IT1062206B - Derivati della tirosina attivi sulla muscolatura liscia - Google Patents
Derivati della tirosina attivi sulla muscolatura lisciaInfo
- Publication number
- IT1062206B IT1062206B IT67286/74A IT6728674A IT1062206B IT 1062206 B IT1062206 B IT 1062206B IT 67286/74 A IT67286/74 A IT 67286/74A IT 6728674 A IT6728674 A IT 6728674A IT 1062206 B IT1062206 B IT 1062206B
- Authority
- IT
- Italy
- Prior art keywords
- thyrosin
- smooth muscle
- derivatives active
- derivatives
- active
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT67286/74A IT1062206B (it) | 1974-02-01 | 1974-02-01 | Derivati della tirosina attivi sulla muscolatura liscia |
GB287875A GB1467927A (en) | 1974-02-01 | 1975-01-22 | Derivatives of tyrosine having a pharmaceutical activity on smooth muscles |
ZA00750530A ZA75530B (en) | 1974-02-01 | 1975-01-24 | New derivatives of tyrosine having a pharmaceutical activity on smooth muscles |
IN179/CAL/75A IN139364B (it) | 1974-02-01 | 1975-01-29 | |
AU77750/75A AU482567B2 (en) | 1975-01-30 | New derivatives of tyrosine having a pharmaceutical activity on smooth muscles | |
FI750255A FI61479C (fi) | 1974-02-01 | 1975-01-30 | Foerfarande foer framstaellning av spasmolytiska nya d,l-tyrosinderivat |
CH110975A CH605658A5 (it) | 1974-02-01 | 1975-01-30 | |
CA75219028A CA1048503A (en) | 1974-02-01 | 1975-01-30 | Method of preparing new derivatives of d, l-tyrosine having a pharmaceutical activity on smooth muscles |
CH110875A CH605657A5 (it) | 1974-02-01 | 1975-01-30 | |
NO750288A NO144211C (no) | 1974-02-01 | 1975-01-30 | Analogifremgangsmaate til fremstilling av nye tyrosinderivater med farmasoeytisk virkning paa glatte muskler |
BE152889A BE824995A (fr) | 1974-02-01 | 1975-01-30 | Nouveaux derives de tyrosine doues d'activite sur les muscles lisses |
FI750256A FI63744C (fi) | 1974-02-01 | 1975-01-30 | Foerfarande foer framstaellning av nya spasmolytiska tyrosinderivat |
NO750287A NO144210C (no) | 1974-02-01 | 1975-01-30 | Analogifremgangsmaate til fremstilling av nye dl-tyrosinderivater med farmasoeytisk virkning paa glatte muskler |
CA219,027A CA1047498A (en) | 1974-02-01 | 1975-01-30 | Method of preparing new derivatives of tyrosine having a pharmaceutical activity on smooth muscles |
ES434323A ES434323A1 (es) | 1974-02-01 | 1975-01-31 | Un metodo para la preparacion de nuevos derivados de d, l- tirosina. |
SE7501115A SE413094B (sv) | 1974-02-01 | 1975-01-31 | Analogiforfarande for framstellning av tyrosinderivat med farmaceutisk aktivitet pa glatt muskulatur |
DE2503992A DE2503992C2 (de) | 1974-02-01 | 1975-01-31 | Tyrosinamide und diese Verbindungen enthaltende Arzneimittel |
NL7501193A NL167683C (nl) | 1974-02-01 | 1975-01-31 | Werkwijze voor het bereiden of vervaardigen van een farmaceutisch n-acylfenylalanylamiden. |
SE7501114A SE410850B (sv) | 1974-02-01 | 1975-01-31 | Forfarande for framstellning av d,l-tyrosinderivat med farmacentisk aktivitet pa glatt muskulatur |
JP1326675A JPS5417728B2 (it) | 1974-02-01 | 1975-01-31 | |
HU75RO821A HU175156B (hu) | 1974-02-01 | 1975-01-31 | Sposob poluchenija novykh proizvodnykh l- i dl-tirozinov |
AT74675A AT343632B (de) | 1974-02-01 | 1975-01-31 | Verfahren zur herstellung von neuen l- oder dl-tyrosinamiden |
