MXPA02011464A - Derivados 1,4-diazepan-2,5-diona y su uso como antagonistas del receptor de la nk-1. - Google Patents

Derivados 1,4-diazepan-2,5-diona y su uso como antagonistas del receptor de la nk-1.

Info

Publication number
MXPA02011464A
MXPA02011464A MXPA02011464A MXPA02011464A MXPA02011464A MX PA02011464 A MXPA02011464 A MX PA02011464A MX PA02011464 A MXPA02011464 A MX PA02011464A MX PA02011464 A MXPA02011464 A MX PA02011464A MX PA02011464 A MXPA02011464 A MX PA02011464A
Authority
MX
Mexico
Prior art keywords
heteroaryl
lower alkyl
halogen
hydrogen
optionally substituted
Prior art date
Application number
MXPA02011464A
Other languages
English (en)
Inventor
Guido Galley
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MXPA02011464A publication Critical patent/MXPA02011464A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

La presente invencion se refiere a compuestos de formula general (I); (Ver formula) en donde R1, R2 son independientemente entre si, arilo o heteroarilo, en donde el grupo heteroarilo contiene uno o dos heteroatomos, seleccionados de N, O o S, y en donde los grupos arilo o heteroarilo estan opcionalmente substituidos con 1 a 3 sustituyentes, los cuales son independientemente entre si, halogeno, CF3, alcoxilo inferior o alquilo inferior; R3 es hidrogeno, alquilo inferior, - (CH2)nN(R)2- (CH2)n-heteroarilo o es un -(CH2)n-heterociclo no aromatico, estos heterociclos estan opcionalmente substituidos por halogeno, CF3, alcoxilo inferior o alquilo inferior; R4 es =O, =N(CH2)nCH3 o =N(CH2)nN(R)2 ; R3 y R4 pueden ser juntamente con los atomos de N y C a los cuales estan unidos al grupo -CR5=N-N=; R5 es hidrogeno, -(CH2)nN(R)2- (CH2)n-heteroarilo o es estos heterociclos estan un -(CH2),-heterociclo no aromatico, opcionalmente substituidos con halogeno, CF3, alcoxilo inferior o alquilo inferior; R es hidrogeno o alquilo inferior; n es 0, 1, 2 o 3; y a las sales de adicion acida farmaceuticamente aceptables y a las formas enantiomericas de los mismos. Los compuestos son utiles en el tratamiento de enfermedades relacionadas con el receptor NK-1.
MXPA02011464A 2000-05-25 2001-05-18 Derivados 1,4-diazepan-2,5-diona y su uso como antagonistas del receptor de la nk-1. MXPA02011464A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00111249 2000-05-25
PCT/EP2001/005723 WO2001090083A1 (en) 2000-05-25 2001-05-18 1,4-diazepan-2,5-dione derivatives and their use as nk-1 receptor antagonists

Publications (1)

Publication Number Publication Date
MXPA02011464A true MXPA02011464A (es) 2003-04-25

Family

ID=8168838

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02011464A MXPA02011464A (es) 2000-05-25 2001-05-18 Derivados 1,4-diazepan-2,5-diona y su uso como antagonistas del receptor de la nk-1.

Country Status (18)

