NO144926B - Analogifremgangsmaate til fremstilling av terapeutisk aktive 1-benzazolylalkyl-4-substituerte piperidiner - Google Patents

Analogifremgangsmaate til fremstilling av terapeutisk aktive 1-benzazolylalkyl-4-substituerte piperidiner Download PDF

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Publication number
NO144926B
NO144926B NO763424A NO763424A NO144926B NO 144926 B NO144926 B NO 144926B NO 763424 A NO763424 A NO 763424A NO 763424 A NO763424 A NO 763424A NO 144926 B NO144926 B NO 144926B
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Norway
Prior art keywords
benzazolylalkyl
preparation
cylinder
plastic
therapeutic active
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Application number
NO763424A
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English (en)
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NO763424L (no
NO144926C (no
Inventor
Jan Vandenberk
Ludo E J Kennis
Marcel J M C Van Der Aa
Albert H M Th Van Heertum
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO763424L publication Critical patent/NO763424L/no
Publication of NO144926B publication Critical patent/NO144926B/no
Publication of NO144926C publication Critical patent/NO144926C/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, ***e
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08Radicals containing only hydrogen and carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Description

Kardus for kunststoffsprøytegods, særlig til fremstilling av tannproteser.
Oppfinnelsen angår karduser som er
fylt med termoplastisk kunststoff til fremstilling av gjenstander, særlig tannproteser. Disse karduser blir som kjent ført inn
i varmesylinderen til en sprøytegodsmaskin
og oppvarmet til innholdet har fått en til-strekkelig plastisk konsistens, hvoretter det
med trykk fra ett stempel i sylinderen blir
sprøytet inn i den foran fastspente form.
Kardusene, som vanligvis er laget av
aluminium, har man hittil fylt med et
granulat. En ulempe ved dette er at den
fullstendige plastifisering av det dårlig
varmeledende kunststoff fordrer meget
lang tid, også når kardusdiameteren holdes
så liten som mulig. Den samme ulempe
oppstår — i enda høyere grad — dersom
man fyller kardusen med kompakt kunststoff. Dessuten oppstår det skader i kunst-stoffets kvalitet på grunn av den lange
oppvarmingstid.
Kardusen og likeså de tilhørende var-mesylindre må på grunn av de forholds-messige små tverrsnitt utføres med store lengder og dette betinger at stempelbeve-gelsen tar tilsvarende lang tid. Innsprøyt-ningen skjer tilsvarende meget langsomt,
slik at det er fare for at formen ikke fylles
helt.
Disse ulemper unngås ved oppfinnelsen
som består i en kardus for formsprøyting
av avmålte porsjoner av plastmateriale,
fortrinnsvis for tannproteser, og fortrinnsvis utformet som en aluminiumssylinder,
hvilken kardus er kjennetegnet ved at den
omfatter en sats perforerte skiver eller
sammenpressbare viklinger av godt varmeledende materiale, hvilke fritt kan gli i sylinderen, dog under varmeledende kontakt med sylinderveggen, og mellom hvilke skiver, respektivt viklinger, plastmaterialet innlegges, fortrinnsvis i på forhånd tablettert form. ■
På tegningen er det vist et utførelses-eksempel av oppfinnelsen.
Fig. 1 er et lengdesnitt gjennom en
ferdig kardus.
Fig. 2 og 3 er et grunnriss av henholdsvis en kunststofftablett og en hullskive. Fig. 4 og 5 er et snitt henholdsvis i lin-jen A—B i fig. 2 og C—D i fig. 3. Fig. 6 er et lengdesnitt gjennom en
kardus etter bruken.
Den i eksemplet sylinderformede kardus er fylt vekselvis med tilpassede kunst-stofftabletter 2 og hullskiver 3. Varmen fra varmesylinderen (ikke vist) blir i løpet av kort tid ledet gjennom hullskivene 3, som er laget av godt varmeledende materiale og ligger tett an mot kardusveggen, til det
indre av kardusen og fordelt på kunststoff -
tablettene som ligger godt an mot hullskivene, slik at kunststoffet hurtig oppnår den nødvendige plastiske konsistens for sprøyting uten at dets gode egenskaper blir forringet. På grunn av den gode varmeover-føring kan kardusen utføres med forholds-messig stor diameter og altså med kortere lengde enn det hittil var mulig, slik at sprøytingen fullføres med betraktelig stør-re hastighet enn før. Idet stempelet i sprøy-tegodssylinderen går ned, blir kunststoffet presset igjennom hullene i de oppstablede skiver, og det får en enhetlig konsistens slik at det oppnås en absolutt garanti for en ordentlig innføring av protesematerialet i sprøytegodsformen.
Oppfinnelsen er ikke begrenset til den her beskrevne utførelsesform, idet likesom kardusene kan ha et annet tverrsnitt, kan metallinnleggene som nevnt ha en annen form; f. eks. kan de være aksialt anordnede vinger eller spiralformede (viklinger) eller lignende innlegg.
Likeledes kan hullene i innleggene ut-føres og anordnes på en annen måte så-lenge bare det i kardusen plaserte sprøyte-godsmateriale blir forsynt med innlegg av godt varmeledende materiale.

Claims (1)

  1. Kardus for formsprøyting av avmålte porsjoner av plastmateriale, fortrinnsvis for tannproteser, og fortrinnsvis utformet som en aluminiumssylinder, karakterisert ved at den omfatter en sats perforerte skiver eller sammenpressbare viklinger av godt varmeledende materiale, hvilke fritt kan gli i sylinderen, dog under varmeledende kontakt med sylinderveggen, og mellom hvilke skiver, respektivt viklinger, plastmaterialet innlegges, fortrinnsvis i på forhånd tablettert form.
NO763424A 1975-10-08 1976-10-07 Analogifremgangsmaate til fremstilling av terapeutisk aktive 1-benzazolylalkyl-4-substituerte piperidiner NO144926C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62072775A 1975-10-08 1975-10-08
US05/713,309 US4035369A (en) 1975-10-08 1976-08-10 1-Benzazolylalkyl-4-substituted-piperidines

Publications (3)

Publication Number Publication Date
NO763424L NO763424L (no) 1977-04-13
NO144926B true NO144926B (no) 1981-08-31
NO144926C NO144926C (no) 1981-12-09

Family

ID=27088773

Family Applications (1)

Application Number Title Priority Date Filing Date
NO763424A NO144926C (no) 1975-10-08 1976-10-07 Analogifremgangsmaate til fremstilling av terapeutisk aktive 1-benzazolylalkyl-4-substituerte piperidiner

Country Status (31)

