MX363667B - Antigenos de consenso del virus sincitial respiratorio humano, constructos de acido nucleico y vacunas hechas de estos, y metodos para utilizarlas. - Google Patents

Antigenos de consenso del virus sincitial respiratorio humano, constructos de acido nucleico y vacunas hechas de estos, y metodos para utilizarlas.

Info

Publication number
MX363667B
MX363667B MX2014012234A MX2014012234A MX363667B MX 363667 B MX363667 B MX 363667B MX 2014012234 A MX2014012234 A MX 2014012234A MX 2014012234 A MX2014012234 A MX 2014012234A MX 363667 B MX363667 B MX 363667B
Authority
MX
Mexico
Prior art keywords
rsv
nucleic acid
methods
disclosed
sequences
Prior art date
Application number
MX2014012234A
Other languages
English (en)
Other versions
MX2014012234A (es
Inventor
B Weiner David
Choo Daniel
Mathumani Karuppiah
Obeng-Adjei Nyamekye
Scott Veronica
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of MX2014012234A publication Critical patent/MX2014012234A/es
Publication of MX363667B publication Critical patent/MX363667B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a moléculas de ácido nucleico y composiciones que comprenden una o más secuencias de ácido nucleico que codifican un antígeno RSV. El ácido nucleico se describe comprendiendo las secuencias que codifican la proteína RSV F de consenso o uno de sus fragmentos inmunogénicos, secuencias que codifican a la proteína RSV G(A) o uno de sus fragmentos inmunogénicos y secuencias que codifican la proteína RSV G(B) o uno de sus fragmentos inmunogénicos. Las composiciones que comprende una, combinaciones de dos o las tres secuencias se describen. Las secuencias de codificación opcionalmente incluyen la secuencia de codificación operablemente enlazada que codifica un péptido de señal. Las moléculas de ácido nucleico y las composiciones que comprenden la quimiocina CC20 y/o una proteína RSV M2-1 de consenso o uno de sus fragmentos inmunogénicos también se describen. Los métodos inmunomoduladores e incluyendo métodos para inducir unan respuesta inmunitaria frente a RSV se describen. El método para la prevención de la infección por RSV y métodos para el tratamiento de individuos afectados con RSV se describen.
MX2014012234A 2012-04-10 2013-04-10 Antigenos de consenso del virus sincitial respiratorio humano, constructos de acido nucleico y vacunas hechas de estos, y metodos para utilizarlas. MX363667B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261622279P 2012-04-10 2012-04-10
PCT/US2013/036008 WO2013155205A1 (en) 2012-04-10 2013-04-10 Human respiratory syncytial virus concensus antigens, nucleic acid constructs and vaccines made thereform, and methods of using same

Publications (2)

Publication Number Publication Date
MX2014012234A MX2014012234A (es) 2014-12-05
MX363667B true MX363667B (es) 2019-03-29

Family

ID=49328131

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014012234A MX363667B (es) 2012-04-10 2013-04-10 Antigenos de consenso del virus sincitial respiratorio humano, constructos de acido nucleico y vacunas hechas de estos, y metodos para utilizarlas.
MX2019003682A MX2019003682A (es) 2012-04-10 2014-10-09 Antigenos de consenso del virus sincitial respiratorio humano, constructos de acido nucleico y vacunas hechas de estos, y metodos para utilizarlas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019003682A MX2019003682A (es) 2012-04-10 2014-10-09 Antigenos de consenso del virus sincitial respiratorio humano, constructos de acido nucleico y vacunas hechas de estos, y metodos para utilizarlas.

Country Status (10)

Country Link
US (2) US10040828B2 (es)
EP (2) EP2836505B1 (es)
JP (3) JP2015514132A (es)
KR (1) KR20140146651A (es)
CN (1) CN104619719A (es)
AU (1) AU2013245950B2 (es)
CA (1) CA2870182A1 (es)
HK (1) HK1210479A1 (es)
MX (2) MX363667B (es)
WO (1) WO2013155205A1 (es)

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MA50335A (fr) 2016-12-08 2020-08-19 Modernatx Inc Vaccins à acide nucléique contre des virus respiratoires
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Also Published As

Publication number Publication date
JP2015514132A (ja) 2015-05-18
JP2018065824A (ja) 2018-04-26
CA2870182A1 (en) 2013-10-17
US20180346522A1 (en) 2018-12-06
JP2019112414A (ja) 2019-07-11
EP2836505A1 (en) 2015-02-18
WO2013155205A9 (en) 2013-12-05
WO2013155205A1 (en) 2013-10-17
EP3511337A1 (en) 2019-07-17
HK1210479A1 (en) 2016-04-22
US20150079121A1 (en) 2015-03-19
CN104619719A (zh) 2015-05-13
EP2836505A4 (en) 2015-12-02
KR20140146651A (ko) 2014-12-26
AU2013245950A1 (en) 2014-10-30
US11021520B2 (en) 2021-06-01
EP2836505B1 (en) 2019-01-23
US10040828B2 (en) 2018-08-07
MX2014012234A (es) 2014-12-05
MX2019003682A (es) 2019-07-18
AU2013245950B2 (en) 2016-04-21

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