MX356853B - Sintesis de una saponina esteroidea. - Google Patents
Sintesis de una saponina esteroidea.Info
- Publication number
- MX356853B MX356853B MX2014014056A MX2014014056A MX356853B MX 356853 B MX356853 B MX 356853B MX 2014014056 A MX2014014056 A MX 2014014056A MX 2014014056 A MX2014014056 A MX 2014014056A MX 356853 B MX356853 B MX 356853B
- Authority
- MX
- Mexico
- Prior art keywords
- provides
- present
- improved synthesis
- class
- steroid
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 150000005856 steroid saponins Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención proporciona una síntesis mejorada de una clase saponinas esteroideas. Además, la presente invención proporciona un método para discriminar selectivamente entre los grupos hidroxilo de C2 y C3 de una saponina esteroidea monoglicosilada -un paso clave en la reparación de ésta clase de compuestos. Adicionalmente, la presente invención proporciona una gama de derivados de saponina esteroidea, y métodos para prepararlos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2012902119A AU2012902119A0 (en) | 2012-05-23 | Improved synthesis | |
AU2013204005A AU2013204005B2 (en) | 2012-05-23 | 2013-04-11 | Improved synthesis |
PCT/AU2013/000416 WO2013173862A1 (en) | 2012-05-23 | 2013-04-24 | Improved synthesis |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014014056A MX2014014056A (es) | 2015-08-14 |
MX356853B true MX356853B (es) | 2018-06-18 |
Family
ID=49622929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014014056A MX356853B (es) | 2012-05-23 | 2013-04-24 | Sintesis de una saponina esteroidea. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20150105543A1 (es) |
EP (1) | EP2852607B1 (es) |
JP (1) | JP2015517535A (es) |
CN (1) | CN104395333B (es) |
AU (1) | AU2013204005B2 (es) |
BR (1) | BR112014029189A2 (es) |
CA (1) | CA2874030A1 (es) |
EA (1) | EA201492194A1 (es) |
HK (1) | HK1202876A1 (es) |
IN (1) | IN2014DN10846A (es) |
MX (1) | MX356853B (es) |
TW (1) | TWI609025B (es) |
WO (1) | WO2013173862A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103193858B (zh) * | 2013-04-12 | 2016-08-03 | 中国海洋大学 | 螺甾碱烷型糖苷生物碱的合成方法 |
EP3580225A4 (en) * | 2017-02-10 | 2021-01-06 | Oncology Research International Limited | STEROIDSAPONINS WITH ANTI-CANCER EFFECT |
CN110790811A (zh) * | 2019-10-10 | 2020-02-14 | 华南农业大学 | 双相体系氯化铝水解制备薯蓣皂素方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1115346C (zh) * | 2000-10-20 | 2003-07-23 | 中国科学院上海有机化学研究所 | 鼠李糖取代的β-D-葡萄糖基-薯蓣皂甙的皂甙库、制备方法和用途 |
CN101130568B (zh) * | 2007-09-07 | 2011-06-15 | 中国科学院上海有机化学研究所 | 一类喷脑皂甙类化合物、合成方法及其用途 |
KR101825315B1 (ko) * | 2008-04-08 | 2018-02-02 | 슬로안-케테링인스티튜트퍼캔서리서치 | 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도 |
CN101635335B (zh) * | 2008-07-25 | 2013-02-27 | 深圳市比克电池有限公司 | 圆柱电池卷芯入壳机 |
-
2013
- 2013-04-11 AU AU2013204005A patent/AU2013204005B2/en active Active
- 2013-04-24 CN CN201380034397.XA patent/CN104395333B/zh active Active
- 2013-04-24 WO PCT/AU2013/000416 patent/WO2013173862A1/en active Application Filing
- 2013-04-24 CA CA2874030A patent/CA2874030A1/en not_active Abandoned
- 2013-04-24 BR BR112014029189A patent/BR112014029189A2/pt not_active IP Right Cessation
- 2013-04-24 EA EA201492194A patent/EA201492194A1/ru unknown
- 2013-04-24 MX MX2014014056A patent/MX356853B/es active IP Right Grant
