MX359736B - Lipidos de aminoacidos. - Google Patents
Lipidos de aminoacidos.Info
- Publication number
- MX359736B MX359736B MX2014010810A MX2014010810A MX359736B MX 359736 B MX359736 B MX 359736B MX 2014010810 A MX2014010810 A MX 2014010810A MX 2014010810 A MX2014010810 A MX 2014010810A MX 359736 B MX359736 B MX 359736B
- Authority
- MX
- Mexico
- Prior art keywords
- group
- formula
- lipids
- orc
- ore
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se dirige a una nueva clase de lípidos, más específicamente éter-lípidos que tienen un grupo principal polar, así como también vesículas que comprenden estos lípidos, métodos para su preparación así como también sus usos en aplicaciones médicas, en donde los éter-lípidos son representados por la fórmula (I) en donde Y representa O, N, S o un enlace covalente; P1 representa H, un grupo protector de Y o un grupo activador de Y o un grupo separador; P2, P3 representan independientemente entre sí H, un grupo protector de amino o un grupo separador, o P2 y P3 forman junto con el átomo de N al cual están unidos una estructura de anillo; L es un grupo de la fórmula (a) en donde la línea discontinua representa el vínculo a N; R1 representa H o un grupo de la fórmula -(CH2)2-ORb1; R1 representa H o un grupo de la fórmula -(CH2)2-ORb2, R2 representa H o un grupo de la fórmula -CH2-ORc; R2 representa H o un grupo de la fórmula -ORd o -CH2-ORc,´ R2 representa H o un grupo de la fórmula -(CH2)2-ORe o -(CH2)3-ORe; Ra, Rb1, Rb2, Rc, Rd, Re representan independientemente entre sí una cadena de hidrocarburo recta o ramificada, saturada o insaturada y m es 1, 2 o 3; con la condición de que por lo menos uno de R1, R1', R2, R2', R3 no sea H.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12001793 | 2012-03-16 | ||
| PCT/EP2013/000699 WO2013135360A1 (en) | 2012-03-16 | 2013-03-11 | Aminoacid lipids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014010810A MX2014010810A (es) | 2014-12-08 |
| MX359736B true MX359736B (es) | 2018-10-09 |
Family
ID=47901939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014010810A MX359736B (es) | 2012-03-16 | 2013-03-11 | Lipidos de aminoacidos. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9796666B2 (es) |
| EP (1) | EP2825157B1 (es) |
| JP (1) | JP6457816B2 (es) |
| KR (1) | KR102081046B1 (es) |
| CN (1) | CN104168887B (es) |
| AU (1) | AU2013231819B2 (es) |
| BR (1) | BR112014022847B1 (es) |
| CA (1) | CA2867184C (es) |
| DK (1) | DK2825157T3 (es) |
| ES (1) | ES2700742T3 (es) |
| HK (1) | HK1199819A1 (es) |
| HU (1) | HUE040256T2 (es) |
| MX (1) | MX359736B (es) |
| NZ (1) | NZ630990A (es) |
| PL (1) | PL2825157T3 (es) |
| PT (1) | PT2825157T (es) |
| RU (1) | RU2670618C2 (es) |
| SG (2) | SG10201610402VA (es) |
| SI (1) | SI2825157T1 (es) |
| TW (1) | TWI606030B (es) |
| WO (1) | WO2013135360A1 (es) |
| ZA (1) | ZA201407491B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2644778T3 (es) * | 2012-03-16 | 2017-11-30 | Merck Patent Gmbh | Administración dirigida de lípidos-aminoácidos |
| EP2959509B1 (en) | 2013-02-14 | 2018-05-23 | Nanopareil, Llc | Electrospun hybrid nanofibre felt, method for making the same, and method for purifying biomolecules |
| EP2971010B1 (en) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US10232050B1 (en) | 2014-12-12 | 2019-03-19 | Clemson University | Multi-functional particles and methods of using the same |
| US11633355B2 (en) | 2014-12-12 | 2023-04-25 | Clemson University Research Foundation | Multi-functional particles and methods of using the same |
| KR101929763B1 (ko) * | 2015-11-11 | 2018-12-17 | 요코하마 고무 가부시키가이샤 | 타이어의 세정 시스템 |
