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Priority to NL7507539ApriorityCriticalpatent/NL7507539A/en
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Cephalosporins of formula (I): (where A and B are each H or an amino-protecting gp.; X = OH or carboxyl-protecting gp.; Y = H, halo, alkyl, alkoxy or alkylthio; R = H or alkyl; Z is =N.NR1-R2; R1 and R2 are each H, opt. substd. hydrocarbyl, acyl, or -C(=M1)MR3; M and M1 are each O or S; R3 = hydrocarbyl, or R1 and R2 can be joined directly or via a heteroatom; m = 0 or 1 and dotted line indicates a double bond at 2 or 3 posn.), are prepd. from corresp. 3-COR cpds. by reaction with H2Z. (I; m = 0) are antibacterials for prophylactic or therapeutic treatment of humans, animals and plants or as disinfectants; and (I; m = 1) are inters.
NL7507539A1975-06-241975-06-243-Hydrazonomethyl cephalosporin antibacterials - prepd. from corresp. 3-oxo cephem and a hydrazine
NL7507539A
(en)
Process for the preparation of a therapeutically active 10-azaspiro-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido [1,2,3-de] [1,4] benzoxazine-6-carboxylic acid derivative