MX354547B - Ensayos y métodos para seleccionar un regimen de tratamiento para un sujeto con depresión. - Google Patents

Ensayos y métodos para seleccionar un regimen de tratamiento para un sujeto con depresión.

Info

Publication number
MX354547B
MX354547B MX2014005786A MX2014005786A MX354547B MX 354547 B MX354547 B MX 354547B MX 2014005786 A MX2014005786 A MX 2014005786A MX 2014005786 A MX2014005786 A MX 2014005786A MX 354547 B MX354547 B MX 354547B
Authority
MX
Mexico
Prior art keywords
subject
depression
biomarkers
treatment regimen
effectiveness
Prior art date
Application number
MX2014005786A
Other languages
English (en)
Other versions
MX2014005786A (es
Inventor
Fava Maurizio
Papakostas George
O Koch Harold Jr
Kronlage David
Original Assignee
Alfasigma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfasigma Spa filed Critical Alfasigma Spa
Publication of MX2014005786A publication Critical patent/MX2014005786A/es
Publication of MX354547B publication Critical patent/MX354547B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a nuevos ensayos, sistemas y kits para la selección de un régimen de tratamiento para un sujeto con depresión al identificar al menos un polimorfismo de ácido nucleico, por ejemplo, pero no limitado a, en el locus de MTHFR, MTR o MTRR, y/o al determinar niveles de expresión de biomarcadores periféricos (por ejemplo, SAM, SAH y 4-HNE) en una muestra de prueba de un sujeto humano. Estos biomarcadores se pueden usar para determinar la eficacia de tratamiento de un sujeto deprimido con un compuesto que contiene folato (solo o como un adjunto a un antidepresivo). Además, estos biomarcadores se pueden usar para seleccionar un régimen de tratamiento apropiado para sujetos con depresión resistente al tratamiento (por ejemplo, resistente a por lo menos un inhibidor selectivo de la recaptación de serotonina). También se proporcionan en la presente métodos y composiciones para tratar a un sujeto con depresión y/o para determinar o mejorar la eficacia de un fármaco antidepresivo tomado por un sujeto.
MX2014005786A 2011-11-14 2012-11-14 Ensayos y métodos para seleccionar un regimen de tratamiento para un sujeto con depresión. MX354547B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161559541P 2011-11-14 2011-11-14
PCT/US2012/065084 WO2013074676A2 (en) 2011-11-14 2012-11-14 Assays and methods for selecting a treatment regimen for a subject with depression

Publications (2)

Publication Number Publication Date
MX2014005786A MX2014005786A (es) 2014-08-27
MX354547B true MX354547B (es) 2018-03-09

Family

ID=47279072

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014005786A MX354547B (es) 2011-11-14 2012-11-14 Ensayos y métodos para seleccionar un regimen de tratamiento para un sujeto con depresión.

Country Status (14)

