NO161914C - Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazo(1,2-a)(1,2)kondenserte ringsystemer. - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazo(1,2-a)(1,2)kondenserte ringsystemer.

Info

Publication number: NO161914C
Authority: NO; Norway
Prior art keywords: pyridazo; preparation; ring systems; therapeutically active; condensed ring
Prior art date: 1984-08-24

Application number

NO853336A

Other languages

English (en)

Norwegian (no)

Other versions

NO161914B (no

NO853336L (no

Inventor

Cedric Herbert Hassall

Geoffrey Lawton

Sally Redshaw

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-08-24

Filing date

1985-08-23

Publication date

1989-10-11

1984-08-24 Priority claimed from GB848421493A external-priority patent/GB8421493D0/en

1985-08-23 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1986-02-25 Publication of NO853336L publication Critical patent/NO853336L/no

1989-07-03 Publication of NO161914B publication Critical patent/NO161914B/no

1989-10-11 Publication of NO161914C publication Critical patent/NO161914C/no

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)

NO853336A 1984-08-24 1985-08-23 Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazo(1,2-a)(1,2)kondenserte ringsystemer. NO161914C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB848421493A GB8421493D0 (en)	1984-08-24	1984-08-24	Bicyclic compounds
GB858513541A GB8513541D0 (en)	1984-08-24	1985-05-29	Bicyclic compounds

Publications (3)

Publication Number	Publication Date
NO853336L NO853336L (no)	1986-02-25
NO161914B NO161914B (no)	1989-07-03
NO161914C true NO161914C (no)	1989-10-11

Family

ID=26288155

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO853336A NO161914C (no)	1984-08-24	1985-08-23	Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazo(1,2-a)(1,2)kondenserte ringsystemer.

Country Status (14)

Country	Link
US (4)	US4692438A (es)
EP (1)	EP0172552A3 (es)
AU (1)	AU583843B2 (es)
CS (1)	CS255893B2 (es)
DK (1)	DK384385A (es)
ES (3)	ES8700258A1 (es)
FI (1)	FI853174L (es)
HU (1)	HU193446B (es)
IL (1)	IL76133A (es)
MC (1)	MC1694A1 (es)
NO (1)	NO161914C (es)
NZ (1)	NZ213130A (es)
PH (1)	PH21749A (es)
PT (1)	PT81015B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4692438A (en) *	1984-08-24	1987-09-08	Hoffmann-La Roche Inc.	Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
ZW11586A1 (en) *	1985-07-01	1987-12-30	Hoffmann La Roche	Bicyclic compounds
GB8629875D0 (en) *	1986-12-15	1987-01-28	Hoffmann La Roche	Pyridazodiazepine derivatives
US5430145A (en) *	1990-10-18	1995-07-04	Merrell Dow Pharmaceuticals Inc.	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) *	1990-12-21	1994-05-03	Merrell Dow Pharmaceuticals Inc.	Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5457196A (en) *	1991-09-27	1995-10-10	Merrell Dow Pharmaceuticals Inc.	2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
EP0534363B1 (en) *	1991-09-27	1997-07-09	Merrell Pharmaceuticals Inc.	Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5455242A (en) *	1991-09-27	1995-10-03	Merrell Dow Pharmaceuticals Inc.	Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
DE69317764T2 (de) *	1992-02-14	1998-07-30	Merrell Pharmaceuticals Inc., Cincinnati, Ohio	Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
EP0640086B1 (en) *	1992-05-15	1999-08-04	Merrell Pharmaceuticals Inc.	MERCAPTOACETYLAMIDO PYRIDAZO[ 1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
US5420271A (en) *	1992-08-24	1995-05-30	Merrell Dow Pharmaceuticals, Inc.	2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
JP3420766B2 (ja) *	1992-10-30	2003-06-30	メレルダウファーマス−ティカルズインコーポレイテッド	エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド二環式ラクタム誘導体類
WO1994022440A1 (en) *	1993-03-29	1994-10-13	Smithkline Beecham Corporation	Bicyclic compounds which inhibit platelet aggregation
DK0745081T3 (da) *	1994-02-14	2002-05-21	Merrell Pharma Inc	Indan-2-mercaptoacetylamiddisulfidderivater, der er anvendelige som enkephalinase-inhibitorer
WO1995021854A1 (en) *	1994-02-14	1995-08-17	Merrell Pharmaceuticals Inc.	Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
ATE177098T1 (de) *	1994-02-14	1999-03-15	Merrell Pharma Inc	Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
US5530013A (en) *	1994-02-14	1996-06-25	American Home Products Corporation	Venlafaxine in the inducement of cognition enhancement
CA2183314C (en) *	1994-02-14	1999-08-31	Gary A. Flynn	Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5484783A (en) *	1994-03-24	1996-01-16	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
EP0751783B1 (en) *	1994-03-24	2000-02-02	Merrell Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic use of aminoacetylmercapto derivatives
DE69531489T2 (de) *	1994-03-24	2004-04-08	Merrell Pharmaceuticals Inc., Cincinnati	Cholesterin senkende mercaptoacetylamiddisulfidderivate
US6703500B2 (en)	1998-08-19	2004-03-09	Vertex Pharmaceuticals, Incorporated	Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
US6559304B1 (en)	1998-08-19	2003-05-06	Vertex Pharmaceuticals Incorporated	Method for synthesizing caspase inhibitors
US6177565B1 (en) *	1998-08-19	2001-01-23	Vertex Pharmaceuticals Inc.	Process for synthesizing piperazic acid
ES2252224T3 (es)	2000-05-04	2006-05-16	Vertex Pharmaceuticals Incorporated	Sisntesis asimetrica de acido piperazico y derivados del mismo.
GB0119305D0 (en)	2001-04-12	2001-10-03	Aventis Pharma Gmbh	Mercaptoacetylamide derivatives,a process for their preparation and their use
US8408396B2 (en) *	2008-07-25	2013-04-02	Chuluun Enkhbold	Method of solid fuel beneficiation and transportation to thermoelectric power stations
US20110313035A1 (en)	2009-12-16	2011-12-22	Hetero Research Foundation	Polymorphs of darunavir
EP2571355B1 (en)	2010-05-20	2016-09-07	Hetero Research Foundation	Crystalline hydrochloride salt of darunavir

