NL180381C - Werkwijze ter bereiding van een 2-(4-isobutylfenyl)propionzure ester bevattend geneesmiddel en werkwijze ter bereiding van de geneeskrachtige verbindingen. - Google Patents

Werkwijze ter bereiding van een 2-(4-isobutylfenyl)propionzure ester bevattend geneesmiddel en werkwijze ter bereiding van de geneeskrachtige verbindingen.

Info

Publication number
NL180381C
NL180381C NLAANVRAGE7614308,A NL7614308A NL180381C NL 180381 C NL180381 C NL 180381C NL 7614308 A NL7614308 A NL 7614308A NL 180381 C NL180381 C NL 180381C
Authority
NL
Netherlands
Prior art keywords
preparing
isobutylphenyl
acid ester
propionic acid
medicinal
Prior art date
Application number
NLAANVRAGE7614308,A
Other languages
English (en)
Other versions
NL180381B (nl
NL7614308A (nl
Original Assignee
Hisamitsu Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co filed Critical Hisamitsu Pharmaceutical Co
Publication of NL7614308A publication Critical patent/NL7614308A/nl
Publication of NL180381B publication Critical patent/NL180381B/nl
Application granted granted Critical
Publication of NL180381C publication Critical patent/NL180381C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NLAANVRAGE7614308,A 1975-12-24 1976-12-23 Werkwijze ter bereiding van een 2-(4-isobutylfenyl)propionzure ester bevattend geneesmiddel en werkwijze ter bereiding van de geneeskrachtige verbindingen. NL180381C (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50156799A JPS5826744B2 (ja) 1975-12-24 1975-12-24 シンキナプロピオンサン エステルユウドウタイノセイゾウホウ

Publications (3)

Publication Number Publication Date
NL7614308A NL7614308A (nl) 1977-06-28
NL180381B NL180381B (nl) 1986-09-16
NL180381C true NL180381C (nl) 1987-02-16

Family

ID=15635562

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7614308,A NL180381C (nl) 1975-12-24 1976-12-23 Werkwijze ter bereiding van een 2-(4-isobutylfenyl)propionzure ester bevattend geneesmiddel en werkwijze ter bereiding van de geneeskrachtige verbindingen.

Country Status (9)

Country Link
JP (1) JPS5826744B2 (nl)
AU (1) AU507661B2 (nl)
CA (1) CA1076134A (nl)
CH (1) CH617919A5 (nl)
DE (1) DE2658610C2 (nl)
FR (1) FR2336126A1 (nl)
GB (1) GB1573322A (nl)
NL (1) NL180381C (nl)
SE (1) SE433492B (nl)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5517358A (en) * 1978-07-24 1980-02-06 Teikoku Seiyaku Kk Butyl propionate derivative, its preparation, and antiphlogistic and analgesic comprising it
JPS54144336A (en) * 1978-07-24 1979-11-10 Teikoku Seiyaku Kk Propionic acid propylester derivative*its manufacture and antiiinflammatory and sedative agent containing it
JPS5587770A (en) * 1978-12-27 1980-07-02 Hisamitsu Pharmaceut Co Inc Preparation of 2-(p-isobutylphenyl)propionic acid 2-pyridinemethyl ester
JPS57203035A (en) * 1981-06-05 1982-12-13 Taisho Pharmaceut Co Ltd Carboxylic acid ester
DE3225290A1 (de) * 1982-07-07 1984-01-12 Merck Patent Gmbh Ringverbindungen
YU43408B (en) * 1985-04-26 1989-06-30 Lek Tovarna Farmacevtskih Process for preparation of 2-(4-isobuthylphenyl)-prophiohydroxamic acid
JPH0635378B2 (ja) * 1985-06-27 1994-05-11 ポ−ラ化成工業株式会社 化粧料
ES2004447A6 (es) * 1987-07-06 1989-01-01 Sune Coma Nuria Procedimiento de obtencion de un nuevo ester del acido 2-(p-isobutilfeni)-propionico
DE3811118C1 (nl) * 1988-03-31 1989-10-12 Merckle Gmbh, 7902 Blaubeuren, De
IT1217589B (it) * 1988-05-13 1990-03-30 Pulitzer Italiana Agente antiinfiammatorio per la terapia dell'ipertrofia prostatica,sua preparazione e relative composizioni farmaceutiche
JPH0639449B2 (ja) * 1989-04-10 1994-05-25 エーザイ株式会社 ポリプレニル系化合物およびその製造方法ならびにそれを含有する医薬
CA2102530C (en) 1991-05-13 2003-07-29 Bernard J. Armitage Therapeutic agent
US6399618B1 (en) * 1997-07-09 2002-06-04 Cardiome Pharma Corp Compositions and methods for modulating sexual activity
CN103948571A (zh) * 2006-07-18 2014-07-30 天津昕晨泰飞尔医药科技有限公司 具有快速皮肤穿透率的带正电荷的水溶性布洛芬前药
AU2006347391B2 (en) * 2006-08-15 2013-03-07 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate
KR101853971B1 (ko) 2007-06-04 2018-05-02 테크필즈 인크 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도
WO2013064153A1 (en) * 2011-10-31 2013-05-10 Claus Selch Larsen Prodrugs of non- steroid anti - inflammatory agents (nsaids)
US9470448B2 (en) 2012-12-13 2016-10-18 Whirlpool Corporation Apparatus to warm plastic side of mold
US9557087B2 (en) 2012-12-13 2017-01-31 Whirlpool Corporation Clear ice making apparatus having an oscillation frequency and angle
US9500398B2 (en) 2012-12-13 2016-11-22 Whirlpool Corporation Twist harvest ice geometry
US9759472B2 (en) 2012-12-13 2017-09-12 Whirlpool Corporation Clear ice maker with warm air flow
CN105461731B (zh) * 2014-08-07 2017-05-24 富力 连翘脂素布洛芬酯、其制备及其应用
WO2016065269A2 (en) 2014-10-23 2016-04-28 Whirlpool Corporation Method and apparatus for increasing rate of ice production in an automatic ice maker
JP6153264B2 (ja) * 2015-01-05 2017-06-28 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
CN109134261A (zh) * 2017-06-15 2019-01-04 北京蓝丹医药科技有限公司 一种洛索洛芬衍生物
CN109134262A (zh) * 2017-06-15 2019-01-04 北京蓝丹医药科技有限公司 一种洛索洛芬衍生物
US10907874B2 (en) 2018-10-22 2021-02-02 Whirlpool Corporation Ice maker downspout

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971700A (en) * 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents

Also Published As

Publication number Publication date
NL180381B (nl) 1986-09-16
JPS5826744B2 (ja) 1983-06-04
SE433492B (sv) 1984-05-28
FR2336126A1 (fr) 1977-07-22
AU2087876A (en) 1978-06-29
GB1573322A (en) 1980-08-20
DE2658610C2 (de) 1982-12-23
DE2658610A1 (de) 1977-07-07
JPS5278848A (en) 1977-07-02
CA1076134A (en) 1980-04-22
NL7614308A (nl) 1977-06-28
CH617919A5 (en) 1980-06-30
AU507661B2 (en) 1980-02-21
FR2336126B1 (nl) 1979-03-09
SE7613651L (sv) 1977-06-25

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Legal Events

Date Code Title Description
BC A request for examination has been filed
A85 Still pending on 85-01-01
SNR Assignments of patents or rights arising from examined patent applications

Owner name: AB NYNAES PETROLEUM

V4 Lapsed because of reaching the maximum lifetime of a patent

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