ES8705444A1 - Procedimiento para la obtencion de poli-hidro piridazo diacepinas, triacepinas o diazocinas - Google Patents

Procedimiento para la obtencion de poli-hidro piridazo diacepinas, triacepinas o diazocinas

Info

Publication number
ES8705444A1
ES8705444A1 ES552398A ES552398A ES8705444A1 ES 8705444 A1 ES8705444 A1 ES 8705444A1 ES 552398 A ES552398 A ES 552398A ES 552398 A ES552398 A ES 552398A ES 8705444 A1 ES8705444 A1 ES 8705444A1
Authority
ES
Spain
Prior art keywords
hydrogen
well
intermediates
preparation
carboxylic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES552398A
Other languages
English (en)
Other versions
ES552398A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848421493A external-priority patent/GB8421493D0/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES552398A0 publication Critical patent/ES552398A0/es
Publication of ES8705444A1 publication Critical patent/ES8705444A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE POLI-HIDROPIRIDAZO DIACEPINAS, TRIACEPINAS O DIAZOCINAS, DE FORMULA GENERAL (I), Y SUS SALES BASICAS FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN TRATAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R11 REPRESENTA ALCANOILO O AROILO; R2 REPRESENTA HIDROGENO O ALQUILO; R3 REPRESENTA HIDROGENO O ARILO; R4 Y R5 REPRESENTAN CADA UNO HIDROGENO Y JUNTOS REPRESENTAN OXO; E Y REPRESENTA -CH2- O -CH2-CH2-, CON UNA BASE. LOS RACEMATOS OBTENIDOS SE PUEDEN SEPARAR, SI SE DESEA. DE APLICACION EN LA OBTENCION DE PREPARADOS FARMACEUTICOS.
ES552398A 1984-08-24 1986-02-17 Procedimiento para la obtencion de poli-hidro piridazo diacepinas, triacepinas o diazocinas Expired ES8705444A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848421493A GB8421493D0 (en) 1984-08-24 1984-08-24 Bicyclic compounds
GB858513541A GB8513541D0 (en) 1984-08-24 1985-05-29 Bicyclic compounds

Publications (2)

Publication Number Publication Date
ES552398A0 ES552398A0 (es) 1987-05-01
ES8705444A1 true ES8705444A1 (es) 1987-05-01

Family

ID=26288155

Family Applications (3)

Application Number Title Priority Date Filing Date
ES546360A Expired ES8700258A1 (es) 1984-08-24 1985-08-23 Procedimiento para la obtencion de poli-hidro piridazo dia- cepinas triacepinas o diazocinas
ES552398A Expired ES8705444A1 (es) 1984-08-24 1986-02-17 Procedimiento para la obtencion de poli-hidro piridazo diacepinas, triacepinas o diazocinas
ES552397A Expired ES8705443A1 (es) 1984-08-24 1986-02-17 Procedimiento para la obtencion de poli-hidro piridazo diacepinas, triacepinas o diazocinas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES546360A Expired ES8700258A1 (es) 1984-08-24 1985-08-23 Procedimiento para la obtencion de poli-hidro piridazo dia- cepinas triacepinas o diazocinas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES552397A Expired ES8705443A1 (es) 1984-08-24 1986-02-17 Procedimiento para la obtencion de poli-hidro piridazo diacepinas, triacepinas o diazocinas

Country Status (14)