Country Link
US (2) US9540691B2 (es)
EP (1) EP2780467B1 (es)
JP (1) JP6285865B2 (es)
KR (1) KR102035877B1 (es)
CN (1) CN104053785A (es)
AU (1) AU2012340015B2 (es)
BR (1) BR112014011491A2 (es)
CA (1) CA2855640C (es)
HK (1) HK1202590A1 (es)
IL (1) IL232407B (es)
IN (1) IN2014DN04226A (es)
MX (1) MX354547B (es)
RU (1) RU2622082C2 (es)
WO (1) WO2013074676A2 (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2780467B1 (en) 2011-11-14 2018-10-17 Alfasigma S.p.A. Assays and methods for selecting a treatment regimen for a subject with depression and methods for treatment
KR20150131147A (ko) * 2013-03-12 2015-11-24 네스텍 소시에테아노님 우울증을 갖는 대상을 위해 치료 섭생법을 선별하기 위한 검정법 및 방법
CN105073096A (zh) 2013-03-15 2015-11-18 詹森药业有限公司 S-盐酸***的药物组合物
US9549937B2 (en) * 2013-12-05 2017-01-24 Burvia, LLC. Composition containing phospholipid-DHA and folate
US20150250813A1 (en) * 2013-12-05 2015-09-10 Buriva, LLC Dietary supplement containing phospholipid-dha, folate, and n-acetyl-l-cysteine
US9610302B2 (en) * 2013-12-05 2017-04-04 Buriva, LLC. Composition containing phospholipid-DHA and B vitamins
CN106536751A (zh) * 2014-03-05 2017-03-22 武田药品工业株式会社 治疗抑郁症和重性抑郁障碍的方法
WO2015136446A1 (en) * 2014-03-11 2015-09-17 Nestec S.A. Methods for selecting antidepressant drug therapy to treat depression
KR101588119B1 (ko) * 2014-05-16 2016-01-25 동아대학교 산학협력단 Ｓｌｃ6ａ3 유전자의 다형성 소위성과 이를 이용한 ｄｎａ 타이핑 키트 및 상기 유전자 관련 질병의 진단키트
CA2957926A1 (en) * 2014-08-13 2016-02-18 Janssen Pharmaceutica Nv Method for the treatment of depression
MX2017003366A (es) 2014-09-15 2018-02-01 Janssen Pharmaceutica Nv Regimenes de dosificacion y métodos especificos para el tratamiento de la depresión con el genotipo val66met (snp rs6265).
CN105671130A (zh) * 2014-11-18 2016-06-15 武汉白原科技有限公司 一种心理性格检测试剂盒和方法
US20160203591A1 (en) * 2015-01-09 2016-07-14 Umm Al-Qura University System and process for monitoring the quality of food in a refrigerator
CN104655705B (zh) * 2015-02-12 2017-03-08 江苏省原子医学研究所 一种用毛细管电泳快速检测生物样本中儿茶酚氧甲基转移酶comt活性的方法
CN104789668A (zh) * 2015-04-10 2015-07-22 浙江博惠生物科技有限公司 一种叶酸代谢能力评估的检测位点rs1801394的检测PCR扩增引物和单碱基延伸引物
WO2016168685A1 (en) * 2015-04-17 2016-10-20 Mayo Foundation For Medical Education And Research Modulating the aryl hydrocarbon receptor system to treat major depressive disorder
WO2016176458A1 (en) * 2015-04-28 2016-11-03 Proove Biosciences, Inc. System and method for processing genotype information relating to opiod risk
US20160332962A1 (en) 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
AU2016267091B2 (en) * 2015-05-25 2020-01-16 Xiujuan Hao Use of fluorescence for the quick and easy determination of S-Adenosylmethionine, S-Adenosylhomocysteine and Homocysteine
WO2017218632A1 (en) 2016-06-14 2017-12-21 Board Of Regents, The University Of Texas System Methods of detecting anti-folic acid antibodies and uses thereof
JP2019530477A (ja) * 2016-09-26 2019-10-24 プレシジョン・メディスン・ホールディングス・プロプライエタリー・リミテッド 精神***病および***情動性精神病の診断、予後、および処置
CN107245527A (zh) * 2017-07-25 2017-10-13 重庆京因生物科技有限责任公司 Mtrr基因多态性快速检测的引物、分子信标、试剂盒及其检测方法
US11399575B2 (en) * 2017-08-02 2022-08-02 Glaxosmithkline Consumer Healthcare Holdings (Us) Llc Wearable device and application for behavioral support
US20200009081A1 (en) 2017-09-13 2020-01-09 Janssen Pharmaceutica N.V. Delivery Of Esketamine For The Treatment Of Depression
RU2020123893A (ru) 2017-12-22 2022-01-24 Янссен Фармасьютикалз, Инк. Эскетамин для лечения депрессии
CN108251522B (zh) * 2018-04-09 2020-11-27 江苏硕世生物科技股份有限公司 人类mthfr和mtrr基因检测试剂盒及其用途
CN108642138B (zh) * 2018-05-02 2021-11-30 广东药科大学 一种检测叶酸代谢相关基因遗传信息的方法及试剂盒
US11681348B2 (en) 2018-05-03 2023-06-20 L. Pierre de Rochemont High speed / low power server farms and server networks
CA3102806A1 (en) 2018-06-05 2019-12-12 L. Pierre De Rochemont Module with high peak bandwidth i/o channels
CN108823299A (zh) * 2018-06-11 2018-11-16 苏州艾达康医疗科技有限公司 一种抑郁症用药相关基因的检测方法及试剂盒
AU2019337088A1 (en) * 2018-09-03 2021-05-06 Visby Medical, Inc. Devices and methods for antibiotic susceptibility testing
US20230117657A1 (en) 2019-03-05 2023-04-20 Janssen Pharmaceuticals, Inc. Esketamine for the treatment of depression
KR20220088529A (ko) 2019-05-14 2022-06-27 프로메테우스 바이오사이언시즈, 인크. Tl1a 환자 선택 방법, 시스템 및 장치
CN110148461B (zh) * 2019-06-26 2021-09-21 周建勋 用于多参数测量的模块切换***
CN110693507A (zh) * 2019-08-30 2020-01-17 中国民用航空飞行学院 一种民航飞行学员心理健康测试和心理援助***
CN111351945B (zh) * 2020-03-18 2021-04-23 东南大学 维生素d结合蛋白作为标志物在精神疾病抑郁症诊断中的应用
US20220165379A1 (en) * 2020-11-24 2022-05-26 Genomind, Inc. Methods and systems for reporting patient- and drug-specific medical data
CN116103385A (zh) * 2021-11-11 2023-05-12 中国科学院深圳理工大学(筹) 一种预测抑郁障碍患者对治疗反应的基因诊断试剂盒和***
CN116298233A (zh) * 2022-03-16 2023-06-23 昱言科技(北京)有限公司 用于诊断双相障碍的生物标记物
WO2023220213A1 (en) * 2022-05-11 2023-11-16 Higgins Evelyn Methods for providing a personalized therapeutic treatment regime for addictions

