ES2086341T3 - Derivados de aminoacidos con propiedades inhibidoras de la renina, procedimiento para su preparacion, agentes que los contienen y su utilizacion. - Google Patents

Derivados de aminoacidos con propiedades inhibidoras de la renina, procedimiento para su preparacion, agentes que los contienen y su utilizacion.

Info

Publication number
ES2086341T3
ES2086341T3 ES90117400T ES90117400T ES2086341T3 ES 2086341 T3 ES2086341 T3 ES 2086341T3 ES 90117400 T ES90117400 T ES 90117400T ES 90117400 T ES90117400 T ES 90117400T ES 2086341 T3 ES2086341 T3 ES 2086341T3
Authority
ES
Spain
Prior art keywords
preparation
derivatives
renine
procedure
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90117400T
Other languages
English (en)
Inventor
Holger Dr Heitsch
Rainer Dr Henning
Wolfgang Dr Linz
Wolf-Ulrich Dr Nickel
Dieter Dr Ruppert
Hansjorg Dr Urbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2086341T3 publication Critical patent/ES2086341T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

EL INVENTO SE REFIERE A UN DERIVADO DE AMINOACIDO DE FORMULA (I), TRATA DE UN PROCEDIMIENTO PARA LA PRODUCCION DEL COMPUESTO DE FORMULA (I) Y DESCRIBE LA APLICACION DEL COMPUESTO DE FORMULA (I) COMO INHIBIDOR DE RENINA. SIENDO: B UN AMINOACIDO DE FORMULA H-B-OH; R1 UN RESTO HETEROCICLO CONTENIENDO NITROGENO COMO PIPERIDINA, X CO, CS, SO2 O SO, Y CH2. TENIENDO R3, R4 Y R5 UN SIGNIFICADO DESCRITO EN LA PATENTE.
ES90117400T 1989-09-12 1990-09-10 Derivados de aminoacidos con propiedades inhibidoras de la renina, procedimiento para su preparacion, agentes que los contienen y su utilizacion. Expired - Lifetime ES2086341T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3930397 1989-09-12
DE3933096 1989-10-04

Publications (1)

Publication Number Publication Date
ES2086341T3 true ES2086341T3 (es) 1996-07-01

Family

ID=25885063

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90117400T Expired - Lifetime ES2086341T3 (es) 1989-09-12 1990-09-10 Derivados de aminoacidos con propiedades inhibidoras de la renina, procedimiento para su preparacion, agentes que los contienen y su utilizacion.

Country Status (18)

