MX9400274A - Nuevos derivados 2-ciano-3-hidroxipropenamidas, su procedimiento de preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen. - Google Patents
Nuevos derivados 2-ciano-3-hidroxipropenamidas, su procedimiento de preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.Info
- Publication number
- MX9400274A MX9400274A MX9400274A MX9400274A MX9400274A MX 9400274 A MX9400274 A MX 9400274A MX 9400274 A MX9400274 A MX 9400274A MX 9400274 A MX9400274 A MX 9400274A MX 9400274 A MX9400274 A MX 9400274A
- Authority
- MX
- Mexico
- Prior art keywords
- hidroxipropenamidas
- ciano
- drugs
- contain
- application
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La invención se refiere a los productos (I): en los que A, B y E representan CH- o N con A o B o EN, R representa cicloalquilo, alquenilo o alquinilo (- C6), R1 representa H o alquilo (C1-3), R2 y R3 representan H, CN, NO2, alquilo, cicloalquilo, alcoxi, alquiltio (C1-6), -(CH2)m-CX3, -O-(CH2)m-CX3, -S-(CH2)m-CX3, -O-(CX2)m-CX3 o -S-(CX2)M-CX3, siendo m O a 3, siendo X halógeno, o -COR4, siendo R4 H, alquilo o cicloalquilo (- C3) o R2 y R3 juntos forman -O-CH2-O-, así como sus formas tautómeras y sus sales con bases. Los productos (I) presentan interesantes propiedades antiinflamatorias.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939300083A GB9300083D0 (en) | 1993-01-05 | 1993-01-05 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9400274A true MX9400274A (es) | 1994-08-31 |
Family
ID=10728304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9400274A MX9400274A (es) | 1993-01-05 | 1994-01-05 | Nuevos derivados 2-ciano-3-hidroxipropenamidas, su procedimiento de preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen. |
Country Status (33)
Country | Link |
---|---|
US (1) | US5346912A (es) |
EP (1) | EP0606175B1 (es) |
JP (1) | JP3334988B2 (es) |
KR (1) | KR100295717B1 (es) |
CN (1) | CN1042935C (es) |
AT (1) | ATE128968T1 (es) |
AU (1) | AU663017B2 (es) |
BR (1) | BR9400017A (es) |
CA (1) | CA2112866C (es) |
CZ (1) | CZ283948B6 (es) |
DE (1) | DE69400024T2 (es) |
DK (1) | DK0606175T3 (es) |
EE (1) | EE03001B1 (es) |
ES (1) | ES2078130T3 (es) |
FI (1) | FI106553B (es) |
GB (1) | GB9300083D0 (es) |
GR (1) | GR3017723T3 (es) |
HR (1) | HRP940006B1 (es) |
HU (1) | HU216835B (es) |
IL (1) | IL107788A (es) |
LT (1) | LT3766B (es) |
LV (1) | LV10712B (es) |
MX (1) | MX9400274A (es) |
NO (1) | NO300839B1 (es) |
NZ (1) | NZ250520A (es) |
PL (1) | PL175135B1 (es) |
RU (1) | RU2126387C1 (es) |
SI (1) | SI9300686A (es) |
SK (1) | SK280508B6 (es) |
TW (1) | TW259785B (es) |
UA (1) | UA40573C2 (es) |
YU (1) | YU49047B (es) |
ZA (1) | ZA939118B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002521441A (ja) * | 1998-07-28 | 2002-07-16 | スミスクライン・ビーチャム・コーポレイション | Ccr5モジュレーターとしてのプロペンアミド |
EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
RU2516290C2 (ru) | 2007-08-27 | 2014-05-20 | Басф Се | Пиразольные соединения и их использование в способе борьбы с беспозвоночными вредителями, в способе защиты материала размножения растений, в способе лечения или защиты животных от инвазии или инфицирования, в материале размножения растений и сельскохозяйственные композиции, содержащие пиразольные соединения |
EA020661B1 (ru) | 2008-09-24 | 2014-12-30 | Басф Се | Пиразольные соединения для борьбы с беспозвоночными вредителями |
US8710056B2 (en) | 2009-07-06 | 2014-04-29 | Basf Se | Pyridazine compounds for controlling invertebrate pests |
JP2012532176A (ja) | 2009-07-06 | 2012-12-13 | ビーエーエスエフ ソシエタス・ヨーロピア | 無脊椎動物系害虫防除用ピリダジン化合物 |
US9125414B2 (en) | 2009-07-24 | 2015-09-08 | Basf Se | Pyridine derivatives compounds for controlling invertebrate pests |
EA201691057A1 (ru) | 2013-11-22 | 2016-10-31 | Джензим Корпорейшн | Новые способы лечения нейродегенеративных заболеваний |
CN105693574B (zh) * | 2014-11-25 | 2017-12-19 | 中国科学院大连化学物理研究所 | 2‑烷硫基烯酰胺衍生物及其合成方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL186239B (nl) | 1975-06-05 | Hoechst Ag | Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze. | |
DE2555789A1 (de) * | 1975-12-11 | 1977-07-07 | Hoechst Ag | Neue cyanessigsaeureanilid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel |
US4435407A (en) * | 1982-01-07 | 1984-03-06 | Ciba-Geigy Corporation | Certain substituted β-oxo-α-carbamoylpyrrolepropionitriles |
DE3534440A1 (de) | 1985-09-27 | 1987-04-02 | Hoechst Ag | Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes |
US4888357A (en) | 1988-01-26 | 1989-12-19 | Bristol-Myers Company | Antiarthritic β-cycloalkyl-β-oxopropionitriles |
IL92508A0 (en) * | 1988-12-08 | 1990-08-31 | Ciba Geigy Ag | Novel alpha-cyano-beta-oxopropionamides |
DE59010701D1 (de) * | 1990-05-18 | 1997-05-22 | Hoechst Ag | Isoxazol-4-carbonsäureamide und hydroxyalkyliden-cyanessigsäureamide, diese verbindungen enthaltende arzneimittel und deren verwendung |
IL99811A (en) * | 1990-10-30 | 1996-03-31 | Roussel Uclaf | 3-Cycloalkyl-propanamides, tautomeric forms of these, their salts, method of preparation, use as drugs and preparations containing them |
IL102790A (en) * | 1991-09-17 | 1996-01-31 | Roussel Uclaf | History of 3-cycloalkyl-prop-2-anamide |
-
1993
- 1993-01-05 GB GB939300083A patent/GB9300083D0/en active Pending
- 1993-11-29 IL IL10778893A patent/IL107788A/en not_active IP Right Cessation
- 1993-12-03 AU AU52130/93A patent/AU663017B2/en not_active Expired
- 1993-12-06 ZA ZA939118A patent/ZA939118B/xx unknown
- 1993-12-20 US US08/170,372 patent/US5346912A/en not_active Expired - Lifetime
- 1993-12-20 NZ NZ250520A patent/NZ250520A/en not_active IP Right Cessation
- 1993-12-20 LT LTIP1634A patent/LT3766B/lt not_active IP Right Cessation
- 1993-12-24 SI SI9300686A patent/SI9300686A/sl unknown
- 1993-12-28 JP JP34951193A patent/JP3334988B2/ja not_active Expired - Lifetime
- 1993-12-29 SK SK1495-93A patent/SK280508B6/sk not_active IP Right Cessation
- 1993-12-29 YU YU82593A patent/YU49047B/sh unknown
- 1993-12-30 CZ CZ932921A patent/CZ283948B6/cs not_active IP Right Cessation
-
1994
- 1994-01-03 PL PL94301774A patent/PL175135B1/pl unknown
- 1994-01-04 DK DK94400009.0T patent/DK0606175T3/da active
- 1994-01-04 FI FI940031A patent/FI106553B/fi not_active IP Right Cessation
- 1994-01-04 CN CN94100187A patent/CN1042935C/zh not_active Expired - Lifetime
- 1994-01-04 EP EP94400009A patent/EP0606175B1/fr not_active Expired - Lifetime
- 1994-01-04 DE DE69400024T patent/DE69400024T2/de not_active Expired - Lifetime
- 1994-01-04 ES ES94400009T patent/ES2078130T3/es not_active Expired - Lifetime
- 1994-01-04 RU RU94000064A patent/RU2126387C1/ru active
- 1994-01-04 KR KR1019940000057A patent/KR100295717B1/ko not_active IP Right Cessation
- 1994-01-04 LV LVP-94-02A patent/LV10712B/en unknown
- 1994-01-04 AT AT94400009T patent/ATE128968T1/de active
- 1994-01-04 UA UA94005036A patent/UA40573C2/uk unknown
- 1994-01-04 HR HR9300083.4A patent/HRP940006B1/xx not_active IP Right Cessation
- 1994-01-04 NO NO940020A patent/NO300839B1/no not_active IP Right Cessation
- 1994-01-04 BR BR9400017A patent/BR9400017A/pt not_active Application Discontinuation
- 1994-01-05 CA CA002112866A patent/CA2112866C/fr not_active Expired - Lifetime
- 1994-01-05 HU HU9400033A patent/HU216835B/hu unknown
- 1994-01-05 MX MX9400274A patent/MX9400274A/es unknown
- 1994-01-31 TW TW083100783A patent/TW259785B/zh not_active IP Right Cessation
- 1994-11-14 EE EE9400360A patent/EE03001B1/xx unknown
-
1995
- 1995-10-12 GR GR950401071T patent/GR3017723T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX9207074A (es) | Piperazinil- y piperidinil -ciclohexanoles y composicion farmaceutica que los comprende | |
ES2079534T3 (es) | Derivados de polietilenglicol, sus peptidos modificados, metodos para producirlos y uso de los peptidos modificados. | |
ES2176204T3 (es) | Antidepresivos que contienen un derivado de xantina. | |
PT97890A (pt) | Processo para a preparacao de ftalidas substituidas e de ftalidas heterociclicas | |
CO4130326A1 (es) | Nuevos derivados de 2-ciano-1,3-diona, composiciones que los contienen, procedimientos para su preparacion y su uso como herbicidas | |
ES2119017T3 (es) | Derivados que contienen azufre de 2-ciano-1,3-dionas y su uso como herbicidas. | |
MX9201356A (es) | Derivados de piperidina, procedimiento para su preparacion y composicion farmaceutica que los contiene. | |
MX9400274A (es) | Nuevos derivados 2-ciano-3-hidroxipropenamidas, su procedimiento de preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen. | |
FI955430A (fi) | Bisyklisiä amidijohdannaisia ja niiden käyttö lihasten jännitystä laukaisevina aineena | |
DK50086A (da) | 3-phenyl-tetrahydropyridinderivater | |
DE69821815D1 (de) | Thiocolchicin-Derivate mit entzündungshemmender und muskelrelaxierender Wirkung | |
ES2125963T3 (es) | Nuevos derivados espiranicos del 3-amino-cromano, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen. | |
FI962587A (fi) | 1,3-oksatsin-4-onijohdannaiset, menetelmä ja välituotteet niiden valmistamiseksi ja niiden käyttö herbisideinä | |
IT1301679B1 (it) | Derivati dell'iperforina, loro uso e formulazioni che licontengono. | |
DE3880304D1 (de) | 2-hydroxy-3-aryloxy-propylaminderivate mit kardiovaskulaerer wirkung. | |
ES2065192T3 (es) | Nuevos nicotinatos de diacil-glicerol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
ES2104295T3 (es) | Derivados ciclopeptidicos de la angiopeptina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
PT90815A (pt) | Processo de preparacao de derivados da fenotiazina | |
PT97255A (pt) | Processo para a preparacao de 3-tia-alquil-flavonas e de 3-oxa-alquil flavonas e substituidas e de composicoes farmaceuticas que as contem | |
ES2103553T3 (es) | Nuevos cicloalquil-(b)-indoles, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. |