AT74575A AT342026B (de) | 1974-02-01 | 1975-01-31 | Verfahren zur herstellung von neuen d,l-n-acyltyrosinamiden |
HU75RO820A HU174825B (hu) | 1974-02-01 | 1975-01-31 | Sposob poluchenija novykh proizvodnykh dl-tirozina |
JP1328575A JPS5417729B2 (it) | 1974-02-01 | 1975-01-31 | |
FR7503079A FR2259592B1 (it) | 1974-02-01 | 1975-01-31 | |
US05/546,481 US4004008A (en) | 1974-02-01 | 1975-02-03 | O-Tertiary amino-alkyl-N-benzoyl tyrosil amides |
HK389/79A HK38979A (en) | 1974-02-01 | 1979-06-14 | New derivatives of tyrosine having a pharmaceutical activity on smooth muscles |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT67286/74A IT1062206B (it) | 1974-02-01 | 1974-02-01 | Derivati della tirosina attivi sulla muscolatura liscia |
Publications (1)
Publication Number | Publication Date |
---|---|
IT1062206B true IT1062206B (it) | 1983-09-20 |
Family
ID=11301149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT67286/74A IT1062206B (it) | 1974-02-01 | 1974-02-01 | Derivati della tirosina attivi sulla muscolatura liscia |
Country Status (19)
Country | Link |
---|---|
US (1) | US4004008A (it) |
JP (2) | JPS5417728B2 (it) |
AT (2) | AT342026B (it) |
BE (1) | BE824995A (it) |
CA (2) | CA1047498A (it) |
CH (2) | CH605657A5 (it) |
DE (1) | DE2503992C2 (it) |
ES (1) | ES434323A1 (it) |
FI (2) | FI61479C (it) |
FR (1) | FR2259592B1 (it) |
GB (1) | GB1467927A (it) |
HK (1) | HK38979A (it) |
HU (2) | HU174825B (it) |
IN (1) | IN139364B (it) |
IT (1) | IT1062206B (it) |
NL (1) | NL167683C (it) |
NO (2) | NO144210C (it) |
SE (2) | SE410850B (it) |
ZA (1) | ZA75530B (it) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5225243A (en) * | 1975-08-20 | 1977-02-25 | Toshiba Electric Equip Corp | Distributing panel |
US4579866A (en) * | 1984-05-29 | 1986-04-01 | Usv Pharmaceutical Corp. | Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents |
CA1320734C (en) * | 1986-02-04 | 1993-07-27 | Suntory Limited | Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same |
US5198458A (en) * | 1986-02-04 | 1993-03-30 | Suntory Limited | Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same |
IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical preparations containing them |
NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
US5258407A (en) * | 1991-12-31 | 1993-11-02 | Sterling Winthrop Inc. | 3,4-disubstituted phenols-immunomodulating agents |
US5206373A (en) * | 1992-02-28 | 1993-04-27 | Merck & Co., Inc. | Process for preparing fibrinogen receptor antagonists |
DE10204951A1 (de) * | 2002-02-06 | 2003-08-14 | Basf Ag | Phenylalaninderivate als Herbizide |
EA200601105A1 (ru) * | 2003-12-19 | 2006-12-29 | Басф Акциенгезельшафт | Замещённые бензоилом фенилаланин-амиды |
BRPI0613423A2 (pt) * | 2005-07-19 | 2012-12-11 | Daiichi Sankyo Co Ltd | composição farmacêutica, composto ou um seu sal farmaceuticamente aceitável, e, uso de um composto ou um sal farmaceuticamente aceitável do mesmo |
WO2011094890A1 (en) | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
US8501982B2 (en) * | 2010-06-09 | 2013-08-06 | Receptos, Inc. | GLP-1 receptor stabilizers and modulators |
US9278910B2 (en) | 2011-05-31 | 2016-03-08 | Receptos, Inc. | GLP-1 receptor stabilizers and modulators |
JP6061949B2 (ja) | 2011-12-12 | 2017-01-18 | レセプトス エルエルシー | 糖尿病などの疾患の治療のためのglp−1受容体モジュレーターとして作用する4つの環を含むカルボン酸誘導体 |
CN102659619A (zh) * | 2012-04-18 | 2012-09-12 | 上海骏捷生化科技有限公司 | 一种合成酪氨酸衍生物的方法 |
CN103508920B (zh) * | 2012-06-21 | 2016-03-02 | 贵州百灵企业集团制药股份有限公司 | 一种苯丙氨醇化合物的光学异构体的制备方法及其用途 |
CN103508921B (zh) * | 2012-06-21 | 2015-09-30 | 贵州百灵企业集团制药股份有限公司 | 一种苯丙氨醇化合物的制备方法 |
EA030857B1 (ru) | 2013-06-11 | 2018-10-31 | Селджин Интернэшнл Ii Сарл | Новые модуляторы рецептора glp-1 |
SG11201700364PA (en) | 2014-07-25 | 2017-02-27 | Celgene Internat Ii Sarl | Novel glp-1 receptor modulators |
EP3230276B1 (en) | 2014-12-10 | 2020-09-02 | Celgene International II Sarl | Glp-1 receptor modulators |
CN107417560B (zh) * | 2017-03-30 | 2020-05-22 | 上海常丰生物医药科技有限公司 | 一种合成盐酸替罗酰胺的方法 |
CN110015978B (zh) * | 2019-04-29 | 2021-03-19 | 康化(上海)新药研发有限公司 | O-[2-[[叔丁氧羰基]氨基]乙基]-n-[芴甲氧羰基]-l-酪氨酸的合成方法 |
CN115850107A (zh) * | 2022-11-30 | 2023-03-28 | 苏州诚和医药化学有限公司 | 一种工业化合成盐酸替罗酰胺的方法 |
-
1974
- 1974-02-01 IT IT67286/74A patent/IT1062206B/it active Protection Beyond IP Right Term
-
1975
- 1975-01-22 GB GB287875A patent/GB1467927A/en not_active Expired
- 1975-01-24 ZA ZA00750530A patent/ZA75530B/xx unknown
- 1975-01-29 IN IN179/CAL/75A patent/IN139364B/en unknown
- 1975-01-30 CH CH110875A patent/CH605657A5/xx not_active IP Right Cessation
- 1975-01-30 FI FI750255A patent/FI61479C/fi not_active IP Right Cessation
- 1975-01-30 CA CA219,027A patent/CA1047498A/en not_active Expired
- 1975-01-30 NO NO750287A patent/NO144210C/no unknown
- 1975-01-30 BE BE152889A patent/BE824995A/xx not_active IP Right Cessation
- 1975-01-30 CH CH110975A patent/CH605658A5/xx not_active IP Right Cessation
- 1975-01-30 NO NO750288A patent/NO144211C/no unknown
- 1975-01-30 CA CA75219028A patent/CA1048503A/en not_active Expired
- 1975-01-30 FI FI750256A patent/FI63744C/fi not_active IP Right Cessation
- 1975-01-31 ES ES434323A patent/ES434323A1/es not_active Expired
- 1975-01-31 AT AT74575A patent/AT342026B/de not_active IP Right Cessation
- 1975-01-31 HU HU75RO820A patent/HU174825B/hu unknown
- 1975-01-31 SE SE7501114A patent/SE410850B/xx not_active IP Right Cessation
- 1975-01-31 NL NL7501193A patent/NL167683C/xx not_active IP Right Cessation
- 1975-01-31 JP JP1326675A patent/JPS5417728B2/ja not_active Expired
- 1975-01-31 AT AT74675A patent/AT343632B/de not_active IP Right Cessation
- 1975-01-31 SE SE7501115A patent/SE413094B/xx unknown
- 1975-01-31 FR FR7503079A patent/FR2259592B1/fr not_active Expired
- 1975-01-31 DE DE2503992A patent/DE2503992C2/de not_active Expired
- 1975-01-31 HU HU75RO821A patent/HU175156B/hu unknown
- 1975-01-31 JP JP1328575A patent/JPS5417729B2/ja not_active Expired
- 1975-02-03 US US05/546,481 patent/US4004008A/en not_active Expired - Lifetime
-
1979
- 1979-06-14 HK HK389/79A patent/HK38979A/xx unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ITCP | Complementary protection certificate |
Free format text: CCP 67 |
|
MEDD | Supplementary protection certificate for pharmaceutical products: granted |
Free format text: CCP 67, 19920323; ROTTA RESEARCH LABORATORIUM S.P.A. |