Country Link
US (1) US4035369A (no)
JP (1) JPS5246082A (no)
AT (1) AT365185B (no)
AU (1) AU511834B2 (no)
BG (1) BG27542A3 (no)
CA (1) CA1085853A (no)
CH (1) CH630915A5 (no)
CS (1) CS225101B2 (no)
DE (1) DE2645125A1 (no)
DK (1) DK151801C (no)
EG (1) EG12969A (no)
ES (1) ES452200A1 (no)
FI (1) FI63228C (no)
FR (1) FR2346009A1 (no)
GB (1) GB1532546A (no)
GR (1) GR61672B (no)
HU (1) HU174927B (no)
IE (1) IE43951B1 (no)
IL (1) IL50631A (no)
IT (1) IT1069293B (no)
LU (1) LU75954A1 (no)
NL (1) NL7611085A (no)
NO (1) NO144926C (no)
NZ (1) NZ182134A (no)
PH (1) PH15417A (no)
PL (1) PL106815B1 (no)
PT (1) PT65688B (no)
RO (1) RO69904A (no)
SE (1) SE417610B (no)
SU (1) SU663306A3 (no)
YU (1) YU39976B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200641A (en) * 1976-12-21 1980-04-29 Janssen Pharmaceutica, N.V. 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives
US4335127A (en) * 1979-01-08 1982-06-15 Janssen Pharmaceutica, N.V. Piperidinylalkyl quinazoline compounds, composition and method of use
EP0034116A3 (en) * 1980-02-11 1981-09-02 Berlex Laboratories, Inc. N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
US4254127A (en) * 1980-04-03 1981-03-03 Janssen Pharmaceutica, N.V. 1,3-Dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives
DE3442757A1 (de) * 1984-11-23 1986-05-28 Wella Ag, 6100 Darmstadt Verwendung von 2-nitroanilinderivaten in haarfaerbemitteln und neue 2-nitroanilinderivate
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
FR2581993B1 (fr) * 1985-05-14 1988-03-18 Synthelabo Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique
FR2702214B1 (fr) * 1993-03-05 1995-04-14 Adir Nouveaux composés (aryl(alkyl)carbonyl)-hétérocycliques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
GB9418326D0 (en) * 1994-09-12 1994-11-02 Lilly Industries Ltd Pharmaceutical compounds
DE69531476T2 (de) 1994-09-12 2004-06-09 Lilly Industries Ltd., Basingstoke Serotonergische Modulatoren
GB2308362A (en) * 1995-12-19 1997-06-25 Lilly Industries Ltd Pharmaceutical indole derivatives
GB9613423D0 (en) * 1996-06-26 1996-08-28 Lilly Industries Ltd Pharmaceutical compounds
EP2392584A1 (en) * 2006-09-19 2011-12-07 Cipla Limited Crystalline Ciclesonide Methanol Solvate Form C
CN101759693B (zh) * 2008-12-23 2011-09-14 江苏恩华药业股份有限公司 苯骈异恶唑哌啶衍生物及在制备镇痛、镇静药物中的应用
US20240199555A1 (en) * 2021-03-19 2024-06-20 Centre National De La Recherche Scientifique Applications of biased ligands of the serotonin 5-ht7 receptor for the treatment of pain, multiple sclerosis and the control of thermoregulation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (no) * 1962-06-13
US3345364A (en) * 1964-05-06 1967-10-03 Janssen Pharmaceutica Nv Benzimidazolinyl piperidines
FR1573739A (no) 1968-07-26 1969-07-04
US3647790A (en) * 1969-04-08 1972-03-07 American Home Prod Ouinoxalinyl-oxazolidines and -oxazines

Also Published As

Publication number Publication date
YU39976B (en) 1985-06-30
IT1069293B (it) 1985-03-25
IE43951L (en) 1977-04-08
NO763424L (no) 1977-04-13
AU511834B2 (en) 1980-09-11
YU248076A (en) 1983-01-21
IL50631A0 (en) 1976-12-31
NL7611085A (nl) 1977-04-13
GB1532546A (en) 1978-11-15
NZ182134A (en) 1979-01-11
ATA745276A (de) 1981-05-15
DK452076A (da) 1977-04-09
EG12969A (en) 1981-03-31
DE2645125A1 (de) 1977-04-21
FR2346009B1 (no) 1978-12-22
LU75954A1 (no) 1977-05-09
DE2645125C2 (no) 1988-11-24
AT365185B (de) 1981-12-28
PH15417A (en) 1983-01-07
CA1085853A (en) 1980-09-16
US4035369A (en) 1977-07-12
PL106815B1 (pl) 1980-01-31
FI762865A (no) 1977-04-09
PT65688B (en) 1978-04-02
GR61672B (en) 1978-12-05
PL192890A1 (pl) 1978-03-28
IL50631A (en) 1980-02-29
CS225101B2 (en) 1984-02-13
RO69904A (fr) 1980-08-15
BG27542A3 (en) 1979-11-12
SE417610B (sv) 1981-03-30
NO144926C (no) 1981-12-09
SE7611137L (sv) 1977-04-09
SU663306A3 (ru) 1979-05-15
AU1807876A (en) 1978-04-06
DK151801B (da) 1988-01-04
JPS6215553B2 (no) 1987-04-08
IE43951B1 (en) 1981-07-01
ES452200A1 (es) 1978-01-16
FI63228B (fi) 1983-01-31
FI63228C (fi) 1983-05-10
JPS5246082A (en) 1977-04-12
HU174927B (hu) 1980-04-28
CH630915A5 (de) 1982-07-15
PT65688A (en) 1976-11-01
FR2346009A1 (fr) 1977-10-28
DK151801C (da) 1988-06-06

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