FI885861A - N-(w-substituerade alkyl)-n'-/imidazol -4-yl/guanidiner. - Google Patents

N-(w-substituerade alkyl)-n'-/imidazol -4-yl/guanidiner. Download PDF

Info

Publication number: FI885861A
Authority: FI; Finland
Prior art keywords: pct; imidazole; isothiourea; sec; reaction
Prior art date: 1986-06-19

Application number

FI885861A

Other languages

English (en)

Other versions

FI885861A0 (fi

Inventor

Geert Jan Sterk

Henk Timmerman

Der Goot Henk Van

Original Assignee

Cedona Pharm Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-19

Filing date

1988-12-19

Publication date

1988-12-19

1988-12-19 Application filed by Cedona Pharm Bv filed Critical Cedona Pharm Bv

1988-12-19 Publication of FI885861A0 publication Critical patent/FI885861A0/fi

1988-12-19 Publication of FI885861A publication Critical patent/FI885861A/fi

Links

-1 IMIDAZOLE-4-YL Chemical class 0.000 title abstract 2
UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 4
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
DEURIUYJZZLADZ-UHFFFAOYSA-N 2-(1h-imidazol-2-yl)ethanamine Chemical compound NCCC1=NC=CN1 DEURIUYJZZLADZ-UHFFFAOYSA-N 0.000 abstract 1
HQNOODJDSFSURF-UHFFFAOYSA-N 3-(1h-imidazol-2-yl)propan-1-amine Chemical compound NCCCC1=NC=CN1 HQNOODJDSFSURF-UHFFFAOYSA-N 0.000 abstract 1
206010027654 Allergic conditions Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
CPEKAXYCDKETEN-UHFFFAOYSA-N benzoyl isothiocyanate Chemical compound S=C=NC(=O)C1=CC=CC=C1 CPEKAXYCDKETEN-UHFFFAOYSA-N 0.000 abstract 1
208000027744 congestion Diseases 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 abstract 1
DQMWMUMCNOJLSI-UHFFFAOYSA-N n-carbamothioylbenzamide Chemical class NC(=S)NC(=O)C1=CC=CC=C1 DQMWMUMCNOJLSI-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003141 primary amines Chemical class 0.000 abstract 1
150000003585 thioureas Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)
Polyurethanes Or Polyureas (AREA)
Analysing Materials By The Use Of Radiation (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
Inks, Pencil-Leads, Or Crayons (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

FI885861A 1986-06-19 1988-12-19 N-(w-substituerade alkyl)-n'-/imidazol -4-yl/guanidiner. FI885861A (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL8601585A NL8601585A (nl)	1986-06-19	1986-06-19	N-(2-gesubstitueerde alkyl)-n-imidazol-4-yl alkyl guanidine.
PCT/NL1987/000013 WO1987007891A1 (en)	1986-06-19	1987-06-19	N-(2-substituted alkyl)-n'-[(imidazole-4-yl)alkyl]guanidine

Publications (2)

Publication Number	Publication Date
FI885861A0 FI885861A0 (fi)	1988-12-19
FI885861A true FI885861A (fi)	1988-12-19

Family

ID=19848186

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI885861A FI885861A (fi)	1986-06-19	1988-12-19	N-(w-substituerade alkyl)-n'-/imidazol -4-yl/guanidiner.

Country Status (15)

Country	Link
US (1)	US5010095A (fi)
EP (1)	EP0302896B1 (fi)
JP (1)	JPH01502981A (fi)
KR (1)	KR880701231A (fi)
AT (1)	ATE66212T1 (fi)
CA (1)	CA1296716C (fi)
DE (1)	DE3772202D1 (fi)
DK (1)	DK81288A (fi)
FI (1)	FI885861A (fi)
HU (1)	HUT56548A (fi)
MC (1)	MC1936A1 (fi)
NL (1)	NL8601585A (fi)
NO (1)	NO172118C (fi)
RU (1)	RU1802811C (fi)
WO (1)	WO1987007891A1 (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL9000132A (nl) *	1990-01-19	1991-08-16	Cedona Pharm Bv	Nieuwe thiazoolderivaten.
NL9100365A (nl) *	1991-02-27	1992-09-16	Seed Capital Investments	Imidazoolderivaten met agonistische of antagonistische activiteit op de histamine h3-receptor.
WO1992015567A1 (en) *	1991-02-27	1992-09-17	Seed Capital Investment (Sci) B.V.	Imidazole-derivatives having agonistic or antagonistic activity on the histamine h3-receptor
USRE37303E1 (en) *	1992-01-10	2001-07-31	Institut National Del La Sante Et De La Recherche Medicale	Imidazole compounds and their therapeutic applications
FR2686084B1 (fr) *	1992-01-10	1995-12-22	Bioprojet Soc Civ	Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
US5424447A (en) *	1993-07-07	1995-06-13	The Medical College Of Wisconsin Research Foundation, Inc.	Heme binding compounds and use thereof
US6448282B1 (en)	1995-05-30	2002-09-10	Gliatech, Inc.	1H-4(5)-substituted imidazole derivatives
ATE213412T1 (de) *	1995-05-30	2002-03-15	Gliatech Inc	1h-4(5)substituierte imidazolderivate
AU2764797A (en) *	1996-05-14	1997-12-05	Novo Nordisk A/S	Somatostatin agonists and antagonists
US6127343A (en) *	1996-05-14	2000-10-03	Novo Nordisk A/S	Somatostatin agonists and antagonists
AU4772497A (en) *	1996-10-31	1998-05-22	Novo Nordisk A/S	Constrained somatostatin agonists and antagonists
US6225332B1 (en) *	1997-10-21	2001-05-01	Alcon Laboratories, Inc.	Compositions containing histamine H2 agonists and methods of use in treating allergy and inflammation
EP1472214A2 (en) *	2002-02-08	2004-11-03	SmithKline Beecham Corporation	Compounds for inhibiting insulin secretion and methods related thereto
DE10245212B4 (de) *	2002-09-27	2008-01-03	Ivoclar Vivadent Ag	Verwendung säurehaltiger Mittel zur Desensibilisierung von Zähnen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4013659A (en) *	1973-07-13	1977-03-22	Smith Kline & French Laboratories Limited	Certain n,n'-disubstituted guanidine compounds and their use
US4192879A (en) *	1975-05-21	1980-03-11	Smith Kline & French Laboratories Limited	Imidazolyl alkylamino nitroethylene compounds
IL49528A (en) *	1975-05-21	1980-11-30	Smith Kline French Lab	Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
US4166860A (en) *	1977-10-11	1979-09-04	William H. Rorer, Inc.	Imidazole amidinoureas for stimulating H2 -receptors
DE3528215A1 (de) *	1985-08-06	1987-02-12	Heumann Ludwig & Co Gmbh	Heteroarylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3512084A1 (de) *	1985-04-02	1986-10-09	Ludwig Heumann & Co GmbH, 8500 Nürnberg	Guanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3528214A1 (de) *	1985-08-06	1987-02-12	Heumann Ludwig & Co Gmbh	Arylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

1986
- 1986-06-19 NL NL8601585A patent/NL8601585A/nl not_active Application Discontinuation
1987
- 1987-06-19 WO PCT/NL1987/000013 patent/WO1987007891A1/en active IP Right Grant
- 1987-06-19 KR KR1019880700188A patent/KR880701231A/ko not_active Application Discontinuation
- 1987-06-19 EP EP87904332A patent/EP0302896B1/en not_active Expired - Lifetime
- 1987-06-19 JP JP62503950A patent/JPH01502981A/ja active Pending
- 1987-06-19 DE DE8787904332T patent/DE3772202D1/de not_active Expired - Lifetime
- 1987-06-19 CA CA000540131A patent/CA1296716C/en not_active Expired - Lifetime
- 1987-06-19 MC MC87NL8700013D patent/MC1936A1/xx unknown
- 1987-06-19 AT AT87904332T patent/ATE66212T1/de not_active IP Right Cessation
- 1987-06-19 HU HU873434A patent/HUT56548A/hu unknown
- 1987-06-19 US US07/297,549 patent/US5010095A/en not_active Expired - Fee Related
1988
- 1988-02-17 DK DK081288A patent/DK81288A/da not_active Application Discontinuation
- 1988-02-19 NO NO880745A patent/NO172118C/no unknown
- 1988-12-16 RU SU884613078A patent/RU1802811C/ru active
- 1988-12-19 FI FI885861A patent/FI885861A/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU604727B2 (en)	1991-01-03
FI885861A0 (fi)	1988-12-19
CA1296716C (en)	1992-03-03
HUT56548A (en)	1991-09-30
NO880745L (no)	1988-02-19
NO172118B (no)	1993-03-01
ATE66212T1 (de)	1991-08-15
NO172118C (no)	1993-06-09
DK81288D0 (da)	1988-02-17
DK81288A (da)	1988-02-17
EP0302896A1 (en)	1989-02-15
MC1936A1 (fr)	1989-05-19
NL8601585A (nl)	1988-01-18
RU1802811C (ru)	1993-03-15
WO1987007891A1 (en)	1987-12-30
KR880701231A (ko)	1988-07-26
DE3772202D1 (de)	1991-09-19
JPH01502981A (ja)	1989-10-12
EP0302896B1 (en)	1991-08-14
US5010095A (en)	1991-04-23
AU7589387A (en)	1988-01-12
NO880745D0 (no)	1988-02-19

Legal Events

Date	Code	Title	Description
1993-07-21	FD	Application lapsed
2004-08-31	FD	Application lapsed	Owner name: CEDONA PHARMACEUTICALS B.V.

Publication	Publication Date	Title
FI885861A0 (fi)	1988-12-19	N-(w-substituerade alkyl)-n'-/imidazol -4-yl/guanidiner.
KR920021523A (ko)	1992-12-18	신규한 우레아 유도체, 이의 제조 방법 및 이들을 함유하는 약제학적 조성물
FI893467A0 (fi)	1989-07-18	Menetelmä lääkeaineena käyttökelpoisten 4-oksokinoliini-3-karboksyylihapon johdannaisten valmistamiseksi
DE69022453D1 (de)	1995-10-26	N-(3-Hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran oder dihydrobenzodioxin)-carboxamid-Derivate.
ATE27273T1 (de)	1987-06-15	Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazolderivate, sowie arzneimittel, die diese verbindungen enthalten.
ATE19878T1 (de)	1986-06-15	Benzimidazol-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE103812T1 (de)	1994-04-15	Zusammensetzung zur behandlung von ischaemischen stoerungen in organen.
GB1437136A (en)	1976-05-26	Anti-inflammatory thiazole compounds compositions and methods for using same
NO924929L (no)	1992-12-18	Farmasoeytisk aktive benzoquinazolinforbindelser
ES2046193T3 (es)	1994-02-01	Un procedimiento para la preparacion de un compuesto de imidazolidinona.
DK0782567T3 (da)	1999-11-22	Isothiourinstofderivater og fremgangsmåder til deres fremstilling
DE2950838A1 (de)	1980-07-03	Neue thiazolylmethylthioderivate, verfahren zu deren herstellung und arzneimittel
ES2004451A6 (es)	1989-01-01	Procedimiento de preparacion de acido 1-(3-mercapto-(2s)-metilpropionil-pirrolidin-(2s)-carboxilico
NO840732L (no)	1984-08-29	Analogifremgangsmaate for fremstilling av den terapeutisk aktive forbindelse n-(3-trifluormetylfenyl)-n`-propargylpiperazin
ES8708213A1 (es)	1987-10-01	Un procedimiento para preparar un derivado de 1-benzhidril--4-cinamilpiperazina
ES8504743A1 (es)	1985-05-01	Un procedimiento para la preparacion de nuevos derivados de triazol
ATE81466T1 (de)	1992-10-15	Verwendung von 2-oxo-imidazolidin-derivaten zur prophylaxe und zur behandlung von herzinsuffizienz.
GB1434645A (en)	1976-05-05	Tetrazole coumarin derivatives
KR930002303A (ko)	1993-02-22	N-아릴알킬파라히드록시페닐아세트아미드 유도체와 그의 제조방법
ATE44741T1 (de)	1989-08-15	2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere.
KR910021383A (ko)	1991-12-20	N-(2, 6-디니트로-3-클로로-4-트리플루오로메틸페닐)-4-아미노-6-플루오로피리미딘 유도체 및 그의 제조방법
ATE81465T1 (de)	1992-10-15	Verwendung von 2-oxo-imidazolidin-derivaten zur behandlung von nierenkrankheiten.
TH2131B (th)	1991-01-25	การเตรียมอนุพันธ์ของเบนซิมิดาโซลและสารผสมของสารเหล่านี้
CH396875A (de)	1965-08-15	Verfahren zur Herstellung neuer Harnstoffe
TH893A (th)	1983-04-08	การเตรียมอนุพันธ์ของเบนซิมิดาโซลและสารผสมของสารเหล่านี้