NL1024676A1 - HIV integrase-remmers, farmaceutische preparaten en methoden voor het gebruik daarvan. - Google Patents

HIV integrase-remmers, farmaceutische preparaten en methoden voor het gebruik daarvan.

Info

Publication number
NL1024676A1
NL1024676A1 NL1024676A NL1024676A NL1024676A1 NL 1024676 A1 NL1024676 A1 NL 1024676A1 NL 1024676 A NL1024676 A NL 1024676A NL 1024676 A NL1024676 A NL 1024676A NL 1024676 A1 NL1024676 A1 NL 1024676A1
Authority
NL
Netherlands
Prior art keywords
methods
pharmaceutical preparations
hiv integrase
integrase inhibitors
inhibitors
Prior art date
Application number
NL1024676A
Other languages
English (en)
Other versions
NL1024676C2 (nl
Inventor
Qiyue Hu
Atsuo Kuki
Dawn Marie Nowlin
Michael Bruno Plewe
Hai Wang
Junhu Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NL1024676A1 publication Critical patent/NL1024676A1/nl
Application granted granted Critical
Publication of NL1024676C2 publication Critical patent/NL1024676C2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NL1024676A 2002-10-31 2003-10-31 HIV integrase-remmers, farmaceutische preparaten en methoden voor het gebruik daarvan. NL1024676C2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42251302P 2002-10-31 2002-10-31
US42251302 2002-10-31

Publications (2)

Publication Number Publication Date
NL1024676A1 true NL1024676A1 (nl) 2004-05-06
NL1024676C2 NL1024676C2 (nl) 2005-12-14

Family

ID=32230367

Family Applications (1)

Application Number Title Priority Date Filing Date
NL1024676A NL1024676C2 (nl) 2002-10-31 2003-10-31 HIV integrase-remmers, farmaceutische preparaten en methoden voor het gebruik daarvan.

Country Status (16)