Country Link
US (1) US6452001B2 (es)
EP (1) EP1296961B1 (es)
JP (1) JP4060596B2 (es)
KR (1) KR100526696B1 (es)
CN (1) CN1178923C (es)
AR (1) AR028607A1 (es)
AT (1) ATE353881T1 (es)
AU (2) AU2001281778B2 (es)
BR (1) BR0111062A (es)
CA (1) CA2409842C (es)
DE (1) DE60126614T2 (es)
DK (1) DK1296961T3 (es)
ES (1) ES2280392T3 (es)
MX (1) MXPA02011464A (es)
PE (1) PE20011266A1 (es)
PT (1) PT1296961E (es)
WO (1) WO2001090083A1 (es)
ZA (1) ZA200208940B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0606187A2 (pt) 2005-02-25 2009-06-09 Hoffmann La Roche comprimidos com capacidade de dispersão da substáncia do fármaco melhorada
US7777030B2 (en) 2005-12-29 2010-08-17 Centre National de la Recherge Scientifique (CNRS) Compositions and methods for the treatment and prevention of disease
CN101395143A (zh) * 2005-12-29 2009-03-25 安姆弗拉玛法国股份公司 用于治疗疟疾或aids的氮杂杂环化合物
WO2007074170A2 (en) * 2005-12-29 2007-07-05 Immupharma France Sa Compositions and methods for the treatment and prevention of disease
AU2006331357B2 (en) * 2005-12-29 2012-05-17 Immupharma France Sa Compositions and methods for synthesizing novel heterocyclic therapeutics
WO2007074169A2 (en) * 2005-12-29 2007-07-05 Immupharma France Sa Compositions and methods for the inhibition of phospholipase a2
EP2029604A2 (en) * 2006-05-26 2009-03-04 Novartis AG Aldosterone synthase and/or 11beta-hydroxylase inhibitors
KR20090112722A (ko) 2007-01-24 2009-10-28 글락소 그룹 리미티드 3,5-디아미노-6-(2,3-디클로로페닐)-1,2,4-트리아진 또는 ｒ(-)-2,4-디아미노-5-(2,3-디클로로페닐)-6-플루오로메틸 피리미딘 및 ｎｋ1을 포함하는 제약 조성물
KR101044833B1 (ko) * 2010-02-10 2011-06-28 (주)혜성나노텍 무차광 온실 보온커텐 종형 개폐장치
JP5858917B2 (ja) * 2010-08-26 2016-02-10 興和株式会社 イソキノリン誘導体又はその塩の新規製造方法
US8460460B2 (en) 2011-06-24 2013-06-11 Construction Research & Technology Gmbh Cementitious composition and admixture
CN108358893A (zh) * 2018-02-10 2018-08-03 安徽唯诗杨信息科技有限公司 一种一锅法合成四氢化苯并-[1,4]-二氮杂环庚烷衍生物的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022765A (en) 1975-01-06 1977-05-10 E. R. Squibb & Sons, Inc. Triazolo[4,3-d][1,4]benzodiazepine-6-ones
IL111960A (en) 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
PL181214B1 (pl) 1993-12-29 2001-06-29 Merck Sharp & Dohme Podstawione związki morfolinowe, sposób ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
IL112778A0 (en) 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
US5719156A (en) 1995-05-02 1998-02-17 Schering Corporation Piperazino derivatives as neurokinin antagonists
US5972938A (en) 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders

Also Published As

Publication number Publication date
DK1296961T3 (da) 2007-06-04
US6452001B2 (en) 2002-09-17
JP2003534332A (ja) 2003-11-18
EP1296961B1 (en) 2007-02-14
CA2409842C (en) 2008-07-29
CN1178923C (zh) 2004-12-08
ZA200208940B (en) 2004-02-04
EP1296961A1 (en) 2003-04-02
PT1296961E (pt) 2007-05-31
CA2409842A1 (en) 2001-11-29
JP4060596B2 (ja) 2008-03-12
CN1430611A (zh) 2003-07-16
BR0111062A (pt) 2003-06-10
DE60126614D1 (de) 2007-03-29
PE20011266A1 (es) 2001-12-14
ES2280392T3 (es) 2007-09-16
AU8177801A (en) 2001-12-03
AR028607A1 (es) 2003-05-14
ATE353881T1 (de) 2007-03-15
WO2001090083A1 (en) 2001-11-29
DE60126614T2 (de) 2007-11-22
US20020010174A1 (en) 2002-01-24
KR20030003759A (ko) 2003-01-10
KR100526696B1 (ko) 2005-11-08
AU2001281778B2 (en) 2005-06-02

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