MX347555B - Un metodo para analizar una muestra de sangre de un sujeto por la presencia de un marcador de enfermedad. - Google Patents
Un metodo para analizar una muestra de sangre de un sujeto por la presencia de un marcador de enfermedad.Info
- Publication number
- MX347555B MX347555B MX2013010594A MX2013010594A MX347555B MX 347555 B MX347555 B MX 347555B MX 2013010594 A MX2013010594 A MX 2013010594A MX 2013010594 A MX2013010594 A MX 2013010594A MX 347555 B MX347555 B MX 347555B
- Authority
- MX
- Mexico
- Prior art keywords
- subject
- disease marker
- analysing
- blood sample
- disease
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
La presente invención se refiere a un método de análisis de la presencia de un marcado de enfermedad en una muestra de sangre de un sujeto, que comprende las etapas de: a) extraer ácido nucleico a partir de células sanguíneas sin núcleo de la muestra de sangre para proporcionar una fracción de ácido nucleico extraído de células sanguíneas sin núcleo, y b) analizar la presencia de un marcado de enfermedad en la fracción de ácido nucleico extraído de células sanguíneas sin núcleo, en el que el marcado de enfermedad es una mutación específica de la enfermedad en un gen de una célula nucleada en el sujeto, o el marcado de enfermedad es un perfil de expresión específico de la enfermedad de los genes de una célula nucleada del sujeto, en el que la fracción de ácido nucleico extraído de células sanguíneas sin núcleo incluye ácido nucleico obtenido a partir de células nucleadas, y en el que la fracción de ácido nucleico extraído de células snaguíneas sin núcleo no es ácido nucleico obtenido de megacariocitos ni ARN obtenido de megacariocitos.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11158912 | 2011-03-18 | ||
| EP11167973 | 2011-05-27 | ||
| PCT/NL2011/050518 WO2012008839A2 (en) | 2010-07-16 | 2011-07-15 | A method of analysing a blood sample of a subject for the presence of a disease marker |
| PCT/NL2012/050025 WO2012128616A1 (en) | 2011-03-18 | 2012-01-16 | A method of analysing a blood sample of a subject for the presence of a disease marker |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013010594A MX2013010594A (es) | 2014-07-09 |
| MX347555B true MX347555B (es) | 2017-04-28 |
Family
ID=45562414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013010594A MX347555B (es) | 2011-03-18 | 2012-01-16 | Un metodo para analizar una muestra de sangre de un sujeto por la presencia de un marcador de enfermedad. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10174365B2 (es) |
| EP (2) | EP3483607A1 (es) |
| JP (1) | JP5934726B2 (es) |
| CN (1) | CN103547920B (es) |
| AU (1) | AU2012231884B2 (es) |
| BR (1) | BR112013023960B1 (es) |
| CA (1) | CA2830461C (es) |
| MX (1) | MX347555B (es) |
| SG (1) | SG193539A1 (es) |
| WO (1) | WO2012128616A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012008839A2 (en) | 2010-07-16 | 2012-01-19 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg | A method of analysing a blood sample of a subject for the presence of a disease marker |
| AU2012231884B2 (en) | 2011-03-18 | 2017-03-09 | Stichting Vumc | A method of analysing a blood sample of a subject for the presence of a disease marker |
| JP2015516565A (ja) * | 2012-03-09 | 2015-06-11 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | 甲状腺機能亢進症を調査するための手段及び方法 |
| WO2017037539A2 (en) * | 2015-09-02 | 2017-03-09 | The Health Corporation Of The Galilee Medical Center | Modulation of the phospholipase a2-activating protein for treatment of myelin related diseases |
| US10233509B2 (en) * | 2016-12-07 | 2019-03-19 | Credo Biomedical Pte Ltd. | Method for detection CPV 2a, 2b, and 2c and for discrimination wild type from vaccine type |
| DE102017125013B4 (de) * | 2017-10-25 | 2019-10-17 | Epiontis Gmbh | MCC als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere basophiler Granulozyten |
| CN112094907B (zh) * | 2019-06-18 | 2023-08-18 | 杭州太铭生物科技有限公司 | 外周血红细胞微核dna及其应用 |
| CN113430264A (zh) * | 2020-03-23 | 2021-09-24 | 南京梅傲红清生物科技有限公司 | 红细胞核酸在鉴定肿瘤的突变类型中的应用 |
| CN114324887A (zh) * | 2021-10-14 | 2022-04-12 | 深圳市华启生物科技有限公司 | 免疫球蛋白a肾病t细胞诊断标志物 |
| GB202203947D0 (en) * | 2022-03-21 | 2022-05-04 | Chancellor Masters And Scholars Of The Univ Of Oxford | Method |
| CN116087490A (zh) * | 2022-12-13 | 2023-05-09 | 安徽医科大学第一附属医院 | 多糖类物质的检测试剂在制备检测颅内感染试剂中的应用 |
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| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| AU622426B2 (en) | 1987-12-11 | 1992-04-09 | Abbott Laboratories | Assay using template-dependent nucleic acid probe reorganization |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5185244A (en) * | 1989-12-08 | 1993-02-09 | Emory University | Genetic test for hereditary neuromuscular disease |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5270184A (en) | 1991-11-19 | 1993-12-14 | Becton, Dickinson And Company | Nucleic acid target generation |
| US5719028A (en) | 1992-12-07 | 1998-02-17 | Third Wave Technologies Inc. | Cleavase fragment length polymorphism |
| SE9400522D0 (sv) | 1994-02-16 | 1994-02-16 | Ulf Landegren | Method and reagent for detecting specific nucleotide sequences |
| US5942391A (en) | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
| CA2359816C (en) * | 1999-01-06 | 2010-08-03 | Genenews Inc. | Method for the detection of gene transcripts in blood and uses thereof |
| WO2000063441A2 (en) * | 1999-04-20 | 2000-10-26 | Mitokor | Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease |
| WO2002070738A2 (en) | 2001-03-07 | 2002-09-12 | Andre Schuh | Diagnosis and treatment of blood disorders |
| GB2380194B (en) | 2001-10-01 | 2005-06-22 | Roger Michael Marchbanks | A mitochondrial mutation associated with schizophrenia and increased oxidative stress |
| US6977162B2 (en) | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
| WO2005043121A2 (en) | 2003-10-31 | 2005-05-12 | Vitatex, Inc. | Blood test prototypes and methods for the detection of circulating tumor and endothelial cells |
| WO2005111231A2 (en) | 2004-05-11 | 2005-11-24 | Heptest Laboratories, Inc. | Compositions, kit and one-step method for monitoring compounds having anti-factor xa and/or anti factor iia activities |
| FR2877013A1 (fr) | 2004-10-27 | 2006-04-28 | Assist Publ Hopitaux De Paris | Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez |
| ATE438856T1 (de) * | 2005-06-22 | 2009-08-15 | Univ Johns Hopkins | Biomarker für eierstockkrebs: mit ctap3 verwandte proteine |
| US20070059774A1 (en) | 2005-09-15 | 2007-03-15 | Michael Grisham | Kits for Prenatal Testing |
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| US20070059781A1 (en) | 2005-09-15 | 2007-03-15 | Ravi Kapur | System for size based separation and analysis |
| US20090042869A1 (en) | 2007-06-20 | 2009-02-12 | University Of Utah Research Foundation | SIGNAL-DEPENDENT SPLICING OF TISSUE FACTOR PRE-mRNA IN PLATELET CELLS |
| CN101298630A (zh) * | 2008-06-11 | 2008-11-05 | 南京大学 | 一种Solexa技术鉴定结肠癌病人血清中微小核糖核酸的方法 |
| CN101363046A (zh) * | 2008-08-29 | 2009-02-11 | 芮屈生物技术（上海）有限公司 | 一种广谱性癌症原位杂交检测试剂盒及其检测方法和应用 |
| US11634747B2 (en) | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
| EP2336353A1 (en) * | 2009-12-17 | 2011-06-22 | febit holding GmbH | miRNA fingerprints in the diagnosis of diseases |
| WO2012008839A2 (en) | 2010-07-16 | 2012-01-19 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg | A method of analysing a blood sample of a subject for the presence of a disease marker |
| AU2012231884B2 (en) | 2011-03-18 | 2017-03-09 | Stichting Vumc | A method of analysing a blood sample of a subject for the presence of a disease marker |
| WO2013022342A1 (en) | 2011-08-09 | 2013-02-14 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg | A method of analysing a blood sample of a subject for the presence of a foetal disease or condition marker |
-
2012
- 2012-01-16 AU AU2012231884A patent/AU2012231884B2/en not_active Ceased
- 2012-01-16 MX MX2013010594A patent/MX347555B/es active IP Right Grant
- 2012-01-16 WO PCT/NL2012/050025 patent/WO2012128616A1/en active Application Filing
- 2012-01-16 JP JP2013558804A patent/JP5934726B2/ja active Active
- 2012-01-16 US US14/006,089 patent/US10174365B2/en active Active
- 2012-01-16 CN CN201280024044.7A patent/CN103547920B/zh active Active
- 2012-01-16 EP EP18198351.1A patent/EP3483607A1/en not_active Withdrawn
- 2012-01-16 EP EP12702324.0A patent/EP2686677B1/en active Active
- 2012-01-16 BR BR112013023960-3A patent/BR112013023960B1/pt active IP Right Grant
- 2012-01-16 CA CA2830461A patent/CA2830461C/en active Active
- 2012-01-16 SG SG2013070487A patent/SG193539A1/en unknown
-
2018
- 2018-11-28 US US16/202,474 patent/US20190233886A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014512811A (ja) | 2014-05-29 |
| US10174365B2 (en) | 2019-01-08 |
| JP5934726B2 (ja) | 2016-06-15 |
| CN103547920B (zh) | 2016-08-17 |
| AU2012231884B2 (en) | 2017-03-09 |
| US20190233886A1 (en) | 2019-08-01 |
| AU2012231884A2 (en) | 2014-05-08 |
| CA2830461A1 (en) | 2012-09-27 |
| CA2830461C (en) | 2021-06-29 |
| BR112013023960B1 (pt) | 2020-12-01 |
| EP3483607A1 (en) | 2019-05-15 |
| EP2686677B1 (en) | 2018-10-03 |
| SG193539A1 (en) | 2013-10-30 |
| BR112013023960A2 (pt) | 2016-12-13 |
| US20140199693A1 (en) | 2014-07-17 |
| AU2012231884A1 (en) | 2013-10-10 |
| MX2013010594A (es) | 2014-07-09 |
| WO2012128616A1 (en) | 2012-09-27 |
| CN103547920A (zh) | 2014-01-29 |
| EP2686677A1 (en) | 2014-01-22 |
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| FG | Grant or registration |