Country Link
US (3) US7135482B2 (nl)
EP (1) EP1558611B1 (nl)
JP (1) JP2006506398A (nl)
AR (1) AR041864A1 (nl)
AT (1) ATE454385T1 (nl)
AU (1) AU2003269421A1 (nl)
BR (1) BR0315820A (nl)
CA (1) CA2500487A1 (nl)
DE (1) DE60330890D1 (nl)
GT (1) GT200300231A (nl)
MX (1) MXPA05004343A (nl)
NL (1) NL1024676C2 (nl)
PA (1) PA8586801A1 (nl)
TW (1) TW200424199A (nl)
UY (1) UY28048A1 (nl)
WO (1) WO2004039803A2 (nl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
JP2006516606A (ja) 2003-01-27 2006-07-06 ファイザー インコーポレイテッド Ｈｉｖインテグラーゼインヒビター、医薬組成物、およびそれらの使用
EP1873155A1 (en) * 2004-04-26 2008-01-02 Pfizer Inc. Inhibitors of the HIV integrase enzyme
BRPI0510319A (pt) 2004-04-26 2007-10-16 Pfizer inibidores da enzima integrase de hiv
JP2007534738A (ja) * 2004-04-26 2007-11-29 ファイザー・インク Ｈｉｖインテグラーゼ酵素の阻害剤
WO2006027694A1 (en) * 2004-09-07 2006-03-16 Pfizer Inc. Inhibitors of the hiv integrase enzyme
US7745459B2 (en) 2004-09-21 2010-06-29 Japan Tobacco Inc. Quinolizinone compound and use thereof as HIV integrase inhibitor
DE102005015005A1 (de) * 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
EP1881825B1 (en) * 2005-05-10 2013-07-24 Merck Sharp & Dohme Corp. Hiv integrase inhibitors
JP2009510157A (ja) * 2005-10-03 2009-03-12 ファイザー・プロダクツ・インク Ｈｉｖインテグラーゼ酵素の阻害剤
AP2008004400A0 (en) * 2005-10-07 2008-04-30 Pfizer Prod Inc Inhibitors of HIV integrase enzyme
US20080079207A1 (en) * 2006-09-28 2008-04-03 Williams Controils Industries, Inc. Methods and apparatus for a lever control
CN102112447B (zh) 2008-06-04 2013-06-26 阿姆布里利亚生物制药公司 来自吡哆醇的hiv整合酶抑制剂
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
SG181423A1 (en) * 2009-12-23 2012-07-30 Univ Leuven Kath Novel antiviral compounds
EP2640705A2 (en) 2010-11-15 2013-09-25 Katholieke Universiteit Leuven Novel antiviral compounds
AU2012345732B2 (en) 2011-11-30 2016-07-14 Emory University Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
GB201321735D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
GB8720125D0 (en) 1987-08-26 1987-09-30 Roussel Lab Ltd Chemical compounds
WO1993003039A1 (en) * 1991-08-08 1993-02-18 Tsumura & Co. Carcinostatic compound and production thereof
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
US5262537A (en) * 1993-03-19 1993-11-16 Anaquest, Inc. Derivatives of 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridinyl-6-carboxylic acid
EP0713877A1 (en) * 1993-07-19 1996-05-29 LUO, Xuande Qinghaosu derivatives against aids
GB2306476A (en) * 1995-10-27 1997-05-07 Merck & Co Inc Hiv integrase inhibitors
US6057297A (en) * 1996-08-06 2000-05-02 Polifarma S.P.A. Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof
FR2754262B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
AU4917397A (en) * 1996-10-31 1998-05-22 Merck & Co., Inc. Benzodiazepine hydrazide derivatives as inhibitors of hiv integrase
GB2327674A (en) * 1997-07-29 1999-02-03 Merck & Co Inc HIV integrase inhibitors
US6403347B1 (en) * 1998-02-03 2002-06-11 Merck & Co., Inc. HIV integrase inhibitors
RU2233841C2 (ru) 1998-06-12 2004-08-10 Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик Сас Бета-карболиновые соединения, фармацевтические композиции на их основе и способы связывания, достижения агонистического/антагонистического эффекта
AU777036B2 (en) * 1999-05-12 2004-09-30 Antonio Garofalo Thiazepine inhibitors of HIV-1 integrase
US6245806B1 (en) * 1999-08-03 2001-06-12 Merck & Co., Inc. HIV integrase inhibitors
AU8009900A (en) * 1999-10-13 2001-04-23 Merck & Co., Inc. Hiv integrase inhibitors
EP1209158A1 (en) 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substituted beta-carbolines
US20030027847A1 (en) * 2000-06-16 2003-02-06 Walker Michael A. HIV integrase inhibitors
WO2002002516A2 (en) * 2000-06-30 2002-01-10 Thomas Jefferson University Inhibitors of hiv integrase
WO2002070491A1 (fr) * 2001-03-01 2002-09-12 Shionogi & Co., Ltd. Derive a noyau heteroaromatique azote presentant une activite d'inhibiteur d'integrase du vih
EP2033952B1 (en) 2001-03-01 2012-08-29 Shionogi&Co., Ltd. Nitrogen-containing Heteroaryl compounds having HIV Integrase Inhibitory Activity
JP2003171381A (ja) 2001-09-25 2003-06-20 Takeda Chem Ind Ltd エントリー阻害剤
JP2003119137A (ja) 2001-10-10 2003-04-23 Japan Tobacco Inc Ｈｉｖ阻害剤
JP2005508968A (ja) 2001-10-19 2005-04-07 トランス　テック　ファーマ，インコーポレイテッド ＰＴＰ阻害剤としてのβ−カルボリン誘導体
US7232819B2 (en) 2001-10-26 2007-06-19 Istituto Di Ricerche Di Biologia P. Angeletti S.P.A. Dihydroxypyrimidine carboxamide inhibitors of HIV integrase
JP4497347B2 (ja) 2001-12-05 2010-07-07 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する誘導体
JP2005515206A (ja) 2001-12-12 2005-05-26 ブリストル−マイヤーズ　スクイブ　カンパニー Ｈｉｖインテグラーゼ・インヒビター
ES2291642T3 (es) 2002-01-17 2008-03-01 MERCK & CO., INC. Hidroxinaftiridinoncarboxamidas utiles como inhibidores de la integrasa de vih.
JP4494020B2 (ja) 2002-03-15 2010-06-30 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖインテグラーゼ阻害剤として有用なｎ−（置換ベンジル）−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミド
WO2003082881A2 (en) * 2002-03-28 2003-10-09 Procyon Biopharma Inc. Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors
EP1499391A2 (en) * 2002-04-10 2005-01-26 Merck & Co., Inc. Pharmaceutical compositions containing an hiv integrase inhibitor and a nonionic surfactant
WO2004035076A1 (en) 2002-10-15 2004-04-29 Chiron Corporation Treatment of tnf-alpha-mediated disorders with casein kinase i epsilon inhibitors
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
JP2006516606A (ja) * 2003-01-27 2006-07-06 ファイザー インコーポレイテッド Ｈｉｖインテグラーゼインヒビター、医薬組成物、およびそれらの使用
JP2007534738A (ja) 2004-04-26 2007-11-29 ファイザー・インク Ｈｉｖインテグラーゼ酵素の阻害剤
BRPI0510319A (pt) 2004-04-26 2007-10-16 Pfizer inibidores da enzima integrase de hiv
WO2006027694A1 (en) 2004-09-07 2006-03-16 Pfizer Inc. Inhibitors of the hiv integrase enzyme

Also Published As

Publication number Publication date
US20080221154A1 (en) 2008-09-11
WO2004039803A2 (en) 2004-05-13
GT200300231A (es) 2004-06-23
TW200424199A (en) 2004-11-16
EP1558611B1 (en) 2010-01-06
US7135482B2 (en) 2006-11-14
EP1558611A2 (en) 2005-08-03
JP2006506398A (ja) 2006-02-23
ATE454385T1 (de) 2010-01-15
PA8586801A1 (es) 2005-02-04
US7368571B2 (en) 2008-05-06
US20040147547A1 (en) 2004-07-29
WO2004039803A3 (en) 2004-09-16
NL1024676C2 (nl) 2005-12-14
US20070004768A1 (en) 2007-01-04
AR041864A1 (es) 2005-06-01
DE60330890D1 (de) 2010-02-25
CA2500487A1 (en) 2004-05-13
UY28048A1 (es) 2004-05-31
BR0315820A (pt) 2005-09-13
MXPA05004343A (es) 2005-08-03
AU2003269421A8 (en) 2004-05-25
AU2003269421A1 (en) 2004-05-25

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Legal Events

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AD1A A request for search or an international type search has been filed
RD2N Patents in respect of which a decision has been taken or a report has been made (novelty report)

Effective date: 20051010

PD2B A search report has been drawn up
VD1 Lapsed due to non-payment of the annual fee

Effective date: 20080501