MX9709416A - Quinolizinone type compounds. - Google Patents

Quinolizinone type compounds.

Info

Publication number
MX9709416A
MX9709416A MX9709416A MX9709416A MX9709416A MX 9709416 A MX9709416 A MX 9709416A MX 9709416 A MX9709416 A MX 9709416A MX 9709416 A MX9709416 A MX 9709416A MX 9709416 A MX9709416 A MX 9709416A
Authority
MX
Mexico
Prior art keywords
loweralkyl
compounds
loweralkoxy
halo
halogen
Prior art date
Application number
MX9709416A
Other languages
Spanish (es)
Inventor
Daniel T Chu
Qun Li
Curt S Cooper
Anthony K Fung
Cheuk M Lee
Jacob J Plattner
Zhenkun Ma
Wei-Bo Wang
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX9709416A publication Critical patent/MX9709416A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Antibacterial compounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, selected preferred examples of which include those compounds wherein A is =CR6-; R1 is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R2 is selected from the group consisting of (a), (b), (c) and (d); R3 is halogen; R4 is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R5 is hydrogen, loweralkyl, halo(loweralkyl), or -NR13R14; and R6 is halogen, loeralkyl, halo(loweralkyl), hydroxy-substituted loweralkyl, loweralkoxy(loweralkyl), loweralkoxy, or amino(loweralkyl), as well as pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.
MX9709416A 1995-06-06 1997-12-02 Quinolizinone type compounds. MX9709416A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46915995A 1995-06-06 1995-06-06
US63811296A 1996-05-29 1996-05-29

Publications (1)

Publication Number Publication Date
MX9709416A true MX9709416A (en) 1998-07-31

Family

ID=27042662

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9709416A MX9709416A (en) 1995-06-06 1997-12-02 Quinolizinone type compounds.

Country Status (8)

Country Link
EP (1) EP0871628A1 (en)
JP (1) JPH11510478A (en)
KR (1) KR19990022524A (en)
AU (1) AU6153096A (en)
CA (1) CA2222322A1 (en)
IL (1) IL122296A0 (en)
MX (1) MX9709416A (en)
WO (1) WO1996039407A1 (en)

Families Citing this family (43)

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EP0920306A2 (en) 1996-07-12 1999-06-09 Leukosite, Inc. Chemokine receptor antagonists and methods of use therefor
US5693813A (en) * 1997-02-26 1997-12-02 Abbott Laboratories Process for preparation of 4H-4-oxo-quinolizine-3-carboxylic acid
KR100241673B1 (en) * 1997-08-09 2000-03-02 김충섭 Quinolizine Carboxylic acid Derivatives
JP4669607B2 (en) 1997-09-15 2011-04-13 ザ プロクター アンド ギャンブル カンパニー Antimicrobial quinolones, compositions thereof and uses thereof
WO2000017197A1 (en) * 1998-09-21 2000-03-30 Biochem Pharma Inc. Quinolizinones as integrin inhibitors
DK1134219T3 (en) * 1998-11-24 2005-10-17 Daiichi Seiyaku Co Cucloalkyl-substituted aminomethylpyrrolidine derivatives
WO2000054811A1 (en) 1999-03-17 2000-09-21 Daiichi Pharmaceutical Co., Ltd. Medicinal compositions
WO2001044243A2 (en) * 1999-12-14 2001-06-21 Neurosearch A/S Novel heteroaryl-diazabicycloalkanes
DE19962470A1 (en) * 1999-12-22 2001-07-12 Schulz Hans Herrmann Use of chemotherapy drugs
SE0100326D0 (en) * 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
EP1437354B1 (en) * 2001-09-28 2008-08-13 Sato Pharmaceutical Co. Ltd. 4-oxoquinolizine antimicrobials having 2-pyridone skeleton as partial structure
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
SI1675852T1 (en) * 2003-09-22 2009-06-30 Janssen Pharmaceutica Nv 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US7569599B2 (en) 2003-12-12 2009-08-04 Daiichi Pharmaceutical Co., Ltd. Intermediates for the production of optically active cyclopropylamine derivatives and process for the production of the intermediates
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
US8039485B2 (en) 2006-03-28 2011-10-18 Warner Chilcott Company, Llc Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
CA2647454A1 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
RU2443698C2 (en) * 2007-01-05 2012-02-27 Дайити Санкио Компани, Лимитед Condensed substituted aminopyrrolidine derivative
CN101622240B (en) * 2007-01-05 2014-07-23 第一三共株式会社 Fused substituted aminopyrrolidine derivative
EP2236494B1 (en) 2007-12-26 2016-08-31 Msd K.K. Sulfonyl substituted 6-membered ring derivative
JP5433992B2 (en) * 2008-06-26 2014-03-05 Ｄｉｃ株式会社 Method for producing fluorochromanol derivative
JP5433996B2 (en) * 2008-07-10 2014-03-05 Ｄｉｃ株式会社 Method for producing fluorophenol derivative
WO2010122774A1 (en) * 2009-04-20 2010-10-28 株式会社カネカ Processes for producing (1s,6s)- or (1r,6r)-cis-2,8-diazabicyclo[4.3.0]nonane and intermediate thereof
US8796297B2 (en) 2009-06-30 2014-08-05 Abbvie Inc. 4-substituted-2-amino-pyrimidine derivatives
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
JP5487425B2 (en) * 2009-09-11 2014-05-07 毅 野田 Optically active 2-substituted-3-aminopiperidine derivatives and production method
JO3267B1 (en) 2009-10-23 2018-09-16 Janssen Pharmaceutica Nv DISUBSTITUTED OCTAHYDROPYRROLO[3,4-c]PYRROLES AS OREXIN RECEPTOR MODULATORS
SG10201609188WA (en) * 2012-02-10 2016-12-29 Ptc Therapeutics Inc Compounds for treating spinal muscular atrophy
EP3310169B1 (en) 2015-05-30 2023-05-17 PTC Therapeutics, Inc. Methods for modulating rna splicing
WO2017100726A1 (en) 2015-12-10 2017-06-15 Ptc Therapeutics, Inc. Methods for treatng huntington's disease
RS63296B1 (en) 2016-03-10 2022-07-29 Janssen Pharmaceutica Nv Methods of treating depression using orexin-2 receptor antagonists
CN106543170B (en) * 2016-10-27 2018-02-23 丹诺医药(苏州）有限公司 The carboxylate of 8 chlorine, 1 cyclopropyl, 7 fluorine, 9 methyl, 4 oxygen, 4 hydrogen quinolizine 3 and its synthetic method
CA3043755A1 (en) 2016-11-28 2018-05-31 Ptc Therapeutics, Inc. Methods for modulating rna splicing
CA3066224A1 (en) 2017-06-05 2018-12-13 Ptc Therapeutics Inc. Compounds for treating huntington's disease
JP2020523365A (en) 2017-06-14 2020-08-06 ピーティーシー セラピューティクス，インコーポレーテッド Method of modifying RNA splicing
EP3645121A4 (en) 2017-06-28 2021-03-17 PTC Therapeutics, Inc. Methods for treating huntington's disease
EP3644996B1 (en) 2017-06-28 2023-07-26 PTC Therapeutics, Inc. Methods for treating huntington's disease
US20210009590A1 (en) 2018-03-27 2021-01-14 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
EP3814357B1 (en) 2018-06-27 2024-05-01 PTC Therapeutics, Inc. Heterocyclic and heteroaryl compounds for treating huntington's disease
EP3814360A1 (en) 2018-06-27 2021-05-05 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69132348T2 (en) * 1990-05-02 2001-03-15 Abbott Lab CHINOLIZINONE TYPE COMPOUNDS
BR9407806A (en) * 1993-10-14 1997-08-19 Abbott Lab Composite process of treating a bacterial infection in a human or veterinary patient and synthetic intermediate

Also Published As

Publication number Publication date
IL122296A0 (en) 1998-04-05
CA2222322A1 (en) 1996-12-12
JPH11510478A (en) 1999-09-14
EP0871628A1 (en) 1998-10-21
AU6153096A (en) 1996-12-24
KR19990022524A (en) 1999-03-25
WO1996039407A1 (en) 1996-12-12

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