NO172118C - Analogifremgangsmaate til fremstilling av terapeutisk aktivt n-(omega-substituert -alkyl)-n'-((imidazol-4-yl)alkyl)-guanidin - Google Patents

Analogifremgangsmaate til fremstilling av terapeutisk aktivt n-(omega-substituert -alkyl)-n'-((imidazol-4-yl)alkyl)-guanidin

Info

Publication number: NO172118C
Authority: NO; Norway
Prior art keywords: alkyl; pct; imidazol; guanidine; omega
Prior art date: 1986-06-19

Application number

NO880745A

Other languages

English (en)

Norwegian (no)

Other versions

NO880745L (no

NO172118B (no

NO880745D0 (no

Inventor

Geert Jan Sterk

Henk Timmerman

Henk Van Der Goot

Original Assignee

Cedona Pharm Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-19

Filing date

1988-02-19

Publication date

1993-06-09

1988-02-19 Application filed by Cedona Pharm Bv filed Critical Cedona Pharm Bv

1988-02-19 Publication of NO880745L publication Critical patent/NO880745L/no

1988-02-19 Publication of NO880745D0 publication Critical patent/NO880745D0/no

1993-03-01 Publication of NO172118B publication Critical patent/NO172118B/no

1993-06-09 Publication of NO172118C publication Critical patent/NO172118C/no

Links

-1 IMIDAZOL-4-YL Chemical class 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title 1
UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 4
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
DEURIUYJZZLADZ-UHFFFAOYSA-N 2-(1h-imidazol-2-yl)ethanamine Chemical compound NCCC1=NC=CN1 DEURIUYJZZLADZ-UHFFFAOYSA-N 0.000 abstract 1
HQNOODJDSFSURF-UHFFFAOYSA-N 3-(1h-imidazol-2-yl)propan-1-amine Chemical compound NCCCC1=NC=CN1 HQNOODJDSFSURF-UHFFFAOYSA-N 0.000 abstract 1
206010027654 Allergic conditions Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
CPEKAXYCDKETEN-UHFFFAOYSA-N benzoyl isothiocyanate Chemical compound S=C=NC(=O)C1=CC=CC=C1 CPEKAXYCDKETEN-UHFFFAOYSA-N 0.000 abstract 1
208000027744 congestion Diseases 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 abstract 1
DQMWMUMCNOJLSI-UHFFFAOYSA-N n-carbamothioylbenzamide Chemical class NC(=S)NC(=O)C1=CC=CC=C1 DQMWMUMCNOJLSI-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003141 primary amines Chemical class 0.000 abstract 1
150000003585 thioureas Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Immunology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)
Polyurethanes Or Polyureas (AREA)
Inks, Pencil-Leads, Or Crayons (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
Analysing Materials By The Use Of Radiation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO880745A 1986-06-19 1988-02-19 Analogifremgangsmaate til fremstilling av terapeutisk aktivt n-(omega-substituert -alkyl)-n'-((imidazol-4-yl)alkyl)-guanidin NO172118C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL8601585A NL8601585A (nl)	1986-06-19	1986-06-19	N-(2-gesubstitueerde alkyl)-n-imidazol-4-yl alkyl guanidine.
PCT/NL1987/000013 WO1987007891A1 (en)	1986-06-19	1987-06-19	N-(2-substituted alkyl)-n'-[(imidazole-4-yl)alkyl]guanidine

Publications (4)

Publication Number	Publication Date
NO880745L NO880745L (no)	1988-02-19
NO880745D0 NO880745D0 (no)	1988-02-19
NO172118B NO172118B (no)	1993-03-01
NO172118C true NO172118C (no)	1993-06-09

Family

ID=19848186

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO880745A NO172118C (no)	1986-06-19	1988-02-19	Analogifremgangsmaate til fremstilling av terapeutisk aktivt n-(omega-substituert -alkyl)-n'-((imidazol-4-yl)alkyl)-guanidin

Country Status (15)

Country	Link
US (1)	US5010095A (da)
EP (1)	EP0302896B1 (da)
JP (1)	JPH01502981A (da)
KR (1)	KR880701231A (da)
AT (1)	ATE66212T1 (da)
CA (1)	CA1296716C (da)
DE (1)	DE3772202D1 (da)
DK (1)	DK81288D0 (da)
FI (1)	FI885861A0 (da)
HU (1)	HUT56548A (da)
MC (1)	MC1936A1 (da)
NL (1)	NL8601585A (da)
NO (1)	NO172118C (da)
RU (1)	RU1802811C (da)
WO (1)	WO1987007891A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL9000132A (nl) *	1990-01-19	1991-08-16	Cedona Pharm Bv	Nieuwe thiazoolderivaten.
NL9100365A (nl) *	1991-02-27	1992-09-16	Seed Capital Investments	Imidazoolderivaten met agonistische of antagonistische activiteit op de histamine h3-receptor.
CA2104946A1 (en) *	1991-02-27	1992-08-28	Hendrik Timmerman	Imidazole-derivatives having agonistic or antagonistic activity on the histamine h3-receptor
USRE37303E1 (en) *	1992-01-10	2001-07-31	Institut National Del La Sante Et De La Recherche Medicale	Imidazole compounds and their therapeutic applications
FR2686084B1 (fr) *	1992-01-10	1995-12-22	Bioprojet Soc Civ	Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
US5424447A (en) *	1993-07-07	1995-06-13	The Medical College Of Wisconsin Research Foundation, Inc.	Heme binding compounds and use thereof
US6448282B1 (en)	1995-05-30	2002-09-10	Gliatech, Inc.	1H-4(5)-substituted imidazole derivatives
JPH11506106A (ja) *	1995-05-30	1999-06-02	グリアテツク・インコーポレイテツド	１ｈ−４（５）−置換イミダゾール誘導体
US6127343A (en) *	1996-05-14	2000-10-03	Novo Nordisk A/S	Somatostatin agonists and antagonists
AU2764797A (en) *	1996-05-14	1997-12-05	Novo Nordisk A/S	Somatostatin agonists and antagonists
AU4772497A (en) *	1996-10-31	1998-05-22	Novo Nordisk A/S	Constrained somatostatin agonists and antagonists
US6225332B1 (en) *	1997-10-21	2001-05-01	Alcon Laboratories, Inc.	Compositions containing histamine H2 agonists and methods of use in treating allergy and inflammation
JP2005526024A (ja) *	2002-02-08	2005-09-02	スミスクラインビーチャムコーポレーション	インスリン分泌を阻害するための化合物及びそれに関連する方法
DE10245212B4 (de) *	2002-09-27	2008-01-03	Ivoclar Vivadent Ag	Verwendung säurehaltiger Mittel zur Desensibilisierung von Zähnen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4013659A (en) *	1973-07-13	1977-03-22	Smith Kline & French Laboratories Limited	Certain n,n'-disubstituted guanidine compounds and their use
IL49528A (en) *	1975-05-21	1980-11-30	Smith Kline French Lab	Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
US4192879A (en) *	1975-05-21	1980-03-11	Smith Kline & French Laboratories Limited	Imidazolyl alkylamino nitroethylene compounds
US4166860A (en) *	1977-10-11	1979-09-04	William H. Rorer, Inc.	Imidazole amidinoureas for stimulating H2 -receptors
DE3512084A1 (de) *	1985-04-02	1986-10-09	Ludwig Heumann & Co GmbH, 8500 Nürnberg	Guanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3528214A1 (de) *	1985-08-06	1987-02-12	Heumann Ludwig & Co Gmbh	Arylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3528215A1 (de) *	1985-08-06	1987-02-12	Heumann Ludwig & Co Gmbh	Heteroarylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