- 2013-04-24 US US14/403,110 patent/US20150105543A1/en not_active Abandoned
- 2013-04-24 EP EP13794398.1A patent/EP2852607B1/en not_active Not-in-force
- 2013-04-24 IN IN10846DEN2014 patent/IN2014DN10846A/en unknown
- 2013-04-24 JP JP2015512969A patent/JP2015517535A/ja not_active Ceased
- 2013-05-17 TW TW102117564A patent/TWI609025B/zh not_active IP Right Cessation
-
2015
- 2015-04-02 HK HK15103375.2A patent/HK1202876A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2874030A1 (en) | 2013-11-28 |
AU2013204005A1 (en) | 2013-12-12 |
MX2014014056A (es) | 2015-08-14 |
EP2852607A1 (en) | 2015-04-01 |
EP2852607B1 (en) | 2018-10-24 |
BR112014029189A2 (pt) | 2017-06-27 |
JP2015517535A (ja) | 2015-06-22 |
CN104395333B (zh) | 2018-01-02 |
IN2014DN10846A (es) | 2015-09-04 |
CN104395333A (zh) | 2015-03-04 |
TW201350497A (zh) | 2013-12-16 |
AU2013204005B2 (en) | 2015-04-16 |
HK1202876A1 (en) | 2015-10-09 |
US20150105543A1 (en) | 2015-04-16 |
WO2013173862A1 (en) | 2013-11-28 |
EP2852607A4 (en) | 2016-02-24 |
TWI609025B (zh) | 2017-12-21 |
EA201492194A1 (ru) | 2015-04-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ712350A (en) | Abiraterone acetate formulation | |
MX2019008212A (es) | Estructuras fibrosas que comprenden particulas y metodos para fabricarlas. | |
MX2015012401A (es) | Composiciones y metodos de alterar niveles de colesterol. | |
WO2012174439A3 (en) | Methods of producing1, 3 - butadiene | |
WO2013177419A3 (en) | Lipid nanoparticle compositions and methods of making and methods of using the same | |
EP3468385A4 (en) | STEVIOL GLYCOSIDE COMPOSITIONS, PRODUCTION METHODS AND USES | |
EP3192527A4 (en) | Cancer-cell-specific antibody, anticancer agent, and cancer testing method | |
WO2012177935A8 (en) | Compositions and methods for the treatment of cancer | |
AU2013225816A8 (en) | Compositions and methods for treating Type III Gaucher Disease | |
MX2017013013A (es) | Estireno funcionalizado con [bis(trihidrocarbilsilil)aminosililo] y un metodo para su preparacion. | |
EP3277820A4 (en) | Methods for producing modified red blood cell compositions, compositions and uses thereof | |
MX356801B (es) | Incremento en la biodisponibilidad de fármacos en la terapia con naltrexona. | |
WO2012075117A3 (en) | Small molecule-polymer conjugates and methods of making same | |
WO2013040251A8 (en) | Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease | |
WO2013163297A8 (en) | Modified glycoproteins | |
UY35986A (es) | Método mejorado para la producción de extractos de ginkgo | |
WO2013052108A3 (en) | Methods and compositions for the treatment and diagnosis of ovarian cancer | |
EP3698144A4 (en) | COMPOSITIONS, METHODS AND KITS FOR DIAGNOSIS OF LUNG CANCER | |
MX356853B (es) | Sintesis de una saponina esteroidea. | |
WO2011100642A3 (en) | Method for treating hematological cancers | |
EP3357943A4 (en) | Modifier and modified conjugated diene based polymer, and preparation methods therefor | |
EP3434765A4 (en) | ANTI-TMEM-180 ANTIBODIES, ANTI-STEM AND TREATMENT FOR CANCER | |
PH12017500013A1 (en) | Compositions and methods for enhancing immunity | |
EP3150638A4 (en) | Conjugated diene polymer, method for producing same, and composition including same | |
MX2015016603A (es) | Composiciones de corticosteroides. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |