus

Info

Publication number
NO20012836L
NO20012836L NO20012836A NO20012836A NO20012836L NO 20012836 L NO20012836 L NO 20012836L NO 20012836 A NO20012836 A NO 20012836A NO 20012836 A NO20012836 A NO 20012836A NO 20012836 L NO20012836 L NO 20012836L
Authority
NO
Norway
Prior art keywords
carbon atoms
alkyl
aryl
hydrogen
heteroaryl
Prior art date
Application number
NO20012836A
Other languages
English (en)
Other versions
NO20012836D0 (no
Inventor
Jonathan David Bloom
Martin Joseph Digrandi
Russel George Dushin
Stanley Albert Lang
Bryan Mark O'hara
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1999/028892 external-priority patent/WO2000034269A1/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of NO20012836D0 publication Critical patent/NO20012836D0/no
Publication of NO20012836L publication Critical patent/NO20012836L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Det er beskrevet forbindelser med formel (I) hvor R1-R5 er uavhengig valgt fra hydrogen, alkyl med 1 til 6 karbonatomer, alkenyl med 2 til 6 karbonatomer, alkynyl med 2 til 6 karbonatomer, perhalogen- alkyl med 1 til 6 kambonatomer, sykloalkyl med 3 til 10 karbonatomer, heterosykloalkyl med 3 til 10 karbonledd, aryl, heteroaryl, halogen, -CN, -NO2, -CO2R6, -CORe, -ORe, -SRs, -SORe, -SC^Rs, -CONR7R8. -NReNfR/Ra), -N(R7R8) eller W-Y-(CH2)n-Z forutsatt at minst en av RrRs ikke er hydrogen; eller R2 og R3, eller R3 og R* sammen danner en 3 til 7-leddet heterosykloalkyl eller 3 til 7 leddet heteroaryl; Re og R7 er uavhengig hydrogen, alkyl med 1 til 6 karbonatomer, perhalogenalkyl med 1 til 6 karbonatomer, eller aryl; Ra er hydrogen, alkyl med 1 til 6 karbonatomer, perhalogenalkyl med 1 til 6 karbon- atomer, sykloalkyl med 3 til 10 karbonatomer, heterosykloalkyl med 3 til 10 ledd, aryl eller heteroaryl, eller R7 eller Ra, sammen kan danne en 3 til 7 leddet heterosykloalkyl; W er O, NRe eller er fraværende; Y er -(CO)- eller -(CO2)- eller er fraværende; Z er alkyl med 1 til 4 karbonatomer, -CN, -CO2R6, -COR6, -CONR7R8, -OCOR6l -NR6COR7, -OCONR6, -OR6, -SR6, -SOR6, -SO2R6, SR6N(R7R8), -N(R7R8) eller fenyl; G er aryl eller kondensert bisyklisk hetero- aryl; X er en binding, -NH, alkyl med 1 til 6 karbonatomer, alkenyl med 1 til 6 karbonatomer, alkoksy med 1 til 6 karbonatomer, tioalkyl med 1 til 6 karbon- atomer, alkylamino med 1 til 6 karbonatomer, eller (CH)J; J er alkyl med 1 til 6 karbonatomer, sykloalkyl med 3 til 7 karbonatomer, fenyl eller benzyl; og n er et tall fra 1 til 6, nyttig for behandling av sykdommer assosiert med herpesvirus inkludert human cytomegalovirus, herpes simplex virus, Epstein-Barr virus, varicella-zoster virus, humane herpesviruser -6 og -7 og Kaposi herpesvirus.
NO20012836A 1998-12-09 2001-06-08 Tiourea-inhibitorer for herpes virus NO20012836L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20854098A 1998-12-09 1998-12-09
PCT/US1999/028892 WO2000034269A1 (en) 1998-12-09 1999-12-06 Thiourea inhibitors of herpes viruses

Publications (2)

Publication Number Publication Date
NO20012836D0 NO20012836D0 (no) 2001-06-08
NO20012836L true NO20012836L (no) 2001-08-08

Family

ID=22774965

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20012836A NO20012836L (no) 1998-12-09 2001-06-08 Tiourea-inhibitorer for herpes virus

Country Status (18)

Country Link
EP (1) EP1140913A1 (no)
JP (1) JP2002531558A (no)
KR (1) KR20010086082A (no)
CN (1) CN1335843A (no)
AU (1) AU756043B2 (no)
BG (1) BG105580A (no)
BR (1) BR9916042A (no)
CA (1) CA2351390A1 (no)
CZ (1) CZ20011958A3 (no)
EA (1) EA200100637A1 (no)
HU (1) HUP0104758A3 (no)
ID (1) ID29064A (no)
IL (1) IL143203A0 (no)
NO (1) NO20012836L (no)
PL (1) PL348177A1 (no)
SK (1) SK7692001A3 (no)
TR (1) TR200101598T2 (no)
ZA (1) ZA200104373B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE309237T1 (de) * 1999-03-12 2005-11-15 Boehringer Ingelheim Pharma Aromatische heterozyklische verbindungen als antientzündungwirkstoffe
JP3938651B2 (ja) * 2000-04-13 2007-06-27 セントラル硝子株式会社 光学活性α−メチル−ビス−３、５−（トリフルオロメチル）ベンジルアミンの製造方法
JP2007500245A (ja) * 2003-06-10 2007-01-11 スミスクライン ビーチャム コーポレーション 化合物
US20100016298A1 (en) * 2005-08-29 2010-01-21 Housey Gerad M Theramutein modulators
CN108642926B (zh) * 2018-04-26 2023-11-14 浙江汉邦新材料股份有限公司 一种涤纶染色清洗用的硫脲衍生物及其制备方法
EP4063349A4 (en) * 2019-11-19 2023-12-20 Takeda Pharmaceutical Company Limited METHOD FOR PRODUCING A PYRROLIDINE COMPOUND

Also Published As

Publication number Publication date
AU756043B2 (en) 2003-01-02
HUP0104758A2 (hu) 2002-04-29
PL348177A1 (en) 2002-05-06
CZ20011958A3 (cs) 2001-10-17
BR9916042A (pt) 2001-12-04
ZA200104373B (en) 2002-09-18
EP1140913A1 (en) 2001-10-10
BG105580A (bg) 2002-01-31
CA2351390A1 (en) 2000-06-15
SK7692001A3 (en) 2002-09-10
NO20012836D0 (no) 2001-06-08
AU3112200A (en) 2000-06-26
KR20010086082A (ko) 2001-09-07
EA200100637A1 (ru) 2001-12-24
TR200101598T2 (tr) 2001-10-22
CN1335843A (zh) 2002-02-13
JP2002531558A (ja) 2002-09-24
IL143203A0 (en) 2002-04-21
ID29064A (id) 2001-07-26
HUP0104758A3 (en) 2002-05-28

Similar Documents

Publication Publication Date Title
NO951266L (no) Imidazol-holdige inhibitorer for farnesyl-protein-transferase
DK484886D0 (da) Bicycliske naphthalenderivater, deres fremstilling og deres anvendelse til medicinske og kosmetiske formaal
DE69013607T2 (de) Pyrazol-Derivate, Verfahren zu deren Herstellung und Anwendung.
JPS6445395A (en) Heterocyclic ketone, manufacture and thrombocyte elastase inhibitor
NO965305L (no) Nye forbindelser, fremgangsmåter ved deres fremstilling og anti-tumormidler
DK0806416T3 (da) Huperzinderivater, deres fremstilling og anvendelse
NO911121D0 (no) Fremgangsmaate for fremstilling av nye skvalen-synetase-inhibitorer.
WO2000034237A3 (en) Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
NO20012836L (no) Tiourea-inhibitorer for herpes virus
NO20012832L (no) Heterocykliske karboksamid-holdige tiourea-inhibitorer for herpesvirus inneholdende fenylendiamingruppe
BG105583A (en) Thiourea as inhibitor of herpes viruses
HUP0203405A2 (hu) Szubsztituált fenilén-diamin-csoportot és heterociklikus karboxamidcsoportot hordozó herpeszvírus inhibitor hatású tiokarbamidszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
WO2000034260A3 (en) Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
ATE244565T1 (de) Verwendung von 2-aryl-3-aroylbenzo(b)thiophene zur behandlung des oestrogenenthaltungssyndroms
DK314380A (da) Fremgangsmaade til fremstilling af thienamycin og mellemprodukter til brug ved udoevelse af fremgangsmaaden
DE3867884D1 (de) Aromatische derivate der butyrsaeure, verfahren zu ihrer herstellung und ihre verwendung in kosmetischen und pharmazeutischen zubereitungen.
DK678287A (da) Fungicide azolylderivater og fremgangsmaade til fremstilling deraf
DK0514942T3 (da) Hidtil ukendte benzopyranderivater og fremgangsmåder til fremstilling deraf
EA200100635A1 (ru) Производные тиомочевины в качестве ингибиторов вирусов герпеса
IL187917A (en) Compounds 1– (Converted phenyl) -pyreno [3,4– b] [1] benzofuran-3-van
NO921908L (no) Aminosyreazetidinylsubstituerte pyridonderivater, deres fremstilling og anvendelse som medikamenter
EA200200352A1 (ru) Фенил- и пиридил-тетрагидропиридины, обладающие ингибирующей активностью в отношении фактора некроза опухоли (фно)
ATA163691A (de) Neues verfahren und neue zwischenprodukte zur herstellung von 7-aminocephalosporansaeurederivaten
DK367488A (da) Fremgangsmaade til fremstilling af bicycliske aminocarboxylsyrer, mellemprodukter ved denne fremgangsmaade og anvendelse heraf
DK0580378T3 (da) Substituerede benzoatderivater

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application