MXPA05004247A - Cromonas y derivados de cromona y usos de los mismos. - Google Patents

Cromonas y derivados de cromona y usos de los mismos.

Info

Publication number
MXPA05004247A
MXPA05004247A MXPA05004247A MXPA05004247A MXPA05004247A MX PA05004247 A MXPA05004247 A MX PA05004247A MX PA05004247 A MXPA05004247 A MX PA05004247A MX PA05004247 A MXPA05004247 A MX PA05004247A MX PA05004247 A MXPA05004247 A MX PA05004247A
Authority
MX
Mexico
Prior art keywords
chromones
chromone derivatives
present
derivatives
disorders
Prior art date
Application number
MXPA05004247A
Other languages
English (en)
Inventor
S C Wu Edwin
Original Assignee
Jenken Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenken Biosciences Inc filed Critical Jenken Biosciences Inc
Publication of MXPA05004247A publication Critical patent/MXPA05004247A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invencion se refiere a las cromonas, los nuevos derivados de cromona, y las formulaciones farmaceuticas que contienen los mismos, y los metodos de uso de los mismos. Los usos de la presente invencion incluyen, pero no estan limitados a, el uso para la prevencion o tratamiento de choque septico, dano a organos y otros trastornos. Los compuestos descritos en la presente pueden ser formas de sales y tambien compuestos solubles en agua.
MXPA05004247A 2002-10-22 2003-10-22 Cromonas y derivados de cromona y usos de los mismos. MXPA05004247A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42030602P 2002-10-22 2002-10-22
US45377103P 2003-03-11 2003-03-11
PCT/US2003/033578 WO2004037193A2 (en) 2002-10-22 2003-10-22 Chromones and chromone derivatives and uses thereof

Publications (1)

Publication Number Publication Date
MXPA05004247A true MXPA05004247A (es) 2005-10-18

Family

ID=32179793

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05004247A MXPA05004247A (es) 2002-10-22 2003-10-22 Cromonas y derivados de cromona y usos de los mismos.

Country Status (6)

Country Link
US (1) US8138165B2 (es)
EP (1) EP1556031A4 (es)
AU (1) AU2003282999A1 (es)
CA (1) CA2502975A1 (es)
MX (1) MXPA05004247A (es)
WO (1) WO2004037193A2 (es)

Families Citing this family (30)