| CN106083637B (zh) * | 2016-06-06 | 2018-11-23 | 大连民族大学 | 味精类脂、味精脂质体的合成方法及其应用 |
| US10501416B2 (en) * | 2016-06-24 | 2019-12-10 | Eisai R&D Management Co., Ltd. | Cationic lipid |
| JP2019524781A (ja) * | 2016-08-03 | 2019-09-05 | ニューロポア セラピーズ インコーポレイテッド | Ｔｌｒ２二量体化調節剤としての脂質置換アミノ１，２−ジオール化合物および脂質置換アミノ１，３−ジオール化合物 |
| EP3733647B1 (en) | 2017-12-27 | 2022-06-15 | Eisai R&D Management Co., Ltd. | Cationic lipid |
| CN112010995A (zh) * | 2019-05-30 | 2020-12-01 | 株式会社大赛璐 | 壳聚糖衍生物及光学异构体用分离剂 |
| CN114177136B (zh) * | 2020-09-12 | 2023-08-01 | 苏州优诺康医药科技有限公司 | 一种可注射用的两亲性嵌段共聚物纳米载药胶束 |
| WO2023232148A1 (zh) * | 2022-06-02 | 2023-12-07 | 厦门赛诺邦格生物科技股份有限公司 | 一种含有不饱和键的氨基酸阳离子脂质 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2967069D1 (en) | 1978-01-16 | 1984-08-02 | Univ Boston | Effecting cellular uptake of molecules |
| US4144034A (en) * | 1978-03-27 | 1979-03-13 | Texaco Inc. | Polyether-maleic anhydride reaction product containing motor fuel composition |
| US4144036A (en) | 1978-03-27 | 1979-03-13 | Texaco Inc. | Detergent fuel composition |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US6030954A (en) | 1991-09-05 | 2000-02-29 | University Of Connecticut | Targeted delivery of poly- or oligonucleotides to cells |
| US6335434B1 (en) | 1998-06-16 | 2002-01-01 | Isis Pharmaceuticals, Inc., | Nucleosidic and non-nucleosidic folate conjugates |
| IT1254135B (it) | 1992-01-16 | 1995-09-08 | Sigma Tau Ind Farmaceuti | Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica. |
| US6214388B1 (en) | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
| DE19521412A1 (de) * | 1995-06-14 | 1996-12-19 | Boehringer Mannheim Gmbh | Neue kationische und polykationische Amphiphile, diese enthaltende Reagenzien und deren Verwendung |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| EP0975370B9 (en) | 1997-05-21 | 2004-11-03 | The Board Of Trustees Of The Leland Stanford Junior University | Composition and method for enhancing transport across biological membranes |
| EP2415486B1 (en) | 2001-05-18 | 2017-02-22 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| JP5093547B2 (ja) * | 2001-08-24 | 2012-12-12 | 日本ケミカルリサーチ株式会社 | 両イオン性脂質およびその用途 |
| WO2003022910A1 (en) | 2001-09-08 | 2003-03-20 | Access Pharmaceuticals, Inc. | Synthesis and uses of polymer gel nanoparticle networks |
| EP1308167A1 (de) | 2001-11-06 | 2003-05-07 | Pickl, Winfried, Ao. Univ. Prof. Dr. | Antigenpräsentierende Vesikel |
| EP1572918B1 (en) * | 2002-04-15 | 2011-10-19 | Oncothyreon Inc. | Synthetic glyco-lipo-peptides as vaccines |
| US7226636B2 (en) * | 2003-07-31 | 2007-06-05 | Los Alamos National Security, Llc | Gold-coated nanoparticles for use in biotechnology applications |
| JP5059411B2 (ja) * | 2003-12-19 | 2012-10-24 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 短鎖干渉ｒｎａの細胞トランスフェクティング処方物、関連する組成物および作製方法ならびに使用 |
| US20100028450A1 (en) | 2006-01-25 | 2010-02-04 | The Board Of Trustees Of The University Of Illinoi S | Tolerogenic biodegradable artificial antigen presenting system |
| JP5253716B2 (ja) * | 2006-02-09 | 2013-07-31 | 日本ケミカルリサーチ株式会社 | ｐＨ応答性分子集合体 |
| WO2008062911A1 (fr) * | 2006-11-24 | 2008-05-29 | Waseda University | Réactif pour l'introduction d'une protéine ou d'un gène |
| HUE040417T2 (hu) * | 2007-05-04 | 2019-03-28 | Marina Biotech Inc | Aminosavlipidek és alkalmazásuk |
| WO2009129387A2 (en) * | 2008-04-16 | 2009-10-22 | Abbott Laboratories | Cationic lipids and uses thereof |
| US20120294924A1 (en) | 2011-04-29 | 2012-11-22 | Thomas Tice | Peptide-Lipid Conjugates And Uses Thereof |
-
2013
