MXPA02006965A - Solvato de etanol de (-) -cis-2 -(2-clorofenil) -5, 7-dihidroxi -8[4r-(3s -hidroxi -1-metil] piperidinil] -4h-1 -benzopiran-4 -ona. - Google Patents
Solvato de etanol de (-) -cis-2 -(2-clorofenil) -5, 7-dihidroxi -8[4r-(3s -hidroxi -1-metil] piperidinil] -4h-1 -benzopiran-4 -ona.Info
- Publication number
- MXPA02006965A MXPA02006965A MXPA02006965A MXPA02006965A MXPA02006965A MX PA02006965 A MXPA02006965 A MX PA02006965A MX PA02006965 A MXPA02006965 A MX PA02006965A MX PA02006965 A MXPA02006965 A MX PA02006965A MX PA02006965 A MXPA02006965 A MX PA02006965A
- Authority
- MX
- Mexico
- Prior art keywords
- cis2
- piperidinyl
- 4hminu
- ethanol solvate
- ethanol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La presente invencion se refiere a una forma de solvato de etanol de (-) -cis-2- (2-clorofenil) -5, 7-dihidroxi- 8[4R-(3S-hidroxi-l-metil) piperidinil]-4H-1-benzopiran-4-ona (Forma II), un metodo de elaboracion de la Forma II y una composicion que comprende la Forma II.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48781500A | 2000-01-18 | 2000-01-18 | |
PCT/US2001/000520 WO2001053294A1 (en) | 2000-01-18 | 2001-01-08 | Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4r-(3s-hydroxy-1-methyl)piperidinyl]-4h-1-benzopyran-4-one |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA02006965A true MXPA02006965A (es) | 2004-09-06 |
Family
ID=23937213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA02006965A MXPA02006965A (es) | 2000-01-18 | 2001-01-08 | Solvato de etanol de (-) -cis-2 -(2-clorofenil) -5, 7-dihidroxi -8[4r-(3s -hidroxi -1-metil] piperidinil] -4h-1 -benzopiran-4 -ona. |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP1252155B1 (es) |
JP (1) | JP2003520798A (es) |
KR (1) | KR100825530B1 (es) |
CN (1) | CN1395577A (es) |
AR (1) | AR027226A1 (es) |
AT (1) | ATE284400T1 (es) |
AU (1) | AU2001230869A1 (es) |
BR (1) | BR0107724A (es) |
CA (1) | CA2397594C (es) |
CZ (1) | CZ301235B6 (es) |
DE (1) | DE60107652T2 (es) |
DK (1) | DK1252155T3 (es) |
EA (1) | EA005182B1 (es) |
ES (1) | ES2228800T3 (es) |
HU (1) | HU225155B1 (es) |
IL (2) | IL150643A0 (es) |
MX (1) | MXPA02006965A (es) |
NO (1) | NO322626B1 (es) |
NZ (1) | NZ520281A (es) |
PL (1) | PL201690B1 (es) |
PT (1) | PT1252155E (es) |
SI (1) | SI1252155T1 (es) |
SK (1) | SK287216B6 (es) |
TW (1) | TWI293072B (es) |
WO (1) | WO2001053294A1 (es) |
ZA (1) | ZA200205640B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109803684B (zh) | 2016-08-23 | 2022-08-23 | 卫材 R&D 管理有限公司 | 用于治疗肝细胞癌的组合疗法 |
JP7219224B2 (ja) | 2017-03-16 | 2023-02-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 乳癌の治療のための組合せ療法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN164232B (es) * | 1986-04-11 | 1989-02-04 | Hoechst India | |
US5284856A (en) * | 1988-10-28 | 1994-02-08 | Hoechst Aktiengesellschaft | Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives |
DE3836676A1 (de) * | 1988-10-28 | 1990-05-03 | Hoechst Ag | Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel |
US5908934A (en) * | 1996-09-26 | 1999-06-01 | Bristol-Myers Squibb Company | Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs |
-
2001
- 2001-01-08 PT PT01902993T patent/PT1252155E/pt unknown
- 2001-01-08 CN CN01803857A patent/CN1395577A/zh active Pending
- 2001-01-08 MX MXPA02006965A patent/MXPA02006965A/es active IP Right Grant
- 2001-01-08 NZ NZ520281A patent/NZ520281A/en not_active IP Right Cessation
- 2001-01-08 IL IL15064301A patent/IL150643A0/xx unknown
- 2001-01-08 BR BR0107724-4A patent/BR0107724A/pt not_active Application Discontinuation
- 2001-01-08 EP EP01902993A patent/EP1252155B1/en not_active Expired - Lifetime
- 2001-01-08 PL PL355992A patent/PL201690B1/pl not_active IP Right Cessation
- 2001-01-08 CA CA2397594A patent/CA2397594C/en not_active Expired - Fee Related
- 2001-01-08 CZ CZ20022467A patent/CZ301235B6/cs not_active IP Right Cessation
- 2001-01-08 SK SK1037-2002A patent/SK287216B6/sk not_active IP Right Cessation
- 2001-01-08 AT AT01902993T patent/ATE284400T1/de active
- 2001-01-08 JP JP2001553768A patent/JP2003520798A/ja active Pending
- 2001-01-08 WO PCT/US2001/000520 patent/WO2001053294A1/en active IP Right Grant
- 2001-01-08 AU AU2001230869A patent/AU2001230869A1/en not_active Abandoned
- 2001-01-08 EA EA200200776A patent/EA005182B1/ru not_active IP Right Cessation
- 2001-01-08 DK DK01902993T patent/DK1252155T3/da active
- 2001-01-08 KR KR1020027009140A patent/KR100825530B1/ko not_active IP Right Cessation
- 2001-01-08 DE DE60107652T patent/DE60107652T2/de not_active Expired - Lifetime
- 2001-01-08 HU HU0204297A patent/HU225155B1/hu not_active IP Right Cessation
- 2001-01-08 ES ES01902993T patent/ES2228800T3/es not_active Expired - Lifetime
- 2001-01-08 SI SI200130293T patent/SI1252155T1/xx unknown
- 2001-01-17 AR ARP010100186A patent/AR027226A1/es not_active Application Discontinuation
- 2001-01-17 TW TW090101052A patent/TWI293072B/zh not_active IP Right Cessation
-
2002
- 2002-07-08 IL IL150643A patent/IL150643A/en not_active IP Right Cessation
- 2002-07-12 NO NO20023385A patent/NO322626B1/no not_active IP Right Cessation
- 2002-07-15 ZA ZA200205640A patent/ZA200205640B/en unknown
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FG | Grant or registration | ||
GB | Transfer or rights |