NO20000452L - Sulfonylated dipeptide compounds that inhibit leukocyte adhesion mediated by VLA-4 - Google Patents

Sulfonylated dipeptide compounds that inhibit leukocyte adhesion mediated by VLA-4

Info

Publication number
NO20000452L
NO20000452L NO20000452A NO20000452A NO20000452L NO 20000452 L NO20000452 L NO 20000452L NO 20000452 A NO20000452 A NO 20000452A NO 20000452 A NO20000452 A NO 20000452A NO 20000452 L NO20000452 L NO 20000452L
Authority
NO
Norway
Prior art keywords
compounds
vla
leukocyte adhesion
sulfonylated
adhesion mediated
Prior art date
Application number
NO20000452A
Other languages
Norwegian (no)
Other versions
NO20000452D0 (en
Inventor
Eugene D Thorsett
Christopher M Semko
Michael A Pleiss
Anthony Kreft
Andrei W Konradi
Francine S Grant
Reinhardt Bernhard Baudy
Dimitrios Sarantakis
Original Assignee
Elan Pharm Inc
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc, American Home Prod filed Critical Elan Pharm Inc
Publication of NO20000452D0 publication Critical patent/NO20000452D0/en
Publication of NO20000452L publication Critical patent/NO20000452L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Det er beskrevet forbindelser som binder VLA-4. Noen av disse forbindelsene kan også inhibere leukocytt-adhesjon og, spesielt, leukocytt- adhesjon mediert av VLA-4. Slike forbindelser er nyttige for behandling av inflammatoriske sykdommer i en pattedyrpasient, for eksempel et menneske, så som astma, Alzheimer's sykdom, aterosklerose, AIDS demens, diabetes, inflammatorisk tarmsykdom, leddgikt, vevstransplantasjon, tumormetastase og myokardial ischemi. Forbindelsene kan også bli administrert for behandling av inflammatoriske hjernesykdommer så som multippel sklerose.Compounds that bind VLA-4 are described. Some of these compounds may also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful for the treatment of inflammatory diseases in a mammalian patient, such as a human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds may also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

NO20000452A 1997-07-31 2000-01-28 Sulfonylated dipeptide compounds that inhibit leukocyte adhesion mediated by VLA-4 NO20000452L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90442397A 1997-07-31 1997-07-31
PCT/US1998/016070 WO1999006437A1 (en) 1997-07-31 1998-07-31 Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4

Publications (2)

Publication Number Publication Date
NO20000452D0 NO20000452D0 (en) 2000-01-28
NO20000452L true NO20000452L (en) 2000-03-27

Family

ID=25419137

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20000452A NO20000452L (en) 1997-07-31 2000-01-28 Sulfonylated dipeptide compounds that inhibit leukocyte adhesion mediated by VLA-4

Country Status (12)

Country Link
EP (1) EP0994896A1 (en)
JP (1) JP2001512139A (en)
KR (1) KR20010022405A (en)
CN (1) CN1265672A (en)
AU (1) AU8823498A (en)
BR (1) BR9811594A (en)
CA (1) CA2290748A1 (en)
HU (1) HUP0003921A3 (en)
IL (1) IL133637A0 (en)
NO (1) NO20000452L (en)
PL (1) PL338457A1 (en)
WO (1) WO1999006437A1 (en)

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ATE375330T1 (en) 2000-04-17 2007-10-15 Ucb Pharma Sa ENAMINE DERIVATIVES AS CELL ADHESION MOLECULES
US6545013B2 (en) 2000-05-30 2003-04-08 Celltech R&D Limited 2,7-naphthyridine derivatives
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JP2004502762A (en) 2000-07-07 2004-01-29 セルテック　アール　アンド　ディ　リミテッド Squaric acid derivatives as integrin antagonists containing bicyclic heteroaromatic rings
AU2001275724A1 (en) 2000-08-02 2002-02-13 Celltech R&D Limited 3-substituted isoquinolin-1-yl derivatives
ATE497385T1 (en) 2000-08-18 2011-02-15 Ajinomoto Kk NEW PHENYLALANINE DERIVATIVES
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US6607735B2 (en) 2000-12-21 2003-08-19 Johnson & Johnson Consumer Companies, Inc. Method for reducing the appearance of dark circles under the eyes
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Also Published As

Publication number Publication date
IL133637A0 (en) 2001-04-30
BR9811594A (en) 2000-09-05
KR20010022405A (en) 2001-03-15
PL338457A1 (en) 2000-11-06
HUP0003921A2 (en) 2001-02-28
EP0994896A1 (en) 2000-04-26
WO1999006437A1 (en) 1999-02-11
CA2290748A1 (en) 1999-02-11
JP2001512139A (en) 2001-08-21
NO20000452D0 (en) 2000-01-28
AU8823498A (en) 1999-02-22
CN1265672A (en) 2000-09-06
HUP0003921A3 (en) 2001-03-28

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