MX351307B - Método para producir el compuesto sulfonilamidina. - Google Patents
Método para producir el compuesto sulfonilamidina.Info
- Publication number
- MX351307B MX351307B MX2015002961A MX2015002961A MX351307B MX 351307 B MX351307 B MX 351307B MX 2015002961 A MX2015002961 A MX 2015002961A MX 2015002961 A MX2015002961 A MX 2015002961A MX 351307 B MX351307 B MX 351307B
- Authority
- MX
- Mexico
- Prior art keywords
- amidine compound
- product
- target compound
- producing
- production method
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
Se proporcionan: un método para producir un compuesto sulfonilamidina, que tiene un excelente antagonismo del receptor de hormona liberadora de gonadotropina y es útil como un agente terapéutico para enfermedades dependientes de gonadotropina (por ejemplo, cáncer de próstata, cáncer de mama, endometriosis, fibroides uterinos, hiperplasia prostática, o similares) o una sal del mismo, y un intermediario de síntesis útil en el método de producción. El método de producción de acuerdo con la presente invención, mediante el cual se inhibe la formación de un subproducto, donde dicho subproducto difícilmente se elimina a menos que se conduzca la purificación de columna, y se inhibe la racemización de un compuesto objetivo y por lo tanto se obtiene el compuesto objetivo a una alta pureza, es adecuado para la producción industrial.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012197914 | 2012-09-07 | ||
PCT/JP2013/074076 WO2014038663A1 (ja) | 2012-09-07 | 2013-09-06 | スルホニルアミジン化合物の製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015002961A MX2015002961A (es) | 2015-09-24 |
MX351307B true MX351307B (es) | 2017-10-10 |
Family
ID=50237268
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015002961A MX351307B (es) | 2012-09-07 | 2013-09-06 | Método para producir el compuesto sulfonilamidina. |
Country Status (8)
Country | Link |
---|---|
US (1) | US9527818B2 (es) |
EP (1) | EP2894152A4 (es) |
JP (1) | JP6222094B2 (es) |
KR (1) | KR20150048762A (es) |
CN (1) | CN104603114B (es) |
CA (1) | CA2883126A1 (es) |
MX (1) | MX351307B (es) |
WO (1) | WO2014038663A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201613579A (en) | 2014-06-24 | 2016-04-16 | Astellas Pharma Inc | Pharmaceutical composition for oral administration |
KR20200027481A (ko) | 2017-06-05 | 2020-03-12 | 옵스에파 에스에이 | 자궁내막증의 치료를 위한 고나도트로핀 방출호르몬 길항제 투약요법 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA06014131A (es) | 2004-06-04 | 2007-03-07 | Astellas Pharma Inc | Derivado de propano-1,3-diona o su sal. |
KR101046039B1 (ko) | 2005-03-31 | 2011-07-01 | 아스텔라스세이야쿠 가부시키가이샤 | 프로판-1,3-디온 유도체 또는 그의 염 |
ZA200708264B (en) * | 2005-03-31 | 2008-12-31 | Astellas Pharma Inc | Propane-1,3-dione derivative or salt thereof |
-
2013
- 2013-09-06 JP JP2014534421A patent/JP6222094B2/ja not_active Expired - Fee Related
- 2013-09-06 KR KR1020157005708A patent/KR20150048762A/ko not_active Application Discontinuation
- 2013-09-06 EP EP13835562.3A patent/EP2894152A4/en not_active Withdrawn
- 2013-09-06 WO PCT/JP2013/074076 patent/WO2014038663A1/ja active Application Filing
- 2013-09-06 US US14/425,196 patent/US9527818B2/en not_active Expired - Fee Related
- 2013-09-06 CA CA2883126A patent/CA2883126A1/en not_active Abandoned
- 2013-09-06 MX MX2015002961A patent/MX351307B/es active IP Right Grant
- 2013-09-06 CN CN201380046596.2A patent/CN104603114B/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2883126A1 (en) | 2014-03-13 |
CN104603114A (zh) | 2015-05-06 |
JP6222094B2 (ja) | 2017-11-01 |
EP2894152A1 (en) | 2015-07-15 |
EP2894152A4 (en) | 2016-03-09 |
WO2014038663A1 (ja) | 2014-03-13 |
KR20150048762A (ko) | 2015-05-07 |
US20150259299A1 (en) | 2015-09-17 |
JPWO2014038663A1 (ja) | 2016-08-12 |
CN104603114B (zh) | 2017-06-20 |
MX2015002961A (es) | 2015-09-24 |
US9527818B2 (en) | 2016-12-27 |
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Legal Events
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FG | Grant or registration |