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4308094A (en) *	1977-02-02	1981-12-29	Sanyo Electric Co., Ltd.	Diaphragm for speaker and method of producing same
IL60617A0 (en) *	1979-07-23	1980-09-16	Sparamedica Ag	Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them
EP0025941B1 (de) *	1979-09-19	1983-05-04	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	Pyridazopyridazinderivate, Verfahren zu deren Herstellung und Arzneimittel enthaltend solche Pyridazopyridazinderivate
EP0042100A1 (de) *	1980-06-13	1981-12-23	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
GB2128984B (en) *	1982-05-12	1985-05-22	Hoffmann La Roche	Diaza-bicyclic compounds
US4692438A (en) *	1984-08-24	1987-09-08	Hoffmann-La Roche Inc.	Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity

1985
- 1985-08-12 US US06/764,372 patent/US4692438A/en not_active Expired - Fee Related
- 1985-08-15 CS CS855928A patent/CS255893B2/cs unknown
- 1985-08-16 NZ NZ213130A patent/NZ213130A/en unknown
- 1985-08-19 AU AU46415/85A patent/AU583843B2/en not_active Ceased
- 1985-08-19 EP EP85110370A patent/EP0172552A3/de not_active Withdrawn
- 1985-08-19 FI FI853174A patent/FI853174L/fi not_active Application Discontinuation
- 1985-08-19 IL IL76133A patent/IL76133A/xx unknown
- 1985-08-21 HU HU853187A patent/HU193446B/hu not_active IP Right Cessation
- 1985-08-21 MC MC851791A patent/MC1694A1/xx unknown
- 1985-08-21 PH PH32671A patent/PH21749A/en unknown
- 1985-08-23 NO NO853336A patent/NO161914C/no unknown
- 1985-08-23 DK DK384385A patent/DK384385A/da not_active Application Discontinuation
- 1985-08-23 ES ES546360A patent/ES8700258A1/es not_active Expired
- 1985-08-23 PT PT81015A patent/PT81015B/pt unknown
1986
- 1986-02-17 ES ES552398A patent/ES8705444A1/es not_active Expired
- 1986-02-17 ES ES552397A patent/ES8705443A1/es not_active Expired
1987
- 1987-05-11 US US07/048,172 patent/US4785093A/en not_active Expired - Fee Related
- 1987-06-15 US US07/062,033 patent/US4762924A/en not_active Expired - Fee Related
1988
- 1988-07-12 US US07/217,805 patent/US4826980A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0172552A2 (de)	1986-02-26
NO161914B (no)	1989-07-03
ES552398A0 (es)	1987-05-01
US4762924A (en)	1988-08-09
ES8700258A1 (es)	1986-10-01
FI853174L (fi)	1986-02-25
MC1694A1 (fr)	1986-07-18
NO853336L (no)	1986-02-25
PT81015A (en)	1985-09-01
DK384385D0 (da)	1985-08-23
PT81015B (en)	1987-08-24
US4826980A (en)	1989-05-02
IL76133A0 (en)	1985-12-31
HUT38644A (en)	1986-06-30
PH21749A (en)	1988-02-18
NZ213130A (en)	1988-05-30
ES8705444A1 (es)	1987-05-01
EP0172552A3 (de)	1989-01-11
ES8705443A1 (es)	1987-05-01
ES552397A0 (es)	1987-05-01
AU583843B2 (en)	1989-05-11
US4692438A (en)	1987-09-08
AU4641585A (en)	1986-02-27
FI853174A0 (fi)	1985-08-19
HU193446B (en)	1987-10-28
DK384385A (da)	1986-02-25
CS592885A2 (en)	1987-07-16
IL76133A (en)	1989-12-15
CS255893B2 (en)	1988-03-15
US4785093A (en)	1988-11-15
ES546360A0 (es)	1986-10-01

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