MXPA03010610A - Metodo para la preparacion de formulaciones solidas de 3-hidroxi-3-metilbutirato de sodio. - Google Patents

Metodo para la preparacion de formulaciones solidas de 3-hidroxi-3-metilbutirato de sodio.

Info

Publication number
MXPA03010610A
MXPA03010610A MXPA03010610A MXPA03010610A MXPA03010610A MX PA03010610 A MXPA03010610 A MX PA03010610A MX PA03010610 A MXPA03010610 A MX PA03010610A MX PA03010610 A MXPA03010610 A MX PA03010610A MX PA03010610 A MXPA03010610 A MX PA03010610A
Authority
MX
Mexico
Prior art keywords
methylbutyrate
hydroxy
sodium
solid formulations
production
Prior art date
Application number
MXPA03010610A
Other languages
English (en)
Inventor
Zacher Uwe
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of MXPA03010610A publication Critical patent/MXPA03010610A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se producen formulaciones solidas de 3-hidroxi-3-metilbutirato de sodio, por medio de la hidrolisis de 4,4-dimetiloxetan-2-ona con hidroxido de sodio acuoso, se obtiene 3-hidroxi-3-metilbutirato de sodio y la solucion asi obtenida se vierte sobre gel de silice. Las soluciones son poco higroscopicas y de facil manejo.
MXPA03010610A 2001-05-18 2002-05-17 Metodo para la preparacion de formulaciones solidas de 3-hidroxi-3-metilbutirato de sodio. MXPA03010610A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01112236 2001-05-18
PCT/EP2002/005435 WO2002094255A1 (de) 2001-05-18 2002-05-17 Verfahren zur herstellung fester formulierungen von natrium-3-hydroxy-3-methylbutyrat

Publications (1)

Publication Number Publication Date
MXPA03010610A true MXPA03010610A (es) 2004-04-02

Family

ID=8177477

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03010610A MXPA03010610A (es) 2001-05-18 2002-05-17 Metodo para la preparacion de formulaciones solidas de 3-hidroxi-3-metilbutirato de sodio.

Country Status (17)

Country Link
US (1) US7026507B2 (es)
EP (1) EP1399138B1 (es)
JP (1) JP4166580B2 (es)
CN (1) CN100542525C (es)
AT (1) ATE317259T1 (es)
AU (1) AU2002338953B2 (es)
BR (1) BR0209820A (es)
CA (1) CA2447417C (es)
CZ (1) CZ302823B6 (es)
DE (1) DE50205794D1 (es)
DK (1) DK1399138T3 (es)
ES (1) ES2257559T3 (es)
HK (1) HK1068813A1 (es)
HU (1) HUP0400080A3 (es)
MX (1) MXPA03010610A (es)
PL (1) PL367221A1 (es)
WO (1) WO2002094255A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402118D0 (en) 2004-01-30 2004-03-03 Merck Sharp & Dohme Polymorphic forms of a GABAA agonist
EP2292222A1 (en) 2005-01-28 2011-03-09 H. Lundbeck A/S Polymorphic Forms of a GABAA Agonist
AU2009242451C1 (en) 2008-05-02 2017-05-18 Gilead Sciences, Inc. The use of solid carrier particles to improve the processability of a pharmaceutical agent
EP2295593A1 (en) 2009-09-15 2011-03-16 Philippe Marliere Method for the enymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA
WO2012140276A2 (en) * 2011-11-17 2012-10-18 Lonza Ltd Process for the preparation of 3-hydroxy-3-methylbutyric acid or its calcium salts
WO2017086447A1 (ja) 2015-11-19 2017-05-26 協和発酵バイオ株式会社 ３－ヒドロキシイソ吉草酸の一価カチオン塩の結晶および該結晶の製造方法
CA3028608A1 (en) 2016-06-24 2017-12-28 Otsuka Pharmaceutical Factory, Inc. Crystal of amino acid salt of 3-hydroxyisovaleric acid and production method thereof
WO2019016883A1 (ja) * 2017-07-19 2019-01-24 小林香料株式会社 ３－ヒドロキシ－３－メチルブタン酸又はその塩の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ256300A (en) 1992-09-16 1997-06-24 Univ Iowa State Res Found Inc Administration of beta-hydroxy-beta-methyl butyric acid, or its convertible forms, to lower cholesterol levels
US5348979A (en) * 1992-12-23 1994-09-20 Iowa State University Research Foundation Inc. Method of promoting nitrogen retention in humans
US6090978A (en) * 1996-07-19 2000-07-18 Met-Rx Usa, Inc. Process for manufacturing 3-hydroxy-3-methylbutanoic acid
WO1998034897A1 (de) 1997-02-10 1998-08-13 Lonza Ag Verfahren zur herstellung von 3-hydroxy-3-methylbuttersäure oder deren salze
DE69927698D1 (de) * 1998-09-03 2006-02-23 Firmenich & Cie Geraniumsäure derivate

Also Published As

Publication number Publication date
CZ302823B6 (cs) 2011-11-30
JP4166580B2 (ja) 2008-10-15
EP1399138B1 (de) 2006-02-08
CZ20032965A3 (cs) 2004-02-18
DK1399138T3 (da) 2006-04-24
US20040143136A1 (en) 2004-07-22
CN100542525C (zh) 2009-09-23
US7026507B2 (en) 2006-04-11
JP2004536065A (ja) 2004-12-02
AU2002338953B2 (en) 2006-06-29
HK1068813A1 (en) 2005-05-06
DE50205794D1 (de) 2006-04-20
BR0209820A (pt) 2004-06-01
HUP0400080A2 (hu) 2004-05-28
AU2002338953C1 (en) 2002-12-03
HUP0400080A3 (en) 2004-10-28
WO2002094255A1 (de) 2002-11-28
EP1399138A1 (de) 2004-03-24
CA2447417C (en) 2011-10-04
PL367221A1 (en) 2005-02-21
CN1523983A (zh) 2004-08-25
ATE317259T1 (de) 2006-02-15
CA2447417A1 (en) 2002-11-28
ES2257559T3 (es) 2006-08-01

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