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US548257A (en) 1895-10-22 Hay rake and loader
US3837376A (en) 1971-06-01 1974-09-24 Metropolitan Pathology Labor I Blood serum collection tube and method
US4336185A (en) 1976-03-02 1982-06-22 Rohm And Haas Company Folic acid derivatives
US4120448A (en) 1977-06-08 1978-10-17 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing apparatus with automatically positioned collection port
US4656035A (en) 1984-12-21 1987-04-07 University Of Tennessee Research Corporation Method of separating blood platelets
US4946773A (en) 1985-12-23 1990-08-07 President And Fellows Of Harvard College Detection of base pair mismatches using RNAase A
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US6270961B1 (en) 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
DE68908054T2 (de) 1988-01-21 1994-03-10 Genentech Inc Verstärkung und nachweis von nukleinsäuresequenzen.
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
WO1989010414A1 (en) 1988-04-28 1989-11-02 Robert Bruce Wallace AMPLIFIED SEQUENCE POLYMORPHISMS (ASPs)
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5118937A (en) 1989-08-22 1992-06-02 Finnigan Mat Gmbh Process and device for the laser desorption of an analyte molecular ions, especially of biomolecules
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US6013431A (en) 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
US5846710A (en) 1990-11-02 1998-12-08 St. Louis University Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension
EP1231282A3 (en) 1990-12-06 2005-05-18 Affymetrix, Inc. Methods and compositions for identification of polymers
US5169766A (en) 1991-06-14 1992-12-08 Life Technologies, Inc. Amplification of nucleic acid molecules
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
ATE242485T1 (de) 1993-05-28 2003-06-15 Baylor College Medicine Verfahren und massenspektrometer zur desorption und ionisierung von analyten
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US6136540A (en) 1994-10-03 2000-10-24 Ikonisys Inc. Automated fluorescence in situ hybridization detection of genetic abnormalities
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5851770A (en) 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
US6566065B1 (en) 1994-05-26 2003-05-20 Mcgill University Method of diagnosing schizophrenia by detecting a mutation in the (MTHFR) gene
GB9410620D0 (en) 1994-05-26 1994-07-13 Univ Mcgill cDNA for human mehylenetetrahydrofolate reductase
US6379897B1 (en) 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
US5849483A (en) 1994-07-28 1998-12-15 Ig Laboratories, Inc. High throughput screening method for sequences or genetic alterations in nucleic acids
US5866337A (en) 1995-03-24 1999-02-02 The Trustees Of Columbia University In The City Of New York Method to detect mutations in a nucleic acid using a hybridization-ligation procedure
US5704888A (en) 1995-04-14 1998-01-06 Cobe Laboratories, Inc. Intermittent collection of mononuclear cells in a centrifuge apparatus
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US6264970B1 (en) 1996-06-26 2001-07-24 Takeda Chemical Industries, Ltd. Sustained-release preparation
US5928870A (en) 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US6465611B1 (en) 1997-02-25 2002-10-15 Corixa Corporation Compounds for immunotherapy of prostate cancer and methods for their use
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
AU9381598A (en) 1997-09-10 1999-03-29 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Method of amplifying dna and rna mismatch cleavage products
JP2002512965A (ja) * 1998-04-24 2002-05-08 スカリスタ リミティッド 鬱病の治療およびそのための薬学的調製物
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
CN1406126A (zh) 1998-10-01 2003-03-26 诺瓦提斯公司 新型缓释口服制剂
US6395481B1 (en) 1999-02-16 2002-05-28 Arch Development Corp. Methods for detection of promoter polymorphism in a UGT gene promoter
US7429466B2 (en) 2000-01-24 2008-09-30 Hypromatrix, Inc Methods and arrays for detecting biological molecules
US6618679B2 (en) 2000-01-28 2003-09-09 Althea Technologies, Inc. Methods for analysis of gene expression
WO2001066172A2 (en) 2000-03-09 2001-09-13 Gambro, Inc. Extracorporeal blood processing method and apparatus
WO2001080896A2 (en) 2000-04-21 2001-11-01 Arch Development Corporation Flavopiridol drug combinations and methods with reduced side effects
DE10022510A1 (de) 2000-05-10 2001-11-15 Basf Ag Zusammensetzungen enthaltend Folsäure und reduziertes Folat
US6355433B1 (en) 2000-06-02 2002-03-12 Dna Sciences, Inc. Determination of nucleotide sequence variations through limited primer extension
EP1304324B1 (en) 2000-07-18 2007-10-03 Dainippon Sumitomo Pharma Co., Ltd. Serotonin reuptake inhibitors
US20030099960A1 (en) 2001-01-26 2003-05-29 The University Of Chicago Compositions and methods for optimizing UGT2B7 substrate dosings and for predicting UGT2B7 substrate toxicity
