MXPA05013234A - Proteinas de capside de adenovirus quimericas. - Google Patents

Proteinas de capside de adenovirus quimericas.

Info

Publication number
MXPA05013234A
MXPA05013234A MXPA05013234A MXPA05013234A MXPA05013234A MX PA05013234 A MXPA05013234 A MX PA05013234A MX PA05013234 A MXPA05013234 A MX PA05013234A MX PA05013234 A MXPA05013234 A MX PA05013234A MX PA05013234 A MXPA05013234 A MX PA05013234A
Authority
MX
Mexico
Prior art keywords
present
adenovirus capsid
capsid protein
chimeric
adenovirus
Prior art date
Application number
MXPA05013234A
Other languages
English (en)
Inventor
Philip J Griebel
Original Assignee
Univ Saskatchewan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Saskatchewan filed Critical Univ Saskatchewan
Publication of MXPA05013234A publication Critical patent/MXPA05013234A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
    • C12N2810/405—Vectors comprising RGD peptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
    • C12N2810/859—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from immunoglobulins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invencion se relaciona proteinas de capside de adenovirus quimerica que comprende una parte de o toda de una proteina de capside de adenovirus y una molecula de union de un sitio de union de la superficie celular sobre una celula presente en tejidos linfoides asociados con el intestino (GALT) de un mamifero, donde la proteina de la capside del adenovirus quimerica es capaz de unirse a la celula presente en los tejidos linfoides asociados con el intestino (GALT). En algunos ejemplos la proteina de la capside de adenovirus se localiza sobre la superficie de la capside del adenovirus La presente invencion proporciona capsides de adenovirus que comprenden una proteina de capside quimerica. La presente invencion tambien proporciona complejos que comprenden una proteina de capside de adenovirus quimerica unida a una celula en GALT. La presente invencion tambien proporciona sistemas y vectores de encapsulacion, en particulas vectores de adenovirus capaces de expresar una proteina de capside de adenovirus quimerica abarcada dentro dela invencion. La presente invencion tambien proporciona particulas virales, celulas anfitrionas y composiciones que comprenden esos vectores, en particular para usarse en vacunas, metodos para producir una respuesta inmune y metodos para la liberacion dirigida de proteinas heterologas, como antigenos, a celulas blanco.
MXPA05013234A 2003-06-10 2004-06-10 Proteinas de capside de adenovirus quimericas. MXPA05013234A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47753903P 2003-06-10 2003-06-10
PCT/IB2004/002532 WO2004108755A2 (en) 2003-06-10 2004-06-10 Chimeric adenovirus capsid proteins

Publications (1)

Publication Number Publication Date
MXPA05013234A true MXPA05013234A (es) 2006-03-09

Family

ID=33511850

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05013234A MXPA05013234A (es) 2003-06-10 2004-06-10 Proteinas de capside de adenovirus quimericas.

Country Status (6)

Country Link
US (1) US20050032045A1 (es)
EP (1) EP1631582A2 (es)
JP (2) JP5698426B2 (es)
CA (1) CA2527721C (es)
MX (1) MXPA05013234A (es)
WO (1) WO2004108755A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032045A1 (en) * 2003-06-10 2005-02-10 Tikoo Suresh K. Chimeric adenovirus capsid proteins
WO2007050128A2 (en) * 2005-05-31 2007-05-03 Vectorlogics, Inc. Shielded adenoviral vectors and methods of use
JP5903045B2 (ja) * 2009-07-31 2016-04-13 パックスバックス， インコーポレイテッド アデノウイルスに基づくベクター
AU2014236207B2 (en) 2013-03-14 2019-05-23 Salk Institute For Biological Studies Oncolytic adenovirus compositions
CN117384961A (zh) 2016-02-23 2024-01-12 萨克生物研究学院 对病毒动力学影响最小的治疗性腺病毒中的外源基因表达
CA3013637A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
WO2018111767A1 (en) 2016-12-12 2018-06-21 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4152415A (en) * 1978-08-18 1979-05-01 Iowa State University Research Foundation, Inc. Method of increasing the effectiveness of oral vaccination for swine dysentery
US5032405A (en) * 1989-09-27 1991-07-16 Warner-Lambert Company Oral pharmaceutical composition for acid sensitive proteinaceous agents
ZA907737B (en) * 1989-09-29 1991-07-31 Nisshin Oil Mills Ltd Stable immunogen composition for oral administration
US5352448A (en) * 1992-07-20 1994-10-04 Purdue Research Foundatioin Oral administration of antigens
US5543328A (en) * 1993-08-13 1996-08-06 Genetic Therapy, Inc. Adenoviruses having modified fiber proteins
US5820868A (en) * 1993-12-09 1998-10-13 Veterinary Infectious Disease Organization Recombinant protein production in bovine adenovirus expression vector system
US5559099A (en) * 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US6060082A (en) * 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
DE69838644T2 (de) * 1997-06-23 2009-05-14 The University Of Saskatchewan Verfahren zur herstellung eines rekombinanten rinderadenovirus-vektors
CA2317941A1 (en) * 1998-01-16 1999-07-22 Genzyme Corporation Adenoviral vectors with modified capsid proteins
US5922576A (en) * 1998-02-27 1999-07-13 The John Hopkins University Simplified system for generating recombinant adenoviruses
US6492343B1 (en) * 1998-04-15 2002-12-10 University Of Saskatchewan Porcine adenovirus type 3 genome
EP1162246A1 (en) * 1999-08-10 2001-12-12 TDK Corporation Coating composition for hard-coat formation on polycarbonate substrate, polycarbonate film with hard coat layer, and polycarbonate molding with hard coat layer
CA2384827A1 (en) * 1999-09-24 2001-03-29 The Uab Research Foundation Capsid-modified recombinant adenovirus and methods of use
US6740525B2 (en) * 2000-02-09 2004-05-25 Genvec, Inc. Adenoviral capsid containing chimeric protein IX
JP2003534805A (ja) * 2000-05-31 2003-11-25 ユニバーシティ オブ サスカチュワン 変化した親和性を有する改変ウシアデノウイルス
MXPA03000373A (es) * 2000-07-14 2003-10-15 Univ Saskatchewan Vectores de adenovirus que comprenden intrones.
EP1432729B1 (en) * 2001-07-02 2008-11-12 Merrion Research III Limited Peyers's patch and/or m-cell targeting ligands
US20050032045A1 (en) * 2003-06-10 2005-02-10 Tikoo Suresh K. Chimeric adenovirus capsid proteins

Also Published As

Publication number Publication date
JP2007535900A (ja) 2007-12-13
WO2004108755A2 (en) 2004-12-16
EP1631582A2 (en) 2006-03-08
WO2004108755A3 (en) 2005-05-19
CA2527721C (en) 2016-05-10
JP5698426B2 (ja) 2015-04-08
CA2527721A1 (en) 2004-12-16
US20050032045A1 (en) 2005-02-10
JP2015051018A (ja) 2015-03-19

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