MX9800418A - Analogos de la hormona paratiroidea. - Google Patents

Analogos de la hormona paratiroidea.

Info

Publication number
MX9800418A
MX9800418A MX9800418A MX9800418A MX9800418A MX 9800418 A MX9800418 A MX 9800418A MX 9800418 A MX9800418 A MX 9800418A MX 9800418 A MX9800418 A MX 9800418A MX 9800418 A MX9800418 A MX 9800418A
Authority
MX
Mexico
Prior art keywords
amino acid
parathyroid hormone
analogs
acid residue
alpha
Prior art date
Application number
MX9800418A
Other languages
English (en)
Inventor
Zheng Xin Dong
Original Assignee
Biomeasure Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomeasure Inc filed Critical Biomeasure Inc
Publication of MX9800418A publication Critical patent/MX9800418A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Variantes de péptido del fragmento (1-34) de la hormona paratiroide, en los cuales al menos uno de los residuos de aminoácidos en las posiciones 7, 11, 23, 24, 28, 31 es ciclohexilalanina, o al menos uno de los residuos de aminoácidos en las posiciones 3, 16, 17, 18, 20, y 34 es un ácido amino alfa-isobutílico; o alternativamente, al menos el residuo de aminoácido en la posicion 1 es ácido, alfa- beta-diaminopropionico, el residuo de aminoácido en la posicion 27 homoarginina, o un residuo de aminoácido en la posicion 31 es norleucina.
MX9800418A 1995-07-13 1998-01-13 Analogos de la hormona paratiroidea. MX9800418A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US110595P 1995-07-13 1995-07-13
US330595P 1995-09-06 1995-09-06
US08/626,186 US5723577A (en) 1995-07-13 1996-03-29 Analogs of parathyroid hormone

Publications (1)

Publication Number Publication Date
MX9800418A true MX9800418A (es) 1998-09-30

Family

ID=27356825

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9800418A MX9800418A (es) 1995-07-13 1998-01-13 Analogos de la hormona paratiroidea.

Country Status (20)

Country Link
US (1) US5723577A (es)
EP (2) EP0847278B1 (es)
JP (3) JPH11509201A (es)
KR (5) KR100563112B1 (es)
CN (3) CN100412091C (es)
AT (2) ATE250425T1 (es)
AU (1) AU707094B2 (es)
DE (2) DE69630133T2 (es)
DK (2) DK0847278T3 (es)
ES (2) ES2207680T3 (es)
HK (2) HK1014876A1 (es)
HU (1) HU226935B1 (es)
IL (1) IL122837A (es)
MX (1) MX9800418A (es)
NZ (1) NZ312899A (es)
PL (1) PL186710B1 (es)
PT (2) PT847278E (es)
SK (1) SK3198A3 (es)
TW (1) TW482766B (es)
WO (1) WO1997002834A1 (es)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
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US5955425A (en) * 1996-08-02 1999-09-21 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
US6110892A (en) * 1994-06-20 2000-08-29 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
US6544949B1 (en) * 1995-07-13 2003-04-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US5969095A (en) * 1995-07-13 1999-10-19 Biomeasure, Inc. Analogs of parathyroid hormone
US7410948B2 (en) * 1995-07-13 2008-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone
CA2290443A1 (en) 1997-05-14 1998-11-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. Peptide parathyroid hormone analogs
RS49707B (sr) * 1997-09-09 2007-12-31 F.Hoffmann-La Roche Ag., Primena polipeptidnog analoga peptida srodnog paratireoidnom hormonu i njegovih soli za proizvodnju medikamenata za lečenje preloma kostiju
AU3673699A (en) * 1998-05-05 1999-11-23 Beth Israel Deaconess Medical Center Pth2 receptor selective compounds
PL345583A1 (en) * 1998-07-20 2001-12-17 Sod Conseils Rech Applic Peptide analogues of pacap
US6495662B1 (en) * 1998-10-22 2002-12-17 The General Hospital Corporation Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)
WO2000040698A1 (en) 1998-12-31 2000-07-13 The General Hospital Corporation Pth receptor and screening assay utilizing the same
US6689566B1 (en) 1999-01-14 2004-02-10 Scantibodies Laboratory, Inc. Methods, kits, and antibodies for detecting parathyroid hormone
US7820393B2 (en) * 1999-01-14 2010-10-26 Scantibodies Laboratory, Inc. Methods, kits and antibodies for detecting parathyroid hormone
WO2004028444A2 (en) * 1999-06-02 2004-04-08 Scantibodies Laboratory, Inc. Parathyroid hormone antagonists and uses thereof
US20080108086A1 (en) * 1999-06-02 2008-05-08 Cantor Thomas L Parathyroid hormone antagonists and uses thereof
ES2316354T3 (es) 1999-09-29 2009-04-16 The General Hospital Corporation Derivados polipeptidos de la hormona paratiroidea (pth).
WO2001023521A2 (en) * 1999-09-29 2001-04-05 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
US7022815B1 (en) 1999-09-29 2006-04-04 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
US6756480B2 (en) * 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US20050124537A1 (en) * 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
BRPI0209748B1 (pt) 2001-06-01 2015-11-24 Novartis Ag composição farmacêutica para administração oral compreendendo hormonio paratireoide(pth), e seu uso
KR100491737B1 (ko) * 2001-07-20 2005-05-27 주식회사 한국아이템개발 공기 정화 기능의 모기 퇴치기
US7572765B2 (en) 2001-07-23 2009-08-11 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
US20040067526A1 (en) * 2002-10-03 2004-04-08 Cantor Thomas L. Methods for diagnosing and guiding treatment of bone turnover disease
JP4334480B2 (ja) * 2003-03-19 2009-09-30 ザ ジェネラル ホスピタル コーポレイション α−ヘリックス安定化剤を用いる高次構造的に制約された副甲状腺ホルモン
KR100540659B1 (ko) * 2003-07-02 2006-01-10 삼성전자주식회사 이미지 확대 인쇄 방법과 장치 및 컴퓨터 프로그램을저장하는 컴퓨터로 읽을 수 있는 기록 매체
WO2005009358A2 (en) 2003-07-17 2005-02-03 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
MXPA06001428A (es) * 2003-08-06 2006-05-15 Rhodia Metodo para promover el crecimiento del hueso.
US7465703B1 (en) 2003-10-01 2008-12-16 Scantibodies Laboratory, Inc. Methods and kits useful for guiding osteoporosis related therapy
US7541140B2 (en) * 2004-06-03 2009-06-02 Scantibodies Laboratory, Inc. Assessing risk for kidney stones using parathyroid hormone agonist and antagonist
CN101355959B (zh) * 2005-11-10 2013-02-27 密歇根理工大学管理委员会 黑熊甲状旁腺素和使用黑熊甲状旁腺素的方法
WO2008019062A2 (en) * 2006-08-04 2008-02-14 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
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CA2782640A1 (en) 2009-12-07 2011-06-16 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
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WO2012111852A1 (ja) * 2011-02-17 2012-08-23 帝人ファーマ株式会社 椎体骨折治療剤及びその評価方法
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RU2769527C2 (ru) 2016-06-22 2022-04-01 Эллипсес Фарма Лтд Способы лечения ar+ рака молочной железы
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FR2550204B1 (fr) * 1983-08-05 1987-11-13 Toyo Jozo Kk Derives peptidiques de (nle8,nle1b, tyr34)-h-pth
EP0293158A3 (en) * 1987-05-26 1990-05-09 Merck & Co. Inc. Parathyroid hormone antagonists
WO1990010067A1 (de) * 1989-02-23 1990-09-07 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Pth-varianten kodierende dna-sequenzen, pth-varianten, expressionsvektor, bakterieller wirt, verwendung und therapeutische zusammensetzung
CA2040264A1 (en) * 1990-04-12 1991-10-13 Tatsuhiko Kanmera Parathyroid hormone antagonists
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Also Published As

Publication number Publication date
HU226935B1 (en) 2010-03-29
KR20040053215A (ko) 2004-06-23
NZ312899A (en) 1999-10-28
KR100563601B1 (ko) 2006-03-22
DE69630133D1 (de) 2003-10-30
IL122837A (en) 2002-11-10
AU6483496A (en) 1997-02-10
DE69630133T2 (de) 2004-06-09
EP0847278A4 (en) 1999-01-13
JP4008825B2 (ja) 2007-11-14
JP2007302682A (ja) 2007-11-22
KR20040053216A (ko) 2004-06-23
CN1199340A (zh) 1998-11-18
KR100563112B1 (ko) 2006-03-27
SK3198A3 (en) 1998-07-08
CN100412091C (zh) 2008-08-20
US5723577A (en) 1998-03-03
CN1521189A (zh) 2004-08-18
CN1247260C (zh) 2006-03-29
HUP9901718A2 (hu) 1999-09-28
KR100500853B1 (ko) 2005-10-24
DK0847278T3 (da) 2003-12-22
ES2207680T3 (es) 2004-06-01
KR100563602B1 (ko) 2006-03-22
EP1405861A2 (en) 2004-04-07
PT1405861E (pt) 2009-09-30
AU707094B2 (en) 1999-07-01
KR19990028947A (ko) 1999-04-15
DK1405861T3 (da) 2009-12-07
IL122837A0 (en) 1998-08-16
JPH11509201A (ja) 1999-08-17
HK1096976A1 (en) 2007-06-15
WO1997002834A1 (en) 1997-01-30
HUP9901718A3 (en) 2000-10-30
TW482766B (en) 2002-04-11
ATE250425T1 (de) 2003-10-15
PL186710B1 (pl) 2004-02-27
KR100563600B1 (ko) 2006-03-22
PT847278E (pt) 2004-02-27
PL325905A1 (en) 1998-08-17
DE69638025D1 (de) 2009-10-22
HK1014876A1 (en) 1999-10-08
ES2329233T3 (es) 2009-11-24
JP2003238595A (ja) 2003-08-27
CN101851288A (zh) 2010-10-06
EP0847278B1 (en) 2003-09-24
EP0847278A1 (en) 1998-06-17
KR20040042907A (ko) 2004-05-20
EP1405861B1 (en) 2009-09-09
KR20040041709A (ko) 2004-05-17
EP1405861A3 (en) 2004-07-21
ATE442159T1 (de) 2009-09-15

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