MX344257B - Agentes antimicrobianos. - Google Patents

Agentes antimicrobianos.

Info

Publication number
MX344257B
MX344257B MX2013007313A MX2013007313A MX344257B MX 344257 B MX344257 B MX 344257B MX 2013007313 A MX2013007313 A MX 2013007313A MX 2013007313 A MX2013007313 A MX 2013007313A MX 344257 B MX344257 B MX 344257B
Authority
MX
Mexico
Prior art keywords
peptide
gram
relates
present
synthetic
Prior art date
Application number
MX2013007313A
Other languages
English (en)
Other versions
MX2013007313A (es
Inventor
Lavigne Rob
Briers Yves
Miller Stefan
Walmagh Maarten
Original Assignee
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leuven Kath filed Critical Univ Leuven Kath
Publication of MX2013007313A publication Critical patent/MX2013007313A/es
Publication of MX344257B publication Critical patent/MX344257B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pest Control & Pesticides (AREA)
  • Analytical Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

La presente invención se refiere a una proteína de fusión compuesta de una enzima que tiene la actividad de degradar la pared celular de las bacterias Gram-negativas y/o bacterias Gram-positivas y al menos dos alargamientos de péptidos fusionados a la enzima en el N-o C-Terminal, caracterizada porque los alargamientos de péptido tienen una longitud de 5 a 50 residuos de aminoácidos y en donde los alargamientos de péptido son un péptido policatiónico y un péptido antimicrobiano; y en donde la enzima exhibe una secuencia de aminoácido que se selecciona del grupo que consiste de las SEC ID NOS: 1ª 18, en donde al menos 70% de los residuos de aminoácido del péptido policatiónico son residuos de aminoácido positivamente cargados, en particular de lisina y/o arginina, y en donde el péptido antimicrobiano exhibe una secuencia de aminoácido que se selecciona del grupo que consiste de la SEC ID Nos: 44 a 63 y 78 a 98.
MX2013007313A 2010-12-23 2011-12-23 Agentes antimicrobianos. MX344257B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10196890A EP2468856A1 (en) 2010-12-23 2010-12-23 Antimicrobial Agents
PCT/EP2011/073908 WO2012085259A2 (en) 2010-12-23 2011-12-23 Antimicrobial agents

Publications (2)

Publication Number Publication Date
MX2013007313A MX2013007313A (es) 2013-10-25
MX344257B true MX344257B (es) 2016-12-09

Family

ID=44310766

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013007313A MX344257B (es) 2010-12-23 2011-12-23 Agentes antimicrobianos.

Country Status (11)

Country Link
US (1) US20130344055A1 (es)
EP (2) EP2468856A1 (es)
JP (1) JP2014507933A (es)
CN (1) CN103403153A (es)
AR (1) AR084536A1 (es)
AU (1) AU2011347152B2 (es)
CA (1) CA2822732C (es)
EA (1) EA201370145A1 (es)
MX (1) MX344257B (es)
TW (1) TW201239095A (es)
WO (1) WO2012085259A2 (es)

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US9388400B2 (en) 2012-06-29 2016-07-12 Lysando Ag Composition for use in mycobacteria diagnosis
EP2679677A1 (en) * 2012-06-29 2014-01-01 Lysando Aktiengesellschaft Composition for use in Mycobacteria therapy
WO2015070911A1 (en) 2013-11-14 2015-05-21 Lysando Ag Modified kz144 endolysin sequence
WO2015070912A1 (en) * 2013-11-14 2015-05-21 Lysando Ag Modified el188 endolysin sequence
WO2015121443A1 (en) * 2014-02-14 2015-08-20 Lysando Ag Antimicrobial agents
EA201692031A1 (ru) 2014-04-08 2017-07-31 Лисандо Аг Фармацевтическая композиция с активным действием в отношении хронических бактериальных инфекций
ES2767294T3 (es) 2014-06-26 2020-06-17 Univ Rockefeller Lisinas de Acinetobacter
WO2016130024A1 (en) * 2015-02-13 2016-08-18 Supreme Biotechnologies Limited Endolysin expression platform
CN115475232A (zh) * 2015-03-23 2022-12-16 激流生物科学有限公司 抗微生物肽及其使用方法
US11357833B2 (en) 2015-09-17 2022-06-14 Contrafect Corporation Use of lysin to restore/augment antibacterial activity in the presence of pulmonary surfactant of antibiotics inhibited thereby
US11208646B2 (en) 2016-05-27 2021-12-28 Sasinapas Co., Ltd. Endolysin variant
AU2017360064C1 (en) * 2016-11-18 2022-04-07 Lysando Ag New antimicrobial agents against staphylococcus aureus
MX2019011808A (es) * 2017-04-03 2020-01-09 Sasinapas Co Ltd Endolisinas de gram-negativas modificadas.
CN110256570B (zh) * 2017-12-26 2021-01-05 杭州皇冠农业生物工程技术研究中心有限公司 一种重组融合抗菌肽及应用
CN108251330B (zh) * 2017-12-28 2021-03-23 江苏世邦生物工程科技有限公司 用于治理土壤污染的复合微生物菌剂及其制备方法和应用
US10738093B2 (en) * 2018-01-25 2020-08-11 The Hong Kong University Of Science And Technology Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
WO2019191633A2 (en) * 2018-03-29 2019-10-03 Contrafect Corporation Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof
CN108410840A (zh) * 2018-04-03 2018-08-17 大连理工大学 一种铜绿假单胞菌噬菌体内溶素及其编码基因与应用
WO2019211643A1 (en) * 2018-05-04 2019-11-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for treating gram positive bacterial infection
AU2019276253A1 (en) * 2018-05-30 2020-11-26 Lysando Ag Novel antimicrobial proteins
US20210198645A1 (en) * 2018-05-30 2021-07-01 Lysando Ag Novel antimicrobial fusion proteins
US11981755B2 (en) * 2018-08-28 2024-05-14 Ultupharma Ab Peptide compounds
GB201901364D0 (en) * 2019-01-31 2019-03-20 Axitan Ltd Endolysins
WO2021042039A1 (en) * 2019-08-29 2021-03-04 Ajk Pharmaceutical Llc Synthetic antimicrobial peptides
IL296529A (en) 2020-03-19 2022-11-01 Micreos Human Health Bv Preferably a stabilized protein
IT202000006481A1 (it) * 2020-03-27 2021-09-27 Sanidrink S R L Condotti tubolari antimicrobici
IT202000006511A1 (it) * 2020-03-27 2021-09-27 Materias S R L Peptidi antimicrobici
WO2021235876A1 (ko) * 2020-05-22 2021-11-25 주식회사 라이센텍 신규한 폴리펩타이드, 융합 폴리펩타이드, 및 이를 포함하는 그람음성균에 대한 항생제
CN111955538B (zh) * 2020-08-10 2022-09-30 浙江工商大学 一种大黄鱼保鲜剂及其使用方法
CN112480230B (zh) * 2020-11-30 2022-05-03 青岛农业大学 一种具有更好抗热功能的抗菌肽及其应用
CN115323023B (zh) * 2021-12-17 2024-05-03 河南牧业经济学院 一种治疗奶牛***炎药物的制备方法
CN114651819A (zh) * 2022-03-10 2022-06-24 上海芜玮建晖生物科技有限公司 一种基于海洋资源的有机消毒剂
CN115433686B (zh) * 2022-06-14 2024-03-22 天津市农业科学院 死亡素和斑点叉尾鮰β-防御素基因重组毕赤酵母的构建方法及应用
CN115873076B (zh) * 2022-11-24 2024-07-16 青岛农业大学 一种抗菌肽及其在枯草芽孢杆菌中的表达和应用
CN118240803B (zh) * 2024-05-23 2024-08-13 中国农业科学院生物技术研究所 牛瘤胃来源的溶菌酶及其应用

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Also Published As

Publication number Publication date
EA201370145A1 (ru) 2013-11-29
AU2011347152B2 (en) 2016-08-04
CA2822732A1 (en) 2012-06-28
EP2655610A2 (en) 2013-10-30
US20130344055A1 (en) 2013-12-26
AR084536A1 (es) 2013-05-22
AU2011347152A1 (en) 2013-07-11
MX2013007313A (es) 2013-10-25
CN103403153A (zh) 2013-11-20
WO2012085259A3 (en) 2012-08-30
WO2012085259A2 (en) 2012-06-28
JP2014507933A (ja) 2014-04-03
TW201239095A (en) 2012-10-01
CA2822732C (en) 2021-01-26
EP2655610B1 (en) 2016-11-16
EP2468856A1 (en) 2012-06-27

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