MX370564B - Un proceso para la preparacion de levotiroxina y sus sales. - Google Patents

Un proceso para la preparacion de levotiroxina y sus sales.

Info

Publication number
MX370564B
MX370564B MX2016012787A MX2016012787A MX370564B MX 370564 B MX370564 B MX 370564B MX 2016012787 A MX2016012787 A MX 2016012787A MX 2016012787 A MX2016012787 A MX 2016012787A MX 370564 B MX370564 B MX 370564B
Authority
MX
Mexico
Prior art keywords
levothyroxine
salts
preparation
present
yields
Prior art date
Application number
MX2016012787A
Other languages
English (en)
Other versions
MX2016012787A (es
Inventor
Sudhakar Deshmukh Swapnil
Murlidhar Jain Adinath
Pal Singh Girij
Dnyaneshwar Dixit Dinesh
Madhav Godbole Himanshu
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of MX2016012787A publication Critical patent/MX2016012787A/es
Publication of MX370564B publication Critical patent/MX370564B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación de Levotiroxina y sus sales. El proceso descrito en la presente invención proporciona un aumento en los rendimientos y pureza que comprende el uso de yoduro de sodio e hipoclorito de sodio como agente yodante.
MX2016012787A 2014-03-31 2015-03-30 Un proceso para la preparacion de levotiroxina y sus sales. MX370564B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IB2015/052330 WO2015151013A1 (en) 2014-03-31 2015-03-30 A process for preparation of levothyroxine and salts thereof
IN1233MU2014 IN2014MU01233A (es) 2014-03-31 2015-03-30

Publications (2)

Publication Number Publication Date
MX2016012787A MX2016012787A (es) 2016-12-12
MX370564B true MX370564B (es) 2019-12-17

Family

ID=54239474

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016012787A MX370564B (es) 2014-03-31 2015-03-30 Un proceso para la preparacion de levotiroxina y sus sales.

Country Status (11)

Country Link
US (1) US9932295B2 (es)
EP (1) EP3126324B1 (es)
JP (1) JP2017510593A (es)
AU (1) AU2015242231B2 (es)
CA (1) CA2944116A1 (es)
ES (1) ES2686194T3 (es)
IN (1) IN2014MU01233A (es)
MX (1) MX370564B (es)
RU (1) RU2673540C2 (es)
WO (1) WO2015151013A1 (es)
ZA (1) ZA201607265B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL2017110B1 (en) 2016-07-05 2018-01-12 Emp Levo Gmbh Methods for the preparation of a levothyroxine solution
US9782376B1 (en) 2016-12-01 2017-10-10 Fresenius Kabi Usa Llc Levothyroxine liquid formulations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB652207A (en) 1948-12-31 1951-04-18 Glaxo Lab Ltd Improvements in or relating to the preparation of thyroxine and its derivatives
US2886592A (en) 1956-03-07 1959-05-12 Hillmann Gunther Process for making iodo derivatives of thyronine
US4997946A (en) * 1987-08-18 1991-03-05 Eastman Kodak Company Process for the iodination of hydroxyaromatic and aminoaromatic compounds
IT1302201B1 (it) 1998-09-11 2000-07-31 Bracco Spa Processo per la produzione di ormoni tiroidei.
WO2009136249A1 (en) 2008-05-09 2009-11-12 Cadila Pharmaceuticals Ltd. An improved process for the preparation of levothyroxine sodium with reduced levels of impurities
EP2338875A1 (en) * 2009-12-18 2011-06-29 Bracco Imaging S.p.A Process for the preparation of thyroid hormones and derivatives thereof
WO2015011573A1 (en) 2013-07-24 2015-01-29 Azico Pharmaceuticals Private Limited Novel process for the preparation of levothyroxine sodium

Also Published As

Publication number Publication date
US9932295B2 (en) 2018-04-03
RU2673540C2 (ru) 2018-11-28
US20170183292A1 (en) 2017-06-29
RU2016142315A (ru) 2018-05-04
MX2016012787A (es) 2016-12-12
IN2014MU01233A (es) 2015-10-02
ZA201607265B (en) 2017-11-29
EP3126324B1 (en) 2018-07-18
EP3126324A1 (en) 2017-02-08
CA2944116A1 (en) 2015-10-08
AU2015242231A1 (en) 2016-10-27
WO2015151013A1 (en) 2015-10-08
AU2015242231B2 (en) 2019-09-12
JP2017510593A (ja) 2017-04-13
ES2686194T3 (es) 2018-10-16
RU2016142315A3 (es) 2018-10-09

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Legal Events

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FG Grant or registration