- 2013-03-11 MX MX2014010810A patent/MX359736B/es active IP Right Grant
- 2013-03-11 WO PCT/EP2013/000699 patent/WO2013135360A1/en active Application Filing
- 2013-03-11 PL PL13710787T patent/PL2825157T3/pl unknown
- 2013-03-11 US US14/385,178 patent/US9796666B2/en active Active
- 2013-03-11 HU HUE13710787A patent/HUE040256T2/hu unknown
- 2013-03-11 SG SG10201610402VA patent/SG10201610402VA/en unknown
- 2013-03-11 JP JP2014561311A patent/JP6457816B2/ja active Active
- 2013-03-11 AU AU2013231819A patent/AU2013231819B2/en active Active
- 2013-03-11 ES ES13710787T patent/ES2700742T3/es active Active
- 2013-03-11 PT PT13710787T patent/PT2825157T/pt unknown
- 2013-03-11 RU RU2014141547A patent/RU2670618C2/ru active
- 2013-03-11 DK DK13710787.6T patent/DK2825157T3/da active
- 2013-03-11 SG SG11201405536YA patent/SG11201405536YA/en unknown
- 2013-03-11 EP EP13710787.6A patent/EP2825157B1/en active Active
- 2013-03-11 CN CN201380013769.0A patent/CN104168887B/zh active Active
- 2013-03-11 CA CA2867184A patent/CA2867184C/en active Active
- 2013-03-11 BR BR112014022847-7A patent/BR112014022847B1/pt active IP Right Grant
- 2013-03-11 SI SI201331279T patent/SI2825157T1/sl unknown
- 2013-03-11 KR KR1020147028907A patent/KR102081046B1/ko active IP Right Grant
- 2013-03-11 NZ NZ630990A patent/NZ630990A/en unknown
- 2013-03-15 TW TW102109379A patent/TWI606030B/zh active
-
2014
- 2014-10-15 ZA ZA2014/07491A patent/ZA201407491B/en unknown
-
2015
- 2015-01-09 HK HK15100275.9A patent/HK1199819A1/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2014010810A (es) | Lipidos de aminoacidos. | |
| CY1121225T1 (el) | Συμπυκνωμενες iμιδαζολυλιμιδαζολες ως αντιiκες ενωσεις | |
| DOP2016000287A (es) | Composiciones y métodos para modular la expresión de ttr y vh | |
| DOP2017000205A (es) | Composiciones y métodos para activar la señalización dependiente del "estimulador del gen de interferon" | |
| EA201890942A1 (ru) | Мультивалентные вакцины с синтетическими наноносителями | |
| TR201903066T4 (tr) | E. colı'de enzimatik konjugasyonla rekombinant aşı üretimi. | |
| MX2016007063A (es) | Peptidos terapeuticos. | |
| CR20130560A (es) | Compuestos de bezotiazol y su uso farmacéutico | |
| BR112014013526A8 (pt) | conjugados de anticorpo-fármaco e compostos, composições e métodos relacionados | |
| IN2014CN04251A (es) | ||
| EA201992133A1 (ru) | Производные пиперидино-пиримидина для лечения вирусных инфекций | |
| WO2013033438A3 (en) | Nanoparticle peg modification with h-phosphonates | |
| EA201390203A1 (ru) | Способы получения тубулизинов | |
| MX2021000715A (es) | Composiciones y metodos para tratar trastornos metabolicos. | |
| IN2015DN03322A (es) | ||
| EA201590667A1 (ru) | Ациламинопиримидиновые производные для лечения вирусных инфекций и других заболеваний | |
| CO7160080A2 (es) | Composiciones lipídicas de racecadotrillo | |
| BR112012030482A2 (pt) | tratamento de diabetes tipo 2 | |
| MX361642B (es) | Composiciones antisépticas catiónicas. | |
| EA201270277A1 (ru) | N-ацилированные октасахариды, активирующие рецепторы fgf, их получение и применение в терапии | |
| BR112016002086A2 (pt) | materiais de lignina contendo composições | |
| RU2012128329A (ru) | Хвойная биологически активная добавка, обогащенная l-аргинином для повышения продуктивных качеств кур-несушек | |
| UA68905U (ru) | Соединение 1,1'-(2"-бром-2"-хлорэтенил)-бис-(бензимидазол), имеющий противоопухолевые свойства | |
| RU2011112753A (ru) | Летательный аппарат | |
| BR112015025222A2 (pt) | suspoemulsão de fomesafen e flutiacet-metila |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |