MX350862B - Acidos de piperidinil naftilacetico. - Google Patents
Acidos de piperidinil naftilacetico.Info
- Publication number
- MX350862B MX350862B MX2014006468A MX2014006468A MX350862B MX 350862 B MX350862 B MX 350862B MX 2014006468 A MX2014006468 A MX 2014006468A MX 2014006468 A MX2014006468 A MX 2014006468A MX 350862 B MX350862 B MX 350862B
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- formula
- piperidinyl
- naphthylacetic acids
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La invención se refiere a los compuestos de fórmula (I): y sales farmacéuticamente aceptables de los mismos, en la que R1, R2, R3 y X son definidos en la descripción detallada y las reivindicaciones. Además, la presente invención se refiere a métodos de fabricación y uso de los compuestos de fórmula (I), así como composiciones farmacéuticas que contienen tales compuestos. Los compuestos de fórmula (I) son antagonistas o agonistas parciales en el receptor CRTH2 y pueden ser útiles en el tratamiento de enfermedades y trastornos asociados con ese receptor, tales como asma.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161569313P | 2011-12-12 | 2011-12-12 | |
PCT/EP2012/074882 WO2013087544A1 (en) | 2011-12-12 | 2012-12-10 | Piperidinyl naphthylacetic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014006468A MX2014006468A (es) | 2014-09-01 |
MX350862B true MX350862B (es) | 2017-09-19 |
Family
ID=47427287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014006468A MX350862B (es) | 2011-12-12 | 2012-12-10 | Acidos de piperidinil naftilacetico. |
Country Status (11)
Country | Link |
---|---|
US (1) | US8691993B2 (es) |
EP (1) | EP2791111B1 (es) |
JP (1) | JP6154397B2 (es) |
KR (1) | KR20140103319A (es) |
CN (1) | CN103958468B (es) |
BR (1) | BR112014013958A2 (es) |
CA (1) | CA2855940A1 (es) |
HK (1) | HK1200453A1 (es) |
MX (1) | MX350862B (es) |
RU (1) | RU2628083C2 (es) |
WO (1) | WO2013087544A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20140107550A (ko) | 2011-12-21 | 2014-09-04 | 액테리온 파마슈티칼 리미티드 | 헤테로시클릴 유도체 및 프로스타글란딘 d2 수용체 조절제로서의 그의 용도 |
EP2885307A1 (en) | 2012-07-05 | 2015-06-24 | Actelion Pharmaceuticals Ltd. | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
CA2889922C (en) | 2012-11-06 | 2016-01-19 | Evolution Engineering Inc. | Fluid pressure pulse generator and method of using same |
CA2894621C (en) | 2012-12-17 | 2019-04-30 | Evolution Engineering Inc. | Mud pulse telemetry apparatus with a pressure transducer and method of operating same |
CA2895346C (en) | 2012-12-17 | 2018-10-23 | Evolution Engineering Inc. | Downhole telemetry signal modulation using pressure pulses of multiple pulse heights |
US10753201B2 (en) | 2012-12-17 | 2020-08-25 | Evolution Engineering Inc. | Mud pulse telemetry apparatus with a pressure transducer and method of operating same |
US9670774B2 (en) | 2014-06-27 | 2017-06-06 | Evolution Engineering Inc. | Fluid pressure pulse generator for a downhole telemetry tool |
US9631487B2 (en) | 2014-06-27 | 2017-04-25 | Evolution Engineering Inc. | Fluid pressure pulse generator for a downhole telemetry tool |
US9631488B2 (en) | 2014-06-27 | 2017-04-25 | Evolution Engineering Inc. | Fluid pressure pulse generator for a downhole telemetry tool |
US20210261495A1 (en) * | 2018-06-29 | 2021-08-26 | Ergon Pharmaceuticals, LLC | Compositions and methods of using itaconic acid derivatives |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4443462A (en) * | 1979-08-06 | 1984-04-17 | Merrell Dow Pharmaceuticals Inc. | Antipsychotic 4-(naphthalenyloxy)piperidine derivatives |
UA90706C2 (ru) * | 2005-02-24 | 2010-05-25 | Милленниум Фармасьютикалз, Инк. | Антагонисты рецептора pgd2 для лечения воспалительных заболеваний |
ES2625378T3 (es) * | 2005-09-27 | 2017-07-19 | Shionogi & Co., Ltd. | Derivado de sulfonamida que tiene actividad antagonista del receptor de PGD2 |
JP2009539881A (ja) * | 2006-06-09 | 2009-11-19 | アイコス コーポレイション | Dp−2アンタゴニストとしての置換フェニル酢酸 |
WO2010045276A2 (en) * | 2008-10-16 | 2010-04-22 | Cara Therapeutics, Inc. | Azabenzimidazolones |
US8621184B1 (en) | 2008-10-31 | 2013-12-31 | Netapp, Inc. | Effective scheduling of producer-consumer processes in a multi-processor system |
MX2011005120A (es) * | 2008-11-17 | 2011-05-30 | Hoffmann La Roche | Acidos naftilaceticos. |
CA2739725A1 (en) * | 2008-11-17 | 2010-05-20 | F. Hoffmann-La Roche Ag | Naphthylacetic acids used as crth2 antagonists or partial agonists |
-
2012
- 2012-12-06 US US13/706,497 patent/US8691993B2/en not_active Expired - Fee Related
- 2012-12-10 CA CA2855940A patent/CA2855940A1/en not_active Abandoned
- 2012-12-10 KR KR1020147019166A patent/KR20140103319A/ko not_active Application Discontinuation
- 2012-12-10 RU RU2014127143A patent/RU2628083C2/ru not_active IP Right Cessation
- 2012-12-10 BR BR112014013958A patent/BR112014013958A2/pt not_active Application Discontinuation
- 2012-12-10 EP EP12805511.8A patent/EP2791111B1/en not_active Not-in-force
- 2012-12-10 MX MX2014006468A patent/MX350862B/es active IP Right Grant
- 2012-12-10 JP JP2014546433A patent/JP6154397B2/ja not_active Expired - Fee Related
- 2012-12-10 WO PCT/EP2012/074882 patent/WO2013087544A1/en active Application Filing
- 2012-12-10 CN CN201280057114.9A patent/CN103958468B/zh not_active Expired - Fee Related
-
2015
- 2015-01-28 HK HK15100955.6A patent/HK1200453A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2013087544A1 (en) | 2013-06-20 |
CA2855940A1 (en) | 2013-06-20 |
JP2015504863A (ja) | 2015-02-16 |
CN103958468B (zh) | 2017-03-01 |
BR112014013958A8 (pt) | 2017-06-13 |
HK1200453A1 (en) | 2015-08-07 |
JP6154397B2 (ja) | 2017-06-28 |
US8691993B2 (en) | 2014-04-08 |
CN103958468A (zh) | 2014-07-30 |
EP2791111B1 (en) | 2017-01-18 |
KR20140103319A (ko) | 2014-08-26 |
RU2628083C2 (ru) | 2017-08-14 |
RU2014127143A (ru) | 2016-02-10 |
US20130150407A1 (en) | 2013-06-13 |
BR112014013958A2 (pt) | 2017-06-13 |
MX2014006468A (es) | 2014-09-01 |
EP2791111A1 (en) | 2014-10-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |