MX341785B - Sistemas de sintasa de poliquetida pufa y uso de los mismos. - Google Patents

Sistemas de sintasa de poliquetida pufa y uso de los mismos.

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Publication number
MX341785B
MX341785B MX2011000195A MX2011000195A MX341785B MX 341785 B MX341785 B MX 341785B MX 2011000195 A MX2011000195 A MX 2011000195A MX 2011000195 A MX2011000195 A MX 2011000195A MX 341785 B MX341785 B MX 341785B
Authority
MX
Mexico
Prior art keywords
systems
pufa
polyketide synthase
pufa pks
nucleic acid
Prior art date
Application number
MX2011000195A
Other languages
English (en)
Inventor
G Metz James
A Weaver Craig
R Barclay William
H Flatt James
Original Assignee
Dsm Ip Assets B V *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets B V * filed Critical Dsm Ip Assets B V *
Publication of MX341785B publication Critical patent/MX341785B/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)

Abstract

La presente invención se refiere generalmente a sistemas de sintasa de poliquétida (PKS) de ácido graso poliinsaturado (PUFA), a homólogos de los mismos, a moléculas aisladas de ácido nucleico y moléculas recombinantes de ácido nucleico que codifican los dominios activos, tales como un sistema PUFA PKS, a organismos modificados genéticamente que comprenden sistemas PUFA PKS, a métodos de elaboración y el uso de dichos sistemas producción de moléculas bioactivas de interés y a para la métodos novedosos para identificar nuevos microorganismos bacterianos y no bacterianos que tienen dicho sistema PUFA PKS.
MX2011000195A 2003-03-26 2004-03-26 Sistemas de sintasa de poliquetida pufa y uso de los mismos. MX341785B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45797903P 2003-03-26 2003-03-26
PCT/US2004/009323 WO2004087879A2 (en) 2003-03-26 2004-03-26 Pufa polyketide synthase systems and uses thereof

Publications (1)

Publication Number Publication Date
MX341785B true MX341785B (es) 2016-09-01

Family

ID=33131738

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2011000195A MX341785B (es) 2003-03-26 2004-03-26 Sistemas de sintasa de poliquetida pufa y uso de los mismos.
MXPA05010214A MXPA05010214A (es) 2003-03-26 2004-03-26 Sistemas de sintasa de poliquetida pufa y uso de los mismos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MXPA05010214A MXPA05010214A (es) 2003-03-26 2004-03-26 Sistemas de sintasa de poliquetida pufa y uso de los mismos.

Country Status (12)

Country Link
EP (1) EP1623008B1 (es)
JP (3) JP2007524377A (es)
KR (3) KR101234200B1 (es)
CN (1) CN101389213B (es)
AU (2) AU2004225485B2 (es)
BR (1) BRPI0409046A (es)
CA (1) CA2520396C (es)
ES (1) ES2516641T3 (es)
HK (1) HK1088632A1 (es)
IL (1) IL200625A0 (es)
MX (2) MX341785B (es)
WO (1) WO2004087879A2 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340742A (en) 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US6566583B1 (en) 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
US7247461B2 (en) 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
US7211418B2 (en) 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US8003772B2 (en) * 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
US7217856B2 (en) 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
CZ301130B6 (cs) 2000-01-28 2009-11-11 Martek Biosciences Corporation Zvýšená produkce lipidu obsahujících polyenové mastné kyseliny ve fermentorech kulturami mikrobu s vysokou hustotou ve fermentorech
WO2007005725A2 (en) 2005-07-01 2007-01-11 Martek Biosciences Corporation Polyunsaturated fatty acid-containing oil product and uses and production thereof
GB0603160D0 (en) * 2006-02-16 2006-03-29 Rothamsted Res Ltd Nucleic acid
JP2009529891A (ja) 2006-03-15 2009-08-27 マーテック バイオサイエンシーズ コーポレーション 多価不飽和脂肪酸を含む植物種子油
US20080145475A1 (en) * 2006-08-29 2008-06-19 Martek Biosciences Corporation Use of DPA(n-6) Oils in Infant Formula
US20120100550A1 (en) * 2009-03-04 2012-04-26 University Of Miyazaki Method for determining fatty acid synthesis pathway of microorganism, and pcr primer set for use in the method
AU2010225930B2 (en) 2009-03-16 2017-01-12 Dsm Ip Assets B.V. Protein production in microorganisms of the phylum Labyrinthulomycota
ES2623610T3 (es) 2009-03-19 2017-07-11 Dsm Ip Assets B.V. Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos
EP2614829A1 (en) 2012-01-11 2013-07-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons
KR101570771B1 (ko) 2013-11-18 2015-11-23 대한민국 고도불포화지방산 생합성을 위한 재조합 벡터 및 이를 이용하여 제작된 형질전환 식물체
JP6682109B2 (ja) * 2015-01-09 2020-04-15 国立大学法人 宮崎大学 ヤブレツボカビ類を用いたリグニン分解活性を有するタンパク質の製造方法
CN109477079A (zh) * 2016-05-12 2019-03-15 帝斯曼知识产权资产管理有限公司 增加微藻中ω-3多不饱和脂肪酸产量的方法
BR112021002299A2 (pt) * 2018-08-10 2021-05-04 Kyowa Hakko Bio Co., Ltd micro-organismo produzindo ácido graxo poli-insaturado e método para produzir ácido graxo poli-insaturado
US11613728B2 (en) 2018-08-10 2023-03-28 Kyowa Hakko Bio Co., Ltd. Microorganism producing eicosapentaenoic acid and method for producing eicosapentaenoic acid

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340742A (en) * 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
JP2002510205A (ja) * 1997-06-04 2002-04-02 カルジーン エルエルシー ポリケチド様合成遺伝子を植物内で発現させることによる多不飽和脂肪酸の製造
US6566583B1 (en) * 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
US6677145B2 (en) * 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US7247461B2 (en) * 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
ATE510908T1 (de) * 2000-09-28 2011-06-15 Bioriginal Food & Science Corp Fad5-2, mitglied der desaturase-familie und verwendungen davon
TWI426126B (zh) * 2001-04-16 2014-02-11 Dsm Ip Assets Bv 多不飽和脂肪酸（ｐｕｆａ）聚乙醯合成酶系統及其用途（二）
WO2002094861A2 (en) * 2001-05-21 2002-11-28 Ecopia Biosciences Inc. Genes and proteins involved in the biosynthesis of enediyne ring structures

Also Published As

Publication number Publication date
WO2004087879A2 (en) 2004-10-14
EP1623008B1 (en) 2014-07-30
ES2516641T3 (es) 2014-10-31
AU2008249169B2 (en) 2012-03-15
JP2013143945A (ja) 2013-07-25
KR101234198B1 (ko) 2013-02-19
IL200625A0 (en) 2011-07-31
KR20120097502A (ko) 2012-09-04
JP5890791B2 (ja) 2016-03-22
JP2007524377A (ja) 2007-08-30
CA2520396C (en) 2016-08-09
JP2016000048A (ja) 2016-01-07
MXPA05010214A (es) 2005-12-14
EP1623008A2 (en) 2006-02-08
KR20060006014A (ko) 2006-01-18
KR101234199B1 (ko) 2013-02-20
WO2004087879A3 (en) 2008-07-24
HK1088632A1 (en) 2006-11-10
BRPI0409046A (pt) 2006-04-18
JP6134361B2 (ja) 2017-05-24
EP1623008A4 (en) 2009-05-27
AU2008249169A1 (en) 2008-12-11
CN101389213B (zh) 2014-05-28
CA2520396A1 (en) 2004-10-14
KR101234200B1 (ko) 2013-02-19
KR20120123726A (ko) 2012-11-09
AU2004225485A1 (en) 2004-10-14
AU2004225485B2 (en) 2008-08-21
CN101389213A (zh) 2009-03-18

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