MX9704435A - Compuestos de tiazolidinona y agente terapeutico o agente de prevencion para angina de pecho, que comprende los compuestos como un ingrediente activo. - Google Patents

Compuestos de tiazolidinona y agente terapeutico o agente de prevencion para angina de pecho, que comprende los compuestos como un ingrediente activo.

Info

Publication number
MX9704435A
MX9704435A MX9704435A MX9704435A MX9704435A MX 9704435 A MX9704435 A MX 9704435A MX 9704435 A MX9704435 A MX 9704435A MX 9704435 A MX9704435 A MX 9704435A MX 9704435 A MX9704435 A MX 9704435A
Authority
MX
Mexico
Prior art keywords
alkyl
angina pectoris
same
substituted
active ingredient
Prior art date
Application number
MX9704435A
Other languages
English (en)
Inventor
Sadao Ishihara
Fujio Saito
Yasuo Ohhata
Shigeki Miyake
Ryosuke Yorikane
Norio Fukuda
Original Assignee
Sankyio Company Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyio Company Ltd filed Critical Sankyio Company Ltd
Publication of MX9704435A publication Critical patent/MX9704435A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de tiazolidinona que tiene la formula general: (Ver Formula) en donde W representa un átomo de azufre o un átomo de oxígeno y X representa un grupo que tiene la formula: -N(R1)-; o X representa un átomo de azufre o un átomo de oxígeno y W representa un grupo que tiene la formula -N(R1)-; R1 representa un átomo de hidrogeno, un grupo alquilo o un grupo alquilo substituido; R2 y R3 pueden ser iguales o diferentes y cada uno representa un átomo de hidrogeno, un grupo alquilo substituido, un grupo arilo o un grupo heterocíclico aromático de 5 a 6 miembros, R4 representa un átomo de hidrogeno, un grupo alquilo o un grupo alquilo de 1 a 4 átomos de carbono sustituido; R5 representa un grupo cicloalquilo sustituido, que contiene opcionalmente de nitrogeno [dicho sustituyente es esencialmente un grupo que tiene la formula: -B- ONO2 (en donde B representa una ligadura simple o un grupo alquileno) y A representa una ligadura simple o un grupo alquilenol o sales farmacologicamente aceptables del mismo; los compuestos tienen excelente accion anti-angina de pecho y son utiles como un agente terapéutico contra la angina de pecho o como un agente de prevencion de la misma.
MX9704435A 1994-12-15 1995-12-13 Compuestos de tiazolidinona y agente terapeutico o agente de prevencion para angina de pecho, que comprende los compuestos como un ingrediente activo. MX9704435A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP31151194 1994-12-15
PCT/JP1995/002545 WO1996018620A1 (fr) 1994-12-15 1995-12-13 Composes thiazolidinone ou medicament pour prevenir ou guerir l'angine de poitrine contenant ces composes en tant qu'ingredient actif

Publications (1)

Publication Number Publication Date
MX9704435A true MX9704435A (es) 1997-10-31

Family

ID=18018119

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704435A MX9704435A (es) 1994-12-15 1995-12-13 Compuestos de tiazolidinona y agente terapeutico o agente de prevencion para angina de pecho, que comprende los compuestos como un ingrediente activo.

Country Status (21)

Country Link
US (1) US5843973A (es)
EP (1) EP0798298B1 (es)
KR (1) KR100312471B1 (es)
CN (1) CN1092649C (es)
AT (1) ATE203987T1 (es)
AU (1) AU692334B2 (es)
CA (1) CA2207794A1 (es)
CZ (1) CZ292626B6 (es)
DE (1) DE69522118T2 (es)
DK (1) DK0798298T3 (es)
ES (1) ES2161916T3 (es)
FI (1) FI972510A (es)
GR (1) GR3036704T3 (es)
HK (1) HK1000494A1 (es)
HU (1) HUT77131A (es)
MX (1) MX9704435A (es)
NO (1) NO309475B1 (es)
NZ (1) NZ297095A (es)
PT (1) PT798298E (es)
RU (1) RU2139283C1 (es)
WO (1) WO1996018620A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200524849A (en) * 2003-07-02 2005-08-01 Hoffmann La Roche Hydroxyalkylamide derivatives
EP1692121A1 (en) 2003-11-18 2006-08-23 University of Tennessee Research Foundation Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof
TR201903981T4 (tr) 2008-06-16 2019-04-22 Univ Ohio State Res Found Kanser tedavisi için bileşikler.
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
EP2290114A1 (de) 2009-08-04 2011-03-02 Gebr. Kemper GmbH + Co. KG Metallwerke Wasserführendes Bauteil
JP5879273B2 (ja) 2010-03-01 2016-03-08 ジーティーエックス・インコーポレイテッド 癌を処置するための化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5213910A (en) * 1975-07-19 1977-02-02 Toshinori Kawabuchi Photogravure printing press
GB8717068D0 (en) * 1987-07-20 1987-08-26 Fujisawa Pharmaceutical Co Nitric ester derivative
AU647599B2 (en) * 1991-03-27 1994-03-24 Sankyo Company Limited New thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators
CZ290989B6 (cs) * 1995-03-02 2002-11-13 Sankyo Company, Limited Opticky aktivní thiazolidinonový derivát, prostředek jej obsahující, pouľití tohoto derivátu a způsob jeho přípravy

Also Published As

Publication number Publication date
CN1092649C (zh) 2002-10-16
NO972731L (no) 1997-08-14
DK0798298T3 (da) 2001-10-22
GR3036704T3 (en) 2001-12-31
RU2139283C1 (ru) 1999-10-10
FI972510A (fi) 1997-08-07
EP0798298B1 (en) 2001-08-08
ATE203987T1 (de) 2001-08-15
EP0798298A1 (en) 1997-10-01
US5843973A (en) 1998-12-01
DE69522118D1 (de) 2001-09-13
KR100312471B1 (ko) 2002-02-28
FI972510A0 (fi) 1997-06-13
CZ183497A3 (en) 1997-12-17
CN1175250A (zh) 1998-03-04
DE69522118T2 (de) 2002-04-25
AU692334B2 (en) 1998-06-04
AU4187996A (en) 1996-07-03
PT798298E (pt) 2001-11-30
NO309475B1 (no) 2001-02-05
HK1000494A1 (en) 2002-03-15
EP0798298A4 (en) 1998-03-25
WO1996018620A1 (fr) 1996-06-20
CA2207794A1 (en) 1996-06-20
HUT77131A (hu) 1998-03-02
NO972731D0 (no) 1997-06-13
CZ292626B6 (cs) 2003-11-12
NZ297095A (en) 1998-09-24
ES2161916T3 (es) 2001-12-16

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