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US6884783B2 (en) 2002-05-03 2005-04-26 Unigen Pharmaceuticals, Inc. 7-Hydroxy chromones as potent antioxidants
US20060134015A1 (en) 2004-12-22 2006-06-22 Trivedi Harsh M Methods for use of oral care compositions containing free-B-ring flavonoid anti-oxidants
JP2008533039A (ja) * 2005-03-11 2008-08-21 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 抗アポトーシスＢｃｌ−２ファミリーメンバーのクロメン−４−オン阻害剤およびその使用
GB0509956D0 (en) * 2005-05-16 2005-06-22 Danisco Method
TWI454261B (zh) 2007-01-09 2014-10-01 Unigen Inc 作為治療劑之色酮類
CN101951768A (zh) * 2007-02-14 2011-01-19 玛尔斯有限公司 神经原性化合物
CN101062029B (zh) * 2007-05-21 2010-05-19 中国药科大学 汉黄芩素在制备治疗胃癌的药物中的应用
KR100898330B1 (ko) 2007-09-12 2009-05-20 건국대학교 산학협력단 항암성을 갖는 새로운 플라보노이드 유도체 7-ｏ-(3-벤질옥시프로필)-5,4' -ｏ-디메틸-아피제닌, 그 제법 및 그것을 포함하는 항암 조성물
JP2011518174A (ja) * 2008-04-18 2011-06-23 シェノゲン ファーマ グループ リミテッド エストロゲン受容体に関連する疾患を処置するための化合物及び方法
CA2731849C (en) 2008-07-25 2017-07-11 Emory University Use of 7,8-dihydroxyflavone and derivatives thereof as neuroprotectants and antidepressants
AU2009303300A1 (en) * 2008-10-10 2010-04-15 Limerick Biopharma, Inc. Pyrones for the treatment of metabolic disorders
CN101486715B (zh) * 2009-02-09 2013-01-23 沈阳药科大学 噁嗪类化合物及其抗血小板聚集的用途
CN101486701B (zh) * 2009-02-09 2013-06-19 沈阳药科大学 色满酮类化合物及其类似物和医药用途
US20100222421A1 (en) * 2009-02-27 2010-09-02 National Defense Medical Center Usage of Baicalein in the Preparation of a Pharmaceutical Composition for the Treatment of Traumatic Brain Injury
JP2012525331A (ja) * 2009-04-27 2012-10-22 リメリック バイオファーマ， インコーポレイテッド 治療的処置のためのリン酸化ピロン類似体
CN103965172A (zh) * 2009-09-11 2014-08-06 盛诺基医药科技有限公司 治疗***受体相关疾病的化合物及其方法
US8481590B2 (en) 2010-02-12 2013-07-09 N30 Pharmaceuticals, Inc. Chromone inhibitors of S-nitrosoglutathione reductase
CN102869255B (zh) 2010-02-12 2016-08-31 内瓦利斯治疗公司 S-亚硝基谷胱甘肽还原酶的新抑制剂
EP2579870B1 (en) 2010-06-09 2018-02-14 Emory University Trkb agonists and methods of use
CN107648216B (zh) 2010-07-27 2021-03-30 波士顿大学管理委员会 作为新型癌症疗法的芳烃受体(AhR)调节剂
WO2012066330A1 (en) 2010-11-17 2012-05-24 Heptares Therapeutics Limited Compounds useful as a2a receptor inhibitors
CN102516301B (zh) * 2011-11-28 2016-08-03 江苏天地人和药业有限公司 用于治疗的汉黄芩素衍生物
CN104487429B (zh) 2012-07-27 2017-07-14 爱默蕾大学 杂环黄酮衍生物、组合物及与其相关的方法
US9884836B2 (en) 2014-01-28 2018-02-06 Virginia Commonwealth University 2-substituted-5-hydroxy-4H-chromen-4-ones as novel ligands for the serotonin receptor 2B (5-HT2B)
WO2017146309A1 (ko) 2016-02-22 2017-08-31 (주)오스티오뉴로젠 유파틸린의 상피간엽이행 억제 활성을 이용한 섬유증 예방 및 치료용 약제학적 조성물로서의 새로운 용도
BR112018068412A2 (pt) * 2016-03-11 2019-01-22 H. Lee Moffitt Cancer Center And Research Institute, Inc. composto, composição farmacêutica, método de tratamento de síndrome mielodisplásica e método para matar uma célula tumoral
CN110115712A (zh) * 2019-07-04 2019-08-13 兰州大学 一种同时激活氧化磷酸化通路和抑制糖酵解途径的激活剂及其应用
CN111039910A (zh) * 2019-12-31 2020-04-21 云南大学 一种光引发的合成3-芳基黄酮或香豆素类化合物的方法及应用
GB202104122D0 (en) * 2021-03-24 2021-05-05 Floratek Pharma Ag Compounds and their use
CN115624546A (zh) * 2022-09-29 2023-01-20 南方医科大学第三附属医院（广东省骨科研究院） 5-羟基黄酮在治疗骨关节炎药物中的用途及其缓释剂的制备

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Publication number Priority date Publication date Assignee Title
US3549662A (en) * 1967-10-12 1970-12-22 Takeda Chemical Industries Ltd Derivatives of baicalein
FR2598414B1 (fr) * 1985-11-12 1988-10-14 Centre Nat Rech Scient Composition pharmaceutique contenant de l'hispiduline ou un derive et utilisation de ces composes dans la preparation de compositions anti-asthmatiques
JPH0729920B2 (ja) * 1987-02-14 1995-04-05 キツセイ薬品工業株式会社 骨粗鬆症治療剤
JPS6450877A (en) * 1987-08-20 1989-02-27 Ichimaru Pharcos Inc Oxygen radical catching and removing agent
AU4272293A (en) * 1992-05-11 1993-12-13 Tsumura & Co. Apoptosis inducer
GB9317071D0 (en) * 1993-08-17 1993-09-29 Univ Strathclyde Flavonoids
AU5259296A (en) * 1995-04-07 1996-10-23 Warner-Lambert Company Flavones and coumarins as agents for the treatment of athero sclerosis
JPH09176009A (ja) * 1995-12-27 1997-07-08 Inahata Koryo Kk 新規な抗変異原剤及び抗変異原性作用物質
US6224872B1 (en) 1997-07-31 2001-05-01 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Composition
AU2298301A (en) * 1999-10-20 2001-05-08 Board Of Trustees Of Southern Illinois University, The Flavones as inducible nitric oxide synthase inhibitors, cyclooxygenase-2 inhibitors and potassium channel activators
US6541613B2 (en) * 2000-12-15 2003-04-01 Uyrex Corporation Isoflavone derivatives

Also Published As

Publication number Publication date
EP1556031A2 (en) 2005-07-27
AU2003282999A1 (en) 2004-05-13
CA2502975A1 (en) 2004-05-06
WO2004037193A3 (en) 2005-02-17
EP1556031A4 (en) 2009-03-25
WO2004037193A2 (en) 2004-05-06
US8138165B2 (en) 2012-03-20
US20060142211A1 (en) 2006-06-29

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