Country Link
US (1) US5374731A (es)
EP (1) EP0417698B1 (es)
JP (1) JPH03106877A (es)
KR (1) KR910006321A (es)
AT (1) ATE135368T1 (es)
AU (1) AU639259B2 (es)
CA (1) CA2025093A1 (es)
DE (2) DE4028741A1 (es)
DK (1) DK0417698T3 (es)
ES (1) ES2086341T3 (es)
FI (1) FI904441A0 (es)
GR (1) GR3019331T3 (es)
HU (1) HU206704B (es)
IE (1) IE903296A1 (es)
IL (1) IL95634A0 (es)
NO (1) NO177143C (es)
NZ (1) NZ235234A (es)
PT (1) PT95278A (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4028741A1 (de) * 1989-09-12 1991-03-28 Hoechst Ag Aminosaeurederivate mit reninhemmenden eigenschaften, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
DE4008403A1 (de) * 1990-03-16 1991-09-19 Merck Patent Gmbh Glykolsaeurederivate
IE68045B1 (en) * 1990-05-11 1996-05-15 Abbott Lab Renin inhibitors
EP0483403A1 (en) * 1990-10-31 1992-05-06 Hoechst Aktiengesellschaft Derivatives of amino acids as inhibitors of renin, methods for their preparation, medicaments containing them and their use
ES2106104T3 (es) * 1991-05-03 1997-11-01 Hoechst Ag Procedimiento para la sintesis enantioselectiva de derivados de monoamida de acido 2(r)-bencilsuccinico.
US5212185A (en) * 1992-08-14 1993-05-18 G. D. Searle & Co. Piperidinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
PL174454B1 (pl) 1992-09-25 1998-07-31 Boehringer Ingelheim Canada Nowe związki, pochodne N-(2-amino-2-oksoetylo)butanodiamidu hamujące reninę i sposób wytwarzania nowych pochodnych N-(2-amino-2-oksoetylo)butanodiamidu
PL174487B1 (pl) * 1992-09-25 1998-08-31 Boehringer Ingelheim Canada Nowe związki, pochodne N-(hydroksyetylo)butanodiamidu i sposób wytwarzania nowych pochodnych N-(hydroksyetylo)butanodiamidu
US5420283A (en) * 1993-08-02 1995-05-30 Pfizer Inc. Resolution of (R)-2-benzylsuccinic acid 4-[4-(N-t-butoxycarbonylmethylamino)-piperidine] amide
EP1553085A1 (en) 1997-11-18 2005-07-13 Teijin Limited Cyclic amine derivatives and their use as drugs
JP2004506593A (ja) * 1999-05-14 2004-03-04 コンビケム　インコーポレイテッド 環状アミン誘導体、およびそれらの用途
US6410566B1 (en) 2000-05-16 2002-06-25 Teijin Limited Cyclic amine derivatives and their use as drugs
AU2001275537A1 (en) 2000-06-20 2002-01-02 Wayne State University N-and o-substituted 4-(2-(diphenylmethoxy)-ethyl)-1-((phenyl)methyl)piperidine analogs and methods of treating cns disorders therewith
US8211916B2 (en) 2000-06-20 2012-07-03 Wayne State University N- and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating CNS disorders therewith
WO2002070523A1 (en) * 2001-03-07 2002-09-12 Pfizer Products Inc. Modulators of chemokine receptor activity
US8017791B2 (en) 2003-03-28 2011-09-13 Wayne State University Tri-substituted 2-benzhydryl-5-benzylamino-tetrahydro-pyran-4-ol and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-ol analogues, and novel, 3,6-disubstituted pyran derivatives
EP1734948B1 (en) 2004-04-16 2014-06-11 Wayne State University Tri-substitued 2-benzhydryl-5-benzylamino-tetrahydro-pyran-4-ol and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-ol analogues, and novel 3,6-disubstituted pyran derivatives
KR100636213B1 (ko) 2004-12-28 2006-10-19 삼성전자주식회사 실시간 주파수 특성 보정 방법 및 그를 적용한 사운드재생 장치
CN104311473B (zh) * 2014-05-27 2016-09-28 斯芬克司药物研发（天津）股份有限公司 一种哌啶类化合物及其制备方法
CN110268727B (zh) * 2017-01-04 2021-06-22 塔特公司 具有先进的环绕处理功能的可配置的多带压缩器架构

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0184855A3 (en) * 1984-12-14 1989-05-03 Abbott Laboratories Resin inhibiting compounds
DK34086A (da) * 1985-01-23 1986-07-24 Abbott Lab Peptidylaminodioler
US4657931A (en) * 1985-05-15 1987-04-14 G. D. Searle & Co. N-(acyldipeptidyl)-aminoglycols
NZ218937A (en) * 1986-01-16 1990-03-27 Abbott Lab Functionalised peptidyl aminodiols and -triols as renin inhibitors and pharmaceutical compositions
IL81234A (en) * 1986-01-16 1992-09-06 Abbott Lab Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
ZA87563B (en) * 1986-02-03 1987-09-30 Squibb & Sons Inc N-heterocyclic alcohol renin inhibitors
CA1309555C (en) * 1986-02-27 1992-10-27 Suvit Thaisrivongs Inhibiting peptides having a dihydroxyethylene isostere transitionstate insert
DE3610593A1 (de) * 1986-03-29 1987-10-01 Hoechst Ag Substituierte 4-amino-3-hydroxybuttersaeure-derivate verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
DE3627877A1 (de) * 1986-07-30 1988-02-04 Hoechst Ag Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
US5032577A (en) * 1986-12-31 1991-07-16 Abbott Laboratories Peptidylaminodiols
US4921855A (en) * 1987-06-22 1990-05-01 Fujisawa Pharmaceutical Co., Ltd. New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same
AU1780588A (en) * 1987-06-29 1989-01-30 Upjohn Company, The Malic acid derivative containing renin inhibiting peptides
US4977141A (en) * 1987-10-01 1990-12-11 G. D. Searle & Co. Peptidyl α-aminoacyl aminodiol carbamates as anti-hypertensive agents
US4877785A (en) * 1987-10-01 1989-10-31 G. D. Searle & Co. Non-peptidyl beta-succinamidoacyl aminodiols as anti-hypertensive agents
DK523288A (da) * 1987-10-06 1989-04-07 Hoffmann La Roche Aminosyrederivater
US5055466A (en) * 1987-11-23 1991-10-08 E. R. Squibb & Sons, Inc. N-morpholino derivatives and their use as anti-hypertensive agents
DE3804793A1 (de) * 1988-02-16 1989-08-24 Hoechst Ag Renin-hemmende aminosaeurederivate
DE3841520A1 (de) * 1988-12-09 1990-06-13 Hoechst Ag Enzymhemmende harnstoffderivate von dipeptiden, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE4028741A1 (de) * 1989-09-12 1991-03-28 Hoechst Ag Aminosaeurederivate mit reninhemmenden eigenschaften, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung

Also Published As

Publication number Publication date
NO177143B (no) 1995-04-18
AU6234090A (en) 1991-03-21
DK0417698T3 (da) 1996-07-22
KR910006321A (ko) 1991-04-29
IL95634A0 (en) 1991-06-30
NO903952L (no) 1991-03-13
DE4028741A1 (de) 1991-03-28
US5374731A (en) 1994-12-20
DE59010189D1 (de) 1996-04-18
HU206704B (en) 1992-12-28
EP0417698A2 (de) 1991-03-20
CA2025093A1 (en) 1991-03-13
HUT55380A (en) 1991-05-28
JPH03106877A (ja) 1991-05-07
IE903296A1 (en) 1991-04-10
EP0417698A3 (en) 1992-01-08
NO177143C (no) 1995-07-26
AU639259B2 (en) 1993-07-22
ATE135368T1 (de) 1996-03-15
HU905859D0 (en) 1991-03-28
GR3019331T3 (en) 1996-06-30
EP0417698B1 (de) 1996-03-13
NO903952D0 (no) 1990-09-11
FI904441A0 (fi) 1990-09-10
PT95278A (pt) 1991-05-22
NZ235234A (en) 1992-12-23

Similar Documents

Publication Publication Date Title
ES2086341T3 (es) Derivados de aminoacidos con propiedades inhibidoras de la renina, procedimiento para su preparacion, agentes que los contienen y su utilizacion.
PT92752A (pt) Processo para a preparacao de benzilideno-azolilmetilcicloalcanos ou alcenos e de composicoes fungicidas que os contem
NZ236589A (en) A-nor-steroid-3-carboxylic acid derivatives and pharmaceutical compositions
FI874570A (fi) Antibakteriska medel -ii.
PT97254A (pt) Processo para a preparacao de azoles substituido e de composicoes farmaceuticas que os contem
DE68922405D1 (de) Deletionsanaloga von magaininpeptiden.
PT90740A (pt) Processo para a preparacao de oligopeptideos com aminoacidos analogos de prolina ciclicos, e de composicoes farmaceuticas que os contem
PT92558A (pt) Processo para a preparacao de derivados de aminoacidos inibidores de enzimas e de composicoes farmaceuticas que os contem
PT93915A (pt) Processo para a preparacao de novos derivados de 4-fenil-metil-1h-indol e de composicoes farmaceuticas que os contem
ES2054989T3 (es) Derivados de aminodiol inhibidores de renina.
ATE101391T1 (de) Verfahren zur herstellung von in stellung 3 durch eine halogenierte gesaettigte kette substituierten cyclopropancarbonsaeurederivaten.
DE59009951D1 (de) Verfahren zur Herstellung von Zwischenprodukten und zur Synthese von N-(2-Hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine.
ATE50992T1 (de) Verbrueckungsreagenz, verfahren zu seiner herstellung und seine anwendung.
DE3560291D1 (en) 1-ûn-(alpha-amino-alpha-methylacetyl)-aminophenyl¨-2-amino propanon derivatives, process for their preparation and their therapeutical use

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 417698

Country of ref document: ES