MX9702270A - Proceso para producir antibioticos beta-lactama aplicando microorganismos con actividad de ligasa aumentada. - Google Patents

Proceso para producir antibioticos beta-lactama aplicando microorganismos con actividad de ligasa aumentada.

Info

Publication number
MX9702270A
MX9702270A MX9702270A MX9702270A MX9702270A MX 9702270 A MX9702270 A MX 9702270A MX 9702270 A MX9702270 A MX 9702270A MX 9702270 A MX9702270 A MX 9702270A MX 9702270 A MX9702270 A MX 9702270A
Authority
MX
Mexico
Prior art keywords
beta
lactam antibiotics
producing
ligase activity
relates
Prior art date
Application number
MX9702270A
Other languages
English (en)
Inventor
Svend Kaasgaard
Klaus Nyegaard Kristiansen
Henrik Molgaard
Original Assignee
Gist Brocades Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv
Publication of MX9702270A publication Critical patent/MX9702270A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invencion se relaciona con la La presente invencion se relaciona con la biosíntesis B-lactama. Más específicamente, la biosíntesis de antibioticos B-lactama. Más invencion se relaciona con procesos de produccion específicamente, la invencion se relaciona con de antibioticos B-lactama in vivo e in vitro. procesos de produccion de antibioticos B-lactama También se contempla una enzima nueva capaz de in vivo e in vitro. También se contempla una catalizar ciertas etapas indicadas en la enzima nueva capaz de catalizar ciertas etapas biosíntesis de la B-lactama. Además, la invencion indicadas en la biosíntesis de la B-lactama. se relaciona a un constructo de ADN que codifica Además, la invencion se relaciona a un constructo para la enzima nueva, un vector recombinante o un de ADN que codifica para la enzima nueva, un vehículo de transformacion que comprende el vector recombinante o un vehículo de constructo de ADN y finalmente una célula que transformacion que comprende el constructo de ADN comprende el constructo de ADN o el vector y finalmente una célula que comprende el recombinante. constructo de ADN o el vector recombinante.
MX9702270A 1994-09-28 1995-09-27 Proceso para producir antibioticos beta-lactama aplicando microorganismos con actividad de ligasa aumentada. MX9702270A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK111794 1994-09-28
PCT/EP1995/003857 WO1996010085A1 (en) 1994-09-28 1995-09-27 PROCESS OF PRODUCING β-LACTAM ANTIBIOTICS APPLYING MICROORGANISMS WITH INCREASED LIGASE ACTIVITY

Publications (1)

Publication Number Publication Date
MX9702270A true MX9702270A (es) 1997-07-31

Family

ID=8101208

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9702270A MX9702270A (es) 1994-09-28 1995-09-27 Proceso para producir antibioticos beta-lactama aplicando microorganismos con actividad de ligasa aumentada.

Country Status (13)

Country Link
US (2) US5942411A (es)
EP (1) EP0783582B1 (es)
JP (1) JPH10506287A (es)
KR (1) KR970706393A (es)
CN (1) CN1271208C (es)
AT (1) ATE290084T1 (es)
AU (1) AU701665B2 (es)
CA (1) CA2201485A1 (es)
DE (1) DE69534041T2 (es)
ES (1) ES2236714T3 (es)
HU (1) HUT77042A (es)
MX (1) MX9702270A (es)
WO (1) WO1996010085A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT77042A (hu) * 1994-09-28 1998-03-02 Gist-Brocades B.V. Eljárás béta-laktám antibiotikumok előállítására fokozott ligázaktivitású mikroorganizmusokkal
GB9513403D0 (en) * 1995-06-30 1995-09-06 Smithkline Beecham Plc Novel product
AU2508897A (en) * 1996-04-04 1997-10-29 Gist-Brocades B.V. An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof
EP0914463A2 (en) * 1996-07-16 1999-05-12 Gist-Brocades B.V. NOVEL PROCESS FOR THE PREPARATION OF CEPHALOSPORINS USING $i(ACREMONIUM CHRYSOGENUM)
US6133227A (en) * 1997-06-23 2000-10-17 The Procter & Gamble Company Enzymatic detergent compositions
US6284483B1 (en) * 1999-10-06 2001-09-04 Board Of Trustees Operating Michigan State University Modified synthetases to produce penicillins and cephalosporins under the control of bicarbonate
WO2003065706A2 (en) * 2002-01-30 2003-08-07 Roher Larry E Multipoint audiovisual conferencing system
NZ536963A (en) * 2002-06-07 2008-04-30 Trillium Therapeutics Inc Use of the discovery that Fc gamma receptor IIA transgenic animals are susceptible to autoimmune disease, to suppress aberrant immune activity and to treat or prevent autoimmune disease
CN115337308B (zh) * 2022-07-15 2024-03-22 山东省农业科学院家禽研究所（山东省无特定病原鸡研究中心） Acss2抑制剂在制备抗h1n1亚型猪流感病毒药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2016476A6 (es) * 1989-07-10 1990-11-01 Antibioticos Sa Procedimientos para sintetizar fenilacetil-coa y para producir bencilpenicilina.
WO1992007079A1 (en) * 1990-10-15 1992-04-30 Gist-Brocades N.V. Transformation selection marker system adapted for penicillium
ES2033590A6 (es) * 1991-04-19 1993-03-16 Antibioticos Sa Procedimientos para sintetizar fenilacetil-coa y para producir bencilpenicilina
HUT77042A (hu) * 1994-09-28 1998-03-02 Gist-Brocades B.V. Eljárás béta-laktám antibiotikumok előállítására fokozott ligázaktivitású mikroorganizmusokkal
GB9513403D0 (en) * 1995-06-30 1995-09-06 Smithkline Beecham Plc Novel product

Also Published As

Publication number Publication date
JPH10506287A (ja) 1998-06-23
ES2236714T3 (es) 2005-07-16
WO1996010085A1 (en) 1996-04-04
CN1271208C (zh) 2006-08-23
AU3744095A (en) 1996-04-19
KR970706393A (ko) 1997-11-03
HUT77042A (hu) 1998-03-02
US5942411A (en) 1999-08-24
DE69534041T2 (de) 2006-04-13
CA2201485A1 (en) 1996-04-04
DE69534041D1 (de) 2005-04-07
US6180360B1 (en) 2001-01-30
EP0783582A1 (en) 1997-07-16
CN1162337A (zh) 1997-10-15
EP0783582B1 (en) 2005-03-02
AU701665B2 (en) 1999-02-04
ATE290084T1 (de) 2005-03-15

Similar Documents

Publication Publication Date Title
WO1999018228A3 (de) Verfahren zur mikrobiellen herstellung von aminosäuren der aspartat- und/oder glutamatfamilie und im verfahren einsetzbare mittel
AU4731596A (en) Novel lipase gene and process for the production of lipase with the use of the same
CA2139670A1 (en) Process for immobilizing enzymes to the cell wall of a microbial cell by producing a fusion protein
AU2443488A (en) Dna-molecules coding for fmdh control regions and structured gene for a protein having fmdh-activity and their uses
IL131241A0 (en) Novel carbonyl reductase gene coding same and method for using such reductase and gene
Kadler et al. Assembly of type I collagen fibrils de novo by the specific enzymic cleavage of pC collagen. The fibrils formed at about 37 degrees C are similar in diameter, roundness, and apparent flexibility to the collagen fibrils seen in connective tissue
MX9702270A (es) Proceso para producir antibioticos beta-lactama aplicando microorganismos con actividad de ligasa aumentada.
DE58901530D1 (de) Verfahren zur herstellung von lys-plasminogen.
EP0260404A3 (en) Amylolytic enzymes producing microorganisms constructed by recombinant dna technology and their use for fermentation processes
DE69529953T2 (de) Hitzebeständige rekombinante Enzyme für die Umsetzung von Maltose in Trehalose
AU667706B2 (en) Endo-xyloglucan transferase
AU4871993A (en) Dictyostelium dipeptidylaminopeptidase
EP1012225A4 (en) METHODS AND COMPOSITIONS FOR REDUCING ALTERATION OF BEER
AUPP031897A0 (en) Mammalian milk growth factor
SG74579A1 (en) Enzyme with leudh activity, nucleotide sequence coding therefor and process for the preparation of the enzyme
GB2296243A (en) Alpha-1,4-glucan lyase from a fungus,its purification gene cloning and expression in microorganisms
CA2172954A1 (en) Enzyme and its use in preparing (s)-pipecolic acid
AU6417396A (en) Phenylacetyl-coa ligase from penicillium chrysogenum
EP0505921A3 (en) Process for the preparation of mature polypeptides by enzymatic cleavage with factor xa
HUP9903006A2 (hu) Eljárás érett csontmorfogenetikus protein előállítására
AU4392297A (en) Method and immobilized biocatalyst for the production of l(-) malic acid
MX9800406A (es) Una acilasa de penicilina g inmovilizada, mejorada.
MX9605058A (es) Composiciones detergentes que contienen amilasa.

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees