MX369369B - Derivados de quinolona como inhibidores del receptor del factor de crecimiento de fibroblastos. - Google Patents
Derivados de quinolona como inhibidores del receptor del factor de crecimiento de fibroblastos.Info
- Publication number
- MX369369B MX369369B MX2016010106A MX2016010106A MX369369B MX 369369 B MX369369 B MX 369369B MX 2016010106 A MX2016010106 A MX 2016010106A MX 2016010106 A MX2016010106 A MX 2016010106A MX 369369 B MX369369 B MX 369369B
- Authority
- MX
- Mexico
- Prior art keywords
- growth factor
- fibroblast growth
- factor receptor
- receptor inhibitors
- quinolone derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108091008794 FGF receptors Proteins 0.000 title 1
- 102000044168 Fibroblast Growth Factor Receptor Human genes 0.000 title 1
- 150000007660 quinolones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000018233 Fibroblast Growth Factor Human genes 0.000 abstract 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940126864 fibroblast growth factor Drugs 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se describen compuestos que son inhibidores del crecimiento de fibroblastos (FGFR) y, por lo tanto, son útiles para el tratamiento de enfermedades que se pueden tratar mediante la inhibición de FGFR. También se describen composiciones farmacéuticas que contienen tales compuestos y procesos para preparar tales compuestos.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461937211P | 2014-02-07 | 2014-02-07 | |
| US201462007562P | 2014-06-04 | 2014-06-04 | |
| US201462069932P | 2014-10-29 | 2014-10-29 | |
| PCT/US2015/014460 WO2015120049A1 (en) | 2014-02-07 | 2015-02-04 | Quinolone derivatives as fibroblast growth factor receptor inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016010106A MX2016010106A (es) | 2016-11-15 |
| MX369369B true MX369369B (es) | 2019-11-06 |
Family
ID=52589764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016010106A MX369369B (es) | 2014-02-07 | 2015-02-04 | Derivados de quinolona como inhibidores del receptor del factor de crecimiento de fibroblastos. |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US9815834B2 (es) |
| EP (1) | EP3102577B1 (es) |
| JP (1) | JP6553629B2 (es) |
| KR (1) | KR102046448B1 (es) |
| CN (1) | CN106459034B (es) |
| AU (1) | AU2015214328B2 (es) |
| BR (1) | BR112016017137B1 (es) |
| CA (1) | CA2937746C (es) |
| CY (1) | CY1121444T1 (es) |
| DK (1) | DK3102577T3 (es) |
| ES (1) | ES2689421T3 (es) |
| HU (1) | HUE041594T2 (es) |
| IL (1) | IL246933B (es) |
| MX (1) | MX369369B (es) |
| PL (1) | PL3102577T3 (es) |
| PT (1) | PT3102577T (es) |
| RU (1) | RU2721723C2 (es) |
| SI (1) | SI3102577T1 (es) |
| WO (1) | WO2015120049A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015214328B2 (en) | 2014-02-07 | 2019-04-18 | Principia Biopharma, Inc. | Quinolone derivatives as Fibroblast Growth Factor Receptor Inhibitors |
| CA2954189A1 (en) | 2014-07-26 | 2016-02-04 | Sunshine Lake Pharma Co., Ltd. | 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof |
| TWI695831B (zh) | 2014-09-13 | 2020-06-11 | 香港商南北兄弟藥業投資有限公司 | Ｃｒｔｈ２拮抗劑化合物及其用途 |
| WO2017027567A1 (en) | 2015-08-11 | 2017-02-16 | Principia Biopharma, Inc. | Processes for preparing an fgfr inhibitor |
| CN108264510A (zh) * | 2017-01-02 | 2018-07-10 | 上海喆邺生物科技有限公司 | 一种选择性抑制激酶化合物及其用途 |
| EP3587419A4 (en) * | 2017-02-27 | 2020-08-05 | Betta Pharmaceuticals Co., Ltd. | FGFR INHIBITOR AND APPLICATION OF IT |
| JP7226804B2 (ja) * | 2017-03-03 | 2023-02-21 | オークランド ユニサービシズ リミテッド | Ｆｇｆｒキナーゼ阻害剤及び医薬用途 |
| CN110914267B (zh) * | 2017-07-19 | 2022-07-12 | 江苏奥赛康药业有限公司 | 嘧啶并吡啶酮或者吡啶并吡啶酮类化合物及其应用 |
| WO2019029541A1 (zh) * | 2017-08-08 | 2019-02-14 | 南京药捷安康生物科技有限公司 | 成纤维细胞生长因子受体抑制剂及其用途 |
| CN110016026B (zh) * | 2018-01-08 | 2022-11-25 | 上海凌济生物科技有限公司 | 一类具有抗肿瘤活性的嘧啶并吡啶酮类化合物、制备方法和用途 |
| CN112119064B (zh) * | 2018-09-14 | 2023-06-23 | 上海和誉生物医药科技有限公司 | Fgfr抑制剂、其制备方法和应用 |
| JP2022515198A (ja) | 2018-12-19 | 2022-02-17 | アレイ バイオファーマ インコーポレイテッド | ＦＧＦＲチロシンキナーゼの阻害剤としての置換ピラゾロ［１，５－ａ］ピリジン化合物 |
| JP2022515197A (ja) | 2018-12-19 | 2022-02-17 | アレイ バイオファーマ インコーポレイテッド | がんを治療するためのｆｇｆｒ阻害剤としての７－（（３，５－ジメトキシフェニル）アミノ）キノキサリン誘導体 |
| AU2020260018A1 (en) | 2019-04-19 | 2021-11-04 | Pfizer Inc. | Anti-proliferative agents for treating PAH |
| CN114174272B (zh) * | 2019-08-08 | 2023-05-12 | 漳州片仔癀药业股份有限公司 | 吡嗪-2(1h)-酮类化合物的制备方法 |
| US11697648B2 (en) | 2019-11-26 | 2023-07-11 | Theravance Biopharma R&D Ip, Llc | Fused pyrimidine pyridinone compounds as JAK inhibitors |
| CN115368219B (zh) * | 2022-10-25 | 2022-12-27 | 苏州康纯医药科技有限公司 | 一种fgfr抑制剂关键中间体的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5620981A (en) | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
| WO2004063195A1 (en) * | 2003-01-03 | 2004-07-29 | Sloan-Kettering Institute For Cancer Research | Pyridopyrimidine kinase inhibitors |
| ATE356124T1 (de) | 2003-11-13 | 2007-03-15 | Hoffmann La Roche | Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7- one |
| WO2005105097A2 (en) | 2004-04-28 | 2005-11-10 | Gpc Biotech Ag | Pyridopyrimidines for treating inflammatory and other diseases |
| WO2008150260A1 (en) | 2007-06-06 | 2008-12-11 | Gpc Biotech, Inc. | 8-oxy-2-aminopyrido (2, 3-d) pyrimidin-7-one derivatives as kinase inhibitors and anticancer agents |
| IT1395724B1 (it) | 2009-02-25 | 2012-10-19 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| AU2012327183A1 (en) * | 2011-11-04 | 2013-05-30 | Afraxis Holdings, Inc. | PAK inhibitors for the treatment of cell proliferative disorders |
| RU2679130C2 (ru) * | 2012-07-11 | 2019-02-06 | Блюпринт Медсинс Корпорейшн | Ингибиторы рецептора фактора роста фибробластов |
| US9630963B2 (en) | 2013-05-09 | 2017-04-25 | Principia Biopharma, Inc. | Quinolone derivatives as fibroblast growth factor inhibitors |
| US9851834B2 (en) | 2013-09-10 | 2017-12-26 | Alsentis, Llc | Time domain differential techniques to characterize various stimuli |
| AU2015214328B2 (en) | 2014-02-07 | 2019-04-18 | Principia Biopharma, Inc. | Quinolone derivatives as Fibroblast Growth Factor Receptor Inhibitors |
-
2015
- 2015-02-04 AU AU2015214328A patent/AU2015214328B2/en active Active
- 2015-02-04 KR KR1020167021267A patent/KR102046448B1/ko active IP Right Grant
- 2015-02-04 SI SI201530358T patent/SI3102577T1/sl unknown
- 2015-02-04 PL PL15706577T patent/PL3102577T3/pl unknown
- 2015-02-04 RU RU2016130932A patent/RU2721723C2/ru active
- 2015-02-04 WO PCT/US2015/014460 patent/WO2015120049A1/en active Application Filing
- 2015-02-04 CN CN201580007653.5A patent/CN106459034B/zh active Active
- 2015-02-04 MX MX2016010106A patent/MX369369B/es active IP Right Grant
- 2015-02-04 ES ES15706577.2T patent/ES2689421T3/es active Active
- 2015-02-04 HU HUE15706577A patent/HUE041594T2/hu unknown
- 2015-02-04 CA CA2937746A patent/CA2937746C/en active Active
- 2015-02-04 DK DK15706577.2T patent/DK3102577T3/en active
- 2015-02-04 EP EP15706577.2A patent/EP3102577B1/en active Active
- 2015-02-04 PT PT15706577T patent/PT3102577T/pt unknown
- 2015-02-04 US US15/022,869 patent/US9815834B2/en active Active
- 2015-02-04 JP JP2016550703A patent/JP6553629B2/ja active Active
- 2015-02-04 BR BR112016017137-3A patent/BR112016017137B1/pt active IP Right Grant
-
2016
- 2016-03-22 US US15/077,442 patent/US9567334B2/en active Active
- 2016-07-25 IL IL246933A patent/IL246933B/en active IP Right Grant
-
2017
- 2017-11-08 US US15/806,525 patent/US10294223B2/en active Active
-
2018
- 2018-10-18 CY CY20181101070T patent/CY1121444T1/el unknown
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2019
- 2019-04-12 US US16/383,237 patent/US11078199B2/en active Active
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2021
- 2021-05-03 US US17/306,528 patent/US20210292323A1/en not_active Abandoned
-
2023
- 2023-06-30 US US18/217,002 patent/US20240092777A1/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |