MX9708781A - Heterociclos como inhibidores de la adhesion de leucocitos y antagonistas de vla-4. - Google Patents

Heterociclos como inhibidores de la adhesion de leucocitos y antagonistas de vla-4.

Info

Publication number
MX9708781A
MX9708781A MX9708781A MX9708781A MX9708781A MX 9708781 A MX9708781 A MX 9708781A MX 9708781 A MX9708781 A MX 9708781A MX 9708781 A MX9708781 A MX 9708781A MX 9708781 A MX9708781 A MX 9708781A
Authority
MX
Mexico
Prior art keywords
compounds
formula
vla
present
leukocytes
Prior art date
Application number
MX9708781A
Other languages
English (en)
Inventor
Hans Ulrich Stilz
Volkmar Wehner
Christoph Huels
Dirk Seiffge
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of MX9708781A publication Critical patent/MX9708781A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos de la formula I: en la que B, D, E, R, W, Y, Z, b, c, d, e, f, g y h tienen los significados indicados en las reivindicaciones, son inhibidores de la adhesion y migracion de leucocitos y/o antagonistas del receptor de adhesion VLA-4 perteneciente al grupo de las integrinas. La invencion se refiere al empleo de compuestos de la formula I y de preparados farmacéuticos que contienen tales compuestos para el tratamiento o la profilaxis de enfermedades que son provocadas por un grado indeseado de adhesion de leucocitos y/o migracion de leucocitos o que están ligadas a ellas, o en las que juegan un papel interacciones célula-célula-matriz que se basan en interacciones de receptores VLA-4 con sus ligandos, por ejemplo de procesos inflamatorios, la artritis reumatoide o de enfermedades alérgicas, al igual que al empleo de compuestos de la formula I para la preparacion de medicamentos para empleo en enfermedades de este tipo. Además, se refiere a nuevos compuestos de la formula I.
MX9708781A 1996-11-15 1997-11-14 Heterociclos como inhibidores de la adhesion de leucocitos y antagonistas de vla-4. MX9708781A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19647382A DE19647382A1 (de) 1996-11-15 1996-11-15 Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten

Publications (1)

Publication Number Publication Date
MX9708781A true MX9708781A (es) 1998-05-31

Family

ID=7811832

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9708781A MX9708781A (es) 1996-11-15 1997-11-14 Heterociclos como inhibidores de la adhesion de leucocitos y antagonistas de vla-4.

Country Status (28)

Country Link
US (2) US5998447A (es)
EP (1) EP0842944B1 (es)
JP (1) JP4510160B2 (es)
CN (1) CN1133647C (es)
AR (1) AR010066A1 (es)
AT (1) ATE244725T1 (es)
AU (1) AU736595B2 (es)
BR (1) BR9705726A (es)
CA (1) CA2220822A1 (es)
CZ (1) CZ292521B6 (es)
DE (2) DE19647382A1 (es)
DK (1) DK0842944T3 (es)
ES (1) ES2202533T3 (es)
HR (1) HRP970606B1 (es)
HU (1) HUP9702034A3 (es)
IL (1) IL122186A (es)
MX (1) MX9708781A (es)
MY (1) MY118176A (es)
NO (1) NO317242B1 (es)
NZ (1) NZ329177A (es)
PL (2) PL323130A1 (es)
PT (1) PT842944E (es)
RU (1) RU2220977C2 (es)
SI (1) SI0842944T1 (es)
SK (1) SK284349B6 (es)
TR (1) TR199701356A3 (es)
TW (1) TW580501B (es)
ZA (1) ZA9710245B (es)

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Also Published As

Publication number Publication date
EP0842944B1 (de) 2003-07-09
PL323130A1 (en) 1998-05-25
HU9702034D0 (en) 1998-01-28
DK0842944T3 (da) 2003-10-27
SI0842944T1 (en) 2004-02-29
MY118176A (en) 2004-09-30
CN1133647C (zh) 2004-01-07
AR010066A1 (es) 2000-05-17
HRP970606B1 (en) 2003-08-31
EP0842944A2 (de) 1998-05-20
CA2220822A1 (en) 1998-05-15
TW580501B (en) 2004-03-21
HUP9702034A3 (en) 1998-12-28
US6514952B1 (en) 2003-02-04
RU2220977C2 (ru) 2004-01-10
PL188042B1 (pl) 2004-11-30
CZ360097A3 (cs) 1998-06-17
PT842944E (pt) 2003-11-28
SK152597A3 (en) 1998-06-03
NZ329177A (en) 1998-11-25
AU736595B2 (en) 2001-08-02
IL122186A0 (en) 1998-04-05
CZ292521B6 (cs) 2003-10-15
NO975245D0 (no) 1997-11-14
TR199701356A2 (xx) 1998-06-22
NO975245L (no) 1998-05-18
HUP9702034A2 (hu) 1998-07-28
JPH10147574A (ja) 1998-06-02
NO317242B1 (no) 2004-09-27
IL122186A (en) 2003-05-29
SK284349B6 (sk) 2005-02-04
AU4525797A (en) 1998-05-21
ES2202533T3 (es) 2004-04-01
ZA9710245B (en) 1998-05-13
CN1193022A (zh) 1998-09-16
BR9705726A (pt) 1999-07-20
ATE244725T1 (de) 2003-07-15
HRP970606A2 (en) 1998-08-31
JP4510160B2 (ja) 2010-07-21
US5998447A (en) 1999-12-07
DE19647382A1 (de) 1998-05-20
DE59710411D1 (de) 2003-08-14
EP0842944A3 (de) 1999-02-24
TR199701356A3 (tr) 1998-06-22

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