US6720003B2 (en) 2001-02-16 2004-04-13 Andrx Corporation Serotonin reuptake inhibitor formulations
WO2002086168A1 (en) 2001-04-19 2002-10-31 Ciphergen Biosystems, Inc. Biomolecule characterization using mass spectrometry and affinity tags
US20030100476A1 (en) 2001-05-11 2003-05-29 Weinberger Daniel R. Effect of COMT genotype on frontal lobe function
EP1390497A2 (en) 2001-05-25 2004-02-25 Genset Human cdnas and proteins and uses thereof
US7112408B2 (en) 2001-06-08 2006-09-26 The Brigham And Women's Hospital, Inc. Detection of ovarian cancer based upon alpha-haptoglobin levels
US20030013208A1 (en) 2001-07-13 2003-01-16 Milagen, Inc. Information enhanced antibody arrays
WO2003017177A2 (en) 2001-08-13 2003-02-27 Beyong Genomics, Inc. Method and system for profiling biological systems
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
AU2003207989A1 (en) 2002-02-21 2003-09-09 Idgene Pharmaceuticals Ltd. Association of snps in the comt locus and neighboring loci with schizophrenia, bipolar disorder, breast cancer and colorectal cancer
US20030215858A1 (en) 2002-04-08 2003-11-20 Baylor College Of Medicine Enhanced gene expression system
US7241281B2 (en) 2002-04-08 2007-07-10 Thermogenesis Corporation Blood component separation method and apparatus
US20030194711A1 (en) 2002-04-10 2003-10-16 Matthew Zapala System and method for analyzing gene expression data
AU2003239152A1 (en) 2002-04-23 2003-11-10 Millipore Corporation Sample preparation of biological fluids for proteomic applications
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
CA2415154C (en) 2002-12-24 2009-06-16 Biovail Laboratories Inc. Modified release formulations of selective serotonin re-uptake inhibitors
US20040203034A1 (en) 2003-01-03 2004-10-14 The University Of Chicago Optimization of cancer treatment with irinotecan
ES2359977T3 (es) 2003-03-31 2011-05-30 Titan Pharmaceuticals, Inc. Dispositivo polimérico implantable para liberación sostenida de agonista de dopamina.
US20050054688A1 (en) 2003-08-08 2005-03-10 Pfizer Inc Selective serotonin reuptake inhibitors in the treatment of disease
US20050069936A1 (en) 2003-09-26 2005-03-31 Cornelius Diamond Diagnostic markers of depression treatment and methods of use thereof
US7893261B2 (en) 2004-03-26 2011-02-22 Baylor University Serotonin reuptake inhibitors
JP2005312435A (ja) 2004-03-29 2005-11-10 Kazuhito Rokutan うつ病の評価方法
WO2006099164A2 (en) 2005-03-10 2006-09-21 Applera Corporation Methods for multiplex amplification
WO2007022248A2 (en) 2005-08-16 2007-02-22 Sloan Kettering Institute For Cancer Research Methods of detection of cancer using peptide profiles
US20070254288A1 (en) 2005-12-06 2007-11-01 The General Hospital Corporation Diagnostic methods for pain sensitivity and chronicity and for tetrahydrobiopterin-related disorders
US20080064702A1 (en) 2006-09-08 2008-03-13 Charalambos Antoniades Use of folates for the prevention and treatment of vascular diseases
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US20100273153A1 (en) 2006-11-29 2010-10-28 Boris Tabakoff Genetic diagnosis of depression
US20090075827A1 (en) 2007-01-19 2009-03-19 Queensland University Of Technology Diagnostic methods and agents
US7947662B2 (en) 2008-02-20 2011-05-24 Gnosis S.P.A. Folates, compositions and uses thereof
US20090307180A1 (en) 2008-03-19 2009-12-10 Brandon Colby Genetic analysis
WO2009131643A1 (en) 2008-04-21 2009-10-29 Monabio, Inc. Immunoassay for specific determination of s-adenosymethionine and analogs thereof in biological samples
EP2485747A4 (en) 2008-06-21 2013-10-23 Kenneth Blum CUSTOMIZATION DIRECTED BY THE DNA OF ANALGESIC COMPOUNDS AS A THERAPEUTIC MODALITY
US20100112589A1 (en) 2008-11-03 2010-05-06 Xie Yagang Allele-allele interactions of mthfr gene variants, and uses thereof in predicting disease risk
WO2010138796A2 (en) 2009-05-29 2010-12-02 Genomind, Llc Methods for assessment and treatment of depression via utilization of single nucleotide polymorphisms analysis
AU2010300475A1 (en) 2009-09-30 2012-05-03 The Regents Of The University Of California Cofactors and methods for use for individuals
US20140088035A1 (en) * 2010-12-03 2014-03-27 The General Hospital Corporation Treating schizophrenia
KR20120092993A (ko) 2011-02-14 2012-08-22 지엘팜텍 주식회사 티아넵틴 또는 이의 약제학적으로 허용되는 염을 포함하는 경구투여용 서방성 정제
AU2012235634B2 (en) 2011-03-28 2017-05-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Sustained-release injectable formulation
WO2012177746A1 (en) 2011-06-21 2012-12-27 Global Healthcare Focus, Llc Methods of preventing or treating disease states related to certain metabolic abnormalities
US20160058766A1 (en) * 2011-11-14 2016-03-03 Nestec S.A. Assays and methods for selecting a treatment regimen for a subject with depression
EP2780467B1 (en) * 2011-11-14 2018-10-17 Alfasigma S.p.A. Assays and methods for selecting a treatment regimen for a subject with depression and methods for treatment

Also Published As

Publication number Publication date
KR20140100524A (ko) 2014-08-14
US20130172361A1 (en) 2013-07-04
US9540691B2 (en) 2017-01-10
CA2855640C (en) 2020-03-10
RU2622082C2 (ru) 2017-06-09
WO2013074676A3 (en) 2013-08-15
JP6285865B2 (ja) 2018-02-28
MX2014005786A (es) 2014-08-27
CA2855640A1 (en) 2013-05-23
EP2780467B1 (en) 2018-10-17
KR102035877B1 (ko) 2019-10-23
CN104053785A (zh) 2014-09-17
IN2014DN04226A (es) 2015-05-22
AU2012340015A1 (en) 2014-05-22
IL232407B (en) 2019-03-31
WO2013074676A2 (en) 2013-05-23
AU2012340015B2 (en) 2017-09-21
US9546401B2 (en) 2017-01-17
BR112014011491A2 (pt) 2017-05-09
NZ624231A (en) 2016-10-28
US20130267523A1 (en) 2013-10-10
EP2780467A2 (en) 2014-09-24
JP2015508281A (ja) 2015-03-19
HK1202590A1 (en) 2015-10-02
RU2014124121A (ru) 2015-12-27
IL232407A0 (en) 2014-06-30

Similar Documents

Publication Publication Date Title
MX354547B (es) Ensayos y métodos para seleccionar un regimen de tratamiento para un sujeto con depresión.
CY1120851T1 (el) Αναλυση γονιδιωματικων κλασματων με χρηση των αριθμων πολυμορφισμων
BR112015021340A2 (pt) composição de revestimento, método de revestimento de um substrato, e substrato
BR112014006344A2 (pt) composições de polietileno e fechamentos para frascos
WO2013074624A3 (en) Silicone resins comprising metallosiloxane
BR112015001690A2 (pt) mutações associadas com a resistência a inibidores da tirosina quinase de bruton (btk)
BR112012008537A2 (pt) processo de caracterização de pelo menos um micro-organismo por espectrometria de massa
BR112014015152A2 (pt) métodos e materiais para a avaliação da perda de heterozigosidade
WO2017201102A8 (en) Method of improved sequencing by strand identification
GB201317477D0 (en) Methods, compositions and kits for determing the presence/absnece of a variant nucleic acid sequence
RU2017101174A (ru) Набор или устройство для обнаружения рака печени и способ обнаружения
BR112016022620A2 (pt) cdna que codifica um polipeptídeo de fusão, vetor, célula procariotica ou eucariotica, sequência polinucleotídica, polipeptídeo de fusão, anticorpo ou fragmento de ligação, par de primers, sonda oligonucleotídica, oligonucleotídeo, sirna dirigido a um rna mensageiro, inibidor da atividade quinase fgfr, método de terapia e método para identificar um composto
WO2012019200A3 (en) Assay systems for determination of source contribution in a sample
ES2660149T3 (es) Identificación, evaluación y terapia de cánceres con resistencia innata o adquirida a inhibidores de ALK
BR112012009262A2 (pt) ''método para inibir a proliferação de células de câncer positivo para ar em um indivíduo diagnosticado com,ou qual se suspeita que tenha cânce positivo para ar e método para identificar se um indivíduo é um candidato para tratamento com uma composiçâo
WO2015094995A3 (en) Gene signature biomarkers of tumor response to pd-1 antagonists
EP4242329A3 (en) Use of markers including filamin a in the diagnosis and treatment of prostate cancer
RU2015143177A (ru) Анализы и способы выбора схемы лечения для субъекта с депрессией
MX2016016742A (es) Ceramidas y su uso en el diagnostico de enfermedad cardiovascular (ecv).
WO2013106844A3 (en) Methods and compositions for the treatment and diaginosis of pancreatic cancer
BR112014026416A2 (pt) composições pc/abs que permanecem estáveis durante o processamento
WO2014124339A3 (en) Use of translational profiling to identify target molecules for therapeutic treatment
BR112015031114A2 (pt) aparelhos e métodos de revestimento fixos e portáteis
WO2009153774A3 (en) Compositions and methods for prognosis of ovarian cancer
BR112013011035A2 (pt) predição in silico de combinações gênicas de elevada expressão e outras combinações de componentes biológicos

Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: ALFASIGMA S.P.A.

GB Transfer or rights

Owner name: ALFASIGMA S.P.A.

FG Grant or registration