MX339973B - Compuestos 3-fenilsulfanilmetil-biciclo [3.1.0] hexano 4-sustituidos como antagonistas de mglur 2/3. - Google Patents

Compuestos 3-fenilsulfanilmetil-biciclo [3.1.0] hexano 4-sustituidos como antagonistas de mglur 2/3.

Info

Publication number
MX339973B
MX339973B MX2013005622A MX2013005622A MX339973B MX 339973 B MX339973 B MX 339973B MX 2013005622 A MX2013005622 A MX 2013005622A MX 2013005622 A MX2013005622 A MX 2013005622A MX 339973 B MX339973 B MX 339973B
Authority
MX
Mexico
Prior art keywords
phenylsulfanylmethyl
mglur
bicyclo
antagonists
substituted
Prior art date
Application number
MX2013005622A
Other languages
English (en)
Other versions
MX2013005622A (es
Inventor
Howard Mitch Charles
Li Renhua
Natali Vetman Tatiana
Cornell Smith Stephon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45099188&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX339973(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2013005622A publication Critical patent/MX2013005622A/es
Publication of MX339973B publication Critical patent/MX339973B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

Abstract

Se describe un antagonista del receptor mGIu2/3 de la fórmula (I): sus usos, y métodos para su preparación (Ver Formula).
MX2013005622A 2010-11-18 2011-11-15 Compuestos 3-fenilsulfanilmetil-biciclo [3.1.0] hexano 4-sustituidos como antagonistas de mglur 2/3. MX339973B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41512110P 2010-11-18 2010-11-18
PCT/US2011/060730 WO2012068067A1 (en) 2010-11-18 2011-11-15 4-substituted-3-phenylsulfanylmethyl-bicyclo[3.1.0]hexane compounds as mglur 2/3 antagonists

Publications (2)

Publication Number Publication Date
MX2013005622A MX2013005622A (es) 2013-07-05
MX339973B true MX339973B (es) 2016-06-20

Family

ID=45099188

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005622A MX339973B (es) 2010-11-18 2011-11-15 Compuestos 3-fenilsulfanilmetil-biciclo [3.1.0] hexano 4-sustituidos como antagonistas de mglur 2/3.

Country Status (36)

Country Link
US (1) US8629169B2 (es)
EP (1) EP2640697B1 (es)
JP (1) JP5877847B2 (es)
KR (2) KR20150140876A (es)
CN (1) CN103228625B (es)
AR (1) AR083845A1 (es)
AU (1) AU2011329076B2 (es)
BR (1) BR112013012118A2 (es)
CA (1) CA2818116C (es)
CL (1) CL2013001345A1 (es)
CO (1) CO6761385A2 (es)
CR (1) CR20130178A (es)
DK (1) DK2640697T3 (es)
DO (1) DOP2013000099A (es)
EA (1) EA021724B1 (es)
EC (1) ECSP13012629A (es)
ES (1) ES2650139T3 (es)
GT (1) GT201300126A (es)
HR (1) HRP20171649T1 (es)
HU (1) HUE037457T2 (es)
IL (1) IL225843A (es)
LT (1) LT2640697T (es)
MA (1) MA34663B1 (es)
MX (1) MX339973B (es)
NO (1) NO2640697T3 (es)
NZ (1) NZ609816A (es)
PE (1) PE20140997A1 (es)
PL (1) PL2640697T3 (es)
PT (1) PT2640697T (es)
RS (1) RS56535B1 (es)
SG (1) SG189959A1 (es)
SI (1) SI2640697T1 (es)
TW (1) TWI520935B (es)
UA (1) UA110039C2 (es)
WO (1) WO2012068067A1 (es)
ZA (1) ZA201302918B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2978B1 (en) * 2009-12-21 2016-03-15 ايلي ليلي اند كومباني MGLU2 aids
EP3000814A1 (en) 2014-09-26 2016-03-30 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
DK3445743T3 (da) 2016-04-18 2021-10-18 Taisho Pharmaceutical Co Ltd Prodrug af aminosyrederivat
WO2018136437A2 (en) 2017-01-17 2018-07-26 Tesaro, Inc. Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
WO2020018670A1 (en) * 2018-07-17 2020-01-23 Board Of Regents, The University Of Texas System Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0669928B2 (ja) 1987-10-06 1994-09-07 宇部興産株式会社 光重合性歯科材料
JP2589812B2 (ja) 1989-07-05 1997-03-12 松下電器産業株式会社 スチームアイロン
ZA969485B (en) 1995-11-16 1998-05-12 Lilly Co Eli Excitatory amino acid receptor antagonists.
AU703093B2 (en) * 1995-11-16 1999-03-18 Eli Lilly And Company Excitatory amino acid receptor antagonists
ZA983930B (en) * 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
CZ20003355A3 (cs) * 1998-03-17 2002-05-15 Pfizer Products Inc. Bicyklo[2,2,1]heptany a příbuzné sloučeniny, farmaceutické kompozice a způsoby léčení na jejich bázi
GB9815542D0 (en) 1998-07-17 1998-09-16 Lilly Co Eli Bicyclohexane derivatives
CH694053A5 (de) 1998-09-03 2004-06-30 Hoffmann La Roche Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten.
EP1370519A1 (en) * 2001-02-22 2003-12-17 Eli Lilly And Company Synthetic excitatory amino acids
PT1459765E (pt) 2001-12-27 2008-10-03 Taisho Pharmaceutical Co Ltd Derivados de 6-fluorobiciclo [3.1.0] hexano
NZ564692A (en) 2002-06-11 2009-05-31 Lilly Co Eli Prodrugs of excitatory amino acids
NZ580554A (en) * 2003-06-26 2011-01-28 Taisho Pharmaceutical Co Ltd 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic ester derivative
US7381746B2 (en) * 2003-06-26 2008-06-03 Taisho Pharmaceutical Co., Ltd. 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative
JP2007063129A (ja) 2003-06-26 2007-03-15 Taisho Pharmaceut Co Ltd ２−アミノ−３−アルコキシビシクロ［３．１．０］ヘキサン誘導体
JO2978B1 (en) * 2009-12-21 2016-03-15 ايلي ليلي اند كومباني MGLU2 aids

