NO168924B - PACKAGED DENTAL CREAM - Google Patents
PACKAGED DENTAL CREAM Download PDFInfo
- Publication number
- NO168924B NO168924B NO863484A NO863484A NO168924B NO 168924 B NO168924 B NO 168924B NO 863484 A NO863484 A NO 863484A NO 863484 A NO863484 A NO 863484A NO 168924 B NO168924 B NO 168924B
- Authority
- NO
- Norway
- Prior art keywords
- packaged
- toothpaste
- toothpaste according
- weight
- packaged toothpaste
- Prior art date
Links
- 239000006071 cream Substances 0.000 title 1
- 239000000606 toothpaste Substances 0.000 claims description 100
- 229940034610 toothpaste Drugs 0.000 claims description 83
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 48
- 239000000463 material Substances 0.000 claims description 37
- -1 polyethylene Polymers 0.000 claims description 35
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 19
- 238000005498 polishing Methods 0.000 claims description 19
- 239000000600 sorbitol Substances 0.000 claims description 19
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 18
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 16
- 239000002202 Polyethylene glycol Substances 0.000 claims description 16
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 16
- 229920001223 polyethylene glycol Polymers 0.000 claims description 16
- 150000004684 trihydrates Chemical class 0.000 claims description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 12
- 239000011734 sodium Substances 0.000 claims description 9
- 229910052708 sodium Inorganic materials 0.000 claims description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- 239000004743 Polypropylene Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 229920001155 polypropylene Polymers 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000004698 Polyethylene Substances 0.000 claims description 6
- 239000001506 calcium phosphate Substances 0.000 claims description 6
- 229920001684 low density polyethylene Polymers 0.000 claims description 6
- 239000004702 low-density polyethylene Substances 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 229920000573 polyethylene Polymers 0.000 claims description 6
- 239000003349 gelling agent Substances 0.000 claims description 5
- 239000002650 laminated plastic Substances 0.000 claims description 5
- 229920001179 medium density polyethylene Polymers 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- 229910052783 alkali metal Inorganic materials 0.000 claims description 4
- 150000001340 alkali metals Chemical class 0.000 claims description 4
- 239000004701 medium-density polyethylene Substances 0.000 claims description 4
- 239000002195 soluble material Substances 0.000 claims description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 3
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims description 3
- 159000000007 calcium salts Chemical class 0.000 claims description 3
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 3
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 3
- 229940038472 dicalcium phosphate Drugs 0.000 claims description 3
- 150000004683 dihydrates Chemical group 0.000 claims description 3
- 229940085991 phosphate ion Drugs 0.000 claims description 3
- 150000004682 monohydrates Chemical group 0.000 claims description 2
- 235000011007 phosphoric acid Nutrition 0.000 claims description 2
- 229910010272 inorganic material Inorganic materials 0.000 claims 1
- 239000011147 inorganic material Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 description 15
- 235000010356 sorbitol Nutrition 0.000 description 13
- 239000000203 mixture Substances 0.000 description 9
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 8
- 229920000098 polyolefin Polymers 0.000 description 8
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 229920006226 ethylene-acrylic acid Polymers 0.000 description 6
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 6
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 6
- 229910052782 aluminium Inorganic materials 0.000 description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 5
- 239000000679 carrageenan Substances 0.000 description 5
- 229920001525 carrageenan Polymers 0.000 description 5
- 229940113118 carrageenan Drugs 0.000 description 5
- QHZOMAXECYYXGP-UHFFFAOYSA-N ethene;prop-2-enoic acid Chemical compound C=C.OC(=O)C=C QHZOMAXECYYXGP-UHFFFAOYSA-N 0.000 description 5
- 239000011888 foil Substances 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 229920005672 polyolefin resin Polymers 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000011737 fluorine Substances 0.000 description 4
- 229910052731 fluorine Inorganic materials 0.000 description 4
- 239000007791 liquid phase Substances 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 239000007790 solid phase Substances 0.000 description 4
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 239000011149 active material Substances 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 229910001679 gibbsite Inorganic materials 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- KZNNRLXBDAAMDZ-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane trihydrate Chemical compound O.O.O.O=[Al]O[Al]=O KZNNRLXBDAAMDZ-UHFFFAOYSA-N 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 3
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 2
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 2
- 229940123208 Biguanide Drugs 0.000 description 2
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 229920000388 Polyphosphate Polymers 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000007844 bleaching agent Substances 0.000 description 2
- 229960003563 calcium carbonate Drugs 0.000 description 2
- 235000010216 calcium carbonate Nutrition 0.000 description 2
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 2
- 229940043256 calcium pyrophosphate Drugs 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 2
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 description 2
- PJQJKHNLFUSIGI-UHFFFAOYSA-K dimagnesium phosphate trihydrate Chemical compound O.O.O.[Mg+2].[Mg+2].[O-]P([O-])([O-])=O PJQJKHNLFUSIGI-UHFFFAOYSA-K 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000003822 epoxy resin Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 2
- 239000001095 magnesium carbonate Substances 0.000 description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 229920000647 polyepoxide Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 239000001205 polyphosphate Substances 0.000 description 2
- 235000011176 polyphosphates Nutrition 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
- 239000011698 potassium fluoride Substances 0.000 description 2
- 229960001462 sodium cyclamate Drugs 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- ILJOYZVVZZFIKA-UHFFFAOYSA-M sodium;1,1-dioxo-1,2-benzothiazol-3-olate;hydrate Chemical compound O.[Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 ILJOYZVVZZFIKA-UHFFFAOYSA-M 0.000 description 2
- 229960002799 stannous fluoride Drugs 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 2
- 229940078499 tricalcium phosphate Drugs 0.000 description 2
- 235000019731 tricalcium phosphate Nutrition 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- ZFTPXVSCHFZJNO-UHFFFAOYSA-N (1e)-1-[amino-(4-chloroanilino)methylidene]-2-dodecylguanidine Chemical compound CCCCCCCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 ZFTPXVSCHFZJNO-UHFFFAOYSA-N 0.000 description 1
- JLPAMKUIIFHLBH-UHFFFAOYSA-N 1,2-dihydroxypropane-1-sulfonic acid Chemical class CC(O)C(O)S(O)(=O)=O JLPAMKUIIFHLBH-UHFFFAOYSA-N 0.000 description 1
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 description 1
- RHUVWEVCJBFSPL-UHFFFAOYSA-N 1-benzyl-2-(n'-chlorocarbamimidoyl)-1-(3-dodecoxypropyl)guanidine Chemical compound CCCCCCCCCCCCOCCCN(C(=N)NC(=N)NCl)CC1=CC=CC=C1 RHUVWEVCJBFSPL-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- HTYFFCPFVMJTKM-UHFFFAOYSA-N 2-(4-chlorophenyl)-1-(diaminomethylidene)guanidine Chemical compound NC(N)=NC(N)=NC1=CC=C(Cl)C=C1 HTYFFCPFVMJTKM-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- LFJJOPDNPVFCNZ-UHFFFAOYSA-N 2-[hexadecanoyl(methyl)amino]acetic acid Chemical class CCCCCCCCCCCCCCCC(=O)N(C)CC(O)=O LFJJOPDNPVFCNZ-UHFFFAOYSA-N 0.000 description 1
- NGOZDSMNMIRDFP-UHFFFAOYSA-N 2-[methyl(tetradecanoyl)amino]acetic acid Chemical class CCCCCCCCCCCCCC(=O)N(C)CC(O)=O NGOZDSMNMIRDFP-UHFFFAOYSA-N 0.000 description 1
- IAHQOCUQMUDGEB-UHFFFAOYSA-N 6-methyloxathiazin-4-one;sodium Chemical compound [Na].CC1=CC(=O)NSO1 IAHQOCUQMUDGEB-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 240000001238 Gaultheria procumbens Species 0.000 description 1
- 235000007297 Gaultheria procumbens Nutrition 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 244000024873 Mentha crispa Species 0.000 description 1
- 235000014749 Mentha crispa Nutrition 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 244000227633 Ocotea pretiosa Species 0.000 description 1
- 235000004263 Ocotea pretiosa Nutrition 0.000 description 1
- 238000013494 PH determination Methods 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- SYIIDWGQTWQDFF-UHFFFAOYSA-N benzyl(18-ethylicosyl)azanium;chloride Chemical compound [Cl-].CCC(CC)CCCCCCCCCCCCCCCCC[NH2+]CC1=CC=CC=C1 SYIIDWGQTWQDFF-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- MHJAJDCZWVHCPF-UHFFFAOYSA-L dimagnesium phosphate Chemical compound [Mg+2].OP([O-])([O-])=O MHJAJDCZWVHCPF-UHFFFAOYSA-L 0.000 description 1
- 229910000395 dimagnesium phosphate Inorganic materials 0.000 description 1
- 235000019791 dimagnesium phosphate Nutrition 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- UMGSFZGNYYDQSL-UHFFFAOYSA-H disodium;tin(4+);hexafluoride Chemical compound [F-].[F-].[F-].[F-].[F-].[F-].[Na+].[Na+].[Sn+4] UMGSFZGNYYDQSL-UHFFFAOYSA-H 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical class CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 150000002169 ethanolamines Chemical class 0.000 description 1
- 229940091249 fluoride supplement Drugs 0.000 description 1
- OMRRUNXAWXNVFW-UHFFFAOYSA-N fluoridochlorine Chemical compound ClF OMRRUNXAWXNVFW-UHFFFAOYSA-N 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Substances CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052816 inorganic phosphate Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 239000004137 magnesium phosphate Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000005026 oriented polypropylene Substances 0.000 description 1
- 125000006353 oxyethylene group Chemical group 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000007739 pm medium Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Dental Preparations (AREA)
- Confectionery (AREA)
Description
Oppfinnelsen vedrører tannkrem emballert i plast-laminattube, mekanisk dispenser, elastisk pute eller lignende. Nærmere bestemt vedrører den tannkrem i direkte kontakt med emballasjeoverflaten i en slik emballasje som en tannkremtube av plastlaminat, mekanisk dispenser eller elastisk pute. The invention relates to toothpaste packaged in a plastic laminate tube, mechanical dispenser, elastic cushion or the like. More specifically, it relates to toothpaste in direct contact with the packaging surface in such packaging as a toothpaste tube made of plastic laminate, mechanical dispenser or elastic cushion.
Tannkremer har i mange år vært emballert i elastiske metalltuber slik som voksforede blytuber, uforede aluminiumstuber eller aluminiumstuber med et lakkbelegg av epoxyharpiks. I de senere år har elastiske laminerte plasttuber som be-holder formen blitt brukt i økende grad. Toothpastes have for many years been packaged in elastic metal tubes such as wax-lined lead tubes, unlined aluminum tubes or aluminum tubes with a varnish coating of epoxy resin. In recent years, elastic laminated plastic tubes which retain their shape have been increasingly used.
Plastlaminerte tannkremtuber omfatter vanligvis et indre lag av polyolefinharpiks som er i direkte kontakt med tannkremen, og minst ett mellomliggende lag, som omfatter et aluminiumfolielag som inhiberer tap av smaksstoff fra tannkremen. Det er ønskelig at også et mellomliggende papirlag som gir stivhet til tuben, også er tilstede. De ytre lagene er vanligvis av polyolefinharpikser, hvorav ett kan være farget hvitt og bærer trykte angivelser med et klart over-trekk av polyolefinlaminat for å beskytte angivelsene. Ytter-ligere mellomliggende laminatlag av elastisk plast kan også være tilstede. Plastic laminated toothpaste tubes usually comprise an inner layer of polyolefin resin which is in direct contact with the toothpaste, and at least one intermediate layer, which comprises an aluminum foil layer which inhibits loss of flavor from the toothpaste. It is desirable that an intermediate paper layer, which gives rigidity to the tube, is also present. The outer layers are usually of polyolefin resins, one of which may be colored white and carry printed indicia with a clear overcoat of polyolefin laminate to protect the indicia. Outer-inner intermediate laminate layers of elastic plastic may also be present.
Mekaniske tannkremdispensere kan også ha en polyolefinoverflate i kontakt med tannkrem som befinner seg i dispen-serne. Faktisk kan polyolefinet selv være dispenserhuset. Elastiske putepakninger kan også ha en polyolefinoverflate Mechanical toothpaste dispensers can also have a polyolefin surface in contact with toothpaste that is in the dispensers. In fact, the polyolefin itself may be the dispenser housing. Elastic cushion gaskets can also have a polyolefin surface
i kontakt med tannkremområder. in contact with toothpaste areas.
Tannkremer inneholder vanligvis en flytende bærer av vann og fuktemiddel, et geldannende middel som fast bærer og et vannoppløselig tannpoleringsmiddel. Tannkremer som er sammensatt av slike materialer hvor fuktemidlet omfatter glycerol og sorbitol og poleringsmaterialet er i det minste hovedsakelig et vannuoppløselig jordalkalimetallsalt eller et a-alumina-trihydrat, har med hell vært emballert i elastiske metalltannpastabeholdere, deriblant aluminiumtuber med et indre belegg av et lakklag av epoxyharpiks. Det er imidlertid blitt iakttatt at når slike tannkremer emballeres i be-holdere med en indre polyolefinoverflate, slik som plastlaminerte tannkremtuber, mekanisk drevne tann-kremdispensere eller elastiske puter, oppstår det synerese og væsker skiller seg fra faste stoffer, noe som gjør tannkremen uønsket, når pH i tannkremen reduseres med et vannoppløselig materiale som tilveiebringer fosfation. Toothpastes usually contain a liquid carrier of water and humectant, a gelling agent as a solid carrier and a water-soluble tooth polishing agent. Toothpastes composed of such materials in which the wetting agent comprises glycerol and sorbitol and the polishing material is at least substantially a water-insoluble alkaline earth metal salt or an α-alumina trihydrate have been successfully packaged in resilient metal toothpaste containers, including aluminum tubes with an inner coating of a lacquer layer of epoxy resin. However, it has been observed that when such toothpastes are packaged in containers with an inner polyolefin surface, such as plastic laminated toothpaste tubes, mechanically operated toothpaste dispensers or elastic cushions, syneresis occurs and liquids separate from solids, making the toothpaste undesirable, when the pH of the toothpaste is reduced with a water-soluble material that provides phosphate ion.
Det er en fordel ved oppfinnelsen at faseseparasjon It is an advantage of the invention that phase separation
av en tannkrem emballert i kontakt med et polyethylen- eller polypropylenmateriale, i det vesentlige forhindres. Andre fordeler vil fremgå av følgende beskrivelse. of a toothpaste packaged in contact with a polyethylene or polypropylene material is essentially prevented. Other advantages will be apparent from the following description.
Foreliggende oppfinnelse vedrører en emballert tannkrem som er kjennetegnet ved at tannkremen er i direkte kontakt med en emballasjeoverflate av polyethylen med The present invention relates to a packaged toothpaste which is characterized by the fact that the toothpaste is in direct contact with a packaging surface of polyethylene with
lav eller middels densitet, eller av polypropylen, og tannkremen omfatter minst 20 vekt% av en flytende bærer low or medium density, or of polypropylene, and the toothpaste comprises at least 20% by weight of a liquid carrier
som omfatter vann, glycerol, sorbitol og polyethylenglycol med gjennomsnittlig molekylvekt på 200 - 1000, idet vektforholdet mellom glycerol og sorbitol er fra 0,25:1 til 3:1 og vektforholdet mellom den samlede mengde glycerol og sorbitol, og polethylenglycolen er fra 60:1 til 6:1, en fast . bærer som omfatter 0,05 - 10 vekt% geldanningsmiddel, 20 - 75 vekt% av et dentalt akseptabelt vannuoppløselig poleringsmateriale, hvorav hoveddelen er enten et vannuoppløselig jordalkalimetallsalt eller trihydrat av a-alumina, og når trihydratet av a-alumina er tilstede som hoveddelen av poleringsmaterialet, et vannoppløselig materiale for å redusere pH i tannkremen til 6-8, som tilveiebringer fosfation. which comprises water, glycerol, sorbitol and polyethylene glycol with an average molecular weight of 200 - 1000, the weight ratio between glycerol and sorbitol being from 0.25:1 to 3:1 and the weight ratio between the total amount of glycerol and sorbitol and the polyethylene glycol being from 60: 1 to 6:1, a fixed . carrier comprising 0.05 - 10% by weight gelling agent, 20 - 75% by weight of a dentally acceptable water-insoluble polishing material, the major part of which is either a water-insoluble alkaline earth metal salt or trihydrate of α-alumina, and when the trihydrate of α-alumina is present as the main part of the polishing material, a water-soluble material to reduce the pH of the toothpaste to 6-8, which provides phosphate ion.
I tannkrempreparater er væskene og de faste stoffene nødvendigvis avpasset slik at det dannes en kremaktig masse med ønsket konsistens som lar seg ekstrudere fra emballasjen. Væskene i foreliggende tannkrem omfatter hovedsakelig vann, glycerol og sorbitol, sammen med en mindre mengde polyethylenglycol med molekylvekt på 200 - 1000, fortrinnsvis 600 - 1000. Den samlede flytende bærer utgjør minst 20 In toothpaste preparations, the liquids and solids are necessarily adjusted so that a creamy mass with the desired consistency is formed which can be extruded from the packaging. The liquids in the present toothpaste mainly comprise water, glycerol and sorbitol, together with a small amount of polyethylene glycol with a molecular weight of 200 - 1000, preferably 600 - 1000. The total liquid carrier amounts to at least 20
vekt% av preparatet. Det er også til stede et geldanningsmiddel i tannkremene, slik som de naturlige og syn-tetiske gummier og gummilignende materialer, slik som krus-karragener eller jota-karragen, tragantgummi, natriumcarboxymethylcellulose, hydroxyethylcellulose, polyvinylpyrrolidon, natriumalginat, guargummi, stivelse, xanthan og lignende, % by weight of the preparation. A gelling agent is also present in the toothpastes, such as the natural and synthetic gums and gum-like materials, such as krus-carrageenan or iota-carrageenan, gum tragacanth, sodium carboxymethylcellulose, hydroxyethylcellulose, polyvinylpyrrolidone, sodium alginate, guar gum, starch, xanthan and the like ,
deriblant blandinger derav. Kruskarragen, natriumcarboxymethylcellulose og hydroxyethylcellulose, inkludert blandinger derav, er særlig forenlige og er foretrukne gel-dannihgsitiidler. Når hovedpoleringsmidlet er vannuoppløselig jordalkalimetallsalt, er også jota-karragen et foretrukket geldanningsmiddel. Gummiinnholdet er vanligvis i en mengde på 0,05-10 vekt%, og fortrinnsvis 0,5-5 vekt%, including mixtures thereof. Carrageenan, sodium carboxymethylcellulose and hydroxyethylcellulose, including mixtures thereof, are particularly compatible and are preferred gel forming agents. When the main polishing agent is a water-insoluble alkaline earth metal salt, iota-carrageenan is also a preferred gelling agent. The rubber content is usually in an amount of 0.05-10% by weight, and preferably 0.5-5% by weight,
av preparatet. of the preparation.
Vann er vanligvis inkorporert i tannkremen i en mengde på 10 - 50 vekt%, fortrinnsvis 15 - 35 vekt%. Glycerol og sorbitol utgjør tilsammen vanligvis 15 - 50 vekt%, fortrinnsvis 20 - 35 vekt% av tannkremen, idet vektforholdet mellom glycerol og sorbitol er fra 0,25:1 til Water is usually incorporated in the toothpaste in an amount of 10 - 50% by weight, preferably 15 - 35% by weight. Glycerol and sorbitol together usually make up 15 - 50% by weight, preferably 20 - 35% by weight of the toothpaste, the weight ratio between glycerol and sorbitol being from 0.25:1 to
3:1, vanligvis fra 0,25:1 til 0,8:1, og fortrinnsvis fra 0,6:1 til 0,8:1. Sorbitolmengder slik de her brukes er av sorbitolsirup, slik denne er kommersielt tilgjengelig, dvs. 70 vekt% sorbitol i 30 vekt% vann. 3:1, usually from 0.25:1 to 0.8:1, and preferably from 0.6:1 to 0.8:1. Amounts of sorbitol as used here are from sorbitol syrup, as this is commercially available, i.e. 70% by weight sorbitol in 30% by weight of water.
Lavmolekylært polyethylenglycol med gjennomsnittlig molekylvekt på 200 - 1000, fortrinnsvis 600 - 1000, dispergeres lett i den flytende bærer og er effektiv når det gjelder å forhindre tannkremen fra å gjennomgå synerese når den er i direkte kontakt med en overflate av polyolefinharpiks i en tannkrememballasje. For å bevirke lett dispersjon, varmes polyethylenglycolsorter som normalt er faste ved værelsetemperatur, for å gjøre dem flytende. Vektforholdet mellom den samlede mengde av glycerol og sorbitol, og polyethylenglycol er fra 60:1 til 6:1, fortrinnsvis fra Low molecular weight polyethylene glycol having an average molecular weight of 200-1000, preferably 600-1000, is readily dispersed in the liquid carrier and is effective in preventing the toothpaste from undergoing syneresis when in direct contact with a surface of polyolefin resin in a toothpaste package. To effect light dispersion, polyethylene glycol grades which are normally solid at room temperature are heated to liquefy them. The weight ratio between the total amount of glycerol and sorbitol, and polyethylene glycol is from 60:1 to 6:1, preferably from
15:1 til 12:1 i tannkrem med jordalkalimetallsalt som poleringsmiddel, eller 10:1 i tannkrem med oc-alumina-trihydrat. Typisk er minst 0,5 vekt% av polyethylenglycol tilstede, fortrinnsvis 0,5-5 vekt%. 15:1 to 12:1 in toothpaste with alkaline earth metal salt as a polishing agent, or 10:1 in toothpaste with oc-alumina trihydrate. Typically at least 0.5% by weight of polyethylene glycol is present, preferably 0.5-5% by weight.
Dentalt akseptabelt vannuoppløselig poleringsmiddel er tilstede i tannkremen i en mengde på 20 - 75 vekt%, fortrinnsvis 35 - 60 vekt%. I minste hoveddelen, dvs. 50 - 100% av poleringsmaterialet, er vannuoppløselig jordalkalimetallsalt eller trihydrat av a-alumina. Dentally acceptable water-insoluble polishing agent is present in the toothpaste in an amount of 20-75% by weight, preferably 35-60% by weight. In the smallest main part, i.e. 50 - 100% of the polishing material, is water-insoluble alkaline earth metal salt or trihydrate of α-alumina.
Typiske vannuoppløselige jordalkalimetallsalter omfatter dihydratet av dikalsiumfosfat, vannfritt dikalsiumfosfat, kalsiumcarbonat, trikalsiumfosfat, kalsiumpyrofosfat, Typical water-insoluble alkaline earth metal salts include dicalcium phosphate dihydrate, dicalcium phosphate anhydrous, calcium carbonate, tricalcium phosphate, calcium pyrophosphate,
trihydratet av dimagnesiumfosfat og magnesiumcarbonat, inkludert blandinger derav. Fortrinnsvis er kalsiumsalt, særlig dihydratet av dikalsiumfosfat eller en blanding av dihydratet av kalsiumfosfat og vannfritt dikalsiumfosfat, tilstede. the trihydrate of dimagnesium phosphate and magnesium carbonate, including mixtures thereof. Preferably, calcium salt, in particular the dihydrate of dicalcium phosphate or a mixture of the dihydrate of calcium phosphate and anhydrous dicalcium phosphate, is present.
Dentalt akseptabel tannpasta som inneholder vannuopp-løselig a-alumina anvendes typisk i liten partikkelstørrelse, f.eks. hvor minst 85% av partiklene er mindre enn 20 um og fortrinnsvis er hydratisert, slik som de som er klassifi-sert som gibbsitt (trihydrat av a-alumina) og normalt angitt kjemisk som A^O^I^O eller AlfOH)^. Den gjennomsnittlige partikkelstørelse til gibbsitt er generelt 6-9 um. Det kan imidlertid også brukes trihydrat av a-alumina med større partikkelstørrelse, f.eks. hvor 20 - 70% av partiklene over-skrider 20 um i størrelse. En særlig ønskelig kvalitet av trihydrat av a-alumina som er tilgjengelig fra Alcoa som "C.333", er en førsteklasses kvalitet av gibbsitt med følgende størrelsefordeling: Dentally acceptable toothpaste containing water-soluble α-alumina is typically used in a small particle size, e.g. where at least 85% of the particles are smaller than 20 µm and are preferably hydrated, such as those classified as gibbsite (trihydrate of α-alumina) and normally indicated chemically as A^O^I^O or AlfOH)^. The average particle size of gibbsite is generally 6-9 µm. However, it is also possible to use trihydrate of α-alumina with a larger particle size, e.g. where 20 - 70% of the particles exceed 20 µm in size. A particularly desirable grade of α-alumina trihydrate available from Alcoa as "C.333" is a premium grade of gibbsite with the following size distribution:
Med mindre pH i tannkremen er regulert, er tannkrem som inneholder en vesentlig mengde trihydrat av a-alumina generelt svært alkalisk, f.eks. pH 9-10,5. Følgelig tilsettes sure materialer ofte til slike tannkremer for å redusere pH, vanligvis til 6-8. Vannoppløselige fosfatmaterialer, særlig uorganiske fosfatmaterialer, er effektive når det gjelder å gi slik reduksjon i alkalitet. Slike materialer omfatter orthofosfater, særlig orthofosforsyre og alkalimetall- eller ammonium-monosyre-orthofosfater eller -disyre-orthofosfater. Natriumdisyreorthofosfat og hydrater derav er foretrukket. Mengden av disse materialene er den som er tilstrekkelig til å regulere pH til 6-8, f.eks. Unless the pH of the toothpaste is regulated, toothpaste containing a significant amount of α-alumina trihydrate is generally very alkaline, e.g. pH 9-10.5. Consequently, acidic materials are often added to such toothpastes to lower the pH, usually to 6-8. Water-soluble phosphate materials, particularly inorganic phosphate materials, are effective in providing such a reduction in alkalinity. Such materials include orthophosphates, particularly orthophosphoric acid and alkali metal or ammonium monoacid orthophosphates or diacid orthophosphates. Sodium diacid orthophosphate and hydrates thereof are preferred. The amount of these materials is that which is sufficient to regulate the pH to 6-8, e.g.
natriumdisyreorthof osf at (monohydrat eller v-annfritt) er sodium disyreorthof osf that (monohydrate or v-other) is
vanligvis tilstede i en mengde på 0,15-0,50 vekt%. Slike pH-regulerende fosfatmaterialer gjør tannkremene utsatt for synerese når de er i kontakt med en overflate av polyolefinharpiks, med mindre det er tilstede additiv for å forhindre synerese. usually present in an amount of 0.15-0.50% by weight. Such pH-adjusting phosphate materials render the dentifrices susceptible to syneresis when in contact with a polyolefin resin surface, unless an additive is present to prevent syneresis.
Når vannuoppløselig jordalkalimetallsalt er hovedbestanddelen i poleringsmaterialet, kan trihydrat av a-alumina, kalsinert alumina eller annet tilleggspoleringsmiddel even-tuelt være tilstede i mindre mengde, f.eks. i et vektforhold mellom jordalkalimetallsalt og aluminamateriale på 2,5:1 til 4:1, idet den samlede mengde poleringsmateriale i tannkremen er 25 - 75 vekt%. When water-insoluble alkaline earth metal salt is the main component of the polishing material, trihydrate of α-alumina, calcined alumina or other additional polishing agent may optionally be present in a smaller amount, e.g. in a weight ratio between alkaline earth metal salt and alumina material of 2.5:1 to 4:1, the total amount of polishing material in the toothpaste being 25 - 75% by weight.
Når trihydrat av a-alumina er hovedbestanddelen i poleringsmaterialet, utgjør den mindre andel av poleringsmaterialet, dersom en slik er tilstede, vanligvis 5-20 vekt% av poleringsmaterialet, og kan være et slikt poleringsmiddel som dihydrat av dikalsiumfosfat, vannfritt dikalsiumfosfat, kalsiumcarbonat, trikalsiumfosfat, kalsiumpyrofosfat, trihydrat av dimagnesiumfosfat, magnesiumcarbonat, kalsinert alumina, zirkonsilikat og uoppløselig natriummetafosfat. When trihydrate of α-alumina is the main component of the polishing material, the smaller proportion of the polishing material, if present, usually 5-20% by weight of the polishing material, and can be such a polishing agent as dicalcium phosphate dihydrate, dicalcium phosphate anhydrous, calcium carbonate, tricalcium phosphate , calcium pyrophosphate, dimagnesium phosphate trihydrate, magnesium carbonate, calcined alumina, zirconium silicate and insoluble sodium metaphosphate.
Organiske overflateaktive midler kan brukes i tannkremen ifølge foreliggende oppfinnelse for å oppnå økt profy-laktisk virkning, hjelpe til med å oppnå grundig og full-stendig dispersjon av preparatene i munnhulen og gjøre tannkremene kosmetisk mer akseptable. Det organiske overflateaktive materiale kan være anionisk, ikke-ionisk, amfolytisk eller kationisk av natur, men det er foretrukket å anvende som det overflateaktive middel et rensende materiale som til-fører preparatet rensende og skummende egenskaper. Egnede typer av slike vaskemidler er vannoppløselige salter av monoglycerid-monosulfater av høyere fettsyre, slik som natriumsaltet av det monosulfaterte monoglycerid av hydrogenerte kokosnøttoljefettsyrer, høyere alkylsylfater, slik som natriumlaurylsulfat, alkylarylsulfonater, slik som natriumdodecyl-benzensulfonat, olefinsulfonater, slik som natriumolefin-sulfonat hvor olefingruppen inneholder 12 - 22 carbonatomer, høyere alkylsulfoacetater, høyere fettsyreester av 1,2-di-hydroxypropansulfonater og de i det vesentlige mettede høyere alifatiske acylamider av lavere alifatiske aminocarboxylsyre-forbindelser, slik som de som inneholder 12 - 16 carbonatomer i fettsyre-, alkyl- eller acylradikalene, og lignende. Eksempler på de sistnevnte amider er N-lauroylsarcosin, og natrium-, kalium- og ethanolaminsaltene av N-lauroyl-, N-myristoyl- eller N-palmitoylsarcosin, som i det vesentlige bør være fri for såpe eller lignende høyere fettsyremateriale som er tilbøyelig til i vesentlig grad å redusere virkningen av disse forbindelsene i preparater ifølge foreliggende oppfinnelse. Amidene er særlig fordelaktige ettersom de gir en forlenget og markert virkning ved inhiberingen av syre-dannelse i munnhulen på grunn av at carbohydrater brytes ned, Organic surfactants can be used in the toothpaste according to the present invention to achieve an increased prophylactic effect, help achieve thorough and complete dispersion of the preparations in the oral cavity and make the toothpastes cosmetically more acceptable. The organic surface-active material can be anionic, non-ionic, ampholytic or cationic in nature, but it is preferred to use as the surface-active agent a cleansing material which adds cleansing and foaming properties to the preparation. Suitable types of such detergents are water-soluble salts of higher fatty acid monoglyceride monosulfates, such as the sodium salt of the monosulfated monoglyceride of hydrogenated coconut oil fatty acids, higher alkyl sulfates, such as sodium lauryl sulfate, alkylaryl sulfonates, such as sodium dodecyl benzene sulfonate, olefin sulfonates, such as sodium olefin sulfonate where the olefinic group contains 12 - 22 carbon atoms, higher alkyl sulfoacetates, higher fatty acid esters of 1,2-di-hydroxypropane sulfonates and the substantially saturated higher aliphatic acylamides of lower aliphatic aminocarboxylic acid compounds, such as those containing 12 - 16 carbon atoms in fatty acid, alkyl - or the acyl radicals, and the like. Examples of the latter amides are N-lauroylsarcosine, and the sodium, potassium and ethanolamine salts of N-lauroyl, N-myristoyl or N-palmitoylsarcosine, which should be substantially free of soap or similar higher fatty acid material which is prone to to a significant extent to reduce the effect of these compounds in preparations according to the present invention. The amides are particularly advantageous as they provide a prolonged and marked effect in the inhibition of acid formation in the oral cavity due to the breakdown of carbohydrates,
i tillegg til å gi en viss reduksjon i oppløseligheten av tannemalje i sure oppløsninger. Et annet ønsket materiale er et natriummonoglyceridsulfonatsalt av en langkjedet fett- in addition to providing a certain reduction in the solubility of tooth enamel in acidic solutions. Another desired material is a sodium monoglyceride sulfonate salt of a long-chain fatty
syre som brukes alene eller i blanding med natriumlaurylsulfat. acid used alone or in mixture with sodium lauryl sulfate.
Andre særlig egnede overflateaktive materialer omfatter ikke-ioniske midler, slik som kondensater av-sorbitanmono-stearat med omtrent 2 0 mol ethylenoxyd, kondensater av ethylenoxyd med propylenglycol (Pluronic<®->materialer) og amfotære midler, slik som langkjedet (alkyl)amino-alkylenalkylerte aminderivater som er tilgjengelige under varemerket Miranol<®>, slik som Miranol<®> C^M. Kationiske overflateaktive germicider og anti-baktérielle forbindelser, slik som diisobutylfenoxy-ethoxyethyldimethylbenzylammoniumklorid, benzyldimethylstearyl-ammoniumklorid, benzyldiethylstearylammoniumklorid, tertiære aminer med en fettalkylgruppe (eller fra 12 - 18 carbonatomer) og to (poly)oxyethylengrupper bundet til nitrogenatomet (vanligvis inneholdende tilsammen fra 2 til 50 ethanoxygrupper pr. molekyl), samt salter derav med syrer, og forbindelser med formelen Other particularly suitable surface-active materials include nonionic agents, such as condensates of sorbitan mono-stearate with about 20 moles of ethylene oxide, condensates of ethylene oxide with propylene glycol (Pluronic<®> materials) and amphoteric agents, such as long-chain (alkyl)amino -alkylenealkylated amine derivatives available under the trademark Miranol<®>, such as Miranol<®> C^M. Cationic surfactant germicides and anti-bacterial compounds, such as diisobutylphenoxy-ethoxyethyldimethylbenzylammonium chloride, benzyldimethylstearylammonium chloride, benzyldiethylstearylammonium chloride, tertiary amines with a fatty alkyl group (or from 12 - 18 carbon atoms) and two (poly)oxyethylene groups attached to the nitrogen atom (usually containing together from 2 to 50 ethaneoxy groups per molecule), as well as salts thereof with acids, and compounds with the formula
hvor R er en fettalkylgruppe som inneholder fra 12 til where R is a fatty alkyl group containing from 12 to
18 carbonatomer, og x, y og z tilsammen er 3 eller høyere, samt salter derav med mineral- eller organiske syrer, kan 18 carbon atoms, and x, y and z together are 3 or higher, as well as salts thereof with mineral or organic acids, can
også brukes. Det er foretrukket å bruke fra 0,05 til 5 vekt% av de ovenfor nevnte overflateaktive materialer i tannkremen. Det er mest foretrukket at det overflateaktive middel er et anionisk materiale, særlig natriumlaurylsulfat. also used. It is preferred to use from 0.05 to 5% by weight of the above-mentioned surface-active materials in the toothpaste. It is most preferred that the surfactant is an anionic material, especially sodium lauryl sulfate.
Tannkremen kan passende også inneholde en fluorholdig forbindelse med en gunstig virkning på pleien av og hygienen i munnhulen, f.eks. reduksjon av emaljeoppløselighet i syre og beskyttelse av tennene mot tannråte. Eksempler omfatter natriumfluorid, tinn(II)fluorid, kaliumfluorid, kalium-tinn (II)-fluorid, (SnF2*KF), natriumhexafluorstannat, tinn(II)-klorfluorid, natriumfluorzirkonat og natriummonofluorfosfat. Disse materialene som løser ut eller avgir fluorholdige ioner ;i vann, kan passende være tilstede i en effektiv, men ikke-giftig, mengde, vanligvis innenfor området 0,01 til 1 vekt% av innholdet av vannoppløselig fluor. ;Den foretrukne fluorholdige forbindelse er natrium-monof luorfosf at, vanligvis tilstede i en mengde på 0,076 til 7,6 vekt%, fortrinnsvis 0,7 6 vekt%. En blanding av natrium-monof luorfosf at og natriumfluorid er også ønskelig, f.eks. i et vektforhold på ca. 2:1 basert på fluorid. ;Hvilke som helst egnede smaksgivende eller søtende materialer kan anvendes ved formulering av en smak for preparatet ifølge foreliggende oppfinnelse. Eksempler på egnede smaksgivende bestanddeler omfatter de smaksgivende oljer, f.eks. oljer av grønnmynte, peppermynte, vintergrønn, sassa-fras, kryddernellik, salvie, eukalyptus, meriam, kanel, ;sitron og appelsin, samt methylsalicylat. Egnede søtnings-midler omfatter sucrose, lactose, maltose, xylitol, natrium-6-methyl-3,4-dihydro-l,2,3-oxathiazin-4-on, natriumcyklamat, perillartin og natriumsaccharin. Passende kan smaks- og søtnings-midler tilsammen utgjøre fra 0,01 til 5% eller mer av preparatene ifølge foreliggende oppfinnelse. ;Forskjellige andre materialer kan innlemmes i tannkremen. Eksempler på slike er farge- eller hvitemidler eller fargestoffer, anti-korrosjonsmidler, silikoner, klorofyllfor-bindelser, ammonierte materialer, slik som urinstoff, di-ammoniumfosfat og blandinger derav, og andre bestanddeler. Hvitemidler, slik som titandioxyd, vanligvis i mengder på ;0,5 - 2%, kan være gunstig for utseendet til tannpreparatet, ettersom en viss misfarging kan opptre etter lagring. ;Hjelpestoffene innlemmes i foreliggende preparater i mengder som ikke i vesentlig grad påvirker de ønskede egenskaper og karakteristika på ugunstig måte, og velges og brukes i passende mengder avhengig av den bestemte type preparat som er involvert. ;Anti-bakterielle midler kan også anvendes i de orale preparatene ifølge foreliggende oppfinnelse i en mengde på ;0,01 - 5 vekt%. Typiske anti-bakterielle midler omfatter: N^"- (4-klorbenzyl) -N^- (2 , 3-diklorbenzyl) -biguanid; ;p-klorfenyl-biguanid; ;4-klorbenzylhydryl-biguanid; ;4- klorbenzhydrylguanylurinstoff; ;N-3-lauroxypropyl-N 5-klorbenzylbiguanid; ;1,6-di-klorfenylbuguanidohexan; ;1,6-bis-(2-ethylhexylbiguanid)-hexan; ;1- (lauryldimethylammonium)-8- (p-klorbenzyldimethylammonium) - octan-diklorid; ;5,6-diklor-2-guanidinobenzimidazol; ;N 1 -p-klorfenyl-N 5-laurylbiguanid; ;5- amino-l,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidin og de ikke-giftige syreaddisjonssalter derav. ;I tannkrem som inneholder jordalkalimetallsalt som poleringsmiddel kan det også anvendes forskjellige kalsium-og magnesiumion-suppresjonsmidler for regulering av fysiske egenskaper hos preparatene. Egnede midler er do vannoppløselige uorganiske polyfosfatsaltene, slik som tetranatriumpyrofosfat eller dinatriumdisyrepyrofosfat, idet det delvis nøytrali-serte eller sure polyfosfatet er foretrukket. Andre egnede midler er alkalimetallsaltene, fortrinnsvis natriumsaltet, ;av sitronsyre. Generelt vil slike forbindelser utgjøre en mindre mengde eller andel av preparatet. Den nøyaktige mengde vil variere avhengig av det bestemte preparat, slik som de fysiske kjennetegn til tannkremen, men vil vanligvis være frå ;0,1 til ca. 3 vekt%. ;Tannkremene bør ha en pH som er praktisk for bruken. Et pH-område fra 5 til 10 er særlig ønskelig for tannkrem med vannuoppløselig jordalkalimetallsalt. Henvisningen til pH ;er ment å være pH-bestemmelsen direkte på tannkremen. Om ønsket kan slike materialer som sitronsyre tilsettes for å regulere pH til f.eks. 6 til 7. For tannkrem med trihydrat av a-alumina er det særlig ønskelig med en pH på 6-8 erholdt ved regulering med et vannoppløselig materiale som gir fosfation. ;Emballasjen som tannkremen er plassert i, kan være hvilken som helst tannkremtube av polyolefinlaminat. F.eks. kan tuben være så enkel som beskrevet i US patentskrift nr. 3 260 410. Som beskrevet i eksemplet i patentskriftet, ble en aluminiumfoliebase med en tykkelse på ca. 0,0013 cm varmet opp til en temperatur på omtrent 177°C og en side av den oppvarmede folie ble bragt i kontakt med en ekstruderbar film av uregelmessig copolymer av ethylen og acrylsyre (syre-innhold 3 <*> 0,5% og smelteindeks 8 ± 1), mens det på den mot-satte overflate ble plassert en film av polyethylen med lav densitet. The toothpaste can suitably also contain a fluorine-containing compound with a beneficial effect on the care and hygiene of the oral cavity, e.g. reduction of enamel solubility in acid and protection of the teeth against tooth decay. Examples include sodium fluoride, stannous fluoride, potassium fluoride, potassium stannous fluoride, (SnF2*KF), sodium hexafluorostannate, stannous chlorofluoride, sodium fluorozirconate and sodium monofluorophosphate. These materials which dissolve or emit fluorine-containing ions in water may conveniently be present in an effective, but non-toxic, amount, usually in the range of 0.01 to 1% by weight of the water-soluble fluorine content. The preferred fluorine-containing compound is sodium monofluorophosphate, usually present in an amount of 0.076 to 7.6% by weight, preferably 0.76% by weight. A mixture of sodium monofluorophosphate and sodium fluoride is also desirable, e.g. in a weight ratio of approx. 2:1 based on fluoride. Any suitable flavoring or sweetening materials can be used when formulating a flavor for the preparation according to the present invention. Examples of suitable flavoring ingredients include the flavoring oils, e.g. oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, meriam, cinnamon, lemon and orange, as well as methyl salicylate. Suitable sweeteners include sucrose, lactose, maltose, xylitol, sodium 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one, sodium cyclamate, perillartin and sodium saccharin. Appropriately, flavoring and sweetening agents can together constitute from 0.01 to 5% or more of the preparations according to the present invention. Various other materials can be incorporated into the toothpaste. Examples of such are coloring or whitening agents or dyes, anti-corrosion agents, silicones, chlorophyll compounds, ammoniated materials, such as urea, di-ammonium phosphate and mixtures thereof, and other ingredients. Whitening agents, such as titanium dioxide, usually in amounts of ;0.5 - 2%, can be beneficial to the appearance of the dental preparation, as some discoloration may occur after storage. ;The excipients are incorporated into the present preparations in amounts that do not significantly affect the desired properties and characteristics in an unfavorable manner, and are selected and used in appropriate amounts depending on the specific type of preparation involved. Antibacterial agents can also be used in the oral preparations according to the present invention in an amount of 0.01 - 5% by weight. Typical anti-bacterial agents include: N^"-(4-chlorobenzyl)-N^-(2,3-dichlorobenzyl)-biguanide; ;p-chlorophenyl-biguanide; ;4-chlorobenzylhydryl-biguanide; ;4-chlorobenzhydrylguanylurea; ; N-3-lauroxypropyl-N 5-chlorobenzylbiguanide; ;1,6-di-chlorophenylbuguanidohexane; ;1,6-bis-(2-ethylhexylbiguanide)-hexane; ;1-(lauryldimethylammonium)-8-(p-chlorobenzyldimethylammonium) - octane dichloride; ;5,6-dichloro-2-guanidinobenzimidazole; ;N 1 -p-chlorophenyl-N 5-laurylbiguanide; ;5-amino-1,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidine and those not -toxic acid addition salts thereof. ;In toothpaste containing alkaline earth metal salt as a polishing agent, various calcium and magnesium ion suppressors can also be used to regulate the physical properties of the preparations. Suitable agents are then the water-soluble inorganic polyphosphate salts, such as tetrasodium pyrophosphate or disodium diacid pyrophosphate, as the partially neutral -cerous or acidic polyphosphate is preferred Other suitable agents are alkali metal ones alten, preferably the sodium salt, of citric acid. In general, such compounds will constitute a smaller amount or proportion of the preparation. The exact amount will vary depending on the particular preparation, such as the physical characteristics of the toothpaste, but will usually be from ;0.1 to approx. 3% by weight. Toothpastes should have a pH that is practical for use. A pH range from 5 to 10 is particularly desirable for toothpaste with water-insoluble alkaline earth metal salt. The reference to pH is meant to be the pH determination directly on the toothpaste. If desired, such materials as citric acid can be added to regulate the pH to e.g. 6 to 7. For toothpaste with trihydrate of α-alumina, it is particularly desirable to have a pH of 6-8 obtained by regulation with a water-soluble material that provides phosphate ions. The packaging in which the toothpaste is placed can be any polyolefin laminate toothpaste tube. E.g. the tube can be as simple as described in US patent document no. 3 260 410. As described in the example in the patent document, an aluminum foil base with a thickness of approx. 0.0013 cm heated to a temperature of about 177°C and one side of the heated foil was brought into contact with an extrudable film of irregular copolymer of ethylene and acrylic acid (acid content 3 <*> 0.5% and melt index 8 ± 1), while a low-density polyethylene film was placed on the opposite surface.
Ved å bruke ruller som ble drevet, ble det erholdt en laminert base hvor copolymerlaget var ca. 152 um tykt og poly-ethylenlaget var omtrent 127 um tykt. Basen ble deretter formet til rørform og lukket. By using rollers that were driven, a laminated base was obtained where the copolymer layer was approx. 152 µm thick and the polyethylene layer was approximately 127 µm thick. The base was then shaped into a tube shape and closed.
Ved oppdeling av rørformen til tubelegemer, kan tubene pakkes med tannkremen ifølge foreliggende oppfinnelse. By dividing the tube shape into tube bodies, the tubes can be packed with the toothpaste according to the present invention.
Tannkremtubene av polyolefinlaminat som inneholder flere mellomliggende lag kan også med hell brukes sammen med tannkremen ifølge foreliggende oppfinnelse uten at det skjer synerese. F.eks. kan den flerlags elastiske arkstruktur for tannkremtuber som er beskrevet som tidligere kjent teknikk i US patentskrift nr. 4 418 841, anvendes likesåvel som de bruddsikre strukturer som der er beskrevet. Faktisk er tannkremer ifølge foreliggende oppfinnelse emballert i tuber av arkmateriale identifisert som tidligere kjent teknikk A og A-I i US patentskrift nr. 4 418 841 svært tilfredsstillende og gjennomgår praktisk talt ingen synerese. Slike tuber A og A-I består av lag som angitt nedenunder, i rekkefølge fra det yttereste lag til det innerste lag. The toothpaste tubes of polyolefin laminate containing several intermediate layers can also be successfully used together with the toothpaste according to the present invention without syneresis occurring. E.g. the multi-layered elastic sheet structure for toothpaste tubes which is described as prior art in US Patent No. 4,418,841 can be used as well as the break-proof structures described there. In fact, toothpastes according to the present invention packaged in tubes of sheet material identified as prior art A and A-I in US Patent No. 4,418,841 are very satisfactory and undergo virtually no syneresis. Such tubes A and A-I consist of layers as indicated below, in order from the outermost layer to the innermost layer.
I A og A-I har forkortelsene følgende betydninger: In A and A-I, the abbreviations have the following meanings:
LDPE polyethylen med lav densitet LDPE polyethylene with low density
EAA ethylenacrylsyre EAA ethylene acrylic acid
OPP orientert polypropylen UP oriented polypropylene
Mekanisk drevne dispensere, slik som dispenseren spesi-elt for deigaktige substanser beskrevet i US -patentskrift nr. 4 437 591 kan også brukes ved utøvelsen av foreliggende oppfinnelse. Huset til slike dispensere er vanligvis sammensatt av en polyolefinharpiks, slik som polypropylen. Hus-harpiksen er således egentlig et lag hvor den indre overflate er i kontakt med tannkrem. Når tannkremen ifølge foreliggende oppfinnelse emballeres i en slik mekanisk dispenser av polypropylen, gjennomgår den praktisk talt ingen synerese. Mechanically driven dispensers, such as the dispenser especially for pasty substances described in US Patent No. 4,437,591 can also be used in the practice of the present invention. The housing of such dispensers is usually composed of a polyolefin resin, such as polypropylene. The house resin is thus essentially a layer where the inner surface is in contact with toothpaste. When the toothpaste according to the present invention is packaged in such a mechanical polypropylene dispenser, it undergoes practically no syneresis.
Fordelene ifølge oppfinnelsen er også tilstede når tannkremen emballeres i en elastisk pute med en polyolefinoverflate, vanligvis av polyethylen med lav eller middels densitet. The advantages according to the invention are also present when the toothpaste is packaged in an elastic cushion with a polyolefin surface, usually of low or medium density polyethylene.
Eksemplene nedenunder illustrerer oppfinnelsen ytter-ligere. Alle mengder og andeler er basert på vekt med mindre annet er angitt. The examples below further illustrate the invention. All quantities and proportions are based on weight unless otherwise stated.
Eksempel 1 Example 1
Følgende tannkremer ble fremstilt til kremaktig konsistens og emballert i tuber av de laminerte strukturer A og A-I angitt ovenfor: The following toothpastes were prepared to a creamy consistency and packaged in tubes of the laminated structures A and A-I indicated above:
Etter lagring i minst 13 uker ved 25°C var tannkremene (2) , (3) og (4) fortsatt kremaktige av konsistens i laminat-tuber av laminatstrukturene A og A-I, mens tannkrem (1) After storage for at least 13 weeks at 25°C, toothpastes (2), (3) and (4) were still creamy in consistency in laminate tubes of laminate structures A and A-I, while toothpaste (1)
skilte seg i flytende og faste faser i løpet av 1 uke ved 25°C i tubene av både struktur A og A-I. separated into liquid and solid phases within 1 week at 25°C in the tubes of both structure A and A-I.
Eksempel 2 Example 2
Tannkremer (1) til (4) ble plassert i en mekanisk dispenser i henhold til US patentskrift nr. 4 437 591 bestående av polypropylenhus. Tannkremer (2), (3) og (4) beholdt sin kremaktige konsistens, mens tannkrem (1) skilte seg i flytende og faste faser. Toothpastes (1) to (4) were placed in a mechanical dispenser according to US Patent No. 4,437,591 consisting of a polypropylene housing. Toothpastes (2), (3) and (4) retained their creamy consistency, while toothpaste (1) separated into liquid and solid phases.
Eksempel 3 Example 3
Lignende resultater som de beskrevet ovenfor for eksemp- Similar results to those described above for example
lene 1 og 2, ble iakttatt når: lanes 1 and 2, were observed when:
(i) de relative mengder glycerol, sorbitol (70%) og polyethylenglycol, gjennomsnittlig molekylvekt 600, var: 6:24:2 vs. 6:24:0 og 18:6:2 vs. 18:6:0, (ii) polyethylenglycol, gjennomsnittlige molekylvekter 200 og 1000, ble brukt i stedet for polyethylenglycol, gjennomsnittlig molekylvekt 600, (iii) tannkremene ble emballert i laminerte tuber ifølge US patentskrift nr. 3 260 410, (iv) tannkremene ble emballert i bruddsikre laminerte tuber ifølge US patentskrift nr. 4 418 841, (v) tannkremene ble emballert i elastiske puter med den følgende struktur fra det ytterste til det innerste lag: (i) the relative amounts of glycerol, sorbitol (70%) and polyethylene glycol, average molecular weight 600, were: 6:24:2 vs. 6:24:0 and 18:6:2 vs. 18:6:0. were packaged in unbreakable laminated tubes according to US Patent No. 4,418,841, (v) the toothpastes were packaged in elastic cushions with the following structure from the outermost to the innermost layer:
12.2 pm polyethylenterefthalat 12.2 pm polyethylene terephthalate
21.3 um hvit ethylenacrylsyre 21.3 µm white ethylene acrylic acid
9,0 um folie 9.0 µm foil
3,3 pm ethylenacrylsyre 3.3 pm ethylene acrylic acid
25.4 um polyethylen med middels densitet 25.4 um medium density polyethylene
(vi) blanding av 0,3 deler natriumcarboxymethylcellulose og 0,6 deler xanthan erstattet natriumcarboxymethylcellulose som det eneste geldannende materiale , (vii) 3000 deler kalsinert alumina erstattet 3,000 eller trihydrat av a-alumina, (viii) 10 deler uoppløselige natriummetafosfat erstattet 10,000 deler trihydrat av a-alumina, og (vi) mixture of 0.3 parts of sodium carboxymethylcellulose and 0.6 parts of xanthan substituted for sodium carboxymethylcellulose as the sole gelling material, (vii) 3000 parts of calcined alumina substituted for 3,000 or trihydrate of α-alumina, (viii) 10 parts of insoluble sodium metaphosphate substituted for 10,000 parts trihydrate of α-alumina, and
(ix) natriumcyklamat erstattet natriumsaccharin. (ix) sodium cyclamate replaced sodium saccharin.
Eksempel 4 Example 4
Følgende tannkremer ble fremstilt til kremaktige kon-sistenser og emballert i tuber av hver av de laminerte strukturer A og A-I som er angitt ovenfor: The following toothpastes were prepared to creamy consistencies and packaged in tubes of each of the laminated structures A and A-I indicated above:
Etter lagring i minst 20 uker ved 25°C hadde tannkrem (1) beholdt konsistensen i hver av de laminerte tuber med strukturene A og A-I, mens tannkrem (2) hadde skilt seg i flytende og faste faser innen 4 til 10 dager ved 25°C i tubene av både struktur A og A-I. After storage for at least 20 weeks at 25°C, toothpaste (1) had retained its consistency in each of the laminated tubes with structures A and A-I, while toothpaste (2) had separated into liquid and solid phases within 4 to 10 days at 25° C in the tubes of both structure A and A-I.
Eksempel 5 Example 5
Tannkremer (1) og (2) ble plassert i en mekanisk dispenser ifølge US patentskrift nr. 4 437 591 sammensatt av polypropylenhus. Tannkrem (1) beholdt sin kremaktige konsistens, mens tannkrem (2) skilte seg i flytende og faste faser. Toothpastes (1) and (2) were placed in a mechanical dispenser according to US Patent No. 4,437,591 composed of a polypropylene housing. Toothpaste (1) retained its creamy consistency, while toothpaste (2) separated into liquid and solid phases.
Lignende resultater som de som er beskrevet ovenfor, ble iakttatt når: (i) kalsiumcarbonat erstattet dihydrat av dikalsiumfosfat, (ii) trihydrat av dimagnesiumfosfat erstattet dihydrat av dikalsiumfosfat, (iii) de relative mengder av glycerol, sorbitol (70%) og polyethylenglycol, gjennomsnittlig molekylvekt 600, var: 6:24:2 vs. 6:24:0 og 18:6:2 vs. 18:6:0, (iv) polyethylenglycol, gjennomsnittlige molekylvekter 200 og 1000, ble brukt i stedet for polyethylenglycol, gjennomsnittlig molekylvekt 600, (v) tannkremene ble emballert i laminerte tuber ifølge US patentskrift nr. 3 260 410, (vi) tannkremene ble emballert i bruddsikre laminerte tuber ifølge US patentskrift nr. 4 418 841, (vii) tannkremene ble emballert i elastiske puter av følgende struktur fra det ytterste til det innerste lag: Similar results to those described above were observed when: (i) calcium carbonate replaced dicalcium phosphate dihydrate, (ii) dimagnesium phosphate trihydrate replaced dicalcium phosphate dihydrate, (iii) the relative amounts of glycerol, sorbitol (70%) and polyethylene glycol, average molecular weight 600, was: 6:24:2 vs. 6:24:0 and 18:6:2 vs. 18:6:0. were packaged in unbreakable laminated tubes according to US Patent No. 4,418,841, (vii) the toothpastes were packaged in elastic cushions of the following structure from the outermost to the innermost layer:
12.2 pm polyethylenterefthalat 12.2 pm polyethylene terephthalate
21.3 pm hvit ethylenacrylsyre 21.3 pm white ethylene acrylic acid
9,0 pm folie 9.0 pm foil
3,3 pm ethylenacrylsyre 3.3 pm ethylene acrylic acid
25.4 pm polyethylen med middels densitet og 25.4 pm medium density polyethylene and
(viii) blanding av 0,3 deler natriumcarboxymethylcellulose og 0,6 deler jota-karragen erstattet natriumcarboxymethylcellulose som det eneste geldannende materiale. (viii) mixture of 0.3 part sodium carboxymethylcellulose and 0.6 part iota-carrageenan replaced sodium carboxymethylcellulose as the sole gelling material.
Claims (21)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/771,378 US4702905A (en) | 1985-08-30 | 1985-08-30 | Packaged dental cream |
| US06/803,040 US4716034A (en) | 1985-11-27 | 1985-11-27 | Packaged dental cream |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO863484D0 NO863484D0 (en) | 1986-08-29 |
| NO863484L NO863484L (en) | 1987-03-02 |
| NO168924B true NO168924B (en) | 1992-01-13 |
| NO168924C NO168924C (en) | 1992-04-22 |
Family
ID=27118453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO863484A NO168924C (en) | 1985-08-30 | 1986-08-29 | PACKAGED DENTAL CREAM |
Country Status (25)
| Country | Link |
|---|---|
| AT (1) | AT388296B (en) |
| AU (1) | AU589442B2 (en) |
| BE (1) | BE905346A (en) |
| BR (1) | BR8604141A (en) |
| CH (1) | CH669111A5 (en) |
| DE (1) | DE3628359A1 (en) |
| DK (1) | DK414086A (en) |
| ES (1) | ES2001916A6 (en) |
| FI (1) | FI87732C (en) |
| FR (1) | FR2586560B1 (en) |
| GB (1) | GB2180155B (en) |
| GR (1) | GR862225B (en) |
| HK (1) | HK102792A (en) |
| IN (1) | IN166518B (en) |
| IT (1) | IT1196596B (en) |
| MX (1) | MX164113B (en) |
| MY (1) | MY100364A (en) |
| NL (1) | NL8602198A (en) |
| NO (1) | NO168924C (en) |
| NZ (1) | NZ217253A (en) |
| OA (1) | OA08405A (en) |
| PT (1) | PT83283B (en) |
| SE (1) | SE464333B (en) |
| SG (1) | SG99292G (en) |
| ZW (1) | ZW16786A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4704102A (en) * | 1982-09-30 | 1987-11-03 | Geneco Inc. | Method of eliminating intra abdominal infections |
| IN168049B (en) * | 1986-01-22 | 1991-01-26 | Colgate Palmolive Co | |
| NZ226378A (en) * | 1987-10-08 | 1989-12-21 | Colgate Palmolive Co | Packaged dental cream containing polyoxyethylene/polyoxypropylene block copolymer |
| US5096698A (en) * | 1987-10-08 | 1992-03-17 | Colgate-Palmolive Company | Packaged dental cream |
| SE8904179L (en) * | 1988-12-29 | 1990-06-30 | Colgate Palmolive Co | PRE-PACKED ORAL ANTI-PLAQUE COMPOSITIONS |
| US5176901A (en) * | 1991-04-10 | 1993-01-05 | Smithkline Beecham Corporation | Dental composition |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1277586A (en) * | 1968-10-29 | 1972-06-14 | Unilever Ltd | Toothpastes |
| GB1310374A (en) * | 1970-11-06 | 1973-03-21 | Unilever Ltd | Toothpaste composition |
| BE792760A (en) * | 1971-12-20 | 1973-06-14 | Unilever Nv | TOOTHPASTE |
| GB1408922A (en) * | 1972-02-02 | 1975-10-08 | Blendax Werke Schneider Co | Process and composition for the remineralisation and prevention of demineralisation of human teeth |
| DE2224560A1 (en) * | 1972-05-19 | 1973-11-29 | Henkel & Cie Gmbh | MOUTH AND DENTAL CARE PRODUCTS TO AVOID CALCULATION |
| ZA737495B (en) * | 1972-10-30 | 1975-05-28 | Colgate Palmolive Co | Toothpastes |
| US4314990A (en) * | 1979-10-15 | 1982-02-09 | The Procter & Gamble Company | Toothpaste compositions |
| US4418841A (en) * | 1982-11-23 | 1983-12-06 | American Can Company | Multiple layer flexible sheet structure |
| US4515772A (en) * | 1982-06-22 | 1985-05-07 | The Procter & Gamble Company | Oral compositions |
| US4565692A (en) * | 1983-12-23 | 1986-01-21 | Colgate-Palmolive Company | Extrudable dentifrice |
-
1986
- 1986-08-14 IN IN737/DEL/86A patent/IN166518B/en unknown
- 1986-08-18 NZ NZ217253A patent/NZ217253A/en unknown
- 1986-08-20 ZW ZW167/86A patent/ZW16786A1/en unknown
- 1986-08-21 DE DE19863628359 patent/DE3628359A1/en not_active Withdrawn
- 1986-08-25 AT AT0228486A patent/AT388296B/en not_active IP Right Cessation
- 1986-08-26 FR FR868612067A patent/FR2586560B1/en not_active Expired - Lifetime
- 1986-08-27 MX MX3562A patent/MX164113B/en unknown
- 1986-08-27 IT IT48406/86A patent/IT1196596B/en active
- 1986-08-27 SE SE8603612A patent/SE464333B/en not_active IP Right Cessation
- 1986-08-27 GB GB8620687A patent/GB2180155B/en not_active Expired
- 1986-08-28 AU AU62051/86A patent/AU589442B2/en not_active Ceased
- 1986-08-28 FI FI863497A patent/FI87732C/en not_active IP Right Cessation
- 1986-08-29 NL NL8602198A patent/NL8602198A/en not_active Application Discontinuation
- 1986-08-29 GR GR862225A patent/GR862225B/en unknown
- 1986-08-29 DK DK414086A patent/DK414086A/en not_active Application Discontinuation
- 1986-08-29 NO NO863484A patent/NO168924C/en unknown
- 1986-08-29 CH CH3479/86A patent/CH669111A5/en not_active IP Right Cessation
- 1986-08-29 PT PT83283A patent/PT83283B/en unknown
- 1986-08-29 BR BR8604141A patent/BR8604141A/en not_active IP Right Cessation
- 1986-08-29 BE BE0/217096A patent/BE905346A/en not_active IP Right Cessation
- 1986-08-29 ES ES8601509A patent/ES2001916A6/en not_active Expired
- 1986-08-29 OA OA58939A patent/OA08405A/en unknown
-
1987
- 1987-09-28 MY MYPI87002052A patent/MY100364A/en unknown
-
1992
- 1992-09-29 SG SG992/92A patent/SG99292G/en unknown
- 1992-12-17 HK HK1027/92A patent/HK102792A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5820852A (en) | Oral compositions containing fluoride, pyrophosphate, and peroxide | |
| US5849269A (en) | Oral compositions containing fluoride, pyrophosphate, peroxide, and nonionic and/or amphoteric surfactants | |
| US4702905A (en) | Packaged dental cream | |
| CA1298791C (en) | Dentifrice sachet | |
| US5096698A (en) | Packaged dental cream | |
| EP0845258A2 (en) | Method of making a tartar control dentifrice containing fluoride and peroxide | |
| NO168924B (en) | PACKAGED DENTAL CREAM | |
| US4716034A (en) | Packaged dental cream | |
| US4705680A (en) | Stable dental cream in polyethylene or polypropylene container | |
| US4716036A (en) | Stabilized dental cream containing vegetable oil | |
| US4770324A (en) | Dental cream package | |
| US4728508A (en) | Dental cream in package | |
| DK166803B1 (en) | STABILIZED TOOTH CREAM | |
| US5041279A (en) | Dental cream package | |
| NO174324B (en) | Packed toothpaste | |
| AU597333B2 (en) | Dental cream package | |
| JPS62155208A (en) | Wrapped dentifrice | |
| NO860890L (en) | ORAL PREPARATION FOR TANNSTEIN. |