MX366223B - Proteinas vinculantes que comprenden al menos dos dominios de repeticion contra her2. - Google Patents
Proteinas vinculantes que comprenden al menos dos dominios de repeticion contra her2.Info
- Publication number
- MX366223B MX366223B MX2015006548A MX2015006548A MX366223B MX 366223 B MX366223 B MX 366223B MX 2015006548 A MX2015006548 A MX 2015006548A MX 2015006548 A MX2015006548 A MX 2015006548A MX 366223 B MX366223 B MX 366223B
- Authority
- MX
- Mexico
- Prior art keywords
- repeat domains
- binding proteins
- against her2
- domains against
- repeat
- Prior art date
Links
- 108091008324 binding proteins Proteins 0.000 title abstract 2
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 title 1
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 abstract 1
- 102000023732 binding proteins Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cell Biology (AREA)
Abstract
La presente invención se refiere a una proteína vinculante o de unión, recombinante, que comprende al menos un primer y un segundo dominio de repetición, en donde cada uno de dichos dos dominios de repetición se vincula o une a la región extracelular del HER2 y en donde dichos dominios de repetición se vinculan o unen covalentemente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12195156.0A EP2738180A1 (en) | 2012-11-30 | 2012-11-30 | Binding proteins comprising at least two binding domains against HER2. |
PCT/EP2013/075290 WO2014083208A1 (en) | 2012-11-30 | 2013-12-02 | Binding proteins comprising at least two repeat domains against her2 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015006548A MX2015006548A (es) | 2015-10-15 |
MX366223B true MX366223B (es) | 2019-07-03 |
Family
ID=47257683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015006548A MX366223B (es) | 2012-11-30 | 2013-12-02 | Proteinas vinculantes que comprenden al menos dos dominios de repeticion contra her2. |
Country Status (11)
Country | Link |
---|---|
US (1) | US10370414B2 (es) |
EP (2) | EP2738180A1 (es) |
JP (1) | JP6410724B2 (es) |
KR (1) | KR102290592B1 (es) |
CN (1) | CN104918959A (es) |
AU (2) | AU2013351096C9 (es) |
CA (1) | CA2892747C (es) |
HK (1) | HK1211297A1 (es) |
MX (1) | MX366223B (es) |
RU (1) | RU2664464C9 (es) |
WO (1) | WO2014083208A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
DK2643349T3 (da) * | 2010-11-26 | 2019-11-25 | Molecular Partners Ag | Designede repeat-proteiner, der binder til serumalbumin |
WO2014060365A1 (en) * | 2012-10-15 | 2014-04-24 | Universität Zürich Prorektorat Mnw | Bispecific her2 ligands for cancer therapy |
CN105209483B (zh) | 2013-05-31 | 2021-07-27 | 分子组合公司 | 与肝细胞生长因子结合的设计锚蛋白重复蛋白 |
CA2931356A1 (en) | 2013-11-27 | 2015-06-04 | Zymeworks Inc. | Bispecific antigen-binding constructs targeting her2 |
US10858405B2 (en) | 2015-02-06 | 2020-12-08 | Navigo Proteins Gmbh | EGFR binding proteins |
ES2953482T3 (es) | 2015-04-02 | 2023-11-13 | Molecular Partners Ag | Dominios de repetición de anquirina diseñados con especificidad de unión para la albúmina sérica |
CN107922483B (zh) | 2015-07-16 | 2021-07-30 | 纳维格蛋白质有限公司 | 新型免疫球蛋白结合蛋白及其在亲和纯化中的用途 |
US10584152B2 (en) | 2015-07-20 | 2020-03-10 | Navigo Proteins Gmbh | Binding proteins based on di-ubiquitin muteins and methods for generation |
DK3325514T3 (da) * | 2015-07-20 | 2019-12-16 | Navigo Proteins Gmbh | Her2-bindende proteiner baseret på di-ubiquitin-muteiner |
US11813336B2 (en) | 2016-05-04 | 2023-11-14 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
