MX9605428A - SINTESIS DE 17 beta-CIANO-3-ETOXI-17ALFA-HIDROXI-6-METILANDROSTA-3,5,9(11)-T RIENO. - Google Patents
SINTESIS DE 17 beta-CIANO-3-ETOXI-17ALFA-HIDROXI-6-METILANDROSTA-3,5,9(11)-T RIENO.Info
- Publication number
- MX9605428A MX9605428A MX9605428A MX9605428A MX9605428A MX 9605428 A MX9605428 A MX 9605428A MX 9605428 A MX9605428 A MX 9605428A MX 9605428 A MX9605428 A MX 9605428A MX 9605428 A MX9605428 A MX 9605428A
- Authority
- MX
- Mexico
- Prior art keywords
- methylandrosta
- triene
- cyano
- beta
- alpha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se prepara 3-etil éter de 17 beta-ciano-3,17alfa-dihidroxi-6-metilandrosta-3,5,9 (11)-trieno (II) haciendo reaccionar un 3-etil éter de 3-hidroxi-6-metilandrosta-3,5,9(11)-trien-17-ona (I) con cianuro de hidrogeno a un pH de aproximadamente 7 a aproximadamente 11. El producto es un intermediario util en la produccion de esteroides farmacologicamente activos que incluyen metilprednisolona.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24003694A | 1994-05-09 | 1994-05-09 | |
PCT/US1995/005026 WO1995030684A1 (en) | 1994-05-09 | 1995-05-02 | SYNTHESIS OF 17β-CYANO-3-ETHOXY-17α-HYDROXY-6-METHYLANDROSTA-3,5,9(11)-TRIENE |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9605428A true MX9605428A (es) | 1997-12-31 |
Family
ID=22904843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9605428A MX9605428A (es) | 1994-05-09 | 1995-05-02 | SINTESIS DE 17 beta-CIANO-3-ETOXI-17ALFA-HIDROXI-6-METILANDROSTA-3,5,9(11)-T RIENO. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0759928A1 (es) |
JP (1) | JPH10500946A (es) |
KR (1) | KR970702873A (es) |
CN (1) | CN1147816A (es) |
AU (1) | AU684946B2 (es) |
CA (1) | CA2187522A1 (es) |
HU (1) | HUT75517A (es) |
MX (1) | MX9605428A (es) |
WO (1) | WO1995030684A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112898365B (zh) * | 2021-03-08 | 2023-02-28 | 营口德瑞化工有限公司 | 一种17β-氰基-17α-羟基雄甾-4-烯-3-酮的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2468617A1 (fr) * | 1979-10-26 | 1981-05-08 | Roussel Uclaf | Nouveaux derives acetyleniques chlores de l'androst-4-ene leur procede de preparation, et leur application a titre de medicament et les compositions pharmaceutiques les renfermant |
DE3585547D1 (de) * | 1984-02-03 | 1992-04-16 | Upjohn Co | Steroide mit einer enamid- oder enimidgruppe sowie ihre herstellung. |
DE3427486A1 (de) * | 1984-07-23 | 1986-01-30 | Schering AG, Berlin und Bergkamen, 1000 Berlin | Verfahren zur herstellung von 6(alpha)-methylsteroiden |
DE3434448A1 (de) * | 1984-09-17 | 1986-03-27 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur herstellung von pregnan-derivaten |
DD281394A5 (de) * | 1984-12-10 | 1990-08-08 | Jenapharm Veb | Verfahren zur herstellung von steroid-c-17 alpha-carbonitrilen |
WO1988002753A2 (en) * | 1986-10-10 | 1988-04-21 | Gist-Brocades N.V. | 9-alpha-hydroxy steroids and process for their preparation |
CA1317283C (en) * | 1986-11-05 | 1993-05-04 | Douglas Alan Livingston | Steroidal 17-silyl ethers and process to corticoids and progesterones |
-
1995
- 1995-05-02 AU AU23628/95A patent/AU684946B2/en not_active Expired - Fee Related
- 1995-05-02 CN CN95192975A patent/CN1147816A/zh active Pending
- 1995-05-02 WO PCT/US1995/005026 patent/WO1995030684A1/en not_active Application Discontinuation
- 1995-05-02 HU HU9603110A patent/HUT75517A/hu unknown
- 1995-05-02 CA CA002187522A patent/CA2187522A1/en not_active Abandoned
- 1995-05-02 JP JP7528991A patent/JPH10500946A/ja active Pending
- 1995-05-02 MX MX9605428A patent/MX9605428A/es unknown
- 1995-05-02 EP EP95917651A patent/EP0759928A1/en not_active Withdrawn
-
1996
- 1996-11-08 KR KR1019960706331A patent/KR970702873A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1147816A (zh) | 1997-04-16 |
HU9603110D0 (en) | 1997-01-28 |
EP0759928A1 (en) | 1997-03-05 |
KR970702873A (ko) | 1997-06-10 |
AU2362895A (en) | 1995-11-29 |
CA2187522A1 (en) | 1995-11-16 |
JPH10500946A (ja) | 1998-01-27 |
HUT75517A (en) | 1997-05-28 |
AU684946B2 (en) | 1998-01-08 |
WO1995030684A1 (en) | 1995-11-16 |
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