MX350966B - Celulas madre pluripotentes. - Google Patents
Celulas madre pluripotentes.Info
- Publication number
- MX350966B MX350966B MX2012004999A MX2012004999A MX350966B MX 350966 B MX350966 B MX 350966B MX 2012004999 A MX2012004999 A MX 2012004999A MX 2012004999 A MX2012004999 A MX 2012004999A MX 350966 B MX350966 B MX 350966B
- Authority
- MX
- Mexico
- Prior art keywords
- pluripotent stem
- stem cells
- cells
- provides methods
- present
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/605—Nanog
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/608—Lin28
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
Abstract
La presente invención se refiere a métodos para producir células madre pluripotentes a partir de células adultas; en particular, la presente invención provee métodos para producir células madre pluripotentes a partir de células somáticas sin el uso de una capa de célula alimentadora o un agente que incremente la eficiencia de la transfección retroviral.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25614909P | 2009-10-29 | 2009-10-29 | |
PCT/US2010/054408 WO2011059725A2 (en) | 2009-10-29 | 2010-10-28 | Pluripotent stem cells |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012004999A MX2012004999A (es) | 2012-09-28 |
MX350966B true MX350966B (es) | 2017-09-26 |
Family
ID=43925858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012004999A MX350966B (es) | 2009-10-29 | 2010-10-28 | Celulas madre pluripotentes. |
Country Status (15)
Country | Link |
---|---|
US (1) | US20110104805A1 (es) |
EP (1) | EP2494035B1 (es) |
JP (2) | JP5957382B2 (es) |
KR (1) | KR101861584B1 (es) |
CN (2) | CN102695790A (es) |
AR (1) | AR078805A1 (es) |
AU (1) | AU2010319921A1 (es) |
BR (1) | BR112012010136A2 (es) |
CA (1) | CA2778817A1 (es) |
ES (1) | ES2665006T3 (es) |
MX (1) | MX350966B (es) |
PL (1) | PL2494035T3 (es) |
RU (1) | RU2012122025A (es) |
SG (1) | SG10201500674YA (es) |
WO (1) | WO2011059725A2 (es) |
Families Citing this family (33)
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US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
RU2473685C2 (ru) | 2007-07-31 | 2013-01-27 | Лайфскен, Инк. | Дифференцировка человеческих эмбриональных стволовых клеток |
BR122017025207B1 (pt) | 2008-02-21 | 2021-03-16 | Centocor Ortho Biotech Inc | superfície que faz parte de um recipiente ou matriz destinada para uso em uma cultura de células ou análises, desprovida de uma camada de células alimentadoras e desprovida de uma camada adsorvente |
CA2729121C (en) | 2008-06-30 | 2019-04-09 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
KR101687344B1 (ko) | 2008-11-20 | 2016-12-16 | 얀센 바이오테크 인코포레이티드 | 평면 기재상의 세포 부착 및 배양을 위한 방법 및 조성물 |
CN107267442A (zh) | 2008-11-20 | 2017-10-20 | 詹森生物科技公司 | 微载体上的多能干细胞培养 |
KR20170118969A (ko) | 2009-07-20 | 2017-10-25 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
BR112012017761A2 (pt) | 2009-12-23 | 2015-09-15 | Centocor Ortho Biotech Inc | diferenciação das células-tronco embrionárias humanas |
CN102791851B (zh) | 2010-03-01 | 2017-07-14 | 詹森生物科技公司 | 纯化衍生自多能干细胞的细胞的方法 |
ES2660897T3 (es) | 2010-08-31 | 2018-03-26 | Janssen Biotech, Inc. | Diferenciación de células madre embrionarias humanas |
SG11201403473QA (en) | 2011-12-22 | 2014-10-30 | Janssen Biotech Inc | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
WO2013151725A1 (en) | 2012-04-05 | 2013-10-10 | The Regents Of The University Of California | Regenerative sera cells and mesenchymal stem cells |
KR102114209B1 (ko) | 2012-06-08 | 2020-05-25 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 췌장 내분비 세포로의 분화 |
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CN111394298A (zh) | 2012-12-31 | 2020-07-10 | 詹森生物科技公司 | 使用hb9调节子使人胚胎干细胞分化为胰腺内分泌细胞的方法 |
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WO2016100909A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
WO2016100930A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived b cells and methods of use thereof |
US10443042B2 (en) | 2014-12-18 | 2019-10-15 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof |
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- 2010-10-28 CA CA2778817A patent/CA2778817A1/en not_active Abandoned
- 2010-10-28 BR BR112012010136A patent/BR112012010136A2/pt not_active Application Discontinuation
- 2010-10-28 AR ARP100103962A patent/AR078805A1/es unknown
- 2010-10-28 RU RU2012122025/10A patent/RU2012122025A/ru not_active Application Discontinuation
- 2010-10-28 PL PL10830437T patent/PL2494035T3/pl unknown
- 2010-10-28 WO PCT/US2010/054408 patent/WO2011059725A2/en active Application Filing
- 2010-10-28 ES ES10830437.9T patent/ES2665006T3/es active Active
- 2010-10-28 EP EP10830437.9A patent/EP2494035B1/en not_active Not-in-force
- 2010-10-28 MX MX2012004999A patent/MX350966B/es active IP Right Grant
- 2010-10-28 US US12/913,834 patent/US20110104805A1/en not_active Abandoned
- 2010-10-28 KR KR1020127013705A patent/KR101861584B1/ko active IP Right Grant
- 2010-10-28 CN CN2010800497211A patent/CN102695790A/zh active Pending
- 2010-10-28 SG SG10201500674YA patent/SG10201500674YA/en unknown
- 2010-10-28 CN CN201611048756.9A patent/CN107058389A/zh active Pending
- 2010-10-28 JP JP2012537026A patent/JP5957382B2/ja not_active Expired - Fee Related
- 2010-10-28 AU AU2010319921A patent/AU2010319921A1/en not_active Abandoned
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Publication number | Publication date |
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ES2665006T3 (es) | 2018-04-24 |
JP6227622B2 (ja) | 2017-11-08 |
BR112012010136A2 (pt) | 2015-09-15 |
SG10201500674YA (en) | 2015-04-29 |
CA2778817A1 (en) | 2011-05-19 |
AU2010319921A1 (en) | 2012-05-17 |
PL2494035T3 (pl) | 2018-07-31 |
CN107058389A (zh) | 2017-08-18 |
JP5957382B2 (ja) | 2016-07-27 |
CN102695790A (zh) | 2012-09-26 |
JP2013509184A (ja) | 2013-03-14 |
MX2012004999A (es) | 2012-09-28 |
KR20120099241A (ko) | 2012-09-07 |
EP2494035B1 (en) | 2018-02-28 |
KR101861584B1 (ko) | 2018-05-28 |
WO2011059725A3 (en) | 2011-07-21 |
EP2494035A2 (en) | 2012-09-05 |
JP2016127828A (ja) | 2016-07-14 |
AR078805A1 (es) | 2011-12-07 |
WO2011059725A2 (en) | 2011-05-19 |
RU2012122025A (ru) | 2013-12-10 |
EP2494035A4 (en) | 2013-09-25 |
US20110104805A1 (en) | 2011-05-05 |
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