RU2627215C1 (ru) * | 2016-05-24 | 2017-08-03 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского" | Рекомбинантный таргетный токсин, специфичный к клеткам, экспрессирующим рецептор her2 |
WO2018029157A1 (en) | 2016-08-11 | 2018-02-15 | Navigo Proteins Gmbh | Novel alkaline stable immunoglobulin-binding proteins |
WO2018054971A1 (en) | 2016-09-22 | 2018-03-29 | Molecular Partners Ag | Recombinant binding proteins and their use |
EP3706804B1 (en) | 2017-11-07 | 2022-02-23 | Navigo Proteins GmbH | Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer |
EP3980444A1 (en) * | 2019-06-04 | 2022-04-13 | Molecular Partners AG | Designed ankyrin repeat domain with improved stability |
JP2022535107A (ja) * | 2019-06-04 | 2022-08-04 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 組換え4-1bb結合タンパク質及びそれらの使用 |
CN114206943A (zh) | 2019-06-04 | 2022-03-18 | 分子伴侣公司 | 多特异性蛋白质 |
JP2022535415A (ja) * | 2019-06-04 | 2022-08-08 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 組換えfap結合タンパク質及びそれらの使用 |
MX2022007120A (es) | 2019-12-11 | 2022-09-09 | Molecular Partners Ag | Proteínas de unión al complejo péptido-mhc recombinantes y su generación y uso. |
PE20231074A1 (es) | 2020-05-06 | 2023-07-17 | Molecular Partners Ag | Nuevas proteinas de union a repeticiones de anquirina y sus usos |
IL298168A (en) | 2020-05-14 | 2023-01-01 | Molecular Partners Ag | Multispecific proteins |
EP4263607A1 (en) | 2020-12-16 | 2023-10-25 | Molecular Partners AG | Novel slow-release prodrugs |
WO2022190008A1 (en) | 2021-03-09 | 2022-09-15 | Molecular Partners Ag | Protease cleavable prodrugs |
EP4304729A1 (en) | 2021-03-09 | 2024-01-17 | Molecular Partners AG | Novel darpin based cd123 engagers |
BR112023018293A2 (pt) | 2021-03-09 | 2023-10-31 | Molecular Partners Ag | Acopladores de célula t multiespecíficos à base de darpin |
CA3211248A1 (en) | 2021-03-09 | 2022-09-15 | Nina RESCHKE | Novel darpin based cd33 engagers |
CA3239407A1 (en) | 2021-12-14 | 2023-06-22 | Simon FONTAINE | Designed repeat domains with dual binding specificity and their use |
WO2024028278A1 (en) | 2022-08-01 | 2024-02-08 | Molecular Partners Ag | Charge modified designed repeat domains and their use |
WO2024038307A1 (en) | 2022-08-19 | 2024-02-22 | Novartis Ag | Dosing regimens for sars-cov-2 binding molecules |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0436597B1 (en) | 1988-09-02 | 1997-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
US5348867A (en) | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
US7371376B1 (en) | 1996-10-18 | 2008-05-13 | Genentech, Inc. | Anti-ErbB2 antibodies |
CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
EP0975748B1 (en) | 1997-04-23 | 2006-03-29 | Universität Zürich | Methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules |
ES2280131T3 (es) | 1998-12-02 | 2007-09-01 | Adnexus Therapeutics, Inc. | Fusiones de adn-proteina y utilizaciones de las mismas. |
US7417130B2 (en) | 2000-09-08 | 2008-08-26 | University Of Zurich | Collection of repeat proteins comprising repeat modules |
CA2565827A1 (en) * | 2004-05-05 | 2005-12-15 | Merrimack Pharmaceuticals, Inc. | Bispecific binding agents for modulating biological activity |
KR20190035967A (ko) * | 2004-07-22 | 2019-04-03 | 제넨테크, 인크. | Her2 항체 조성물 |
MX2008000345A (es) | 2005-07-08 | 2008-04-02 | Univ Zuerich | Visualizacion en fagos usando transcolocacion contraduccional de polipeptidos de fusion. |
WO2007103515A2 (en) | 2006-03-06 | 2007-09-13 | Amunix, Inc. | Unstructured recombinant polymers and uses thereof |
CA2691386C (en) | 2007-06-21 | 2014-12-23 | Technische Universitaet Muenchen | Biological active proteins having increased in vivo and/or in vitro stability |
CA2700391A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zuerich | Designed armadillo repeat proteins |
AU2008328784B2 (en) | 2007-11-27 | 2014-03-27 | Ablynx N.V. | Immunoglobulin constructs |
US20100260668A1 (en) * | 2008-04-29 | 2010-10-14 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
CN102272148A (zh) | 2008-11-03 | 2011-12-07 | 分子组合公司 | 抑制vegf-a受体相互作用的结合蛋白 |
TW201120210A (en) * | 2009-11-05 | 2011-06-16 | Hoffmann La Roche | Glycosylated repeat-motif-molecule conjugates |
AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
DK2643349T3 (da) | 2010-11-26 | 2019-11-25 | Molecular Partners Ag | Designede repeat-proteiner, der binder til serumalbumin |
WO2012149439A2 (en) | 2011-04-29 | 2012-11-01 | Janssen Biotech, Inc. | Il4/il13 binding repeat proteins and uses |
WO2012162418A1 (en) * | 2011-05-23 | 2012-11-29 | The University Of North Carolina At Chapel Hill | Methods and compositions for heterodimeric targeting ligands |
RU2014150224A (ru) | 2012-06-28 | 2016-08-20 | Молекьюлар Партнерс Аг | Сконструированный белок с анкириновым повтором, связывающийся с фактором роста тромбоцитов |
WO2014060365A1 (en) | 2012-10-15 | 2014-04-24 | Universität Zürich Prorektorat Mnw | Bispecific her2 ligands for cancer therapy |
CN105209483B (zh) | 2013-05-31 | 2021-07-27 | 分子组合公司 | 与肝细胞生长因子结合的设计锚蛋白重复蛋白 |
-
2012
- 2012-11-30 EP EP12195156.0A patent/EP2738180A1/en not_active Withdrawn
-
2013
- 2013-12-02 JP JP2015544498A patent/JP6410724B2/ja active Active
- 2013-12-02 CA CA2892747A patent/CA2892747C/en active Active
- 2013-12-02 KR KR1020157017376A patent/KR102290592B1/ko active IP Right Grant
- 2013-12-02 US US14/648,611 patent/US10370414B2/en active Active
- 2013-12-02 MX MX2015006548A patent/MX366223B/es active IP Right Grant
- 2013-12-02 WO PCT/EP2013/075290 patent/WO2014083208A1/en active Application Filing
- 2013-12-02 AU AU2013351096A patent/AU2013351096C9/en active Active
- 2013-12-02 CN CN201380062520.9A patent/CN104918959A/zh active Pending
- 2013-12-02 EP EP13811818.7A patent/EP2925784B1/en active Active
- 2013-12-02 RU RU2015120663A patent/RU2664464C9/ru active
-
2015
- 2015-10-15 HK HK15110090.1A patent/HK1211297A1/xx unknown
-
2018
- 2018-11-01 AU AU2018256592A patent/AU2018256592A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US10370414B2 (en) | 2019-08-06 |
JP2015537044A (ja) | 2015-12-24 |
AU2013351096C1 (en) | 2018-11-08 |
US20150299265A1 (en) | 2015-10-22 |
KR102290592B1 (ko) | 2021-08-19 |
AU2013351096C9 (en) | 2019-01-31 |
RU2015120663A (ru) | 2017-01-10 |
RU2664464C9 (ru) | 2018-12-19 |
AU2013351096A1 (en) | 2015-07-09 |
CA2892747A1 (en) | 2014-06-05 |
JP6410724B2 (ja) | 2018-10-24 |
WO2014083208A9 (en) | 2014-12-24 |
AU2018256592A1 (en) | 2018-11-22 |
KR20150091138A (ko) | 2015-08-07 |
BR112015012436A2 (pt) | 2017-09-12 |
WO2014083208A8 (en) | 2014-10-30 |
CA2892747C (en) | 2022-07-19 |
MX2015006548A (es) | 2015-10-15 |
AU2013351096B2 (en) | 2018-08-09 |
CN104918959A (zh) | 2015-09-16 |
EP2925784A1 (en) | 2015-10-07 |
WO2014083208A1 (en) | 2014-06-05 |
EP2738180A1 (en) | 2014-06-04 |
RU2664464C2 (ru) | 2018-08-17 |
HK1211297A1 (en) | 2016-05-20 |
EP2925784B1 (en) | 2021-02-17 |
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