Also Published As

Publication number Publication date
ZA201302918B (en) 2014-10-29
EP2640697B1 (en) 2017-09-20
US20120129902A1 (en) 2012-05-24
MX2013005622A (es) 2013-07-05
EA201390498A1 (ru) 2013-07-30
UA110039C2 (xx) 2015-11-10
AR083845A1 (es) 2013-03-27
CN103228625B (zh) 2014-12-03
CA2818116A1 (en) 2012-05-24
WO2012068067A1 (en) 2012-05-24
KR20150140876A (ko) 2015-12-16
TW201307271A (zh) 2013-02-16
SG189959A1 (en) 2013-06-28
ECSP13012629A (es) 2013-07-31
PT2640697T (pt) 2017-12-11
GT201300126A (es) 2014-02-27
TWI520935B (zh) 2016-02-11
US8629169B2 (en) 2014-01-14
MA34663B1 (fr) 2013-11-02
EP2640697A1 (en) 2013-09-25
RS56535B1 (sr) 2018-02-28
IL225843A0 (en) 2013-06-27
JP5877847B2 (ja) 2016-03-08
CR20130178A (es) 2013-07-09
BR112013012118A2 (pt) 2016-09-27
CA2818116C (en) 2016-04-05
DOP2013000099A (es) 2013-08-15
EA021724B1 (ru) 2015-08-31
HRP20171649T1 (hr) 2017-12-15
SI2640697T1 (sl) 2017-11-30
LT2640697T (lt) 2018-01-10
PE20140997A1 (es) 2014-08-25
JP2014505664A (ja) 2014-03-06
CO6761385A2 (es) 2013-09-30
PL2640697T3 (pl) 2018-02-28
NO2640697T3 (es) 2018-02-17
DK2640697T3 (en) 2017-10-23
KR20130101094A (ko) 2013-09-12
CL2013001345A1 (es) 2013-11-15
NZ609816A (en) 2014-12-24
AU2011329076B2 (en) 2015-03-12
AU2011329076A1 (en) 2013-05-02
IL225843A (en) 2015-05-31
CN103228625A (zh) 2013-07-31
ES2650139T3 (es) 2018-01-17
HUE037457T2 (hu) 2018-08-28

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