Country Link
US (4) US4692438A (es)
EP (1) EP0172552A3 (es)
AU (1) AU583843B2 (es)
CS (1) CS255893B2 (es)
DK (1) DK384385A (es)
ES (3) ES8700258A1 (es)
FI (1) FI853174L (es)
HU (1) HU193446B (es)
IL (1) IL76133A (es)
MC (1) MC1694A1 (es)
NO (1) NO161914C (es)
NZ (1) NZ213130A (es)
PH (1) PH21749A (es)
PT (1) PT81015B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
EP0534363B1 (en) * 1991-09-27 1997-07-09 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
DE69317764T2 (de) * 1992-02-14 1998-07-30 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
EP0640086B1 (en) * 1992-05-15 1999-08-04 Merrell Pharmaceuticals Inc. MERCAPTOACETYLAMIDO PYRIDAZO[ 1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
JP3420766B2 (ja) * 1992-10-30 2003-06-30 メレルダウファーマス−ティカルズ インコーポレイテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド二環式ラクタム誘導体類
WO1994022440A1 (en) * 1993-03-29 1994-10-13 Smithkline Beecham Corporation Bicyclic compounds which inhibit platelet aggregation
DK0745081T3 (da) * 1994-02-14 2002-05-21 Merrell Pharma Inc Indan-2-mercaptoacetylamiddisulfidderivater, der er anvendelige som enkephalinase-inhibitorer
WO1995021854A1 (en) * 1994-02-14 1995-08-17 Merrell Pharmaceuticals Inc. Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
ATE177098T1 (de) * 1994-02-14 1999-03-15 Merrell Pharma Inc Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
CA2183314C (en) * 1994-02-14 1999-08-31 Gary A. Flynn Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
EP0751783B1 (en) * 1994-03-24 2000-02-02 Merrell Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic use of aminoacetylmercapto derivatives
DE69531489T2 (de) * 1994-03-24 2004-04-08 Merrell Pharmaceuticals Inc., Cincinnati Cholesterin senkende mercaptoacetylamiddisulfidderivate
US6703500B2 (en) 1998-08-19 2004-03-09 Vertex Pharmaceuticals, Incorporated Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
US6559304B1 (en) 1998-08-19 2003-05-06 Vertex Pharmaceuticals Incorporated Method for synthesizing caspase inhibitors
US6177565B1 (en) * 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
ES2252224T3 (es) 2000-05-04 2006-05-16 Vertex Pharmaceuticals Incorporated Sisntesis asimetrica de acido piperazico y derivados del mismo.
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
US8408396B2 (en) * 2008-07-25 2013-04-02 Chuluun Enkhbold Method of solid fuel beneficiation and transportation to thermoelectric power stations
US20110313035A1 (en) 2009-12-16 2011-12-22 Hetero Research Foundation Polymorphs of darunavir
EP2571355B1 (en) 2010-05-20 2016-09-07 Hetero Research Foundation Crystalline hydrochloride salt of darunavir

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308094A (en) * 1977-02-02 1981-12-29 Sanyo Electric Co., Ltd. Diaphragm for speaker and method of producing same
IL60617A0 (en) * 1979-07-23 1980-09-16 Sparamedica Ag Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them
EP0025941B1 (de) * 1979-09-19 1983-05-04 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyridazopyridazinderivate, Verfahren zu deren Herstellung und Arzneimittel enthaltend solche Pyridazopyridazinderivate
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity

Also Published As

Publication number Publication date
EP0172552A2 (de) 1986-02-26
NO161914B (no) 1989-07-03
ES552398A0 (es) 1987-05-01
US4762924A (en) 1988-08-09
ES8700258A1 (es) 1986-10-01
FI853174L (fi) 1986-02-25
MC1694A1 (fr) 1986-07-18
NO853336L (no) 1986-02-25
PT81015A (en) 1985-09-01
DK384385D0 (da) 1985-08-23
PT81015B (en) 1987-08-24
US4826980A (en) 1989-05-02
IL76133A0 (en) 1985-12-31
HUT38644A (en) 1986-06-30
PH21749A (en) 1988-02-18
NZ213130A (en) 1988-05-30
EP0172552A3 (de) 1989-01-11
ES8705443A1 (es) 1987-05-01
ES552397A0 (es) 1987-05-01
AU583843B2 (en) 1989-05-11
US4692438A (en) 1987-09-08
NO161914C (no) 1989-10-11
AU4641585A (en) 1986-02-27
FI853174A0 (fi) 1985-08-19
HU193446B (en) 1987-10-28
DK384385A (da) 1986-02-25
CS592885A2 (en) 1987-07-16
IL76133A (en) 1989-12-15
CS255893B2 (en) 1988-03-15
US4785093A (en) 1988-11-15
ES546360A0 (es) 1986-10-01

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