ES2123796T3 - Derivados de acidos fosfono-succinicos y su utilizacion como medicamentos. - Google Patents

Derivados de acidos fosfono-succinicos y su utilizacion como medicamentos.

Info

Publication number
ES2123796T3
ES2123796T3 ES94918879T ES94918879T ES2123796T3 ES 2123796 T3 ES2123796 T3 ES 2123796T3 ES 94918879 T ES94918879 T ES 94918879T ES 94918879 T ES94918879 T ES 94918879T ES 2123796 T3 ES2123796 T3 ES 2123796T3
Authority
ES
Spain
Prior art keywords
pct
phosphone
medicines
derivatives
succinic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94918879T
Other languages
English (en)
Inventor
Christos Tsaklakidis
Angelika Esswein
Gerd Zimmermann
Frieder Bauss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2123796T3 publication Critical patent/ES2123796T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3826—Acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/383—Cycloaliphatic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3882—Arylalkanephosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPUESTOS DE LA FORMULA (I), EN DONDE R 1 . R 2} DE FORMA INDEPENDIENTE UNO DE OTRO PUEDEN SER HIDROGENO, ALQUILO INFERIOR, CICLOALQUILO O ARIL METILO; R{SUP, 3}, R{SUP, 4} INDEPENDIENTE UNO DE OTRO PUEDEN SER RESPECTIVAMENTE HIDROGENO, ALQUILO INFERIOR, O UNO DE LOS GRUPOS - OR{SUP, 6} O - NR{SUP, 7}R{SUP, 8}, O CONJUNTAMENTE CON LOS ATOMOS, A LOS QUE ESTAN LIGADOS, PUEDEN FORMAR UN ANILLO HETEROCICLICO DE 5 HASTA 7 MIEMBROS CARBOCICLICOS O CONTENIENDO DESDE 1 HASTA 2 HETEROATOMOS; R{SUP, 5} ES ALQUENILO INFERIOR, CICLOALQUILO, CICLOALQUENILO, ARILALQUILO MONOLITICO, ARILO BICICLICO, BIARILO, O UN GRUPO DE LAS FORMULAS (A): R{SUP, 9} - X - ALK - O (B), O CONJUNTAMENTE CON R{SUP, 4} Y EL ATOMO DE CARBONO AL QUE ESTA LIGADO, FORMAN UN ANILLO HETEROCICLICO O CARBOCICLICO DE 5 HASTA 7 MIEMBROS EVENTUALMENTE SUSTITUIDO; R{SUP, 6} ES HIDROGENO, ALQUILO INFERIOR O ALQUILMETILO; R{SUP, 7}, R{SUP, 8} DE FORMA INDEPENDIENTE UNO DE OTRO SIGNIFICAN HIDROGENO O ALQUILO INFERIOR O CONJUNTAMENTE CON ELATOMO DE NITROGENO AL QUE ESTAN LIGADOS, FORMAN UN ANILLO HETEROCICLICO DE 5 HASTA 6 MIEMBROS; R{SUP, 9} SIGNIFICA HIDROGENO, ALQUILO INFERIOR, ALQUENILO INFERIOR, CICLOALQUILO, CICLOALQUENILO, ARILO MONO O BICICLICO, BIARILO, R{SUP, 10} SIGNIFICA UN GRUPO DE LA FORMULA (A); X ES UNA RAYA DE VALENCIA, OXIGENO O AZUFRE; Q ES OXIGENO, AZUFRE O NITROGENO; ALK ES UNA RAYA DE VALENCIA, UNA CADENA ALQUILENO SATURADA O NO SATURADA, O CADENA METILENO, CON 2 - 6 ATOMOS DE CARBONO; N = 0 3; M = 0 - 2 Y P = 0 - 5. LA INVENCION SE REFIERE TAMBIEN A UN PROCESO PARA SU ELABORACION ASI COMO MEDICAMENTOS QUE CONTIENEN ESTOS COMPUESTOS, PARA TRATAMIENTO DE PERTURBACIONES DE CAMBIO DE SUSTANCIAS DE CALCIO.
ES94918879T 1993-06-18 1994-06-17 Derivados de acidos fosfono-succinicos y su utilizacion como medicamentos. Expired - Lifetime ES2123796T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4320223A DE4320223A1 (de) 1993-06-18 1993-06-18 Neue Phosphonobernsteinsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
ES2123796T3 true ES2123796T3 (es) 1999-01-16

Family

ID=6490632

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94918879T Expired - Lifetime ES2123796T3 (es) 1993-06-18 1994-06-17 Derivados de acidos fosfono-succinicos y su utilizacion como medicamentos.

Country Status (12)

Country Link
US (1) US5683994A (es)
EP (1) EP0703919B1 (es)
JP (1) JPH08511552A (es)
AT (1) ATE170527T1 (es)
AU (1) AU7000994A (es)
CA (1) CA2166813A1 (es)
DE (2) DE4320223A1 (es)
ES (1) ES2123796T3 (es)
IL (1) IL110025A0 (es)
TW (1) TW311140B (es)
WO (1) WO1995000522A1 (es)
ZA (1) ZA944317B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE239697T1 (de) * 1997-03-14 2003-05-15 Basf Ag Cycloalkylalkancarbonsäureamide, deren herstellung und verwendung
US5909050A (en) * 1997-09-15 1999-06-01 Microchip Technology Incorporated Combination inductive coil and integrated circuit semiconductor chip in a single lead frame package and method therefor
JP2013544787A (ja) * 2010-10-13 2013-12-19 タケダ カリフォルニア インコーポレイテッド アザインダゾール誘導体の調製方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2360797C2 (de) * 1973-12-06 1985-05-23 Henkel KGaA, 4000 Düsseldorf Pharmazeutische Präparate
DE4141928A1 (de) * 1991-12-19 1993-06-24 Boehringer Mannheim Gmbh Neue phosphonobernsteinsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US5731299A (en) * 1992-05-29 1998-03-24 The Procter & Gamble Company Phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism

Also Published As

Publication number Publication date
CA2166813A1 (en) 1995-01-05
EP0703919A1 (de) 1996-04-03
WO1995000522A1 (de) 1995-01-05
AU7000994A (en) 1995-01-17
DE4320223A1 (de) 1994-12-22
US5683994A (en) 1997-11-04
EP0703919B1 (de) 1998-09-02
JPH08511552A (ja) 1996-12-03
ATE170527T1 (de) 1998-09-15
TW311140B (es) 1997-07-21
ZA944317B (en) 1995-12-18
DE59406844D1 (de) 1998-10-08
IL110025A0 (en) 1994-10-07

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