MXPA05010045A - Metodos y aparatos para la fragmentacion y estabilizacion de particulas pequenas. - Google Patents

Metodos y aparatos para la fragmentacion y estabilizacion de particulas pequenas.

Info

Publication number
MXPA05010045A
MXPA05010045A MXPA05010045A MXPA05010045A MXPA05010045A MX PA05010045 A MXPA05010045 A MX PA05010045A MX PA05010045 A MXPA05010045 A MX PA05010045A MX PA05010045 A MXPA05010045 A MX PA05010045A MX PA05010045 A MXPA05010045 A MX PA05010045A
Authority
MX
Mexico
Prior art keywords
suspension
methods
small particles
comminution
stabilization
Prior art date
Application number
MXPA05010045A
Other languages
English (en)
Inventor
Garcia Rhonda
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Publication of MXPA05010045A publication Critical patent/MXPA05010045A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
    • Y10S516/925—Phase inversion
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Colloid Chemistry (AREA)

Abstract

Se proporcionan metodos y aparatos para fragmentar y estabilizar pequenas particulas. en una modalidad, un aparato mueve un compuesto organico disuelto en un solvente para formar una suspension de particulas en una primera corriente de fluido y mueve la suspension en una segunda corriente de fluido, en donde la segunda corriente de fluido esta orientada y posicionada con respecto a la primera corriente para causar esfuerzo cortante entre las corrientes y mezcla de al menos algunas de las particulas en la primera y segunda corrientes.
MXPA05010045A 2003-03-24 2004-03-24 Metodos y aparatos para la fragmentacion y estabilizacion de particulas pequenas. MXPA05010045A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45742403P 2003-03-24 2003-03-24
US10/806,050 US7511079B2 (en) 2003-03-24 2004-03-22 Methods and apparatuses for the comminution and stabilization of small particles
PCT/US2004/009242 WO2004084860A2 (en) 2003-03-24 2004-03-24 Methods for the comminution and stabilization of small particles in suspension

Publications (1)

Publication Number Publication Date
MXPA05010045A true MXPA05010045A (es) 2005-10-26

Family

ID=33101285

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05010045A MXPA05010045A (es) 2003-03-24 2004-03-24 Metodos y aparatos para la fragmentacion y estabilizacion de particulas pequenas.

Country Status (10)

Country Link
US (1) US7511079B2 (es)
EP (1) EP1605915A2 (es)
JP (1) JP2006521396A (es)
KR (1) KR20050115298A (es)
AU (1) AU2004224307A1 (es)
BR (1) BRPI0408707A (es)
CA (1) CA2519536A1 (es)
MX (1) MXPA05010045A (es)
NO (1) NO20054908L (es)
WO (1) WO2004084860A2 (es)

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US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US6962006B2 (en) * 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US7511079B2 (en) 2003-03-24 2009-03-31 Baxter International Inc. Methods and apparatuses for the comminution and stabilization of small particles
CA2533887A1 (en) * 2003-09-30 2005-04-14 Acusphere, Inc. Injectable, oral, or topical sustained release pharmaceutical formulations
ES2338039T3 (es) * 2005-04-13 2010-05-03 ABBOTT GMBH & CO. KG Procedimiento para la obtencion cuidadosa de supensiones de particulas de elevada finura y particulas de elevada finura, asi como su aplicacion.
DE102005053862A1 (de) * 2005-11-04 2007-05-10 Pharmasol Gmbh Verfahren und Vorrichtung zur Herstellung hochfeiner Partikel sowie zur Beschichtung solcher Partikel
US7913223B2 (en) * 2005-12-16 2011-03-22 Dialogic Corporation Method and system for development and use of a user-interface for operations, administration, maintenance and provisioning of a telecommunications system
US8946200B2 (en) * 2006-11-02 2015-02-03 Southwest Research Institute Pharmaceutically active nanosuspensions
US8282266B2 (en) 2007-06-27 2012-10-09 H R D Corporation System and process for inhibitor injection
US20090187135A1 (en) * 2008-01-18 2009-07-23 Eilaz Babaev Ultrasonic syringe
US8404850B2 (en) * 2008-03-13 2013-03-26 Southwest Research Institute Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors
US8187554B2 (en) * 2008-04-23 2012-05-29 Microfluidics International Corporation Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems
US8722706B2 (en) * 2008-08-15 2014-05-13 Southwest Research Institute Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts
US8309134B2 (en) * 2008-10-03 2012-11-13 Southwest Research Institute Modified calcium phosphate nanoparticle formation
US9028873B2 (en) * 2010-02-08 2015-05-12 Southwest Research Institute Nanoparticles for drug delivery to the central nervous system
US10350556B2 (en) 2011-01-07 2019-07-16 Microfluidics International Corporation Low holdup volume mixing chamber
US9199209B2 (en) 2011-04-13 2015-12-01 Microfluidics International Corporation Interaction chamber with flow inlet optimization
US9079140B2 (en) 2011-04-13 2015-07-14 Microfluidics International Corporation Compact interaction chamber with multiple cross micro impinging jets
US10500282B2 (en) * 2012-12-19 2019-12-10 Kashiv Biosciences, Llc Supersaturated stabilized nanoparticles for poorly soluble drugs
JP6462403B2 (ja) * 2015-02-23 2019-01-30 大川原化工機株式会社 湿式分散器
US11191723B2 (en) 2018-06-22 2021-12-07 Delphi Scientific, Llc Apparatus, systems, and methods for continuous manufacturing of nanomaterials and high purity chemicals
CN112867707A (zh) * 2018-08-22 2021-05-28 艾弗林制药有限公司 吸入用尼达尼布和尼达尼布盐类的特定调配的组合物

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Also Published As

Publication number Publication date
NO20054908L (no) 2005-12-21
CA2519536A1 (en) 2004-10-07
JP2006521396A (ja) 2006-09-21
NO20054908D0 (no) 2005-10-24
BRPI0408707A (pt) 2006-03-07
US20040266890A1 (en) 2004-12-30
WO2004084860A3 (en) 2005-03-24
WO2004084860A2 (en) 2004-10-07
EP1605915A2 (en) 2005-12-21
KR20050115298A (ko) 2005-12-07
US7511079B2 (en) 2009-03-31
AU2004224307A1 (en) 2004-10-07

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