MX370598B - Fenoxiacetamidas apareadas novedosas. - Google Patents

Fenoxiacetamidas apareadas novedosas.

Info

Publication number
MX370598B
MX370598B MX2018001945A MX2018001945A MX370598B MX 370598 B MX370598 B MX 370598B MX 2018001945 A MX2018001945 A MX 2018001945A MX 2018001945 A MX2018001945 A MX 2018001945A MX 370598 B MX370598 B MX 370598B
Authority
MX
Mexico
Prior art keywords
phenoxyacetamides
formula
compounds
annelated
novel
Prior art date
Application number
MX2018001945A
Other languages
English (en)
Other versions
MX2018001945A (es
Inventor
Wiedenmayer Dieter
Heckel Armin
Kley Joerg
Hamprecht Dieter
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2018001945A publication Critical patent/MX2018001945A/es
Publication of MX370598B publication Critical patent/MX370598B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/16—Halogenated acetic acids
    • C07C53/18—Halogenated acetic acids containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Abstract

La presente invención se refiere a los compuestos de la Fórmula (I): (ver Fórmula) en donde R1, R2, R3 y Z¯ tienen uno de los significados que se indican en la memoria descriptiva, o una sal aceptable desde el punto de vista farmacéutico de aquellos, al uso de los compuestos de la Fórmula (I) como un medicamento, a una composición farmacéutica que comprende al menos un compuesto de la Fórmula (I), así como a combinaciones de medicamentos que contienen uno o más compuestos de la Fórmula (I).
MX2018001945A 2015-08-20 2015-08-20 Fenoxiacetamidas apareadas novedosas. MX370598B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2015/069152 WO2017028927A1 (en) 2015-08-20 2015-08-20 Novel annelated phenoxyacetamides

Publications (2)

Publication Number Publication Date
MX2018001945A MX2018001945A (es) 2018-06-19
MX370598B true MX370598B (es) 2019-12-18

Family

ID=54065852

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018001945A MX370598B (es) 2015-08-20 2015-08-20 Fenoxiacetamidas apareadas novedosas.

Country Status (27)

Country Link
EP (1) EP3298022B1 (es)
JP (1) JP6620171B2 (es)
KR (1) KR20180044333A (es)
CN (1) CN108200769B (es)
AU (1) AU2015406100B2 (es)
BR (1) BR112018001035A2 (es)
CA (1) CA2996087A1 (es)
CO (1) CO2018001700A2 (es)
CY (1) CY1122077T1 (es)
DK (1) DK3298022T3 (es)
EA (1) EA035738B1 (es)
ES (1) ES2739893T3 (es)
HR (1) HRP20191339T1 (es)
HU (1) HUE046014T2 (es)
IL (1) IL257136B (es)
LT (1) LT3298022T (es)
ME (1) ME03534B (es)
MX (1) MX370598B (es)
MY (1) MY194711A (es)
PH (1) PH12018500378B1 (es)
PL (1) PL3298022T3 (es)
PT (1) PT3298022T (es)
RS (1) RS59169B1 (es)
SA (1) SA518390920B1 (es)
SI (1) SI3298022T1 (es)
UA (1) UA121414C2 (es)
WO (1) WO2017028927A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201610854D0 (en) * 2016-06-21 2016-08-03 Entpr Therapeutics Ltd Compounds
GB201619694D0 (en) 2016-11-22 2017-01-04 Entpr Therapeutics Ltd Compounds
GB201717051D0 (en) 2017-10-17 2017-11-29 Enterprise Therapeutics Ltd Compounds
GB201808093D0 (en) 2018-05-18 2018-07-04 Enterprise Therapeutics Ltd Compounds
AU2021341508A1 (en) 2020-09-10 2023-05-25 Precirix N.V. Antibody fragment against fap
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011079087A1 (en) * 2009-12-23 2011-06-30 Glaxo Group Limited Enac blockers
EP3022198B1 (en) * 2013-07-15 2019-09-11 Boehringer Ingelheim International GmbH Novel 5-substituted benzimidazolium compounds
EP3022196B1 (en) * 2013-07-15 2017-09-06 Boehringer Ingelheim International GmbH Novel benzimidazolium compounds
JP6461133B2 (ja) * 2013-07-15 2019-01-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規４置換及び５置換ベンゾイミダゾリウム化合物

Also Published As

Publication number Publication date
MY194711A (en) 2022-12-15
MX2018001945A (es) 2018-06-19
HRP20191339T1 (hr) 2020-02-21
NZ738967A (en) 2021-09-24
CN108200769B (zh) 2021-07-27
CA2996087A1 (en) 2017-02-23
EA201890534A1 (ru) 2018-09-28
ME03534B (me) 2020-04-20
JP6620171B2 (ja) 2019-12-11
JP2018522841A (ja) 2018-08-16
PH12018500378A1 (en) 2018-08-29
BR112018001035A2 (pt) 2018-12-04
SA518390920B1 (ar) 2021-12-14
IL257136B (en) 2022-02-01
SI3298022T1 (sl) 2019-08-30
IL257136A (en) 2018-03-29
ES2739893T3 (es) 2020-02-04
UA121414C2 (uk) 2020-05-25
CY1122077T1 (el) 2020-11-25
AU2015406100A1 (en) 2018-02-01
DK3298022T3 (da) 2019-08-26
EA035738B1 (ru) 2020-08-03
PH12018500378B1 (en) 2018-08-29
PT3298022T (pt) 2019-09-26
LT3298022T (lt) 2019-09-25
CN108200769A (zh) 2018-06-22
HUE046014T2 (hu) 2020-01-28
CO2018001700A2 (es) 2018-05-21
KR20180044333A (ko) 2018-05-02
RS59169B1 (sr) 2019-10-31
EP3298022A1 (en) 2018-03-28
EP3298022B1 (en) 2019-06-05
AU2015406100B2 (en) 2020-04-23
PL3298022T3 (pl) 2019-12-31
WO2017028927A1 (en) 2017-02-23

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