MX365923B - Derivados de acido carboxilico que comprenden cuatro ciclos, que actuan como moduladores del receptor del peptido 1 similar al glucagon (glp-1) para terapia de enfermedades como la diabetes. - Google Patents

Derivados de acido carboxilico que comprenden cuatro ciclos, que actuan como moduladores del receptor del peptido 1 similar al glucagon (glp-1) para terapia de enfermedades como la diabetes.

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Publication number
MX365923B
MX365923B MX2014006622A MX2014006622A MX365923B MX 365923 B MX365923 B MX 365923B MX 2014006622 A MX2014006622 A MX 2014006622A MX 2014006622 A MX2014006622 A MX 2014006622A MX 365923 B MX365923 B MX 365923B
Authority
MX
Mexico
Prior art keywords
glp
diabetes
compounds
diseases
therapy
Prior art date
Application number
MX2014006622A
Other languages
English (en)
Other versions
MX2014006622A (es
Inventor
Tamiya Junko
F Boehm Marcus
Martinborough Esther
Moorjani Manisha
Huang Liming
r yeager Adam
Brahmachary Enugurthi
Fowler Thomas
Novak Andrew
Meghani Premji
Knaggs Michael
Original Assignee
Celgene Int Ii Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Int Ii Sarl filed Critical Celgene Int Ii Sarl
Publication of MX2014006622A publication Critical patent/MX2014006622A/es
Publication of MX365923B publication Critical patent/MX365923B/es

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    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
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Abstract

La invención se refiere a los compuestos que están caracterizados por poseer al menos cuatro ciclos (A-C y anillo de fenileno). Tales compuestos modulan el receptor del péptido 1 similar al glucagón (GLP-1) y tienen un uso terapéutico que incluye trastornos tales como diabetes, obesidad y apetito excesivo. Los compuestos actúan como moduladores o potenciadores del receptor de GLP-1, o actúan con los ligandos del receptor incluyendo los péptidos de GLP-1, GLP-1(7-36) y GLP-1(9-36), o con las terapias basadas en péptidos, tales como exenátido y el liraglútido. Se reclaman los compuestos de las siguientes estructuras generales ("~"1 representa estereoquímica no definida): [Fórmula I] donde las variables A, B, C, Y1, Y2, Z, R1, R2, R3, R4, R5, W1, n, p y q son como se definen en las reivindicaciones.
MX2014006622A 2011-12-12 2012-12-12 Derivados de acido carboxilico que comprenden cuatro ciclos, que actuan como moduladores del receptor del peptido 1 similar al glucagon (glp-1) para terapia de enfermedades como la diabetes. MX365923B (es)

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