1986
- 1986-06-19 NL NL8601585A patent/NL8601585A/nl not_active Application Discontinuation
1987
- 1987-06-19 AT AT87904332T patent/ATE66212T1/de not_active IP Right Cessation
- 1987-06-19 CA CA000540131A patent/CA1296716C/en not_active Expired - Lifetime
- 1987-06-19 EP EP87904332A patent/EP0302896B1/en not_active Expired - Lifetime
- 1987-06-19 MC MC87NL8700013D patent/MC1936A1/xx unknown
- 1987-06-19 US US07/297,549 patent/US5010095A/en not_active Expired - Fee Related
- 1987-06-19 WO PCT/NL1987/000013 patent/WO1987007891A1/en active IP Right Grant
- 1987-06-19 KR KR1019880700188A patent/KR880701231A/ko not_active Application Discontinuation
- 1987-06-19 HU HU873434A patent/HUT56548A/hu unknown
- 1987-06-19 DE DE8787904332T patent/DE3772202D1/de not_active Expired - Lifetime
- 1987-06-19 JP JP62503950A patent/JPH01502981A/ja active Pending
1988
- 1988-02-17 DK DK081288A patent/DK81288D0/da not_active Application Discontinuation
- 1988-02-19 NO NO880745A patent/NO172118C/no unknown
- 1988-12-16 RU SU884613078A patent/RU1802811C/ru active
- 1988-12-19 FI FI885861A patent/FI885861A0/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU604727B2 (en)	1991-01-03
DE3772202D1 (de)	1991-09-19
EP0302896B1 (en)	1991-08-14
EP0302896A1 (en)	1989-02-15
DK81288A (da)	1988-02-17
NL8601585A (nl)	1988-01-18
HUT56548A (en)	1991-09-30
NO880745L (no)	1988-02-19
US5010095A (en)	1991-04-23
FI885861A (fi)	1988-12-19
NO172118B (no)	1993-03-01
KR880701231A (ko)	1988-07-26
ATE66212T1 (de)	1991-08-15
DK81288D0 (da)	1988-02-17
AU7589387A (en)	1988-01-12
RU1802811C (ru)	1993-03-15
NO880745D0 (no)	1988-02-19
MC1936A1 (fr)	1989-05-19
CA1296716C (en)	1992-03-03
WO1987007891A1 (en)	1987-12-30
JPH01502981A (ja)	1989-10-12
FI885861A0 (fi)	1988-12-19

Publication	Publication Date	Title
NO172118C (no)	1993-06-09	Analogifremgangsmaate til fremstilling av terapeutisk aktivt n-(omega-substituert -alkyl)-n'-((imidazol-4-yl)alkyl)-guanidin
KR920021523A (ko)	1992-12-18	신규한 우레아 유도체, 이의 제조 방법 및 이들을 함유하는 약제학적 조성물
DE69022453D1 (de)	1995-10-26	N-(3-Hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran oder dihydrobenzodioxin)-carboxamid-Derivate.
NO874454D0 (no)	1987-10-26	Nye derivater av benzimidazoler med anti-ulcusaktivitet og fremgangsmaate for deres fremstilling.
KR910015562A (ko)	1991-09-30	뇌부전 질환치료용 약제, 신규 2-(1-피페라지닐)-4-페닐시클로알카노 피리미딘 유도체, 및 그의 제법
DK597687D0 (da)	1987-11-13	Imidazolidinonforbindelse, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat dermed
ATE89547T1 (de)	1993-06-15	Dopamin-vorlaeufer.
DE3774795D1 (de)	1992-01-09	Phenoxyessigsaeure-verbindungen, ihre herstellung, pharmazeutische zusammensetzungen und deren verwendung.
ES2028838T3 (es)	1992-07-16	Procedimiento para la obtencion de nuevos derivados de 4,5-hidro-oxazoles.
DK166281C (da)	1993-08-23	Tetrahydroisoxazoloe4,5-caapyridin derivater og farmaceutisk acceptable syreadditionssalte deraf, farmaceutiske praeparater indeholdende disse forbindelser, og fremgangsmaade til deres fremstilling
DE2236876B2 (de)	1980-06-04	N-Substituierte Aminocarbonsäuren und diese Verbindungen enthaltende Arzneimittel
DE69910738D1 (de)	2003-10-02	Fungizide zusammensetzung enthaltend ein n-benzoyl-n'-phenyl-harnstoff derivat
US3098008A (en)	1963-07-16	Method for treatment of dermatological disorders
ES8708213A1 (es)	1987-10-01	Un procedimiento para preparar un derivado de 1-benzhidril--4-cinamilpiperazina
DE3782235D1 (de)	1992-11-19	Verwendung von 2-oxo-imidazolidin-derivaten zur prophylaxe und zur behandlung von herzinsuffizienz.
ATE105476T1 (de)	1994-05-15	Dihydropyridin-verbindung zur verbesserung der adernausdehnung und hemmung der herzhypertrophie.
KR910002789A (ko)	1991-02-26	아크릴산염, 이것의 제조방법, 이것을 함유한 제약조성물 및 의약에서 이것을 사용하는 방법
TH2131B (th)	1991-01-25	การเตรียมอนุพันธ์ของเบนซิมิดาโซลและสารผสมของสารเหล่านี้
ATE44741T1 (de)	1989-08-15	2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere.